Pharmacological profiles of new orally active nonpeptide tachykinin NK1 receptor antagonists

European Journal of Pharmacology

Volumn 341, Issue 2-3, 1998, Pages 235-241

  Hosoki, Rumiko ^a   Yanagisawa, Mitsuhiko ^a   Onishi, Yuko ^a   Yoshioka, Koichi ^a   Otsuka, Masanori ^a  

^a TOKYO MEDICAL AND DENTAL UNIVERSITY   (Japan)

Author keywords

Ileum, guinea pig; Portal vein, rat; Spinal cord; Substance P; Tachykinin receptor antagonist; Vas deferens, rat

Indexed keywords

3 (2 METHOXYBENZYLAMINO) 2 PHENYLPIPERIDINE; ACETYLCHOLINE; ATROPINE; GLUTAMIC ACID; INDOMETACIN; MEPYRAMINE; N [3,5 BIS(TRIFLUOROMETHY)BENZYL] 5 (4 FLUOROPHENYL) 7,8 DIHYDRO N,7 DIMETHYL 8 OXO 1,7 NAPHTHYRIDINE 6 CARBOXAMIDE; N [3,5 BIS(TRIFLUOROMETHYL)BENZYL] 1,2 DIHYDRO N METHYL 1 OXO 4 PHENYL 3 ISOQUINOLINE CARBOXAMIDE; N [3,5 BIS(TRIFLUOROMETHYL)BENZYL] 5 (4 FLUOROPHENYL) 6, 7 DIHYRO N,6 DIMETHYL 7 OXOTHIENO[2,3 C]PYRIDINE 5 CARBOXAMIDE; NEUROKININ 1 RECEPTOR; NEUROKININ 1 RECEPTOR ANTAGONIST; NEUROKININ A; SENKTIDE; SUBSTANCE P; TETRODOTOXIN; UNCLASSIFIED DRUG;

ANIMAL TISSUE; ARTICLE; CONCENTRATION RESPONSE; DEPOLARIZATION; DRUG SYNTHESIS; GERBIL; GUINEA PIG; ILEUM; MALE; NONHUMAN; PORTAL VEIN; PRIORITY JOURNAL; RAT; SPINAL CORD; VAS DEFERENS; VENTRAL ROOT;

ADMINISTRATION, ORAL; ANIMALS; DOSE-RESPONSE RELATIONSHIP, DRUG; FEMALE; GERBILLINAE; GUINEA PIGS; ILEUM; MALE; PIPERIDINES; PORTAL VEIN; RATS; RATS, WISTAR; RECEPTORS, TACHYKININ; SPINAL CORD; SUBSTANCE P; VAS DEFERENS;

EID: 0032509710     PISSN: 00142999     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0014-2999(97)01468-4     Document Type: Article

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