Filling the hole: Evidence of a small molecule binding to the fusion core pocket in human respiratory syncytial virus

Expert Opinion on Investigational Drugs

Volumn 14, Issue 2, 2005, Pages 195-197

  Gao, George F ^a,b  

^a INSTITUTE OF MICROBIOLOGY   (China)

^b UNIVERSITY OF OXFORD   (United Kingdom)

Author keywords

BMS 356188; BMS 433771; Fusion core; Heptad repeat; Inner coiled core; Pocket; Small molecule; Trimer of hairpin; Viral fusion

Indexed keywords

ANTIVIRUS AGENT; BMS 356188; BMS 433771; IODINE 125; MONOCLONAL ANTIBODY; SHORT HAIRPIN RNA; UNCLASSIFIED DRUG; VIRUS ENVELOPE PROTEIN; VIRUS FUSION PROTEIN;

AMINO ACID SUBSTITUTION; ANIMAL EXPERIMENT; ANIMAL MODEL; ANTIVIRAL ACTIVITY; ARTICLE; BINDING AFFINITY; BINDING SITE; CONCENTRATION RESPONSE; CRYSTAL STRUCTURE; DOSE RESPONSE; EXPERIMENTAL DESIGN; IN VITRO STUDY; IN VIVO STUDY; NONHUMAN; PHOTOAFFINITY LABELING; RAT; RESPIRATORY SYNCYTIAL PNEUMOVIRUS; SEQUENCE ANALYSIS; ULTRAVIOLET IRRADIATION; VIRUS INHIBITION; VIRUS REPLICATION;

BENZIMIDAZOLES; BINDING SITES; HUMANS; PROTEIN STRUCTURE, TERTIARY; RESPIRATORY SYNCYTIAL VIRUS, HUMAN; VIRAL FUSION PROTEINS;

EID: 15544386225     PISSN: 13543784     EISSN: None     Source Type: Journal    
DOI: 10.1517/13543784.14.2.195     Document Type: Article

References (9)

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