Animal models of anxiety and their molecular dissection

Seminars in Cell and Developmental Biology

Volumn 14, Issue 1, 2003, Pages 37-42

  Flint, Jonathan ^a  

^a UNIVERSITY OF OXFORD   (United Kingdom)

Author keywords

Anxiety; Genetics; Mouse; QTL

Indexed keywords

BENZODIAZEPINE DERIVATIVE; HALOPERIDOL; IMIPRAMINE; MIANSERIN;

ALLELE; ANIMAL; ANIMAL BEHAVIOR; ANIMAL MODEL; ANXIETY DISORDER; AUDITORY STIMULATION; AVOIDANCE BEHAVIOR; BEHAVIOR DISORDER; BODY POSTURE; CHROMOSOME 10; CHROMOSOME 5; DISEASE MODEL; EMOTIONALITY; ENVIRONMENT; FEAR; GENE IDENTIFICATION; GENE LOCATION; GENE LOCUS; GENE MAPPING; GENE MUTATION; GENETIC ANALYSIS; GENETIC PROCEDURES; GENETIC TRAIT; GENETIC VARIABILITY; GENETICS; GROOMING; HUMAN; MAZE TEST; MEASUREMENT; MENTAL DISEASE; METHODOLOGY; MOLECULAR BIOLOGY; MOLECULAR CLONING; NONHUMAN; OPEN FIELD BEHAVIOR; PHENOTYPE; REARING; REVIEW; SHOCK; SOCIAL INTERACTION; VALIDATION PROCESS;

ANIMALIA;

EID: 0037327678     PISSN: 10849521     EISSN: None     Source Type: Journal    
DOI: 10.1016/S1084-9521(02)00170-2     Document Type: Review

References (27)

1. Bailey A., Lecouteur A., Gottesman I., Bolton P., Simonoff E., Yuzda E.et al. Autism as a strongly genetic disorder - evidence from a British twin study. Psychol. Med. 25:1995;63-77.
2. Plomin R., Owen M.J., McGuffin P. The genetic basis of complex human behaviours. Science. 264:1994;1733-1739.
3. Baron M. The search for complex disease genes: fault by linkage or fault by association? Mol. Psychiatry. 6:2001;143-149.
4. Montgomery K.C. The relation between fear induced by novel stimulation and exploratory behaviour. J. Comp. Physiol. Psychol. 48:1958;254-260.
5. Rodgers R.J., Cao B.J., Dalvi A., Holmes A. Animal models of anxiety: an ethological perspective. Br. J. Med. Bio. Res. 30:1997;289-304.
6. Rodgers RJ, Cole JC. The elevated plus maze: pharmacology, methodology and ethology. In: Cooper SJ, editor. Ethology and psychopharmacology. Chichester: Wiley, 1994. p. 1-22.
7. Rodgers R.J., Johnson J.T. Factor analysis of spatiotemporal and ethological measures in the murine elevated plus maze of anxiety. Pharmacol. Biochem. Behav. 52:1995;297-303.
8. Willner P. Animal models for clinical psychopharmacology: depression, anxiety, schizophrenia. Int. Rev. Psychiatry. 2:1990;253-276.
9. Pellow S., File S.E. Anxiolytic and anxiogenic drug effects in exploratory activity in an elevated plus maze: a novel test of anxiety in the rat. Pharmacol. Biochem. Behav. 24:1986;525.
10. Pellow S., Chopin P., File S., Briley M. Validation of open:closed arms entries in an elevated plus maze as a measure of anxiety in the rat. J. Neurosci. Methods. 14:1985;149-167.
11. File S.E., Mabbutt P.S., Hitchcott P.K. Characterisation of the phenomenon of 'one-trial tolerance' to the anxiolytic effect of chlordiazepoxide in the elevated plus maze. Psychopharmacology. 102:1990;98-101.
12. File S.E., Zangrossi H. Jr. 'One-trial tolerance' to the anxiolytic actions of benzodiazepines in the elevated plus maze, or the development of a phobic state? Psychopharmacology. 110:1993;240-244.
13. Dawson G.R., Crawford S.P., Collinson N., Iversen S.D., Tricklebank M.D. Evidence that the anxiolytic-like effects of chlordiazepoxide on the elevated plus maze are confounded by increases in locomotor-activity. Psychopharmacology. 118:1995;316-323.
14. Gray JA. The neuropsychology of anxiety: an enquiry into the function of the septo-hippocampal system. Oxford: Oxford University Press, 1982.
15. Turri M.G., Datta S.R., DeFries J., Henderson N.D., Flint J. QTL analysis identifies multiple behavioral dimensions in ethological tests of anxiety in laboratory mice. Curr. Biol. 11:2001;725-734.
16. Turri M.G., Henderson N.D., DeFries J.C., Flint J. Quantitative trait locus mapping in laboratory mice derived from a replicated selection experiment for open-field activity. Genetics. 158:2001;1217-1226.
17. Fernandez-Teruel A., Escorihuela R.M., Gray J.A., Aguilar R., Gil L., Gimenez-Llort L.et al. A quantitative trait locus influencing anxiety in the laboratory rat. Genome Res. 12:2002;618-626.
18. Hogg S. A review of the validity and variability of the elevated plus maze as an animal model of anxiety. Pharmacol. Biochem. Behav. 54:1996;21-30.
19. Rodgers R.J., Dalvi A. Anxiety. Neurosci. Biobehav. Rev. 21:1997;801-810.
20. Lister R.G. Ethologically based animal models of anxiety disorders. Pharmacol. Ther. 46:1990;321-340.
21. Knott S.A., Haley C.S. Multitrait least squares for quantitative trait loci detection. Genetics. 156:2000;899-911.
22. Darvasi A., Soller M. Advanced intercross lines, an experimental population for fine genetic mapping. Genetics. 141:1995;1199-1207.
23. Talbot C.J., Nicod A., Cherny S.S., Fulker D.W., Collins A.C., Flint J. High-resolution mapping of quantitative trait loci in outbred mice. Nat. Genet. 21:1999;305-308.
24. Mott R., Talbot C.J., Turri M.G., Collins A.C., Flint J. A method for fine mapping quantitative trait loci in outbred animal stocks. Proc. Natl. Acad. Sci. U.S.A. 97:2000;12649-12654.
25. Mott R., Flint J. Simultaneous detection and fine mapping of quantitative trait loci in mice using heterogeneous stocks. Genetics. 160:2002;1609-1618.
26. Mackay T.F. Quantitative trait loci in Drosophila. Nat. Rev. Genet. 2:2001;11-20.
27. Gurganus M.C., Nuzhdin S.V., Leips J.W., Mackay T.F. High-resolution mapping of quantitative trait loci for sternopleural bristle number in Drosophila melanogaster. Genetics. 152:1999;1585-1604.