Over-expression of hepatic neutral cytosolic cholesteryl ester hydrolase in mice increases free cholesterol and reduces expression of HMG-CoAR, CYP27, and CYP7A1

Lipids

Volumn 40, Issue 1, 2005, Pages 31-38

  Langston, Timothy B ^a   Hylemon, Phillip B ^a   Grogan, W M ^a  

^a VIRGINIA COMMONWEALTH UNIVERSITY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

BIOCHEMISTRY; BIOLOGICAL ORGANS; CHOLESTEROL; ENZYMES; ESTERIFICATION; LIPIDS; LIVING SYSTEMS STUDIES; PRECIPITATION (CHEMICAL); VIRUSES;

ADENOVIRUS CONSTRUCT (ADCEH); FREE CHOLESTEROL (FC); HEPATIC NEUTRAL CYTOSOLIC CHOLESTERYL ESTER HYDROLASE (HNCCEH); MITOCHONDRIAS;

ESTERS;

4 NITROPHENOL; BETA GALACTOSIDASE; CHOLESTEROL; CHOLESTEROL 7ALPHA MONOOXYGENASE; CHOLESTEROL ESTER; CHOLESTEROL ESTERASE; COMPLEMENTARY DNA; HYDROXYMETHYLGLUTARYL COENZYME A REDUCTASE; MESSENGER RNA; OCTANOIC ACID; STEROL 27 HYDROXYLASE;

ADENOVIRUS; ANIMAL EXPERIMENT; ARTICLE; CONCENTRATION (PARAMETERS); CONTROLLED STUDY; ENZYME ACTIVITY; HOMEOSTASIS; HUMAN; HUMAN CELL; MITOCHONDRION; MOUSE; NONHUMAN; PROTEIN EXPRESSION; SUPERNATANT;

ANIMALS; CARBOXYLIC ESTER HYDROLASES; CHOLESTEROL; CHOLESTEROL 7-ALPHA-HYDROXYLASE; CHOLESTEROL ESTERASE; CHOLESTEROL ESTERS; CYTOCHROME P-450 CYP27A1; GENE EXPRESSION REGULATION, ENZYMOLOGIC; HYDROXYMETHYLGLUTARYL COA REDUCTASES; LIVER; MICE; RATS; STEROID HYDROXYLASES; SUBSTRATE SPECIFICITY; TRANSFECTION;

ADENOVIRIDAE; HUMAN HERPESVIRUS 5; TRIXIS;

EID: 15444374560     PISSN: 00244201     EISSN: None     Source Type: Journal    
DOI: 10.1007/s11745-005-1357-5     Document Type: Article

References (42)

1. Brown, J.S., and Goldstein, J.L. (1980) Multivalent Feedback Regulation of HMG CoA Reductase, a Control Mechanism Coordinating Isoprenoid Synthesis and Cell Growth, J. Lipid Res. 21, 505-517.
2. Schroepfer, G.J. (2000) Oxysterols: Modulators of Cholesterol Metabolism and Other Processes, Physiol. Rev. 80, 361-554.
3. Ness, G.C., and Chambers, C.M. (2000) Feedback and Hormonal Regulation of Hepatic 3-Hydroxy-3-methylglutaryl Coenzyme A Reductase: The Concept of Cholesterol Buffering Capacity, Proc. Soc. Exp. Biol. Med. 224, 8-19.
4. Erickson, S.K., Shrewsbury, M.A., Brools, C., and Myers, D.J. (1980) Rat Liver Acyl-Coenzyme A:Cholesterol Acyltransferase: Its Regulation in vivo and Some of Its Properties, J. Lipid Res. 21, 930-940.
5. Harry, D.S., Dini, M., and McIntyre, N. (1972) Effect of Cholesterol Feeding and Biliary Obstruction on Hepatic Cholesterol Biosynthesis in the Rat, Biochim. Biophys. Acta 296, 209-220.
6. Yap, P.M., and Tabas, I. (2001) Free Cholesterol Loading of Macrophage Is Associated with Widespread Mitochondrial Dysfunction and Activation of the Mitochondrial Apoptosis Pathway, J. Biol. Chem. 276, 42468-42476.
7. Tabas, I., Marathe, S., Kessler, G.A., Beatini, N., and Shiratori, Y. (1996) Evidence That the Initial Up-regulation of Phosphatidylcholine Biosynthesis in Free Cholesterol-Loaded Macrophages Is an Adaptive Response That Prevents Cholesterol-Induced Cellular Necrosis. Proposed Role of an Eventual Failure of This Response in Foam Cell Necrosis in Advanced Atherosclerosis. J. Biol. Chem. 271, 22773-22781.
8. Grogan, W.M., Bailey, M.L., Heuman, D.M., and Vlahcevic, Z.R. (1991) Effects of Perturbations in Hepatic Free and Esterified Cholesterol Pools on Bile Acid Synthesis, Cholesterol 7α-Hydroxylase, HMG-CoA Reductase, Acyl-CoA:Cholesterol Acyltransferase and Cytosolic Cholesteryl Ester Hydrolase, Lipids 26, 907-914.
9. Ghosh, S., Mallonee, D.H., Hylemon, P.B., and Grogan, W.M. (1995) Molecular Cloning and Expression of Rat Hepatic Neutral Cholesteryl Ester Hydrolase, Biochim. Biophys. Acta 1259, 305-312.
10. Ghosh, S., Natarajan, R., Pandak, W.M., Hylemon, P.B., and Grogan, W.M. (1998) Regulation of Hepatic Neutral Cholesteryl Ester Hydrolase by Hormones and Changes in Cholesterol Flux, Am. J. Physiol. 274, G662-G668.
11. Natarajan, R., Ghosh, S., and Grogan. W.M. (1998) Molecular Cloning of the Promoter for Rat Hepatic Neutral Cholesterol Ester Hydrolase: Evidence for Transcriptional Regulation by Sterols, Biochem. Biophys. Res. Commun. 243 349-355.
12. Natarajan, R., Ghosh, S., and Grogan, W.M. (1996) Catalytic Properties of the Purified Rat Cytosolic Cholesteryl Ester Hydrolase, Biochem. Biophys. Res. Commun. 225, 413-419.
13. Natarajan, R., Ghosh, S., and Grogan. W.M. (1999) Regulation of the Rat Neutral Cytosolic Cholesteryl Ester Hydrolase Promoter by Hormones and Sterols: A Role for Nuclear Factor-Y in the Sterol-Mediated Response, J. Lipid Res. 40, 2091-2098.
14. Osborne, T.F., and LaMorte, V.J. (1998) Molecular Aspects in Feedback Regulation of Gene Expression by Cholesterol in Mammalian Cells, Methods 16, 42-48.
15. Pandak, W.M., Schwarz, C., Hylemon, P.B., Mallonee, D., Valerie, K., Heuman, D.M., Fisher, R.A., Redford, K., and Vlahcevie, Z.R. (2001) Effects of CYP7A1 Overexpression on Cholesterol and Bile Acid Homeostasis, Am. J. Physiol. Gastrointest. Liver Physiol 281, G878-G889.
16. Simons, K., and Ikonen, E. (2000) How Cells Handle Cholesterol, Science 290, 1721-1726.
17. Hylemon, P.B., Pandak, W.M., and Vlahcevic, Z.R. (2001) Regulation of Hepatic Cholesterol Homeostasis, in Liver Biology and Pathobiology (Arias, I.M., Boyer, J.L., Chisari, F.V., Fausto, N., Schachter, D.A., and Shafritz, D.A., eds., pp. 231-247, Lippincott Williams & Wilkins, New York.
18. Gerard, R.D., and Meidell, R.S. (1995) Adenovirus Vectors, in DNA Cloning 4: Mammalian Systems (Glover, D.M., and Hames, B.D., eds.), pp. 285-306, Oxford University Press, New York.
19. Natarajan, R., Ghosh, S., and Grogan, W.M. (1996) Age Related Changes in mRNA, Protein and Catalytic Activity of Hepatic Cholesterol Ester Hydrolase in Male Rats: Evidence for Transcriptional Regulation, Biochim. Biophys. Acta 1302, 153-156.
20. Bligh, E., and Dyer, W. (1959) A Rapid Method of Total Lipid Extraction and Purification, Can. J. Biochem. Phys. 37, 911-917.
21. Hylemon, P.B., Gurley, B.C., Stravitz, R.T., Litz, J.S., Pandak, W.M., Chiang, J.Y., and Vlahcevic, Z.R. (1992) Hormonal Regulation of Cholesterol 7 α-Hydroxylase mRNA Levels and Transcriptional Activity in Primary Rat Hepatocyte Cultures, J. Biol. Chem. 267, 16866-16871.
22. Ghosh, S., and Grogan, W.M. (1989) Activation of Rat Liver Cholesterol Ester Hydrolase by cAMP-Dependent Protein Kinase and Protein Kinase C, Lipids 24, 733-736.
23. Eisenhardt, E., and von Deimling, O. (1982). Interstrain Variation of Esterase-22, a New Isozyme of the House Mouse, Comp. Biochem. Physiol. B 73, 719-724.
24. Natarajan, R., Ghosh, S., and Grogan, W.M. (1996) Age-Related Changes in mRNA, Protein and Catalytic Activity of Hepatic Neutral Cholesterol Ester Hydrolase in Male Rats: Evidence for Transcriptional Regulation, Biochim. Biophys. Acta 1302, 153-158.
25. Natarajan, R., Ghosh, S., and Grogan, W.M. (1997) Age-Related Changes in Catalytic Activity, Enzyme Mass, mRNA, and Subcellular Distribution of Hepatic Neutral Cholesterol Ester Hydrolase in Female Rats, Lipids 32, 463-470.
26. Escary, J.L., Choy, H.A., Reue, K., and Schotz, M.C. (1998) Hormone-Sensitive Lipase Overexpression Increases Cholesteryl Ester Hydrolysis in Macrophage Foam Cells, Arterioscler. Thromb. Vasc. Biol. 18, 991-998.
27. Okazaki, H., Osuga, J., Tsukamoto, K., Isoo, N., Kitamine, T., Tamura, Y., Tomita, S., Sekiya, M., Yahagi, N., lizuka, Y., Ohashi, K., et al. (2002) Elimination of Cholesterol Ester from Macrophage Foam Cells by Adenovirus-Mediated Gene Transfer of Hormone-Sensitive Lipase, J. Biol. Chem. 277, 31893-31899.
28. Sztalryd, C., Komaromy, M.C., and Kraemer, F.B. (1995) Overexpression of Hormone-Sensitive Lipase Prevents Triglyceride Accumulation in Adipocytes, J. Clin. Invest. 95, 2652-2661.
29. Khoo, J.C., Steinberg, D., Huang, J.J., and Vagelos, P.R. (1976) Triglyceride, Diglyceride, Monoglyceride, and Cholesterol Ester Hydrolases in Chicken Adipose Tissue Activated by Adenosine 3′:5′-Monophosphate- Dependent Protein Kinase. Chromatographic Resolution and Immunochemical Differentiation from Lipoprotein Lipase, J. Biol. Chem. 251, 2882-2890.
30. Post, S.M., Zoeteweij, J.P., Bos, M.H., deWit, B.C., Havinga, R., Kuipers, F., and Princen, H.M. (1999) Acyl-Coenzyme A:Cholesterol Acyltransferase Inhibitor, Avasimbe, Stimulates Bile Acid Synthesis and Cholesterol 7α-Hydroxylase in Cultured Rat Hepatocytes and in vivo in the Rat, Hepatology 30, 491-500.
31. Azuma, Y., Kawasaki, T., Ohno, K., Seto, J., Yamada, T., Yamasaki, M., and Nobuhara, Y. (1999) Effects of NTE-122, a Novel Acyl-CoA:Cholesterol Acyltransferase Inhibitor, on Cholesterol Esterification and Lipid Secretion from Caco-2 Cells, and Cholesterol Absorption in Rats, Jpn. J. Pharmacol. 80, 81-84.
32. Murakami, S., Yamagishi, I., Sato, M., Tomisawa, K., Nara, Y., and Yamori, Y. (1997) ACAT Inhibitor HL-004 Accelerates the Regression of Hypercholesterolemia in Stroke-Prone Spontaneously Hypertensive Rats (SHRSP): Stimulation of Bile Acid Production by HL-004, Atherosclerosis 133, 97-104.
33. Lu, T.T., Makishima, M., Repa, J.J., Schoonjans, K., Kerr, T.A., Auwerx, J., and Mangelsdorf, D.J. (2000) Molecular Basis for Feedback Regulation of Bile Acid Synthesis by Nuclear Receptors, Mol. Cell 6, 507-515.
34. Peet, D.J., Turley, S.D., Ma, W.M., Janowski, B.A., Lobaccaro, J., Hammer, R.E., and Mangelsdorf, D.J. (1998) Cholesterol and Bile Acid Metabolism Are Impaired in Mice Lacking the Nuclear Oxysterol Receptor LXRα, Cell 93, 693-704.
35. Brown, A.J., and Jessup, W. (1999) Oxysterols and Atherosclerosis, Atherosclerosis 142, 1-28.
36. Smith, L.L., and Johnson, B.H. (1989) Biological Activities of Oxysterols, Free Radic. Biol. Med. 7, 285-332.
37. Stroup, D., Crestani, M., and Chiang, J.Y. (1991) Identification of a Bile Acid Response Element in the Cholesterol 7 α-Hydroxylase Gene CYP7A, Am. J. Physiol. 273, G508-G517.
38. Chen, W., and Chiang, J.Y.L. (2003) Regulation of Human Sterol 27-Hydroxylase Gene (CYP27A1) by Bile Acids and Hepatocyte Nuclear Factor 4α (HNF4α), Gene 313, 71-82.
39. Wang, L., Han, Y., Kim, C., Lee, Y., and Moore, D. (2003) Resistance of SHP-Null Mice to Bile Acid-Induced Liver Damage, J. Biol. Chem. 278, 44475-44481.
40. Li-Hawkins, J., Gafvels, M., Olin, M., Lund, E.G., Andersson, U., Schuster, G., Bjorkhem, I., Russell, D.W., and Eggertsen, G. (2002) Cholic Acid Mediates Negative Feedback Regulation on Bile Acid Synthesis in Mice, J. Clin. Invest. 110, 1191-1200.
41. Gupta, S., Stravitz, R.T., Dent, P., and Hylemon, P.B. (2001) Down Regulation of Cholesterol 7α-Hydroxylase (CYP7A1) Gene Expression by Bile Acids in Primary Rat Hepatocytes Is Mediated by the c-Jun N-Terminal Kinase Pathway, J. Biol. Chem. 276, 15816-15822.
42. Heuman, D.M., Pandak, W.M., Hylemon, P.B., and Vlahcevic, Z.R. (1991) Conjugates of Ursodeoxycholate Protect Against Cytotoxicity of More Hydrophobic Bile Salts: In vitro Studies in Rat Hepatocytes and Human Erythrocytes, Hepatology 14, 920-926.