ACAT inhibitor HL-004 accelerates the regression of hypercholesterolemia in stroke-prone spontaneously hypertensive rats (SHRSP): Stimulation of bile acid production by HL-004

Atherosclerosis

Volumn 133, Issue 1, 1997, Pages 97-104

  Murakami, Shigeru ^a   Yamagishi, Izumi ^a   Sato, Masakazu ^a   Tomisawa, Kazuyuki ^a   Nara, Yasuo ^b   Yamori, Yukio ^b  

^a TAISHO PHARMACEUTICAL CO LTD   (Japan)

^b KYOTO UNIVERSITY   (Japan)

Author keywords

ACAT; ACAT inhibitor; Bile acid; HL 004; SHRSP

Indexed keywords

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BILE ACID BLOOD LEVEL; BILE ACID SYNTHESIS; CHOLESTEROL BLOOD LEVEL; DISEASE ASSOCIATION; HYPERCHOLESTEROLEMIA; HYPERTENSION; NONHUMAN; PRIORITY JOURNAL; RAT; REGRESSION ANALYSIS; STROKE;

EID: 0030862598     PISSN: 00219150     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0021-9150(97)00121-4     Document Type: Article

References (42)

1. Spector AA, Mathur SN, Kaduce TL. Role of acylcoenzyme Axholesterol O-acyltransferase in cholesterol metabolism. Prog Lipid Res 1979;18:31.
2. Chang T, Doolittle GM. Acylcoenzyme A:cholesterol O- acyltransferase. In: Boyer PD, editor. The Enzymes. New York: Academic Press, 1983:523.
3. Suckling KE, Stange EF. Role of acyl-CoA:cholesterol acyltransferase in cellular cholesterol metabolism. J Lipid Res 1985;26:647.
4. Haugen R, Norum KR. Coenzyme-A-dependent esterification of cholesterol in rat intestinal mucosa. Scand J Gastroenterol 1976;11:615.
5. Norum KU, Lilljeqvist A-C, Drevon CA. Coenzyme-A-dependnet esterification of cholesterol in intestinal mucosa from guinea pigs. Influence of diet on enzyme activity. Scand J Gastroenterol 1977;12:281.
6. Field FJ, Salome RG. Effect of dietary fat saturation, cholesterol and cholestyramine on acyl-CoA:cholesterol acyltransferase activity in rabbit intestinal microsomes. Biochim Biophys Acta 1982;712:557.
7. Heider JG, Pickens CE, Kelly LA. Role of acyl CoA:cholesterol acyltransferase in cholesterol absorption and its inhibition by 57-118 in rabbit. J Lipid Res 1983;24:1127.
8. Drevon CA, Engelhorn SC, Steinberg D. Secretion of very low density lipoproteins enriched in cholesteryl esters by cultured rat hepatocytes during stimulation of intracellular cholesterol esterification. J Lipid Res 1980;21:1065.
9. Khan B, Wilcox HG, Heimberg M. Cholesterol is required for secretion of very-low-density lipoprotein by rat liver. Biochem 1989;J 259:807.
10. Cianflone KM, Yasruel Z, Rodriguez MA, Sniderman AD. Regulation of apoB secretion from HepG2 cells: evidence for a critical role for cholesteryl ester synthesis in the response to a fatty acid challenge. J Lipid Res 1990;31:2045.
11. Krause BR, Anderson M, Bisgaier CL, et al. In vivo evidence that the lipid-regulating activity of the ACAT inhibitor CI-976 in rats is due to inhibition of both intestinal and liver ACAT. J Lipid Res 1993;34:279.
12. Carr TP, Hamilton RL, Rudel LL. ACAT inhibitors decrease secretion of cholesteryl esters and apolipoprotein B by perfused livers of African green monkeys. J Lipid Res 1995;36:25.
13. Brecher PI, Chobanian AV. Cholesterol ester synthesis in normal and atherosclerotic aortas of rabbit and rhesus monkeys. Circ Res 1974;35:692.
14. Day AJ, Proudlock JW. Changes in aortic cholesterol-esterifying activity in rabbits fed cholesterol for three days. Atherosclerosis 1974;19:253.
15. Hashimoto S, Dayton S. Studies of the mechanism of augmented synthesis of cholesteryl ester in atherosclerotic rabbit aortic microsomes. Atherosclerosis 1977;28:447.
16. Bell FP, Schaub RG. Chlorpromazine inhibits arterial ACAT and reduces arterial cholesterol and cholesteryl ester accumulation in cholesterol-fed rabbits. Arteriosclerosis 1986;6:42.
17. Sliskovic DR, White AD. Therapeutic potential of ACAT inhibitors as lipid lowering and anti-atherosclerotic agents. TiPS 1991;12:194.
18. Ross AC, Go KJ, Heider JG, Rothblat GH. Selective inhibition of acyl coenzyme A:cholesterol acyltransferase by compound 58-035. J Biol Chem 1984;259:815.
19. + + antagonists and ACAT inhibitors promote cholesterol efflux from macrophages by different mechanisms. 1. Characterization of cellular lipid metabolism. Artheriosclerosis 1988;8:46.
20. Largis EE, Wang CH, DeVries VG, Schaffer SA. CL 277,082: a novel inhibitor of ACAT-catalyzed cholesterol esterification and cholesterol absorption. J Lipid Res 1989;30:681.
21. Harris WS, Dujovne CA, Bergmann K, et al. Effects of the ACAT inhibitor CL 277,082 on cholesterol metabolism in humans. Clin Pharmacol Ther 1990;48:189.
22. Bell FP, Gammill RB, St. John LC. U-73482: a novel ACAT inhibitor that elevates HDL-cholesterol, lowers plasma triglyceride and facilitates hepatic cholesterol metabolism in the rat. Atherosclerosis 1992;92:115.
23. Tanaka H, Ohtuka I, Kogushi M, et al. Effect of the acyl-CoA:cholesterol acyltransferase inhibitor, E5324, on experimental atherosclerosis in rabbits. Atherosclerosis 1994;107:187.
24. Sugiyama Y, Ishikawa E, Odaka H, Miki N, Tawada H, Ikeda H. TMP-153, a novel ACAT inhibitor, inhibits cholesterol absorption and lowers plasma cholesterol in rats and hamsters. Atherosclerosis 1995;113:71.
25. Murakami S, Araki H, Otomo S, Nara Y, Yamori Y. Effects of HL-004, a novel ACAT inhibitor, on cholesterol accumulation and removal in cultured smooth muscle cells from stroke-prone spontaneously hypertensive rats (SHRSP). Life Sci 1995;56:509.
26. Murakami S, Nara Y, Yamori Y. Hypolipidemic and antiatherosclerotic effects of a novel ACAT inhibitor, HL-004, in stroke-prone spontaneously hypertensive rats. Exp Mol Pathol 1996;63:23.
27. Murakami S, Ohta Y, Asami Y, et al. The hypolipidemic action of the ACAT inhibitor HL-004 in hamsters fed normal chow. Gen Pharmacol 1996;27:1383.
28. Murakami S, Ohta Y, Asami Y, et al. Hypolipidemic effects of HL-004, a novel ACAT inhibitor, in hamsters fed normal chow. Atherosclerosis 1994;109:311.
29. Yanagita T, Sonda K, Yamamoto K, Yotsumoto H, Nunez JH, Murakami S. Effect of a new acyl-coenzyme A:cholesterol acyltransferase inhibitor, HL-004, on cholesterol esterification and lipid metabolism in HepG2 cells. Curr Ther Res 1995;56:787.
30. Yamori Y, Horie R, Sato M, Fukase M. Hypertension as an important factor for cerebrovascular atherogenesis in rats. Stroke 1976;7:120.
31. Yamori Y, Horie R, Nara Y et al. Pathogenesis and dietary prevention of cerebrovascular diseases in animal models and epidemiological evidence for the applicability in man. In: Yamori Y, Lanfant C, editors. Prevention of Cardiovascular Diseases: an Approach to an Active Long Life. Amsterdam: Elsevier, 1987:163.
32. Murakami S, Nara Y, Yamori Y. Peritoneal macrophages from stroke-prone spontaneously hypertensive rats accumulate more cholesteryl ester than do macrophages from Wistar-Kyoto rats. Biochem Biophys Res Commun 1995;211:547.
33. 2+ precipitation procedure for quantification of high-density-lipoprotein cholesterol. Clin Chem 1982;28:1379.
34. Lowry OH, Rosebrough NJ, Farr AL, Randall RJ. Protein measurement with the Folin phenol reagent. J Biol Chem 1951;193:265.
35. Helgerud P, Saarem K, Norum KR. Acyl-CoA:cholesterol acyltransferase in human small intestine: its activity and some properties of the enzyme reaction. J Lipid Res 1981;22:271.
36. Nicolau G, Shefer S, Salen G, Mosbach EH. Determination of hepatic cholesterol 7α-hydroxylase activity in man. J Lipid Res 1974;15:146.
37. Miettinen TA. Mode of action of a new hypocholesterolemic drug (DH-581) in familial hypercholesterolemia. Atherosclerosis 1972;15:163.
38. Nestel PJ, Billington T. Effects of probucol on low density lipoprotein removal and high density lipoprotein synthesis. Atherosclerosis 1981;38:203.
39. Podrez EA, Kosykh VA, Lakeev YV, et al. Bile acid and very low density lipoprotein production by cultured hepatocytes from hypo- or hyperresponsive rabbits fed cholesterol. Lipids 1993;28:709.
40. Sampson WJ, Suffolk RA, Bowers P, Houghton JD, Botham KM, Sackling KE. The role of acyl-CoA:cholesterol acyltransferase in the metabolism of free cholesterol to cholesteryl esters or bile acids in primary cultures of rat hepatocytes. Biochim Biophys Acta 1987;920:1.
41. Hoang V-Q, Botham KM, Benson GM, et al. Bile acid synthesis in hamster hepatocytes in primary culture: source of cholesterol and comparison with other species. Biochim Biophy Acta 1993;1210:73.
42. Yamori Y, Nara Y, Kihara M, et al. Possible involvement of taurine in pathological cholesterol metabolism of arteriolipidosis-prone rats (ALR). Sulfur-containing Amino Acids 1980;3:107.