Requirement of thyrotropin-dependent complex formation of protein kinase A catalytic subunit with inhibitor of κB proteins for activation of p65 nuclear factor-κB by tumor necrosis factor-α

Endocrinology

Volumn 146, Issue 4, 2005, Pages 1999-2005

  Cao, Xia ^a   Kambe, Fukushi ^a   Seo, Hisao ^a  

^a NAGOYA UNIVERSITY   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

9 (TETRAHYDRO 2 FURYL)ADENINE; CYCLIC AMP; CYCLIC AMP DEPENDENT PROTEIN KINASE; DNA; I KAPPA B; I KAPPA B ALPHA; I KAPPA B BETA; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; N [2 (4 BROMOCINNAMYLAMINO)ETHYL] 5 ISOQUINOLINESULFONAMIDE; PROTEIN KINASE AC; SYNAPTOTAGMIN; THYROTROPIN; TUMOR NECROSIS FACTOR ALPHA; UNCLASSIFIED DRUG;

ANIMAL CELL; ARTICLE; BINDING AFFINITY; COMPLEX FORMATION; ENZYME ACTIVATION; ENZYME SUBUNIT; GENETIC TRANSCRIPTION; NONHUMAN; PRIORITY JOURNAL; PROTEIN BINDING; PROTEIN DEGRADATION; PROTEIN DNA BINDING; PROTEIN MODIFICATION; RAT; THYROID CELL; WESTERN BLOTTING;

ACTIVE TRANSPORT, CELL NUCLEUS; ADENYLATE CYCLASE; ANIMALS; CATALYTIC DOMAIN; CELL LINE; CYCLIC AMP; CYCLIC AMP-DEPENDENT PROTEIN KINASES; I-KAPPA B PROTEINS; LIPOPOLYSACCHARIDES; NF-KAPPA B; PHOSPHORYLATION; RATS; THYROTROPIN; TRANSCRIPTION FACTOR RELA; TUMOR NECROSIS FACTOR-ALPHA;

EID: 15444374341     PISSN: 00137227     EISSN: None     Source Type: Journal    
DOI: 10.1210/en.2004-1178     Document Type: Article

References (34)

1. Baldwin Jr AS 1996 The NF-κB and IκB proteins: new discoveries and insights. Annu Rev Immunol 14:649-683
2. Zandi E, Rothwarf DM, Delhase M, Hayakawa M, Karin M 1997 The IκB kinase complex (IKK) contains two kinase subunits, IKKα and IKKβ, necessary for IκB phosphorylation and NF-κB activation. Cell 91:243-252
3. DiDonato J, Mercurio F, Rosette C, Wu-Li J, Suyang H, Ghosh S, Karin M, Roff M 1996 Mapping of the inducible IκB phosphorylation sites that signal its ubiquitination and degradation: role of IκBα ubiquitination in signal-induced activation of NFκB in vivo. Mol Cell Biol 16:1295-1304
4. Zhong H, SuYang H, Erdjument-Bromage H, Tempst P, Ghosh S 1997 The transcriptional activity of NF-κB is regulated by the IκB-associated PKAc subunit through a cyclic AMP-independent mechanism. Cell 89:413-424
5. Carnegie GK, Scott JD 2003 A-kinase anchoring proteins and neuronal signaling mechanisms. Genes Dev 17:1557-1568
6. Kikumori T, Kambe F, Nagaya T, Funahashi H, Seo H 2001 Thyrotropin modifies activation of nuclear factor κB by tumour necrosis factor-α in rat thyroid cell line. Biochem J 354:573-579
7. Kambe F, Seo H 1996 Mediation of the hormone- and serum-dependent regulation of thyroglobulin gene expression by thyroid-transcription factors in rat thyroid FRTL-5 cells. J Endocrinol 150:287-298
8. Kambe F, Nomura Y, Okamoto T, Seo H 1996 Redox regulation of thyroid-transcription factors, Pax-8 and TTF-1, is involved in their increased DNA-binding activities by thyrotropin in rat thyroid FRTL-5 cells. Mol Endocrinol 10:801-812
9. Kikumori T, Kambe F, Nagaya T, Imai T, Funahashi H, Seo H 1998 Activation of transcriptionally active nuclear factor-κ by tumor necrosis factor-α and its inhibition by antioxidants in rat thyroid FRTL-5 cells. Endocrinology 139: 1715-1722
10. Baeuerle PA, Baltimore D 1988 IκB: a specific inhibitor of the NF-κB transcription factor. Science 242:540-546
11. Cao X, Kambe F, Ohmori S, Seo H 2002 Oxidoreductive modification of two cysteine residues in paired domain by Ref-1 regulates DNA-binding activity of Pax-8. Biochem Biophys Res Commun 297:288-293
12. Le Bail O, Schmidt-Ullrich R, Israel A 1993 Promoter analysis of the gene encoding the IκB-α/MADS inhibitor of NF-κB: positive regulation by members of the rel/NF-κB family. EMBO J 12:5043-5049
13. Chijiwa T, Mishima A, Hagiwara M, Sano M, Hayashi K, Inoue T, Naito K, Toshioka T, Hidaka H 1990 Inhibition of forskolin-induced neurite outgrowth and protein phosphorylation by a newly synthesized selective inhibitor of cyclic AMP-dependent protein kinase, N-[2-(p-bromocinnamylamino)ethyl]-5- isoquinolinesulfonamide (H-89), of PC12D pheochromocytoma cells. J Biol Chem 265:5267-5272
14. Shirakawa F, Mizel SB 1989 In vitro activation and nuclear translocation of NF-κB catalyzed by cyclic AMP-dependent protein kinase and protein kinase C. Mol Cell Biol 9:2424-2430
15. Naumann M, Scheidereit C 1994 Activation of NF-κB in vivo is regulated by multiple phosphorylations. EMBO J 13:4597-4607
16. Geng Y, Zhang B, Lotz M 1993 Protein tyrosine kinase activation is required for lipopolysaccharide induction of cytokines in human blood monocytes. J Immunol 151:6692-6700
17. Lapointe R, Lemieux R, Olivier M, Darveau A 1996 Tyrosine kinase and cAMP-dependent protein kinase activities in CD40-activated human B lymphocytes. Eur J Immunol 26:2376-2382
18. Um JH, Kang CD, Lee BG, Kim DW, Chung BS, Kim SH 2001 Increased and correlated nuclear factor-κB and Ku autoantigen activities are associated with development of multidrug resistance. Oncogene 20:6048-6056
19. Bhat-Nakshatri P, Sweeney CJ, Nakshatri H 2002 Identification of signal transduction pathways involved in constitutive NF-κB activation in breast cancer cells. Oncogene 21:2066-2078
20. Neumann M, Grieshammer T, Chuvpilo S, Kneitz B, Lohoff M, Schimpl A, Franza BJ, Serfling E 1995 RelA/p65 is a molecular target for the immunosuppressive action of protein kinase A. EMBO J 14:1991-2004
21. Ollivier V, Parry GC, Cobb RR, de Prost D, Mackman N 1996 Elevated cyclic AMP inhibits NF-κB-mediated transcription in human monocytic cells and endothelial cells. J Biol Chem 271:20828-20835
22. Takahashi N, Tetsuka T, Uranishi H, Okamoto T 2002 Inhibition of the NF-κB transcriptional activity by protein kinase A. Eur J Biochem 269:4559-4565
23. Griffioen G, Thevelein JM 2002 Molecular mechanisms controlling the localisation of protein kinase A. Curr Genet 41:199-207
24. Fraser ID, Cong M, Kim J, Rollins EN, Daaka Y, Lefkowitz RJ, Scott JD 2000 Assembly of an A kinase-anchoring protein-β2-adrenergic receptor complex facilitates receptor phosphorylation and signaling. Curr Biol 10:409-412
25. Mercurio F, Zhu H, Murray BW, Shevchenko A, Bennett BL, Li J, Young DB, Barbosa M, Mann M, Manning A, Rao A 1997 IKK-1 and IKK-2: cytokine-activated IκB kinases essential for NF-κB activation. Science 278:860-866
26. Yamamoto Y, Kim DW, Kwak YT, Prajapati S, Verma U, Gaynor RB 2001 IKKγ /NEMO facilitates the recruitment of the IκB proteins into the IκB kinase complex. J Biol Chem 276:36327-36336
27. Zhong H, Voll RE, Ghosh S 1998 Phosphorylation of NF-κB p65 by PKA stimulates transcriptional activity by promoting a novel bivalent interaction with the coactivator CBP/p300. Mol Cell 1:661-671
28. Wang D, Baldwin Jr AS 1998 Activation of nuclear factor-κB- dependent transcription by tumor necrosis factor-α is mediated through phosphorylation of RelA/p65 on serine 529. J Biol Chem 273:29411-29416
29. Wang D, Westerheide SD, Hanson JL, Baldwin Jr AS 2000 Tumor necrosis factor α-induced phosphorylation of RelA/p65 on Ser529 is controlled by casein kinase II. J Biol Chem 275:32592-32597
30. Sakurai H, Chiba H, Miyoshi H, Sugita T, Toriumi W 1999 IκB kinases phosphorylate NF-κB p65 subunit on serine 536 in the transactivation domain. J Biol Chem 274:30353-30356
31. Vermeulen L, De Wilde G, Van Damme P, Vanden Berghe W, Haegeman G 2003 Transcriptional activation of the NF-κB p65 subunit by mitogen- and stress-activated protein kinase-1 (MSK1). EMBO J 22:1313-1324
32. Hou S, Guan H, Ricciardi RP 2003 Phosphorylation of serine 337 of NF-κB p50 is critical for DNA binding. J Biol Chem 278:45994-45998
33. Pikarsky E, Porat RM, Stein I, Abramovitch R, Amit S, Kasem S, Gutkovich-Pyest E, Urieli-Shoval S, Galun E, Ben-Neriah Y 2004 NF-κB functions as a tumour promoter in inflammation-associated cancer. Nature 431:461-466
34. Greten FR, Eckmann L, Greten TF, Park JM, Li ZW, Egan LJ, Kagnoff MF, Karin M 2004 IKKβ links inflammation and tumorigenesis in a mouse model of colitis-associated cancer. Cell 118:285-296