Gene expression of leptin, leptin receptor, prolactin receptor and whey acidic protein in mammary glands of late-pregnant gilts from two breeds

Canadian Journal of Animal Science

Volumn 84, Issue 4, 2004, Pages 621-629

  Palin, M F ^a   Beaudry, D ^a   Farmer, C ^a  

^a AGRICULTURE AND AGRI FOOD CANADA   (Canada)

Author keywords

Genetics; Mammary glands; Meishan; mRNA; Pig

Indexed keywords

PIERIS BRASSICAE; SUS SCROFA;

EID: 15444371209     PISSN: 00083984     EISSN: None     Source Type: Journal    
DOI: 10.4141/A04-026     Document Type: Article

References (63)

1. Agriculture and Agri-Food Canada 1993. Recommended code of practice for the care and handling of farm animals - pigs. Agriculture and Agri-Food Canada, Ottawa, ON. Publication No. 1898E.
2. Aoki, N., Kawamura, M. and Matsuda, T. 1999. Lactation-dependent down regulation of leptin production in mouse mammary gland. Biochim. Biophys. Acta. 1427: 298-306.
3. Baratta, M., Grolli, S. and Tamanini, C. 2003. Effect of leptin in proliferating and differentiated HC11 mouse mammary cells. Regul. Pept. 113: 101-107.
4. Bonnet, M., Gourdou, I., Leroux, C., Chilliard, Y. and Djiane, J. 2002. Leptin expression in ovine mammary gland: Putative sequential involvement of adipose, epithelial, and myoepithelial cells during pregnancy and lactation. J. Anim. Sci. 80: 723-728.
5. Briscoe, C. P., Hanif, S., Arch, J. R. S. and Tadayyon, M. 2001a. Fatty acids inhibit leptin signalling in BRIN-BD11 insulinoma cells. J. Mol. Endocrinol. 26: 145-154.
6. Briscoe, C. P., Hanif, S., Arch, J. R. S. and Tadayyon, M. 2001b. Leptin receptor long-form signalling in human liver cell line. Cytokine 14: 225-229.
7. Casabiell, X., Pineiro, V., Tomé, M. A., Peino, R., Dieguez, C., Casanueva, F. F. 1997. Presence of leptin in colostrum and/or breast milk from lactating mothers: a potential role in the regulation of neonatal food intake. J. Clin. Endocrinol. Metab. 82: 4270-4273.
8. Cassy, S., Charlier, M., Bélair, L., Guillomot, M., Laud, K. and Djiane, J. 2000. Increase in prolactin receptor (PRL-R) mRNA level in the mammary gland after hormonal induction of lactation in virgin ewes. Domest. Anim. Endocrinol. 18: 41-55.
9. Chilliard, Y., Bonnet, M., Delavaud, C., Faulconnier, Y., Leroux, C., Djiane, J. and Bocquier, F. 2001. Leptin in ruminants. Gene expression in adipose tissue and mammary gland, and regulation of plasma concentration. Domest. Anim. Endocrinol. 21: 271-295.
10. Clevenger, C. V. and Plank, T. L. 1997. Prolactin as an autocrine/paracrine factor in breast tissue. J. Mammary Gland Biol. Neoplasia 2: 59-68.
11. Estienne, M. J., Harper, A. F., Barb, C. R. and Azain, M. J. 2000. Concentration of leptin in serum and milk collected from lactating sows differing in body condition. Domest. Anim. Endocrinol. 19: 275-280.
12. Farmer, C., Palin, M. F. and Sorensen, M. T. 2000. Mammary gland development and hormone levels in pregnant Upton-Meishan and Large White gilts. Domest. Anim. Endocrinol. 18: 241-251.
13. Farmer, C., Palin, M. F., Sorensen, M. T. and Robert S. 2001. Lactational performance, nursing and maternal behaviour of Upton-Meishan and Large White sows. Can. J. Anim. Sci. 81: 487-493.
14. Farmer, C. and Petitclerc, D. 2003. Specific window of prolactin inhibition in late gestation decreases mammary parenchymal tissue development in gilts. J. Anim. Sci. 81: 1823-1829.
15. Galleno, M.I., Binart, N., Robinson, G.W., Okagaki, R., Coschigano, K.T., Perry, J., Kopchick, J.J., Oka, T., Kelly, P.A. and Hennighausen L. 2001. Prolactin, growth hormone, and epidermal growth factor activate Stat5 in different compartments of mammary tissue and exert different and overlapping developmental effects. Dev. Biol. 229: 163-175.
16. Gonzalez, L.C., Pinilla, L., Tena-Sempere, M. and Aguilar, E. 1999. Leptin (116-130) stimulates prolactin and luteinizing hormone secretion in fasted adult male rats. Neuroendocrinology 70: 213-220.
17. Gualillo, O., Lago, F., Garcia, M., Menendez, C., Senaris, R., Casanueva, N. N. and Dieguez, C. 1999. Prolactin stimulates leptin secretion by rat white adipose tissue. Endocrinology 140: 5149-5153.
18. Hennighausen, L. and Robinson, G. W. 2001. Signaling pathways in mammary gland development. Dev. Cell 1: 467-475.
19. Herpin, P. and Le Dividich, J. 1998. Conséquences de l'augmentation de la prolificité des truies sur la survie et la croissance des porcelets. INRA Prod. Anim. 11:253:255.
20. Hodgkinson, S. C., Spencer, G. S., Bass, J. J., Davis, S. R. and Gluckman, P. D. 1991. Distribution of circulating insulin-like growth factor-I (IGF-I) into tissues. Endocrinology 129: 2085-2093.
21. Horseman, N. D. 1999. Prolactin and mammary gland development. J. Mammary Gland. Biol. Neoplasia 4: 79-88.
22. Houseknecht, K. L., Baile, C. A., Matteri, R. L. and Spurlock, M. E. 1998. The biology of leptin: A review. J. Anim. Sci. 76: 1405-1420.
23. Hovey, R. C., MacKenzie, D. D. and McFadden, T. B. 1998. The proliferation of mouse mammary epithelial cells in response to specific mitogens is modulated by the mammary fat pad in vitro. In Vitro Cell Dev. Biol. Anim. 34: 385-392.
24. Hu, X., Juneja, S. C., Maihle, N. J. and Cleary, M. P. 2002. Leptin, a growth factor in normal and malignant breast cells and for normal mammary gland development. J. Natl. Cancer Inst. 94: 1704-1711.
25. Jahn, G. A., Edery, M., Belair, L., Kelly, P. A. and Djiane, J. 1991. Prolactin receptor gene expression in rat mammary gland and liver during pregnancy and lactation. Endocrinology 128: 2976-2984.
26. Kimura, M., Irahara, M., Yasui, T., Saito, S., Tezuka, M., Yamano, S., Kamada, M. and Aono, T. 2002. The obesity in bilateral ovariectomized rats is related to a decrease in the expression of leptin receptors in the brain. Biochem. Biophys. Res. Commun. 290: 1349-1353.
27. Kleinberg, D. L. 1998. Role of IGF-I in normal mammary development. Breast Cancer Res. Treat. 47: 201-208.
28. Koshiba, H., Kitawaki, J., Ishihara, H., Kado, N., Kusuki, I., Tsukamoto, K. and Honjo, H. 2001. Progesterone inhibition of functional leptin receptor mRNA expression in human endometrium. Mol. Hum. Reprod. 7: 567-572.
29. Kohsaka, A., Watanobe, H., Kakizaki, Y., Habu, S. and Suda, T. 1999. A significant role of leptin in the generation of steroid-induced luteinizing hormone and prolactin surges in female rats. Biochem. Biophys. Res. Commun. 254: 578-581.
30. Laud, K., Gourdou, I., Belair, L., Keisler, D. H. and Djiane, J. 1999. Detection and regulation of leptin receptor mRNA in ovine mammary epithelial cells during pregnancy and lactation. FEBS Lett. 463: 194-198
31. Laud, K., Gourdou, I., Pessemesse, L., Peyrat, J. P. and Djiane, J. 2002. Identification of leptin receptors in human breast cancer: functional activity in the T47-D breast cancer cell line. Mol. Cell. Endocrinol. 188: 219-226.
32. Lee, C. Y., Bazer, F. W. and Simmen, F. A. 1993. Expression of components of the insulin-like growth factor system in pig mammary glands and serum during pregnancy and pseudopregnancy: effects of oestrogen. J. Endocrinol. 137: 473-483.
33. Li, S. and Rosen, J. M. 1995. Nuclear factor I and mammary gland factor (STAT5) play a critical role in regulating rat whey Biol. 15: 2063-2070.
34. Littell, R. C., Freund, R. and Spector, P. C. 1991. SAS system for linear models. 3rd ed. SAS series in statistical applications. SAS Institute, Inc., Cary, NC.
35. Liu, X., Robinson, G. W., Gouilleux, F., Groner, B. and Hennighausen, L. 1995. Cloning and expression of Stat5 and an additional homologue (Stat5b) involved in prolactin signal transduction in mouse mammary tissue. Proc. Natl. Acad. Sci. USA 92: 8831-8835.
36. Liu, X., Robinson, G. W., Wagner, K. U., Garrett, L., Wynshaw-Boris, A. and Hennighausen L. 1997. Stat5a is mandatory for adult mammary gland development and lactogenegis. Genes Dev. 11: 179-186.
37. Maroulakou, I. G. and Bowe, D. B. 2000. Expression and function of Ets transcription factors in mammalian development: a regulatory network. Oncogene 19: 6432-6442.
38. Mastronardi, C. A., Walczewska, A., Yu, W. H., Karanth, S., Parlow, A. F. and McCann, S. M. 2000. The possible role of prolactin in the circadian rhythm of leptin secretion in male rats. Proc. Soc. Exp. Biol. Med. 224:152-158.
39. McKnight, R. A., Spencer, M., Dittmer, J., Brady, J. N., Wall, R. J. and Hennighausen, L. 1995. An Ets site in the whey acidic protein gene promoter mediates transcriptional activation in the mammary gland of pregnant mice but is dispensable during lactation. Mol. Endocrinol. 9: 717-724.
40. Millot, B., Montoliu, L., Fontaine, M. L., Mata, T. and Devinoy E. 2003. Hormone-induced modifications of the chromatin structure surrounding upstream regulatory regions conserved between the mouse and rabbit whey acidic protein genes. Biochem. J. 372: 41-52.
41. Mol, J. A., Lantinga-van Leeuwen, I., Van Garderen, E. and Rijnberk, A. 2000. Progestin-induced mammary growth hormone (GH) production. Adv. Exp. Med. Biol. 480: 71-76.
42. Neville, M. C., McFadden, T. B. and Forsyth, I. 2002. Hormonal regulation of mammary differentiation and milk secretion. J. Mammary Gland Biol. Neoplasia 7: 49-66.
43. Ormandy, C. J., Camus, A., Barra, J., Damotte, D., Lucas, B., Buteau, H., Edery, M., Brousse, N., Babinet, C., Binart, N. and Kelly, P. A. 1997. Null mutation of the prolactin receptor gene produces multiple reproductive defects in the mouse. Genes Dev. 11: 167-178.
44. Palin, M. F., Beaudry, D., Roberge, C. and Farmer, C. 2002. Expression levels of STAT5A and STAT5B in mammary parenchymal tissue from Upton-Meishan and Large White gilts. Can. J. Anim. Sci. 82: 507-518.
45. Pellegrini, S. and Dusanter-Fourt, I. 1997. The structure, regulation and function of the Janus kinases (JAKs) and the signal transducers and activators of transcription (STATs). Eur. J. Biochem. 248: 615-633.
46. Pluske, J. R., Williams, I. H. and Aherne, F. X. 1995. Nutrition of the neonatal pig. Pages 187-235 in M. A. Varley, ed. The neonatal pig-development and survival. CAB International, Wallingford, UK.
47. Purup, S. and Sejrsen K. 2000. Influence of leptin on proliferation of bovine mammary epithelial cells in collagen gel culture. Page 230 in J. A. M. van Arendonk, A. Hofer, Y. van der Honing, F. Madec, K. Sejrsen, D. Pullar, L. Bodin, J. A. Fernandez, and E. W. Bruns, eds. Book of abstracts of the 51st Annual Meeting of the European Association for Animal Production, The Hague, The Netherlands.
48. Robert, C., Palin, M. F., Coulombe, N., Roberge, C., Silversides, F. G., Benkel, B. F., McKay, R. M. and Pelletier, G. 1998. Backfat thickness in pigs is positively associated with leptin mRNA levels. Can. J. Anim. Sci. 78: 473-482.
49. Robinson, G. W., McKnight, R. A., Smith, G. H. and Hennighausen, L. 1995. Mammary epithelial cells undergo secretory differentiation in cycling virgins but require pregnancy for the establishment of terminal differentiation. Development 121: 2079-2090.
50. Ruan, W. and Kleinberg, D. L. 1999. Insulin-like growth factor I is essential for terminal end bud formation and ductal morphogenesis during mammary development. Endocrinology 140: 5075-5081.
51. Rui, H., Kirken, R. A. and Farrar, W. L. 1994. Activation of receptor-associated tyrosine kinase JAK2 by prolactin. J. Biol. Chem. 269: 5364-5368.
52. Shamay, A., Pursel, V. G., Wilkinson, E., Wall, R. J. and Hennighausen, L. 1992. Expression of the whey acidic protein in transgenic pigs impairs mammary development. Transgenic Res. 1: 124-132.
53. Silva, L. F. P., VanderHaar, M. J., Weber Nielsen, M. S. and Smith, G. W. 2002. Evidence for a local effect of leptin in bovine mammary gland. J. Dairy Sci. 85: 3277-3286.
54. Simpson, K. J., Bird, P., Shaw, D. and Nicholas, K. 1998. Molecular characterisation and hormone-dependent expression of the porcine whey acidic protein gene. J. Mol. Endocrinol. 20: 27-35.
55. Simpson, K. J. and Nicholas, K. R. 2002. The comparative biology of whey proteins. J. Mammary Gland Biol. Neoplasia 7: 313-326.
56. Smith-Kirwin, S. M., O'Connor, D. M., De Johnston, J., Lancey, E. D., Hassink, S. G. and Funanage, V. L. 1998. Leptin expression in human mammary epithelial cells and breast milk. J. Clin. Endocrinol. Metab. 83: 1810-1813.
57. Topper, Y. J. and Freeman, C. S. 1980. Multiple hormone interactions in the developmental biology of the mammary gland. Physiol. Rev. 60:1049-1106.
58. Tseng, L. and Zhu, H. H. 1998. Progestin, estrogen, and insulin-like growth factor-I stimulate the prolactin receptor mRNA in human endometrial stromal cells. J. Soc. Gynecol. Investig. 5: 149-155.
59. Wang, Y., Kuropatwinski, K. K., Whites, D. W., Hawley, T. S., Hawley, R. G., Tartaglia, L. A. and Baumann, H. 1997. Leptin receptor action in hepatic cells. J. Biol. Chem. 272: 6216-16223.
60. Watanobe, H., Schioth, H. B. and Suda, T. 2000. Stimulation of prolactin secretion by chronic, but not acute, administration of leptin in the rat. Brain Res. 887: 426-431.
61. Watson, C. J. and Burdon, T. G. 1996. Prolactin signal transduction mechanisms in the mammary gland: the role of the Jak/Stat pathway. Rev. Reprod. 1: 1-5.
62. Yang, J., Kennelly, J. J. and Baracos, V. E. 2000. The activity of transcription factor Stat5 responds to prolactin, growth hormone, and IGF-I in rat and bovine mammary explant culture. J. Anim. Sci. 78: 3114-3125.
63. Zhang, Y., Proenca, R., Maffei, M., Barone, M., Leopol, L. and Friedman, J. M. 1994. Positional cloning of the mouse obese gene and its human homologue. Nature 372: 425-432.