GPIIb/IIIa integrin antagonists with the new conformational restriction unit, trisubstituted β-amino acid derivatives, and a substituted benzamidine structure

Journal of Medicinal Chemistry

Volumn 41, Issue 13, 1998, Pages 2345-2360

  Hayashi, Yoshio ^a   Katada, Jun ^a   Harada, Takeo ^a   Tachiki, Akira ^a   Iijima, Kiyoko ^a   Takiguchi, Yoshimi ^a   Muramatsu, Michiko ^a   Miyazaki, Hiroshi ^a   Asari, Tohru ^a   Okazaki, Takeo ^a   Sato, Yoshimi ^a   Yasuda, Emiko ^a   Yano, Mako ^a   Uno, Isao ^a   Ojima, Iwao ^b  

^a NIPPON STEEL CORPORATION   (Japan)

^b STONY BROOK UNIVERSITY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

BENZAMIDINE DERIVATIVE; BETA AMINO ACID; FIBRINOGEN RECEPTOR; FIBRINOGEN RECEPTOR ANTAGONIST; N [3 (N 4 AMIDINOBENZOYL)AMINO 2,2 DIMETHYL 3 PHENYLPROPIONYL]PIPERIDINE 4 ACETIC ACID; N [3 [2 FLUORO 4 [THIAZOLIDIN 3 YL(IMINO)METHYL]BENZOYL]AMINO 2,2 DIMETHYLPENTANOYL]PIPERIDINE 4 ACETIC ACID ETHYL ESTER; NSL 96173; UNCLASSIFIED DRUG; XEMILOFIBAN;

ANIMAL EXPERIMENT; ARTICLE; CONTROLLED STUDY; DOSE TIME EFFECT RELATION; DRUG BIOAVAILABILITY; DRUG CONFORMATION; DRUG HALF LIFE; DRUG POTENCY; GUINEA PIG; INTRAVENOUS DRUG ADMINISTRATION; MALE; NONHUMAN; ORAL DRUG ADMINISTRATION; RAT; STRUCTURE ACTIVITY RELATION; THROMBOCYTE AGGREGATION INHIBITION;

ADMINISTRATION, ORAL; ANIMALS; BENZAMIDINES; ENZYME-LINKED IMMUNOSORBENT ASSAY; GUINEA PIGS; HUMANS; MALE; MODELS, MOLECULAR; MOLECULAR CONFORMATION; PIPERIDINES; PLATELET AGGREGATION; PLATELET AGGREGATION INHIBITORS; PLATELET GLYCOPROTEIN GPIIB-IIIA COMPLEX; RATS; RATS, SPRAGUE-DAWLEY; STRUCTURE-ACTIVITY RELATIONSHIP; THIAZOLIDINES;

EID: 15444346262     PISSN: 00222623     EISSN: None     Source Type: Journal    
DOI: 10.1021/jm980126v     Document Type: Article

References (42)

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