Quantitative morphometric analysis of pulmonary deposition of aerosol particles inhaled via intratracheal nebulization, intratracheal instillation or nose-only inhalation in rats

Journal of Applied Toxicology

Volumn 18, Issue 2, 1998, Pages 149-160

  Leong, B K J ^a,b   Coombs, J K ^a   Sabaitis, C P ^a   Rop, D A ^a   Aaron, C S ^a  

^a PFIZER INC   (United States)

^b Occupational Toxicology   (United States)

Author keywords

Inhalation; Instillation; Intratracheal; Nebulization; Particles; Pulmonary distribution; Quantitative morphometric analyses; Rats

Indexed keywords

AEROSOL; ANIMAL EXPERIMENT; ARTICLE; INHALATION; LUNG DEPOSIT; MALE; NEBULIZATION; NONHUMAN; PARTICLE SIZE; PRIORITY JOURNAL; RAT; TOXICITY; TOXICITY TESTING;

ABSORPTION; ADMINISTRATION, INTRANASAL; AEROSOLS; ANIMALS; COLORING AGENTS; DIAZONIUM COMPOUNDS; DRUG DELIVERY SYSTEMS; INHALATION EXPOSURE; LUNG; MALE; NEBULIZERS AND VAPORIZERS; PARTICLE SIZE; RATS; RATS, SPRAGUE-DAWLEY; TRACHEA;

EID: 0031961340     PISSN: 0260437X     EISSN: None     Source Type: Journal    
DOI: 10.1002/(SICI)1099-1263(199803/04)18:2<149::AID-JAT490>3.0.CO;2-L     Document Type: Article

References (26)

1. J. D. Brain and P. A. Valberg, Deposition of aerosol in the respiratory tract. Am. Rev. Respir. Dis. 120, 1325-1373 (1979).
2. S. J. Enna and L. S. Schanker, Absorption of saccharides and urea from the rat lung. Am. J. Physiol. 222, 409-414 (1972).
3. M. Aihara, R. P. Sharma and J. L. Shupe, Auto radio-graphic assessment of the disposition of different forms of intratracheally administered cadmium in rat lung. Toxicologist. 5, 33 (1985).
4. J. D. Brain, D. E. Knudson, S. P. Sorokin and M. A. Davis, Pulmonary distribution of particles given by intratracheal instillation or by aerosol inhalation. Environ. Res. 11, 13-33 (1976).
5. B. K. J. Leong, J. K. Coombs, E. N. Petzold, A. H. Hanchar and M. L. McNee, Endotracheal nebulization of drugs into the lungs of anesthetized animals. Toxicologist 5, 31 (1985).
6. 14C-lodoxamide tromethamine by inhalation, intravenous and oral routes of administration in the monkey. Toxicologist 5, 245 (1985).
7. B. K. J. Leong, J. K. Coombs, M. M. Imlay and C. P. Sabaitis, Morphometric analyses of the pulmonary distribution of particles given by nose-only aerosol inhalation or endotracheal nebulization or instillation. Toxicologist 6, 35 (1986).
8. R. M. Schreck, J. J. Sekuterski and K. B. Gross, Synchronized intratracheal aerosol generation for rodent studies. In Aerosols, Formation and Reactivity. Second International Aerosol Conference, Berlin, Pergamon Press, New York (1986).
9. B. K. J. Leong, J. K. Coombs, E. N. Petzold and A. J. Hanchar, A dosimetric endotracheal nebulization technique for pulmonary metabolic disposition studies in laboratory animals, Inhal. Toxicol. 1, 37-51 (1988).
10. R. M. Schreck, J. Sekuterski, G. Oberdörster and J. Wojciak, Aerosol distribution in the lung from a miniature synchronized intratracheal aerosol generator. Research Publication GMR-5561. General Motors Research Laboratories, Warren (1986).
11. M. L. Crosfill and J. G. Widdicombe, Physical characteristics of the chest and lungs and the work of breathing in different mammalian species. J. Physiol 158, 1 (1961).
12. B. K. J. Leong, G. F. Dowd and H. N. MacFarland, A new technique for tidal volume measurement in unanesthetized small animals. Can. J. Physiol. Pharmacol. 42, 189-198 (1964).
13. H.-G. Liebich, The segmentation of the lung of the white rat. Anat. Histol. Embryol. 3, 243-249 (1974).
14. D. W. Baxter and C. D. Port, Large-volume intratracheal instillation of particulate suspensions to hamster. In Experimental Lung Cancer. Carcinogenesis and bioassay, ed. by E. Karbe and J. F. Parks, pp. 86-91, Springer-Verlag, Berlin (1974).
15. J. D. Sun, R. K. Wolff, S. M. Maio and E. B. Barr, Influence of adsorption to carbon black particles on the retention and metabolic activation of benzo[a]pyrene in rat lungs following inhalation exposure or intratracheal instillation. Inhal. Toxicol. 1, 1-19 (1989).
16. S. J. Enna and L. S. Schanker, Absorption of drugs from the rat lung. Am. J. Physiol. 223, 1227-1231 (1972).
17. B. M. Taylor, J. M. Justin, B. K. J. Leong, C. P. Sabaitis, D. A. Rop, W. E. Fleming and I. M. Richard, Validating a dosimetric intratracheal nebulization technique for evaluation of pulmonary anti-inflammatory drugs. Toxicologist 30, 326 (1997).
18. 99mTc labeled aerosol in a whole-body exposure. In Inhalation Toxicology Research Annual Report, Lovelace Biomedical Environmental Research Institute, Albuquerque, pp. 259-265 (1979).
19. T. P. Haynie, L. R. Ellis, G. A. Wood and M. Youngerman, Lung scans following inhalation of nebulized radionuclides. J. Asthma Res. 5, 231-240 (1968).
20. D. S. Davis, Pharmacokinetics of inhaled substances. Postgrad. Med. J. 51, 69-75 (1975).
21. C. S. Nessel, M. A. Amoruso, T. H. Umbreit and M. A. Gallo, Hepatic aryl hydroxylase and cytochrome P450 induction following the transpulmonary absorption of TCDD from intratracheally instilled particles. Fundam. Appl. Toxicol. 15, 500-509 (1990).
22. K. E. Driscoll and J. K. Maurer, Cytokine and growth factor release by alveolar macrophages: potential biomarkers of pulmonary toxicity. Toxicol. Pathol. 19, 398-495 (1991).
23. K. E. Driscoll, J. K. Maurer, R. C. Lindenschmidt, D. Romberger, S. I. Rennard and L. Crosby. Respiratory tract responses to dust: Relationship between dust burden, lung injury, alveolar macrophage fibronectin release, and development of pulmonary fibrosis. Toxicol. Appl. Pharmacol. 106, 88-101 (1990).
24. H. L. Ritz, B. L. Evans, R. D. Bruce, E. R. Fletcher, G. L. Fisher and K. Sarlo, Respiratory and immunological responses of guinea pigs to enzymes containing detergents: a comparison of intratracheal and inhalation modes of exposure. Fundam. Appl. Toxicol. 21, 31-37 (1993).
25. G. Oberdörster, C. Cox and R. Gelein. Intratracheal instillation versus intratracheal inhalation of tracer particles for measuring lung clearance function. Exp. Lung Res. 23, 17-34 (1997).
26. R. F. Henderson, K. E. Driscoll, J. R. Harkema, R. C. Lindenschmidt, I.-Y. Chang, K. R. Maples, and E. B. Barr, A comparison of the inflammatory response of the lung to inhaled versus instilled particles in F344 rats. Fundam. Appl. Toxicol. 24, 183-197 (1995).