Pulmonary toxicity of simulated lunar and Martian dusts in mice: I. Histopathology 7 and 90 days after intratracheal instillation

Inhalation Toxicology

Volumn 14, Issue 9, 2002, Pages 901-916

  Lam, Chiu Wing ^a   James, John T ^a   McCluskey, Richard ^a   Cowper, Shawn ^b   Balis, John ^b   Muro Cacho, Carlos ^b  

^a NASA JOHNSON SPACE CENTER   (United States)

^b UNIVERSITY OF SOUTH FLORIDA   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

OZONE; SILICON DIOXIDE; SODIUM CHLORIDE; TITANIUM DIOXIDE;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; ASTRONOMY; CHRONIC INFLAMMATION; CONTROLLED STUDY; DISEASE SEVERITY; DOSE RESPONSE; DUST; DUST EXPOSURE; HEALTH HAZARD; HISTOPATHOLOGY; LUNG ALVEOLITIS; LUNG EDEMA; LUNG FIBROSIS; LUNG TOXICITY; MACROPHAGE; MOUSE; NONHUMAN; OXIDATION; PNEUMONIA; PRIORITY JOURNAL; SIMULATION; SOIL POLLUTION; VOLCANIC ASH;

ANIMALIA; FRAXINUS;

EID: 0036738190     PISSN: 08958378     EISSN: None     Source Type: Journal    
DOI: 10.1080/08958370290084683     Document Type: Article

References (28)

1. Adamson, I. Y., Prieditis, H., and Bowden, D. H. 1992. Instillation of chemotactic factor to silica-injected lungs lowers interstitial particle content and reduces pulmonary fibrosis. Am. J. Pathol. 141:319-326.
2. Allen, C., Morris, R. V., Jager, K. M., Golden, D. C., Lindstrom, D. J., Lindstrom, M. M., and Lockwood, J. P. 1998. JSC Mars-1: A Martian soil simulant. Space 98 Proceedings of the Conference of American Society of Civil Engineers, pp. 469-475. 26-30 April, Albuquerque, NM.
3. 2). Toxicologist 54:314.
4. Boggs, D. F. 1992. Comparative control of respiration. In Treatise on pulmonary toxicology, Vol. I: Comparative biology of the normal lung, ed. R. A. Parent, pp. 309-350. Boca Raton, FL: CRC Press.
5. Driscoll, K. E., Costa, D. L., Hatch, G., Henderson, R., Oberdorster, G., Salem, H., and Schlesinger, R. B. 2000. Intratracheal instillation as an exposure technique for the evaluation of respiratory tract toxicity: Uses and limitations. Toxicol. Sci. 55:24-35.
6. Everitt, J. I., Mangum J. B., Bermudez, E., Wong, B. A., Asgarian, B., Reverdy, E. E., Hext, P. M., and Warheit, D. B. 2000. Comparison of selected pulmonary responses of rats, mice, and Syrian golden hamsters to inhaled pigmentary titanium dioxide. Inhal. Toxicol. 12(suppl. 3):275-282.
7. Glaser, P. E. 1992. Mitigation of dust contamination during EVA operations on the moon and Mars. In Engineering, construction, and operations in space, III: Space'92: Proceedings of the 3rd International Conference, Denver, Colorado, May 31-June 4.
8. Henderson, R. F., Driscoll, K. E., Harkema, J. R., Lindenschmidt, R. C., Chang, I.-Y., Maples, K. R., and Barr, E. B. 1995. A comparison of the inflammatory response of the lung to inhaled versus instilled particles in F344 Rats. Fundam. Appl. Toxicol. 24:183-197.
9. Hext, P. M. 1994. Current perspectives on particulate induced pulmonary tumours. Hum. Exp. Toxicol. 13:700-715.
10. Hoffman, S., and Kaplan, D. 1997. Human exploration of Mars: The reference mission of the NASA Mars exploration study team. NASA Special Publication 61-7, Linthicum Heights, MD: NASA Center for Aerospace Information.
11. Holland, J. M., and Simmonds, R. C. 1972. The mammalian response to lunar particulates. Space Life Sci. 4(1):97-109.
12. Kirichenko, A., Li, L., Morandi, M. T., and Holian, A. 1996. 4-Hydroxyl-2-nonenal-protein adducts and apoptosis in murine lung cells after acute ozone exposure., Toxicol. Appl. Pharmacol. 141:416-424.
13. Kustov, V. V., Ostapvenko, O. F., and Petrukhin, V. G. 1974. [Research on the biological effect of a fine fraction of lunar soil sent to Earth by the unmanned station Luna-16]. In [Lunar soil from the Sea of Fertility], p. 592. Moscow: M. Nauka.
14. Kustov, V. V., Belkin, V. I., and Kruglikov, G. G. 1989. [Biological effects of lunar soil]. [Problems in Space Biology] 61:1-146.
15. Lai, Y.-L. 1992. Comparative ventilation of the normal lung. In Treatise on pulmonary toxicology, Vol. I: Comparative biology of the normal lung, ed. R. A. Parent, pp. 217-239. Boca Raton, FL: CRC Press.
16. Lam, C.-W., James, J. T., Latch, J. N., Hamilton R. F., and Holian, A. 2002. Pulmonary toxicity of simulated lunar and Martian dusts in mice: II. Biomarkers of acute responses after intratracheal instillation. Inhal. Toxicol. 14:917-928.
17. Leigh, J., Nonin, A., and Wang, H. 2000. In vivo genotoxicity of crystalline silica as evidenced by micronuclei in pulmonary alveolar macrophage: Low-dose study. Inhal. Toxicol. 12:199-204.
18. McKay, D. S., Carter, J. L., Boles, W. W., Allen, C. C., and Allton, J. H. 1994. JSC-1: A new lunar soil simulant. Proceedings of Space '94, Conference of American Society of Civil Engineers, 26 February-3 March, Albuquerque, NM.
19. Morrow, P. E. 1992. Dust overloading of the lungs: Update and appraisal. Toxicol. Appl. Pharmacol. 113:1-12.
20. Muhle, H., Bellmann, B., Creutzenberg, O., Heinrich, U., Ketkar, M., and Mermelstein, R. 1990. Dust overloading of lungs after exposure of rats to particles of low solubility: Comparative studies. J. Aerosol Sci. 21:374-377.
21. NASA. 1969. Apollo 11 technical crew debriefing. Houston, TX. Cited in Final report: Dust control and protection for planetary exposure. Prepared by Lockheed Engineering & Sciences Company. NASA Document JSC-25975. Houston, TX: National Aeronautics and Space Administration, Johnson Space Center.
22. NASA. 1970. Apollo 12 preliminary science report. Washington, DC: NASA SP-235, Scientific and Technical Information, Division, Office of Technology Utilization, National Aeronautics and Space Administration.
23. Oyama, V. I., and Berdahl, B. J. 1977. The Viking gas exchange experiment results from Chryse and Utopia surface samples. J. Geophys. Res. 82:4669-4676.
24. Reuzel, P. G., Bruijntjes, J. P., Feron, V., and Woutersen, R. A. 1991. Subchronic inhalation toxicity of amorphous silicas and quartz dust in rats. Food Chem. Toxicol. 29(5):341-354.
25. Smith, W. B., Wilson, R. R., and Harris, D. B. 1979. A five-stage cyclone system for in situ sampling. Environ. Sci. Technol. 13:1387-1392.
26. Trochimowicz, H. J., Lee, K. P., and Reinhardt, C. F. 1988. Chronic inhalation exposure of rats to titanium dioxide dust. J. Appl. Toxicol. 8:383-385.
27. Tsapin, A. I., Goldeld, M. G., McDonald, G. D., Nealson, K. H., Moscowitz, B., Solheid, P., Kemner, K. H., Kelly, S. D., and Orlandini, K. A. 2000. Iron(VI): Hypothetical candidate for the Martian oxidant. Cirrus 147:68-79.
28. Yen, A. S., Kim, S. S., Hecht, M. H., Frant, M. S., and Murray, B. 2000. Evidence that the reactivity of the Martian soil is due to superoxide ions. Science 289:1909-1912.