Efficient synthesis of trans- or cis-4(5)-(5-aminomethyltetrahydrofuran-2- yl)imidazoles via diazafulvene intermediates: Synthetic approach toward human histamine H4-ligands

Chemical and Pharmaceutical Bulletin

Volumn 51, Issue 7, 2003, Pages 832-837

  Harusawa, Shinya ^a   Araki, Lisa ^a   Terashima, Hirotaka ^a   Kawamura, Makoto ^a   Takashima, Seiichiro ^a   Sakamoto, Yasuhiko ^b   Hashimoto, Takeshi ^c   Yamamoto, Yumiko ^c   Yamatodani, Atsushi ^c   Kurihara, Takushi ^a  

^a OSAKA MEDICAL COLLEGE   (Japan)

^b Azwell Inc   (Japan)

^c OSAKA UNIVERSITY   (Japan)

Author keywords

Diazafulvene; H4 receptor; Imifuramine

Indexed keywords

4(5)(5 AMINOMETHYLTETRAHYDROFURAN 2 YL)IMIDAZOLE; DIAZAFULVENE; ETHYL 4(5)(5 HYDROXYMETHYLTETRAHYDROFURAN 2 YL)IMIDAZOLE; FURAN DERIVATIVE; HISTAMINE H4 RECEPTOR; IMIDAZOLE DERIVATIVE; IMUFURAMINE; UNCLASSIFIED DRUG; G PROTEIN COUPLED RECEPTOR; HISTAMINE RECEPTOR; HRH4 PROTEIN, HUMAN; LIGAND;

ARTICLE; CARBONYLATION; CHEMICAL REACTION; CRYSTAL STRUCTURE; CYCLIZATION; DEOXYGENATION; DRUG SELECTIVITY; DRUG SYNTHESIS; METHODOLOGY; NUCLEAR MAGNETIC RESONANCE; PROTON NUCLEAR MAGNETIC RESONANCE; CHEMISTRY; HUMAN; METABOLISM; PHYSIOLOGY; PROTEIN BINDING; STEREOISOMERISM; SYNTHESIS;

HUMANS; IMIDAZOLES; LIGANDS; PROTEIN BINDING; RECEPTORS, G-PROTEIN-COUPLED; RECEPTORS, HISTAMINE; STEREOISOMERISM;

EID: 1542680620     PISSN: 00092363     EISSN: 13475223     Source Type: Journal    
DOI: 10.1248/cpb.51.832     Document Type: Article

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