2-Chloro-2′-deoxyadenosine synergistically enhances azidothymidine cytotoxicity in azidothymidine resistant T-lymphoid cells

Biochemical and Biophysical Research Communications

Volumn 316, Issue 2, 2004, Pages 518-522

  Han, Tieran ^a   Fernandez, Marilyn ^a   Chou, Ting Chao ^a,b   Agarwal, Ram P ^a  

^a UNIVERSITY OF MIAMI MILLER SCHOOL OF MEDICINE   (United States)

^b MEMORIAL SLOAN KETTERING CANCER CENTER   (United States)

Author keywords

Azidothymidine; Cladribine; Effect of cladribine on azidothymidine activation; Synergistic cytotoxicity

Indexed keywords

CLADRIBINE; CYTARABINE; DEOXYCYTIDINE KINASE; THYMIDINE KINASE; ZIDOVUDINE;

ARTICLE; CALCULATION; CELL GROWTH; CELL LINE; COMPUTER PROGRAM; CONCENTRATION RESPONSE; CROSS RESISTANCE; DRUG POTENTIATION; ENZYME ACTIVITY; GROWTH INHIBITION; HUMAN; HUMAN CELL; IC 50; LYMPHOCYTE CULTURE; LYMPHOID CELL; PRIORITY JOURNAL; QUANTITATIVE ANALYSIS; T LYMPHOCYTE;

ANTINEOPLASTIC AGENTS; CELL DIVISION; CELL LINE; CLADRIBINE; DOSE-RESPONSE RELATIONSHIP, DRUG; DRUG RESISTANCE; DRUG SYNERGISM; HUMANS; T-LYMPHOCYTES; ZIDOVUDINE;

EID: 1542635081     PISSN: 0006291X     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bbrc.2004.02.085     Document Type: Article

References (28)

1. DeClercq E. Antiviral therapy for human immunodeficiency virus infections. Clin. Microb. Rev. 8:1995;200-239.
2. n-deoxy-b-d-lyxofuranosyl)thymines. Org. Chem. Ser. Monogr. 29:1964;2076-2078.
3. Tosi P., Calabresi P., Goulette F.A., Renaud C.A., Darnowski J.W. Azidothymidine-induced cytotoxicity and incorporation into DNA in the human colon tumor cell line HT-8 is enhanced by methotrexate in vitro and in vivo. Cancer Res. 52:1992;4069-4073.
4. Scanlon K.J., Kashani-Sabet M., Sowers L.C. Overexpression of DNA replication and repair enzymes in cisplatin-resistant human colon carcinoma HTC-8 cells and circumvention by azidothymidine. Cancer Commun. 1:1989;269-275.
5. Newman E.M., Miyachi H., Reiling C., Jiao C., Sowers L.C., Scanlon K.J. Increased sensitivity to azidothymidine in a subline of CCRF-CEM human leukemic cell resistant to methotrexate. Proc. Am. Assoc. Cancer Res. 32:1991;413.
6. Weber G., Ichikawa S., Nagai M., Natsumeda Y. Azidothymidine inhibition of thymidine kinase and synergistic cytotoxicity with methotrexate and 5-fluorouracil in rat hepatoma and human colon cancer cells. Cancer Commun. 2:1990;129-134.
7. Lee R.K., Cai J.-P., Deyev V., Gill P.S., Cabral L., Wood C., Agarwal R.P., Xia W., Boise L.H., Podack E., Harrington W.J. Jr. Azidothymidine and interferon-α-induce apoptosis in herpes virus-associated lymphomas. Cancer Res. 59:1999;5514-5520.
8. Posner M.R., Darnowski J.W., Calabresi P., Brunetti I., Corvese D., Curt G., Cummings F.J., Clark J., Browne M., Beitz J.M., Weitberg A.B. Oral azidothymidine, continuous infusion 5-fluorouracil and oral leucovorin: a phase I study. J. Natl. Cancer Inst. 82:1990;1710-1714.
9. Danesi R., Falcone A., Conte P.F., Del Tacca M. Pharmacokinetic optimization of the treatment of cancer with high dose zidovudine. Clin. Pharmacokinet. 34:1998;173-180.
10. ′ -triphosphate with human immunodeficiency virus reverse transcriptase Proc. Natl. Acad. Sci. USA. 83:1986;8333-8337.
11. ′ -deoxythymidine with evidence of incorporation into DNA of human bone marrow cells Mol. Pharmacol. 36:1989;9-14.
12. ′ -triphosphate (AZTTP) levels in cultured CEM T-lymphoblastoid cells Biochem. Pharmacol. 49:1995;829-837.
13. ′ -deoxyadenosine (2-CdA) Arch. Immulo. Ther. Exp. Warsz. 42:1994;17-23.
14. ′ -deoxyadenosine and 9-β-D-arabinosyl-2-fluoroadenine Blood. 81:1993;143-150.
15. Beutler E. Cladribine (2-chlorodeoxyadenosine). Lancet. 340:1992;952.
16. Juliusson G., Elmhorn-Rosenborg A., Liliemark J. Response to 2-chlorodeoxyadenosine in patients with B-cell chronic lymphocytic leukemia resistant to fludarabine. N. Engl. J. Med. 327:1992;1056-1061.
17. Arnér E.S. On the phosphorylation of 2-chlorodeoxyadenosine (CdA) and its correlation with clinical response in leukemia treatment. Leuk. Lymphoma. 21:1996;225-231.
18. Griffig J., Koob R., Blakley R.L. Mechanism of inhibition of DNA synthesis by 2-chlorodeoxyadenosine in human lymphoblastic cells. Cancer Res. 49:1989;6923-6928.
19. Hirota Y., Yoshioka A., Tanaka S., Watanabe K., Otani T., Minowada J., Matsuda A., Ueda T., Wataya Y. Imbalance of deoxyribonucleoside triphosphates, DNA double-strand breaks, and cell death caused by 2-chlorodeoxyadenosine in mouse FM3A cells. Cancer Res. 49:1989;915-919.
20. ′ -deoxyadenosine (cladribine) in human lymphocytes Biochem. Pharmacol. 56:1998;1175-1179.
21. Agarwal R.P., Han T., Fernandez M. Reduced cellular transport and activation of fluoropyrimidine nucleosides and resistance in human lymphocytic cell lines selected for arabinosyl-cytosine resistance. Biochem. Pharmacol. 61(2110):2001;39-47.
22. Han T., Fernandez M., Sarkar M., Agarwal R.P. Arabinosylcytosine down- regulates thymidine kinase and induces cross-resistance to zidovudine in T-lymphoid cells. Biochem. Biophys. Res. Commun. 307:2003;564-568.
23. Chou T.C., Talalay P. Applications of the median-effect principle for the assessment of low-dose risk of carcinogens and for the quantitation of synergism and antagonism of chemotherapeutic agents. Harrap K.R., Connors T.A. New Avenues of Developmental Cancer Chemotherapy, Bristol-Myers Symposium Series. 1987;37-64 Academic Press, New York.
24. Chou J. Quantitation of synergism and antagonism of two or more drugs by computerized analysis. Chou T.C., Rideout D.C. Synergism and Antagonism in Chemotherapy. 1991;223-244 Academic Press, New York.
25. Chou T,C., Hayball M. CalcuSyn for Windows, Multiple-Drug Dose-Effect Analyzer and Manual. 1996;Biosoft, Cambridge Place, Cambridge, UK.
26. Agarwal R.P., Wang W., Yo P., Han T., Fernandez Cross resistance of dideoxycytidine resistant cell lines to azidothymidine. Biochem. Pharmacol. 58:1999;1603-1608.
27. Chou T.C., Motzer R.J., Tong Y., Bosl G.J. Computerized quantitation of synergism and antagonism of taxol, topotecan, and cisplatin against human teratocarcinoma cell growth: a rational approach to clinical protocol design. J. Natl. Cancer Inst. 86:1994;1517-1524.
28. Chou T.C. Drug combinations: from laboratory to practice. J. Lab. Clin. Med. 131:1998.