Direct binding of C1q to apoptotic cells and cell blebs induces complement activation

European Journal of Immunology

Volumn 32, Issue 6, 2002, Pages 1726-1736

  Nauta, Alma J ^a   Trouw, Leendert A ^a   Daha, Mohamed R ^a   Tijsma, Odette ^a   Nieuwland, Rienk ^a   Schwaeble, Wilhelm J ^b   Gingras, Alexandre R ^b   Mantovani, Alberto ^c   Hack, Erik C ^d   Roos, Anja ^a  

^a LEIDEN UNIVERSITY MEDICAL CENTER   (Netherlands)

^b UNIVERSITY OF LEICESTER   (United Kingdom)

^c MARIO NEGRI INSTITUTE FOR PHARMACOLOGICAL RESEARCH   (Italy)

^d CENTRAL LABORATORY   (Netherlands)

Author keywords

Apoptosis; Blebs; C1q; Complement; Pentraxin

Indexed keywords

COMPLEMENT COMPONENT C1Q; COMPLEMENT COMPONENT C3; COMPLEMENT COMPONENT C4;

APOPTOSIS; ARTICLE; CELL SURFACE; COMPLEMENT ACTIVATION; COMPLEMENT DEPOSITION; COMPLEMENT FIXATION; CONTROLLED STUDY; HUMAN; HUMAN CELL; PHAGOCYTOSIS; PLASMA; PRIORITY JOURNAL; PROTEIN PURIFICATION; PROTEIN STRUCTURE;

APOPTOSIS; COMPLEMENT ACTIVATION; COMPLEMENT C1Q; COMPLEMENT C3; COMPLEMENT C4; HUMANS; JURKAT CELLS; PHAGOCYTES;

EID: 0036083789     PISSN: 00142980     EISSN: None     Source Type: Journal    
DOI: 10.1002/1521-4141(200206)32:6<1726::AID-IMMU1726>3.0.CO;2-R     Document Type: Article

References (48)

1. Cell death in health and disease: The biology and regulation of apoptosis
2. Apoptosis
3. Vitronectin receptor-mediated phagocytosis of cells undergoing apoptosis
4. CD36 gene transfer confers capacity for phagocytosis of cells undergoing apoptosis
5. A receptor for phosphatidylserine-specific clearance of apoptotic cells
6. Human CD14 mediates recognition and phagocytosis of apoptotic cells
7. The ATP binding cassette transporter ABC1, is required for the engulfment of corpses generated by apoptotic cell death
8. Macrophage recognition of cells undergoing programmed cell death (apoptosis)
9. Role for the class A macrophage scavenger receptor in the phagocytosis of apoptotic thymocytes in vitro
10. C-Reactive protein binds to apoptotic cells, protects the cells from assembly of the terminal complement components, and sustains an anti-inflammatory innate immune response. Implications for systemic autoimmunity
11. Complement-dependent clearance of apoptotic cells by human macrophages
12. The long pentraxin PTX3 binds to apoptotic cells and regulates their clearance by antigen-presenting dendritic cells
13. A hierarchical role for classical pathway complement proteins in the clearance of apoptotic cells in vivo
14. Complement deficiency and disease
15. Autoantigens targeted in systemic lupus erythematosus are clustered in two populations of surface structures on apoptotic keratinocytes
16. Systemic exposure to irradiated apoptotic cells induces autoantibody production
17. Dendritic cells acquire antigen from apoptotic cells and induce class I-restricted CTLs
18. Role of antigen-presenting cells in cross-priming of cytotoxic T lymphocytes by apoptotic cells
19. Homozygous C1q deficiency causes glomerulonephritis associated with multiple apoptotic bodies
20. C1q binds directly and specifically to surface blebs of apoptotic human keratinocytes: Complement deficiency and systemic lupus erythematosus revisited
21. The globular heads of C1q specifically recognize surface blebs of apoptotic vascular endothelial cells
22. Complement activation by apoptotic endothelial cells following hypoxia/reoxygenation
23. Multimer formation and ligand recognition by the long pentraxin PTX3. Similarities and differences with the short pentraxins C-reactive protein and serum amyloid P component
24. Specific cleavage of the 70-kDa protein component of the U1 small nuclear ribonucleoprotein is a characteristic biochemical feature of apoptotic cell death
25. DNA-dependent protein kinase is one of a subset of autoantigens specifically cleaved early during apoptosis
26. Selective cleavage of nuclear autoantigens during CD95 (Fas/APO-1)-mediated T cell apoptosis
27. Processing of engulfed apoptotic bodies yields T cell epitopes
28. Dendritic cells resurrect antigens from dead cells
29. Cellular origin and procoagulant properties of microparticles in meningococcal sepsis
30. Complement binding is an early feature of necrotic and a rather late event during apoptotic cell death
31. Isolation, cDNA cloning, and overexpression of a 33-kD cell surface glycoprotein that binds to the globular "heads" of C1q
32. Serum amyloid P component controls chromatin degradation and prevents antinuclear autoimmunity
33. Chromatin-independent binding of Serum amyloid P component (SAP) to apoptotic cells
34. C1q-how many functions? How many receptors?
35. C1q and mannose binding lectin engagement of cell surface calreticulin and CD91 initiates macropinocytosis and uptake of apoptotic cells
36. Rapid isolation and biochemical characterization of rat C1 and C1q
37. Regulation of the function of the first component of complement by human C1q receptor
38. The biochemistry of complement
39. Annexin V for flow cytometric detection of phosphatidylserine expression on B cells undergoing apoptosis
40. Culture of human endothelial cells derived from umbilical veins. Identification by morphologic and immunologic criteria
41. The distortive mechanism for the activation of complement component C1 supported by studies with a monoclonal antibody against the "arms" of C1q
42. Administration of IgG Fc fragments prevents glomerular injury in experimental immune complex nephritis
43. Characterisation of the rat and mouse homologues of gC1qBP, a 33 kDa glycoprotein that binds to the globular 'heads' of C1q
44. Direct detection of activated platelets and platelet-derived microparticles in humans
45. Activation of the alternative pathway of complement by calcium-loaded erythrocytes resulting from loss of membrane phospholipid asymmetry
46. Specific inhibition of the classical complement pathway by C1q-binding peptides
47. Application of a monoclonal antibody against a neoepitope on activated C4 in an ELISA for the quantification of complement activation via the classical pathway
48. Both IgG and IgM anti-pig antibodies induce complement activation and cytotoxicity