메뉴 건너뛰기




Volumn 20, Issue 3, 2004, Pages 359-367

Selective imidazoline agonist moxonidine plus the ACE inhibitor ramipril in hypertensive patients with impaired insulin sensitivity: Partners in a successful MARRIAGE?

Author keywords

Diabetes mellitus; Dysglycaemia; Hypertension; Insulin resistance; Metabolic syndrome; Moxonidine; Ramipril

Indexed keywords

ALPHA ADRENERGIC RECEPTOR; ALPHA ADRENERGIC RECEPTOR BLOCKING AGENT; AMLODIPINE; ANGIOTENSIN; ANTIHYPERTENSIVE AGENT; ATENOLOL; BETA ADRENERGIC RECEPTOR BLOCKING AGENT; CALCIUM CHANNEL BLOCKING AGENT; CAPTOPRIL; CHLORTALIDONE; CLONIDINE; DIPEPTIDYL CARBOXYPEPTIDASE INHIBITOR; DIURETIC AGENT; DOXAZOSIN; FOSINOPRIL; GLUCOSE; GLYCOSYLATED HEMOGLOBIN; HIGH DENSITY LIPOPROTEIN CHOLESTEROL; IMIDAZOLINE I1 RECEPTOR; IMIDAZOLINE RECEPTOR AGONIST; INSULIN; LISINOPRIL; LOSARTAN; MOXONIDINE; PLACEBO; RAMIPRIL; THIAZIDE DIURETIC AGENT; TRANDOLAPRIL; TRIACYLGLYCEROL; UNCLASSIFIED DRUG; UNINDEXED DRUG;

EID: 1542615355     PISSN: 03007995     EISSN: None     Source Type: Journal    
DOI: 10.1185/030079904125002991     Document Type: Review
Times cited : (18)

References (68)
  • 1
    • 0027406191 scopus 로고
    • Diabetes, other risk factors and 12-year mortality for men screened in the multiple risk factor intervention trial
    • Stamler J, Vaccaro O, Neaton JD, et al. Diabetes, other risk factors and 12-year mortality for men screened in the multiple risk factor intervention trial. Diabetes Care 1993;16:434-44
    • (1993) Diabetes Care , vol.16 , pp. 434-444
    • Stamler, J.1    Vaccaro, O.2    Neaton, J.D.3
  • 2
    • 0032560807 scopus 로고    scopus 로고
    • Mortality from coronary heart disease in subjects with type 2 diabetes and in nondiabetic subjects with and without prior myocardial infarction
    • Haffner SM, Lehto S, Ronnemaa T, et al. Mortality from coronary heart disease in subjects with type 2 diabetes and in nondiabetic subjects with and without prior myocardial infarction. N Engl J Med 1998;339:229-34
    • (1998) N Engl J Med , vol.339 , pp. 229-234
    • Haffner, S.M.1    Lehto, S.2    Ronnemaa, T.3
  • 3
    • 0041903645 scopus 로고    scopus 로고
    • Cardiovascular events in type 2 diabetes: Comparison with nondiabetic individuals without and with prior cardiovascular disease - 10-year follow-up of the Hoorn Study
    • Becker A, Bos G, de Vegt F, et al. Cardiovascular events in type 2 diabetes: comparison with nondiabetic individuals without and with prior cardiovascular disease - 10-year follow-up of the Hoorn Study. Eur Heart J 2003;24:1406-3
    • (2003) Eur Heart J , vol.24 , pp. 1406-1403
    • Becker, A.1    Bos, G.2    De Vegt, F.3
  • 4
    • 0037527647 scopus 로고    scopus 로고
    • 2003 European Society of Hypertension - European Society of Cardiology guidelines for the management of arterial hypertension
    • Guidelines Committee. 2003 European Society of Hypertension - European Society of Cardiology guidelines for the management of arterial hypertension. J Hypertens 2003;21:1011-53
    • (2003) J Hypertens , vol.21 , pp. 1011-1053
  • 5
    • 0024160877 scopus 로고
    • Role of insulin resistance in human disease
    • Reaven GM. Role of insulin resistance in human disease. Diabetes 1988;37:1595-607
    • (1988) Diabetes , vol.37 , pp. 1595-1607
    • Reaven, G.M.1
  • 6
    • 0345476305 scopus 로고    scopus 로고
    • Syndrome X 10 years after
    • Reaven G. Syndrome X 10 years after. Drugs 1999;58(Suppl 1):19-20
    • (1999) Drugs , vol.58 , Issue.SUPPL. 1 , pp. 19-20
    • Reaven, G.1
  • 7
    • 0035897696 scopus 로고    scopus 로고
    • Expert Panel on Detection, Evaluation and Treatment of High Blood Cholesterol in Adults. Executive summary of the Third Report of the National Cholesterol Education Program (NCEP) on detection, evaluation and treatment of high blood cholesterol in adults
    • Expert Panel on Detection, Evaluation and Treatment of High Blood Cholesterol in Adults. Executive summary of the Third Report of the National Cholesterol Education Program (NCEP) on detection, evaluation and treatment of high blood cholesterol in adults. JAMA 2001;285:2486-97
    • (2001) JAMA , vol.285 , pp. 2486-2497
  • 8
    • 0037116641 scopus 로고    scopus 로고
    • Prevalence of the metabolic syndrome among US adults. Findings from the Third National Health and Nutrition Examination Survey
    • Ford ES, Giles WH, Dietz WH. Prevalence of the metabolic syndrome among US adults. Findings from the Third National Health and Nutrition Examination Survey. JAMA 2002;287:356-9
    • (2002) JAMA , vol.287 , pp. 356-359
    • Ford, E.S.1    Giles, W.H.2    Dietz, W.H.3
  • 9
    • 0018775947 scopus 로고
    • Relationship of glucose tolerance and plasma insulin to the incidence of coronary heart disease: Results from two population studies in Finland
    • Pyörälä K. Relationship of glucose tolerance and plasma insulin to the incidence of coronary heart disease: results from two population studies in Finland. Diabetes Care 1979;2:131-41
    • (1979) Diabetes Care , vol.2 , pp. 131-141
    • Pyörälä, K.1
  • 10
    • 0037236652 scopus 로고    scopus 로고
    • A disturbed glucose metabolic state (dysglycaemia) is a key factor for cardiovascular events
    • Gerstein HC. A disturbed glucose metabolic state (dysglycaemia) is a key factor for cardiovascular events. Eur Heart J 2003;24(Suppl B):B1-B2
    • (2003) Eur Heart J , vol.24 , Issue.SUPPL. B
    • Gerstein, H.C.1
  • 11
    • 0029957413 scopus 로고    scopus 로고
    • Risk factors for myocardial infarction and death in newly detected NIDDM: The Diabetes Intervention Study, 11-year follow-up
    • Hanefeld M, Fischer S, Julius U, et al. Risk factors for myocardial infarction and death in newly detected NIDDM: the Diabetes Intervention Study, 11-year follow-up. Diabetologia 1996;39:1577-83
    • (1996) Diabetologia , vol.39 , pp. 1577-1583
    • Hanefeld, M.1    Fischer, S.2    Julius, U.3
  • 12
    • 0025367559 scopus 로고
    • Cardiovascular risk factors in confirmed prediabetic individuals. Does the clock for coronary heart disease start ticking before the onset of diabetes?
    • Haffner SM, Stern MP, Hazuda HP, et al. Cardiovascular risk factors in confirmed prediabetic individuals. Does the clock for coronary heart disease start ticking before the onset of diabetes? JAMA 1990;263:2893-8
    • (1990) JAMA , vol.263 , pp. 2893-2898
    • Haffner, S.M.1    Stern, M.P.2    Hazuda, H.P.3
  • 13
    • 0032902850 scopus 로고    scopus 로고
    • The relationship between glucose and incident cardiovascular events. A metaregression analysis of published data from 20 studies of 95,783 individuals followed for 12.4 years
    • Coutinho M, Gerstein HC, Wang Y, Yusuf S. The relationship between glucose and incident cardiovascular events. A metaregression analysis of published data from 20 studies of 95,783 individuals followed for 12.4 years. Diabetes Care 1999;22:233-40
    • (1999) Diabetes Care , vol.22 , pp. 233-240
    • Coutinho, M.1    Gerstein, H.C.2    Wang, Y.3    Yusuf, S.4
  • 14
    • 0032511580 scopus 로고    scopus 로고
    • Tight blood pressure control and risk of macrovascular and microvascular complications in type 2 diabetes: UKPDS 38
    • UK Prospective Diabetes Study Group. Tight blood pressure control and risk of macrovascular and microvascular complications in type 2 diabetes: UKPDS 38. BMJ 1998;317:703-13
    • (1998) BMJ , vol.317 , pp. 703-713
  • 15
    • 0029825467 scopus 로고    scopus 로고
    • Antihypertensive treatment in insulin resistant patients
    • Lithell HO, Andersson PE. Antihypertensive treatment in insulin resistant patients. Hypertens Res 1996;19(Suppl 1):S75-S79
    • (1996) Hypertens Res , vol.19 , Issue.SUPPL. 1
    • Lithell, H.O.1    Andersson, P.E.2
  • 16
    • 0028877228 scopus 로고
    • Effects of losartan on insulin sensitivity in severe hypertension: Connections through sympathetic nervous system activity?
    • Moan A, Hoieggen A, Nordby G, Eide IK, Kjeldsen SE. Effects of losartan on insulin sensitivity in severe hypertension: connections through sympathetic nervous system activity? J Hum Hypertens 1995;9(Suppl 5):S45-50
    • (1995) J Hum Hypertens , vol.9 , Issue.SUPPL. 5
    • Moan, A.1    Hoieggen, A.2    Nordby, G.3    Eide, I.K.4    Kjeldsen, S.E.5
  • 17
    • 0344373794 scopus 로고    scopus 로고
    • Major outcomes in high-risk hypertensive patients randomized to angiotensin-converting enzyme inhibitor or calcium channel blocker vs diuretic
    • The ALLHAT Officers and Coordinators for the ALLHAT Collaborative Research Group. Major outcomes in high-risk hypertensive patients randomized to angiotensin-converting enzyme inhibitor or calcium channel blocker vs diuretic. JAMA 2002;288:2981-97
    • (2002) JAMA , vol.288 , pp. 2981-2997
  • 18
    • 0035714450 scopus 로고    scopus 로고
    • Metabolic profile of indapamide sustained-release in patients with hypertension: Data from three randomised double-blind studies
    • Weidmann P. Metabolic profile of indapamide sustained-release in patients with hypertension: data from three randomised double-blind studies. Drug Safety 2001;25:1155-65
    • (2001) Drug Safety , vol.25 , pp. 1155-1165
    • Weidmann, P.1
  • 19
    • 0034933505 scopus 로고    scopus 로고
    • Perindopril/indapamide 2/0.635 mg/day: A review of its place in the management of hypertension
    • Metheson AJ, Cheer SM, Goa KL. Perindopril/indapamide 2/0.635 mg/day: a review of its place in the management of hypertension. Drugs 2001;61:1211-29
    • (2001) Drugs , vol.61 , pp. 1211-1229
    • Metheson, A.J.1    Cheer, S.M.2    Goa, K.L.3
  • 20
    • 0642274857 scopus 로고    scopus 로고
    • Comparative metabolic effects of hydrochlorothiazide and indapamide in hypertensive diabetic patients receiving ACE inhibitor therapy
    • Krum H, Skiba M, Gilbert RE. Comparative metabolic effects of hydrochlorothiazide and indapamide in hypertensive diabetic patients receiving ACE inhibitor therapy. Diabetes Med 2003;20:708-12
    • (2003) Diabetes Med , vol.20 , pp. 708-712
    • Krum, H.1    Skiba, M.2    Gilbert, R.E.3
  • 21
    • 0034098507 scopus 로고    scopus 로고
    • Effects of indapamide versus hydrochlorothiazide on plasma lipids and lipoproteins in hypertensive patients: A direct comparison
    • Spence JD, Huff M, Barnett PA. Effects of indapamide versus hydrochlorothiazide on plasma lipids and lipoproteins in hypertensive patients: a direct comparison. Can J Clin Pharmacol 2000;7:32-7
    • (2000) Can J Clin Pharmacol , vol.7 , pp. 32-37
    • Spence, J.D.1    Huff, M.2    Barnett, P.A.3
  • 22
    • 0031767559 scopus 로고    scopus 로고
    • Antihypertensive therapy and insulin sensitivity: Do we have to redefine the role of beta-blocking agents?
    • Jacob S, Rett K, Henriksen EJ. Antihypertensive therapy and insulin sensitivity: do we have to redefine the role of beta-blocking agents? Am J Hypertens 1998;11:1258-65
    • (1998) Am J Hypertens , vol.11 , pp. 1258-1265
    • Jacob, S.1    Rett, K.2    Henriksen, E.J.3
  • 23
    • 0034097806 scopus 로고    scopus 로고
    • Induction of insulin resistance by beta-blockade but not by ACE-inhibition: Long-term treatment with atenolol or trandolapril
    • Reneland R, Alvarez E, Andersson PL, et al. Induction of insulin resistance by beta-blockade but not by ACE-inhibition: long-term treatment with atenolol or trandolapril. J Hum Hypertens 2000;14:175-80
    • (2000) J Hum Hypertens , vol.14 , pp. 175-180
    • Reneland, R.1    Alvarez, E.2    Andersson, P.L.3
  • 24
    • 0032513878 scopus 로고    scopus 로고
    • Effects of intensive blood-pressure lowering and low-dose aspirin in patients with hypertension: Principal results of the Hypertension Optimal Treatment (HOT) randomised trial
    • Hansson L, Zanchetti A, Carruthers SG, et al. for the HOT Study Group. Effects of intensive blood-pressure lowering and low-dose aspirin in patients with hypertension: principal results of the Hypertension Optimal Treatment (HOT) randomised trial. Lancet 1998;351:1755-62
    • (1998) Lancet , vol.351 , pp. 1755-1762
    • Hansson, L.1    Zanchetti, A.2    Carruthers, S.G.3
  • 25
    • 0025831464 scopus 로고
    • Prevention of stroke by antihypertensive drug treatment in older persons with isolated systolic hypertension. Final results of the systolic hypertension in the elderly program (SHEP)
    • SHEP Cooperative Research Group. Prevention of stroke by antihypertensive drug treatment in older persons with isolated systolic hypertension. Final results of the systolic hypertension in the elderly program (SHEP). JAMA 1991;265:3255-64
    • (1991) JAMA , vol.265 , pp. 3255-3264
  • 26
    • 0031044480 scopus 로고    scopus 로고
    • Health outcomes associated with antihypertensive therapies used as first-line agents a systematic review and meta-analysis
    • Psaty BM, Smith NL, Siscovick DS, et al. Health outcomes associated with antihypertensive therapies used as first-line agents a systematic review and meta-analysis. JAMA 1997;277:739-45
    • (1997) JAMA , vol.277 , pp. 739-745
    • Psaty, B.M.1    Smith, N.L.2    Siscovick, D.S.3
  • 27
    • 0033911687 scopus 로고    scopus 로고
    • Therapeutic benefits of ACE inhibitors and other antihypertensive drugs in patients with type 2 diabetes
    • Pahor M, Psaty BM, Alderman MH, et al. Therapeutic benefits of ACE inhibitors and other antihypertensive drugs in patients with type 2 diabetes. Diabetes Care 2000;23:888-92
    • (2000) Diabetes Care , vol.23 , pp. 888-892
    • Pahor, M.1    Psaty, B.M.2    Alderman, M.H.3
  • 28
    • 0033034404 scopus 로고    scopus 로고
    • Effect of angiotensin-converting-enzyme inhibition compared with conventional therapy on cardiovascular morbidity and mortality in hypertension: The Captopril Prevention Project (CAPPP) randomised trial
    • Hansson L, Lindholm LH, Niskanen L, et al. Effect of angiotensin-converting-enzyme inhibition compared with conventional therapy on cardiovascular morbidity and mortality in hypertension: the Captopril Prevention Project (CAPPP) randomised trial. Lancet 1999;353:611-6
    • (1999) Lancet , vol.353 , pp. 611-616
    • Hansson, L.1    Lindholm, L.H.2    Niskanen, L.3
  • 29
    • 0035653491 scopus 로고    scopus 로고
    • Reduced cardiovascular morbidity and mortality in hypertensive diabetic patients on first-line therapy with an ACE inhibitor compared with a diuretic/β-blocker-based treatment regimen
    • Niskanen L, Hedner T, Hansson L, et al. Reduced cardiovascular morbidity and mortality in hypertensive diabetic patients on first-line therapy with an ACE inhibitor compared with a diuretic/β-blocker-based treatment regimen. Diabetes Care 2001;24:2091-6
    • (2001) Diabetes Care , vol.24 , pp. 2091-2096
    • Niskanen, L.1    Hedner, T.2    Hansson, L.3
  • 30
    • 0032511601 scopus 로고    scopus 로고
    • Efficacy of atenolol and captopril in reducing risk of macrovascular and microvascular complications in type 2 diabetes: UKPDS 39
    • UK Prospective Diabetes Study Group. Efficacy of atenolol and captopril in reducing risk of macrovascular and microvascular complications in type 2 diabetes: UKPDS 39. BMJ 1998;317:713-20
    • (1998) BMJ , vol.317 , pp. 713-720
  • 31
    • 0026720597 scopus 로고
    • The cardiovascular effects of alpha-receptor blocking agents
    • Leren P. The cardiovascular effects of alpha-receptor blocking agents. J Hypertens 1992;10(Suppl):S11-14
    • (1992) J Hypertens , vol.10 , Issue.SUPPL.
    • Leren, P.1
  • 32
    • 0030022644 scopus 로고    scopus 로고
    • Antihypertensive and metabolic effects of doxazosin in hypertensive patients with concomitant non-insulin-dependent diabetes mellitus
    • Inoue Y, Kaneko T, Matsumara S, et al. Antihypertensive and metabolic effects of doxazosin in hypertensive patients with concomitant non-insulin-dependent diabetes mellitus. J Int Med Res 1996;24:138-46
    • (1996) J Int Med Res , vol.24 , pp. 138-146
    • Inoue, Y.1    Kaneko, T.2    Matsumara, S.3
  • 33
    • 0026445233 scopus 로고
    • Glucose, insulin, and lipid metabolism in doxazosin-treated patients with hypertension
    • Shieh SM, Sheu WH, Shen DC, et al. Glucose, insulin, and lipid metabolism in doxazosin-treated patients with hypertension. Am J Hypertens 1992;5:827-31
    • (1992) Am J Hypertens , vol.5 , pp. 827-831
    • Shieh, S.M.1    Sheu, W.H.2    Shen, D.C.3
  • 34
    • 0031882732 scopus 로고    scopus 로고
    • Hemodynamic and metabolic effects of transdermal clonidine in patients with hypertension and non-insulin-dependent diabetes mellitus
    • Giugliano D, Acampora R, Marfella R, et al. Hemodynamic and metabolic effects of transdermal clonidine in patients with hypertension and non-insulin-dependent diabetes mellitus. Am J Hypertens 1998;11:184-9
    • (1998) Am J Hypertens , vol.11 , pp. 184-189
    • Giugliano, D.1    Acampora, R.2    Marfella, R.3
  • 35
    • 0037160968 scopus 로고    scopus 로고
    • Cardiovascular morbidity and mortality in the Losartan Intervention for Endpoint reduction in hypertension study (LIFE): A randomised trial against atenolol
    • Dahlof B, Devereux RB, Kjeldsen SE et al. Cardiovascular morbidity and mortality in the Losartan Intervention For Endpoint reduction in hypertension study (LIFE): a randomised trial against atenolol. Lancet 2002;359:995-1003
    • (2002) Lancet , vol.359 , pp. 995-1003
    • Dahlof, B.1    Devereux, R.B.2    Kjeldsen, S.E.3
  • 36
    • 0037160969 scopus 로고    scopus 로고
    • Cardiovascular morbidity and mortality in patients with diabetes in the Losartan Intervention for Endpoint reduction in hypertension study (LIFE)
    • Lindholm LH, Ibsen H, Dahlöf B, et al. Cardiovascular morbidity and mortality in patients with diabetes in the Losartan Intervention for Endpoint reduction in hypertension study (LIFE). Lancet 2002;359:1004-10
    • (2002) Lancet , vol.359 , pp. 1004-1010
    • Lindholm, L.H.1    Ibsen, H.2    Dahlöf, B.3
  • 37
    • 0042466544 scopus 로고    scopus 로고
    • Effect of losartan on sudden cardiac death in people with diabetes: Data from the LIFE study
    • Lindholm LH, Dahlöf B, Edelmans JM, et al. Effect of losartan on sudden cardiac death in people with diabetes: data from the LIFE study. Lancet 2003;362:619-20
    • (2003) Lancet , vol.362 , pp. 619-620
    • Lindholm, L.H.1    Dahlöf, B.2    Edelmans, J.M.3
  • 38
    • 0034674022 scopus 로고    scopus 로고
    • Impact of diabetes on cardiac structure and function: The Strong Heart Study
    • Devereux RB, Roman MJ, Paranicas M, et al. Impact of diabetes on cardiac structure and function: the Strong Heart Study. Circulation 2000;101:2271-6
    • (2000) Circulation , vol.101 , pp. 2271-2276
    • Devereux, R.B.1    Roman, M.J.2    Paranicas, M.3
  • 39
    • 0034732256 scopus 로고    scopus 로고
    • Hypertension and antihypertensive therapy as risk factors for type 2 diabetes mellitus
    • Gress TW, Nieto FJ, Shamar E, et al. Hypertension and antihypertensive therapy as risk factors for type 2 diabetes mellitus. N Engl J Med 2000;342:905-12
    • (2000) N Engl J Med , vol.342 , pp. 905-912
    • Gress, T.W.1    Nieto, F.J.2    Shamar, E.3
  • 40
    • 0034688194 scopus 로고    scopus 로고
    • Effects of an angiotensin-converting-enzyme inhibitor, ramipril, on cardiovascular events in high-risk patients
    • The Heart Outcomes Prevention Evaluation Study Investigators. Effects of an angiotensin-converting-enzyme inhibitor, ramipril, on cardiovascular events in high-risk patients. N Engl J Med 2000;342:145-53
    • (2000) N Engl J Med , vol.342 , pp. 145-153
  • 41
    • 0034700790 scopus 로고    scopus 로고
    • Effects of ramipril on cardiovascular and microvascular outcomes in people with diabetes mellitus: Results of the HOPE study and MICRO-HOPE substudy
    • HOPE Study Investigators. Effects of ramipril on cardiovascular and microvascular outcomes in people with diabetes mellitus: results of the HOPE study and MICRO-HOPE substudy. Lancet 2000;355:253-9
    • (2000) Lancet , vol.355 , pp. 253-259
  • 42
    • 0038460302 scopus 로고    scopus 로고
    • The seventh report of the Joint National Committee on Prevention, Detection, Evaluation, and Treatment of High Blood Pressure. The JNC 7 Report
    • Chobanian A, Bakris GL, Black HR, et al. The seventh report of the Joint National Committee on Prevention, Detection, Evaluation, and Treatment of High Blood Pressure. The JNC 7 Report. JAMA 2003;289:2560-82
    • (2003) JAMA , vol.289 , pp. 2560-2582
    • Chobanian, A.1    Bakris, G.L.2    Black, H.R.3
  • 43
    • 0034729993 scopus 로고    scopus 로고
    • Morbidity and mortality in patients randomised to double-blind treatment with long-acting calcium-channel blocker or diuretic in the International Nifedipine GITS study: Intervention as a goal in hypertension treatment (INSIGHT)
    • Brown MJ, Palmer CJ, Castaigne A, et al. Morbidity and mortality in patients randomised to double-blind treatment with long-acting calcium-channel blocker or diuretic in the International Nifedipine GITS study: Intervention as a goal in hypertension treatment (INSIGHT). Lancet 2000;356:366-72
    • (2000) Lancet , vol.356 , pp. 366-372
    • Brown, M.J.1    Palmer, C.J.2    Castaigne, A.3
  • 44
    • 0034730027 scopus 로고    scopus 로고
    • Randomised trial of effects of calcium antagonists compared with diuretics and β-blockers on cardiovascular morbidity and mortality in hypertension: The Nordic Diltiazem (NORDIL) study
    • Hansson L, Hedner T, Lund-Johansen P, et al. Randomised trial of effects of calcium antagonists compared with diuretics and β-blockers on cardiovascular morbidity and mortality in hypertension: the Nordic Diltiazem (NORDIL) study. Lancet 2000;356:359-65
    • (2000) Lancet , vol.356 , pp. 359-365
    • Hansson, L.1    Hedner, T.2    Lund-Johansen, P.3
  • 45
    • 0037534905 scopus 로고    scopus 로고
    • The study on cognition and prognosis in the elderly (SCOPE): Principal results of a randomized double-blind intervention trial
    • Lithell H, Hansson K, Skoog I, et al. The study on cognition and prognosis in the elderly (SCOPE): principal results of a randomized double-blind intervention trial. J Hypertens 2003;21:875-86
    • (2003) J Hypertens , vol.21 , pp. 875-886
    • Lithell, H.1    Hansson, K.2    Skoog, I.3
  • 46
    • 18544376399 scopus 로고    scopus 로고
    • Risk of new-onset diabetes in the losartan intervention for endpoint reduction in hypertension study
    • Lindholm LH, Ibsen H, Borch-Johnsen B, et al. Risk of new-onset diabetes in the losartan intervention for endpoint reduction in hypertension study. J Hypertens 2002;20:1879-86
    • (2002) J Hypertens , vol.20 , pp. 1879-1886
    • Lindholm, L.H.1    Ibsen, H.2    Borch-Johnsen, B.3
  • 47
    • 0042154108 scopus 로고    scopus 로고
    • Metabolic outcome during 1 year in newly detected hypertensives: Results of the Antihypertensive and Lipid Profile in a North of Sweden Efficacy Evaluation (ALPINE study)
    • Lindholm LH, Persson M, Alaupovic P, Carlberg B, Svensson A, Samuelsson O. Metabolic outcome during 1 year in newly detected hypertensives: results of the Antihypertensive and Lipid Profile in a North of Sweden Efficacy Evaluation (ALPINE study). J Hypertens 2003;21:1563-74
    • (2003) J Hypertens , vol.21 , pp. 1563-1574
    • Lindholm, L.H.1    Persson, M.2    Alaupovic, P.3    Carlberg, B.4    Svensson, A.5    Samuelsson, O.6
  • 48
    • 0034762402 scopus 로고    scopus 로고
    • Antihypertensive treatment of patients with diabetes and hypertension
    • Julius S, Majahalma S, Palatini P. Antihypertensive treatment of patients with diabetes and hypertension. Am J Hypertens 2001;14:310S-6S
    • (2001) Am J Hypertens , vol.14
    • Julius, S.1    Majahalma, S.2    Palatini, P.3
  • 49
    • 0037376636 scopus 로고    scopus 로고
    • Insulin resistance: A global epidemic in need of effective therapies
    • Califf RM. Insulin resistance: a global epidemic in need of effective therapies. Eur Heart J Suppl 2003;(Suppl C):C13-C18
    • (2003) Eur Heart J Suppl , Issue.SUPPL. C
    • Califf, R.M.1
  • 50
    • 0027286024 scopus 로고
    • Hypertension in Diabetes Study (HDS): 1. Prevalence of hypertension in newly presenting type 2 diabetic patients and the association with risk factors for cardiovascular and diabetic complications
    • The Hypertension in Diabetes Study Group. Hypertension in Diabetes Study (HDS): 1. Prevalence of hypertension in newly presenting type 2 diabetic patients and the association with risk factors for cardiovascular and diabetic complications. J Hypertens 1993;11:309-17
    • (1993) J Hypertens , vol.11 , pp. 309-317
  • 51
    • 0035050460 scopus 로고    scopus 로고
    • Diabetes, hypertension, and cardiovascular disease: An update
    • Sowers JR, Epstein M, Frohlich ED. Diabetes, hypertension, and cardiovascular disease: an update. Hypertension 2001;37:1053-9
    • (2001) Hypertension , vol.37 , pp. 1053-1059
    • Sowers, J.R.1    Epstein, M.2    Frohlich, E.D.3
  • 52
    • 0033224334 scopus 로고    scopus 로고
    • Metabolic effects on moxonidine and other centrally acting antihypertensives
    • Schachter M. Metabolic effects on moxonidine and other centrally acting antihypertensives. Diabetes Obes Metab 1999;1:317-22
    • (1999) Diabetes Obes Metab , vol.1 , pp. 317-322
    • Schachter, M.1
  • 53
    • 0007942073 scopus 로고    scopus 로고
    • Chemistry, mechanism of action and preclinical pharmacology of moxonidine
    • van Zwieten PA, Hamilton CA, Julius S, Prichard BNC, editors. London: Royal Society of Medicine Press Ltd
    • 1-imidazoline receptor agonist moxonidine: a new antihypertensive. London: Royal Society of Medicine Press Ltd, 1996:7-30
    • (1996) 1-Imidazoline Receptor Agonist Moxonidine: A New Antihypertensive , pp. 7-30
    • Hamilton, C.A.1
  • 54
    • 0031054324 scopus 로고    scopus 로고
    • The use of moxonidine in the treatment of hypertension
    • Prichard BNC, Graham BR. The use of moxonidine in the treatment of hypertension. J Hypertens 1997;15(Suppl 1): S47-S55
    • (1997) J Hypertens , vol.15 , Issue.SUPPL. 1
    • Prichard, B.N.C.1    Graham, B.R.2
  • 55
    • 0031038675 scopus 로고    scopus 로고
    • Placebo-controlled comparison of the efficacy and tolerability of once-daily moxonidine and enalapril in mild-to-moderate essential hypertension
    • Küppers H, Jäger B, Luszick JH, et al. Placebo-controlled comparison of the efficacy and tolerability of once-daily moxonidine and enalapril in mild-to-moderate essential hypertension. J Hypertens 1997;15:93-7
    • (1997) J Hypertens , vol.15 , pp. 93-97
    • Küppers, H.1    Jäger, B.2    Luszick, J.H.3
  • 56
    • 0027538272 scopus 로고
    • Renal imidazoline preferring sites and sodium excretion in the rat
    • Penner SB, Smyth DD. Renal imidazoline preferring sites and sodium excretion in the rat. Br J Clin Pharmacol 1993;108:870-5
    • (1993) Br J Clin Pharmacol , vol.108 , pp. 870-875
    • Penner, S.B.1    Smyth, D.D.2
  • 57
    • 0003122203 scopus 로고
    • Effects of agmatine and moxonidine on glucose metabolism: An integrated approach towards pathophysiological mechanisms in cardiovascular metabolic disorders
    • Kaan EC, Brückner R, Frohly P, et al. Effects of agmatine and moxonidine on glucose metabolism: an integrated approach towards pathophysiological mechanisms in cardiovascular metabolic disorders. J Cardiac Risk Factors 1995;5:10-27
    • (1995) J Cardiac Risk Factors , vol.5 , pp. 10-27
    • Kaan, E.C.1    Brückner, R.2    Frohly, P.3
  • 58
    • 0031047598 scopus 로고    scopus 로고
    • Experimental benefit of moxonidine on glucose metabolism and insulin secretion in the fructose-fed rat
    • Rösen P, Ohly P, Gleichmann H. Experimental benefit of moxonidine on glucose metabolism and insulin secretion in the fructose-fed rat. J Hypertens 1997;15(Suppl 1):S31-S38
    • (1997) J Hypertens , vol.15 , Issue.SUPPL. 1
    • Rösen, P.1    Ohly, P.2    Gleichmann, H.3
  • 59
    • 0030639995 scopus 로고    scopus 로고
    • 1-imidazoline receptor: From binding site to therapeutic target in cardiovascular disease
    • 1-imidazoline receptor: from binding site to therapeutic target in cardiovascular disease. J Hypertens 1997;15(Suppl 1):S9-S23
    • (1997) J Hypertens , vol.15 , Issue.SUPPL. 1
    • Ernsberger, P.1    Freidman, J.E.2    Koletsky, R.J.3
  • 60
    • 0032912061 scopus 로고    scopus 로고
    • Mechanisms of antihyperglycemic effects of moxonidine in the obese spontaneously hypertensive Koletsky rat (SHROB)
    • Ernsberger P, Ishizuka T, Liu S, et al. Mechanisms of antihyperglycemic effects of moxonidine in the obese spontaneously hypertensive Koletsky rat (SHROB). J Pharmacol Exp Ther 1999;288:139-47
    • (1999) J Pharmacol Exp Ther , vol.288 , pp. 139-147
    • Ernsberger, P.1    Ishizuka, T.2    Liu, S.3
  • 61
    • 0032954960 scopus 로고    scopus 로고
    • Metabolic and hemodynamic effects of moxonidine in the Zucker diabetic rat model of type 2 diabetes
    • Yakubu-Madus FE, Johnson WT, Zimmerman KM, et al. Metabolic and hemodynamic effects of moxonidine in the Zucker diabetic rat model of type 2 diabetes. Diabetes 1999;48:1093-100
    • (1999) Diabetes , vol.48 , pp. 1093-1100
    • Yakubu-Madus, F.E.1    Johnson, W.T.2    Zimmerman, K.M.3
  • 62
    • 0036070879 scopus 로고    scopus 로고
    • The role of the angiotensin system in cardiac glucose homeostasis: Therapeutic implications
    • Bernobich E, de Angelis L, Lerin C, Bellini G. The role of the angiotensin system in cardiac glucose homeostasis: therapeutic implications. Drugs 2002;62:1295-314
    • (2002) Drugs , vol.62 , pp. 1295-1314
    • Bernobich, E.1    De Angelis, L.2    Lerin, C.3    Bellini, G.4
  • 63
    • 0033176270 scopus 로고    scopus 로고
    • Moxonidine improves insulin sensitivity in insulin-resistant hypertensives
    • Haenni A, Lithell HO. Moxonidine improves insulin sensitivity in insulin-resistant hypertensives. J Hypertens 1999;17(Suppl 3): S29-S35
    • (1999) J Hypertens , vol.17 , Issue.SUPPL. 3
    • Haenni, A.1    Lithell, H.O.2
  • 64
    • 0347922129 scopus 로고    scopus 로고
    • Insulin resistance and arterial hypertension. The influence of moxonidine and metformin therapy
    • abstract 2B.6
    • Almazov VA, Shlyatko EV, Blagosklonnaya YV, et al. Insulin resistance and arterial hypertension. The influence of moxonidine and metformin therapy. J Hypertens 2000;18(Suppl 2): [abstract 2B.6]
    • (2000) J Hypertens , vol.18 , Issue.SUPPL. 2
    • Almazov, V.A.1    Shlyatko, E.V.2    Blagosklonnaya, Y.V.3
  • 65
    • 0347291854 scopus 로고    scopus 로고
    • Effect of a imidazoline agonist on sympathetic activity and components of the insulin resistance syndrome in obese hypertensive Brazilian patients
    • abstract
    • Sanjuliani AF, Genelhu-Fagunde V, Barroso SG, et al. Effect of a imidazoline agonist on sympathetic activity and components of the insulin resistance syndrome in obese hypertensive Brazilian patients. J Hypertens 2002;20:S206[abstract]
    • (2002) J Hypertens , vol.20
    • Sanjuliani, A.F.1    Genelhu-Fagunde, V.2    Barroso, S.G.3
  • 66
    • 0038220757 scopus 로고    scopus 로고
    • Rosiglitazone improves insulin sensitivity and lowers blood pressure in hypertensive patients
    • Raji A, Seely EW, Bekins SA, et al. Rosiglitazone improves insulin sensitivity and lowers blood pressure in hypertensive patients. Diabetes Care 2003;26:172-8
    • (2003) Diabetes Care , vol.26 , pp. 172-178
    • Raji, A.1    Seely, E.W.2    Bekins, S.A.3
  • 67
    • 0033985343 scopus 로고    scopus 로고
    • Screening for type 2 diabetes
    • American Diabetes Association. Screening for type 2 diabetes. Diabetes Care 2000;23(Suppl 1):S20-S23
    • (2000) Diabetes Care , vol.23 , Issue.SUPPL. 1
  • 68
    • 0033404927 scopus 로고    scopus 로고
    • Use of moxonidine as initial therapy and in combination in the treatment of essential hypertension - Results of the TOPIC (Trial of Physiotens in combination) Study
    • Waters J, Ashford J, Jäger B, Wonnacott S, Verboom C-N for the OPIC Investigators. Use of moxonidine as initial therapy and in combination in the treatment of essential hypertension - results of the TOPIC (Trial of Physiotens in combination) Study. J Clin Basic Cardiol 1999;2:219-24
    • (1999) J Clin Basic Cardiol , vol.2 , pp. 219-224
    • Waters, J.1    Ashford, J.2    Jäger, B.3    Wonnacott, S.4


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.