Hemodynamic and metabolic effects of transdermal clonidine in patients with hypertension and non-insulin-dependent diabetes mellitus

American Journal of Hypertension

Volumn 11, Issue 2, 1998, Pages 184-189

  Giugliano, Dario ^a,b   Acampora, Rita ^a   Marfella, Raffaele ^a   La Marca, Carmine ^a   Marfella, Maria ^a   Nappo, Francesco ^a   D'Onofrio, Felice ^a  

^a SECOND UNIVERSITY OF NAPLES   (Italy)

^b NONE   (Italy)

Author keywords

Clonidine; Glucose metabolism; Hemodynamics; Hypertension; Non insulin dependent diabetes mellitus

Indexed keywords

C PEPTIDE; CLONIDINE; GLUCOSE; INSULIN; ISOPHANE INSULIN; PLACEBO;

ADULT; ARTICLE; CLINICAL ARTICLE; CLINICAL TRIAL; CONTROLLED STUDY; CROSSOVER PROCEDURE; DIASTOLIC BLOOD PRESSURE; FEMALE; GLUCOSE CLAMP TECHNIQUE; GLUCOSE METABOLISM; HEART LEFT VENTRICLE MASS; HEMODYNAMICS; HUMAN; HYPERTENSION; MALE; NON INSULIN DEPENDENT DIABETES MELLITUS; PRIORITY JOURNAL; PROTEINURIA; RANDOMIZED CONTROLLED TRIAL; SINGLE BLIND PROCEDURE; SYSTOLIC BLOOD PRESSURE; TRANSDERMAL DRUG ADMINISTRATION;

ADMINISTRATION, CUTANEOUS; ADULT; AGED; ALBUMINURIA; BLOOD GLUCOSE; CLONIDINE; CROSS-OVER STUDIES; DIABETES MELLITUS, TYPE 2; FEMALE; HUMANS; HYPERTENSION; HYPERTROPHY, LEFT VENTRICULAR; MALE; MIDDLE AGED; SINGLE-BLIND METHOD;

EID: 0031882732     PISSN: 08957061     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0895-7061(97)00319-1     Document Type: Article

References (33)

1. Sowers JR, Epstein M: Diabetes mellitus and associated hypertension, vascular disease and nephropathy. An update. Hypertension 1995;26:145-158.
2. Després J-P, Moorjiani S, Lupien PJ, et al: Regional distribution of body fat, plasma lipoproteins, and cardiovascular disease. Arteriosclerosis 1990;10:497-511.
3. The National High Blood Pressure Education Program Working Group: National High Blood Pressure Education Program Working Group report on hypertension and diabetes. Hypertension 1994;23:145-158.
4. Murphy MB, Lewis PJ, Kohner E, et al: Glucose intolerance in hypertensive patients treated with diuretics: a fourteen year follow-up. Lancet 1982;ii:1293-1295.
5. Bengtsson C, Blohmé G, Lapidus L, et al: Do antihypertensive drugs precipitate diabetes? Br Med J 1984; 289:1495-1497.
6. Lithell HOL: Effect of antihypertensive drugs on insulin, glucose and lipid metabolism. Diabetes Care 1991; 14:203-209.
7. Black H: The coronary artery disease paradox: the role of hyperinsulinemia and insulin resistance and impli-cation for therapy. J Cardiovasc Pharmacol 1990; 15(suppl 5):S26-S38.
8. Anavekar SN, Jarrott B, Toscano M, Louis WJ: Pharmacokinetic and pharmacodynamic studies of oral clonidine in normotensive subjects. Eur J Clin Pharmacol 1982;23:1-5.
9. Hollifield J: Clinical acceptability of transdermal clonidine: a large-scale evaluation by practioners. Am Heart J 1986;112:900-906.
10. Sclar DA, Skaer TL, Chin A, et al: Utility of transdermal delivery system for antihypertensive therapy. Part 1. Am J Med 1991;91(1A):50S-56S.
11. DeFronzo RA, Tobin JD, Andres R: Glucose-clamp technique: a method for quantifying insulin secretion and resistance. Am J Physiol 1979;237:E214-E233.
12. Giugliano D, De Rosa N, Marfella R, et al: Comparison of nitrendipine and cilazapril in patients with hypertension and non-insulin-dependent diabetes mellitus. Am J Hypertens 1993;6:927-932.
13. Schiller NB, Shah PM, Crawford M, et al: Recommendations for quantitation of the left ventricle by two-dimensional echocardiography. J Am Soc Echocard 1989;2:358-367.
14. Giugliano D, Salvatore T, Paolisso G, et al: Impaired glucose metabolism and reduced insulin clearance in elderly hypertensives. Am J Hypertens 1992;5:345-353.
15. Clauss A: Rapid physiological coagulation method in determination of fibrinogen. Acta Haematol 1957;17: 237-241.
16. MacMahon S, Peto R, Cutler J, et al: Blood pressure, stroke and coronary heart disease. Lancet 1990;335:765-774.
17. Jarrett RJ, McCarthy P, Keen H: The Bedford Survey: ten year mortality rates in newly diagnosed diabetics, borderline diabetics and normoglycemic controls and risk indices from coronary heart disease in borderline diabetics. Diabetologia 1982;22:79-84.
18. Levy D, Garrison RJ, Savage DD, et al: Prognostic implications of echocardiographically determined left ventricular mass in the Framingham Heart Study. N Engl J Med 1990;322:1561-1566.
19. Weber MA, Drayer JIM, Baird WM: Echocardiographic evaluation of left ventricular hypertrophy. J Cardiovasc Pharmacol 1986;8:S61-S69.
20. DeFronzo RA: The triumvirate: β-cell, muscle, liver - a collusion responsible for NIDDM. Diabetes 1988;37: 667-687.
21. Swislocki ALM, Chen Y-DI, Golay A, et al: Insulin suppression of plasma free fatty acid concentration in normal individuals and patients with type 2 (non-insulin-dependent) diabetes. Diabetologia 1987;30:622-626.
22. Singer P, Godicke W, Voigt S, et al: Postprandial hyperinsulinemia in patients with mild essential hypertension. Hypertension 1985;7:182-186.
23. Villenueve A, Carpene C, Berlan M, Lafontan M: Lack of desensitization of α-2-mediated inhibition of lipolysis in fat cells after acute and chronic treatment with clonidine. J Pharmacol Exp Ther 1985;233:433-440.
24. Swislocki ALM, Vestal RE, Reaven GM, Hoffman BB: Acute metabolic effects of clonidine and adenosine in man. Horm Metab Res 1993;25:90-95.
25. Julius S, Gudbrandsson T, Jamerson K, The hemodynamic link between insulin resistance and hypertension. J Hypertens 1991;9:983-986.
26. Deibert DC, DeFronzo RA: Epinephrine-induce insulin resistance in man. J Clin Invest 1980;65:717-721.
27. Jamerson KA, Julius S, Gudbrandsson T, et al: Reflex sympathetic activation induces acute insulin resistance in the human forearm. Hypertension 1993;21:618-623.
28. Garcia-Morales P, du Frane SP, Sener A, et al: Inhibitory effect of clonidine upon adenylate cyclase activity, cyclic AMP production and insulin release in rat pancreatic islets. Biosci Rep 1984;4:511-521.
29. Viberti G, Keen M: The pattern of proteinuria in diabetes mellitus. Diabetes 1984;33:686-691.
30. Mogensen CE: Microalbuminuria as a predictor of clinical diabetic nephropathy. Kidney Int 1987;31:673-689.
31. Valentino V, Wilson M, Weart W, Bakris GL: A perspective on converting enzyme inhibitors and calcium channel antagonists in diabetic renal disease. Arch Intern Med 1991;151:2367-2372.
32. Ganda OP, Arkin CF: Hyperfibrinogenemia. An important risk factor for vascular complications in diabetes. Diabetes Care 1992;15:1245-1250.
33. Sowers JR, Zemzl MB: Clinical implications of hypertension in the diabetic patient. Am J Hypertens 1990;3: 415-424.