Synthesis of 2′-Substituted MMI Linked Nucleosidic Dimers: An Optimization Study in Search of High Affinity Oligonucleotides for Use in Antisense Constructs

Nucleosides, Nucleotides and Nucleic Acids

Volumn 23, Issue 1-2, 2004, Pages 411-438

  Peoc'h, Didier ^a   Swayze, Eric E ^a   Bhat, Balkrishen ^a   Sanghvi, Yogesh S ^a  

^a ISIS PHARMACEUTICALS   (United States)

Author keywords

Antisense; MMI dimer; Oligonucleotide

Indexed keywords

ANTISENSE OLIGONUCLEOTIDE; CARBENE; DIMER; METHYLENE(METHYLIMINO)OLIGODEOXYRIBONUCLEOTIDE; NUCLEOSIDE; OLIGONUCLEOTIDE; UNCLASSIFIED DRUG; COMPLEMENTARY DNA; COMPLEMENTARY RNA;

ARTICLE; DIMERIZATION; GENE CONSTRUCT; NUCLEOTIDE METABOLISM; NUCLEOTIDE SEQUENCE; PROTEIN MODIFICATION; PROTEIN STABILITY; PROTEIN STRUCTURE; SYNTHESIS; THERMODYNAMICS; CHEMISTRY;

DIMERIZATION; DNA, ANTISENSE; NUCLEOSIDES; RNA, ANTISENSE;

EID: 1542574042     PISSN: 15257770     EISSN: None     Source Type: Journal    
DOI: 10.1081/NCN-120028337     Document Type: Article

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