Image Analysis of the Shape of Granulated Powder Grains

Journal of Pharmaceutical Sciences

Volumn 93, Issue 3, 2004, Pages 621-634

  Almeida Prieto, Sergio ^a   Blanco Méndez, José ^a   Otero Espinar, Francisco J ^a  

^a UNIVERSITY OF SANTIAGO DE COMPOSTELA   (Spain)

Author keywords

Extrusion; Granulation; Image analysis; Microencapsulation; Morphology; Pellets; Physical characterization; Powder technology; Shape analysis; Spheronization

Indexed keywords

DEXTRIN; HEMICELLULOSE; MICROCRYSTALLINE CELLULOSE; STARCH;

ARTICLE; DRUG FORMULATION; DRUG GRANULATION; IMAGE ANALYSIS; MICROENCAPSULATION; PERIMETER; POPULATION RESEARCH; POWDER; PROCESS MONITORING; STATISTICAL SIGNIFICANCE; TABLET MANUFACTURE; TABLET PROPERTY; TECHNOLOGY;

EID: 1542515219     PISSN: 00223549     EISSN: None     Source Type: Journal    
DOI: 10.1002/jps.10572     Document Type: Article

References (31)

1. Barret PJ. 1980. The shape of rock particles, a critical review. Sedimentology 27:291-303.
2. Bowman ET, Soya K, Drummond TW. 2001. Particle shape characterization using Fourier analysis. Geotechnique 51:545-554.
3. Heywood H. 1963. The evaluation of powders. J Pharm Pharmacol 15:56T-74T.
4. Chapman SR, Rowe RC, Newton JM. 1988. Characterization of the sphericity of particles by the one plane critical stability. J Pharm Pharmacol 40:503-505.
5. Eriksson M, Alderborn G, Podczeck F, Newton JM. 1997. Comparison between and evaluation of some methods for the assessment of the sphericity of pellets. Int J Pharm 148:149-154.
6. Pinto JF, Buckton G, Newton JM. 1992. The influence of four selected processing and formulation factors on the production of spheres by extrusion and spheronisation. Int J Pharm 83:187-196.
7. Hellén L, Yliruusi J. 1993. Process variables of instant granulator and spheroniser: III. Shape and shape distributions of pellets. Int J Pharm 96:217-223.
8. Cow EP. 1927. A method of assigning numerical and percentage values to the degree of roundness of sand grains. J Paleontol 1:179-183.
9. Wan LSC, Heng WPW, Liew CV. 1993. Spheronization conditions on spheroid shape and size. Int J Pharm 96:59-65.
10. Deasy PB, Law MFL. 1997. Use of extrusion-spheronization to develop an improved oral dosage form of indomethacin. Int J Pharm 148:201-209.
11. Shah RD, Kabadi M, Pope DG, Augsburger LL. 1995. Physico-mechanical characterization of the extrusion-spheronization process. Part II: Rheological determinants for successful extrusion and spheronization. Pharm Res 12:496-507.
12. Iyer RM, Augsburger LL, Pope DG, Shah RD. 1996. Extrusion/spheronization effect of moisture content and spheronization time on pellet characteristics. Pharm Devel Technol 1:325-331.
13. Hileman GA, Upadrashta SM, Neau SH. 1997. Drug solubility effects on predicting optimum conditions for extrusion and spheronization of pellets. Pharm Devel Technol 2:43-52.
14. Baert L, Vermeersch H, Remon JP, Smeyers-Verbeke J, Massort DL. 1993. Study of parameters important in the spheronization process. Int J Pharm 96:225-229.
15. Lövgren K, Lundberg PJ. 1989. Determination of sphericity of pellets prepared by extrusion/spheronization and the impact of some process parameters. Drug Devel Ind Pharm 15:2375-2392.
16. Schneiderhöhn P. 1954. Eine verleichende studie über methoden zur quantitativen bestimmung von abrundung und form an sandkörnern. Heidelberger Beiträge Mineralogie Petrographie 4:172-191.
17. Linder H, Kleinebudde P. 1994. Use of powdered cellulose for the production of pellets by extrusion/spheronization. J Pharm Pharmacol 46:2-7.
18. Podczeck F, Newton MJ. 1994. A shape factor to characterize the quality of spheroids. J Pharm Pharmacol 46:82-85.
19. Podczeck F, Newton MJ. 1995. The evaluation of a three-dimensional shape factor for the quantitative assessment of the sphericity and surface roughness of pellets. Int J Pharm 124:253-259.
20. Podczeck F, Rahman SH, Newton MJ. 1999. Evaluation of a standardised procedure to assess the shape of pellets using image analysis. Int J Pharm 19:123-138.
21. Lusting-Gustafsson C, Johal HK, Podczeck F, Newton JM. 1999. The influence of water content and drug solubility on the formulation of pellets by extrusion and spheronisation. Eur J Pharm Sci 8:147-152.
22. Sousa JJ, Sousa A, Podczeck F, Newton JM. 1996. Influence of process conditions on drug release from pellets. Int J Pharm 144:159-169.
23. Sousa JJ, Sousa A, Podczeck F, Newton JM. 2002. Factors influencing the physical characteristics of pellets obtained by extrusion-spheronization. Int J Pharm 232:91-106.
24. Boutell S, Newton JM, Bloor JR, Hayes G. 2002. The influence of liquid binder on the liquid mobility and preparation of spherical granules by the process of extrusion/spheronization. Int J Pharm 238:61-76.
25. Tomer G, Podczeck F, Newton JM. 2002. The influence of model drugs on the preparation of pellets by extrusion/spheronization: II Spheronization parameters. Int J Pharm 231:107-119.
26. Barber TA. 1996. Image analysis (Automated Microscopy) for particle analysis. In: Knapp JZ, Barber TA, Lieberman A, editors. Liquid and surface borne particle measurement handbook. New York: Marcel Dekker. pp. 61-112.
27. Kanerva BH, Kiesvaara J, Muttonen E, Yliruusi J. 1993. Use of laser light diffraction in determining the size distributions of different shaped particles. Pharm Ind 55:849-853.
28. Kleinebudde PK. 1995. Use of a power-consumption-controlled extruder in the development of pellets formulations. J Pharm Sci 84:1259-1264.
29. Schmidt C, Linder H, Kleinebudde P. 1997. Comparison between a twin-screw extruder and rotary ring die press. Part I: Influence of formulation variables. Eur J Pharm Biopharm 44:169-176.
30. Baert L, Remon JP, Knight P, Newton JM. 1992. A comparison between the extrusion forces and sphere quality of a gravity feed extruder and a ram extruder. Int J Pharm 86:187-192.
31. Vervaet C, Remon JP. 1996. Influence of impeller design, method of screen perforation and perforation geometry on the quality of pellets made by extrusion-spheronisation. Int J Pharm 133:29-37.