Influence of impeller design, method of screen perforation and perforation geometry on the quality of pellets made by extrusion-spheronisation

International Journal of Pharmaceutics

Volumn 133, Issue 1-2, 1996, Pages 29-37

  Vervaet, C ^a   Remon, J P ^a  

^a GHENT UNIVERSITY   (Belgium)

Author keywords

Basket extruder; Extrusion; Pellet quality; Spheronisation

Indexed keywords

CALCIUM PHOSPHATE DIBASIC; LACTOSE;

APPARATUS; ARTICLE; DRUG DOSAGE FORM; DRUG FORMULATION; DRUG GRANULATION; DRUG QUALITY; GEOMETRY; PARTICLE SIZE; PERFORATION; PRIORITY JOURNAL; SURFACE PROPERTY; TECHNIQUE;

EID: 0029955292     PISSN: 03785173     EISSN: None     Source Type: Journal    
DOI: 10.1016/0378-5173(95)04408-6     Document Type: Article

References (12)

1. Baert, L., Fanara, D., Remon, J.P. and Massart, D., Correlation of extrusion forces, raw materials and sphere characteristics. J. Pharm. Pharmacol., 44 (1992) 676-678.
2. Baert, L., Remon, J.P., Elbers, J.A.C. and Van Bommel, E.M.G., Comparison between a gravity feed extruder and a twin screw extruder. Int. J. Pharm., 99 (1993) 7-12.
3. Chariot, M., Francès, J., Lewis, G.A., Mathieu, D., Phan Tan Luu, R. and Stevens, H.N.E., A factorial approach to process variables of extrusion-spheronisation of the wet powder mass. Drug Dev. Ind. Pharm., 13 (1987) 1639-1649.
4. Dietrich, R. and Brausse, R., Erste Erfahrungen und Validierungsversuche an einem neu entwickelten GMP-gerechten und instrumentierten Pharma-Extruder. Pharm. Ind., 50 (1988) 1179-1186.
5. Goodhart, F.W., Draper, J.R. and Ninger, F.C., Design and use of a laboratory extruder for pharmaceutical granulations, J. Pharm. Sc., 62 (1973) 133-136.
6. Harrison, P.J., Newton, J.M. and Rowe, R.C., Flow defects in wet powder mass extrusion. J. Pharm. Pharmacol., 37 (1985) 81-83.
7. Hellén, L., Ritala, M., Yliruusi, J., Palmroos, P. and Kristoffersson, E., Process variables of the radial screen extruder: Part I - Production capacity of the extruder and properties of the extrudate. Pharm. Technol. Int. Biophys., 4 (1992) 50-60.
8. Hellén, L., Yliruusi, J., Muttonen, E. and Kristoffersson, E., Process variables of the radial screen extruder: Part II - Size and size distributions of pellets. Pharm. Technol. Int. Biophys., 5 (1993) 44-53.
9. Hileman, G.A., Goskonda S.R., Spalitto A.J. and Upadrashta S.M., A factorial approach to high dose product development by an extrusion/spheronisation process. Drug Dev. Ind. Pharm., 19 (1993) 483-491.
10. Malinowski, H.J. and Smith, W.E., Use of factorial design to evaluate granulations prepared by spheronization. J. Pharm. Sci., 64 (1975) 1688-1692.
11. Pinto, J.F., Buckton, G. and Newton, J.M., The influence of four selected processing and formulation factors on the production of spheres by extrusion and spheronisation. Int. J. Pharm., 83 (1992) 187-196.
12. Vervaet, C., Baert, L., Risha, P.A. and Remon J.P., The influence of the extrusion screen on pellet quality using an instrumented basket extruder. Int. J. Pharm., 107 (1994) 29-39.