The influence of liquid binder on the liquid mobility and preparation of spherical granules by the process of extrusion/spheronization

International Journal of Pharmaceutics

Volumn 238, Issue 1-2, 2002, Pages 61-76

  Boutell, S ^a   Newton, J M ^a   Bloor, J R ^b   Hayes, G ^b  

^a UNIVERSITY OF LONDON   (United Kingdom)

^b Hoechst Roussel Ltd   (United Kingdom)

Author keywords

Barium sulphate; Extrusion spheronization; Glycerol; Microcrystalline cellulose; Pellets; Pressure membrane; Surfactants

Indexed keywords

ANIONIC SURFACTANT; BARIUM SULFATE; DODECYL SULFATE SODIUM; GLYCEROL; MICROCRYSTALLINE CELLULOSE; NONIONIC SURFACTANT; POLOXAMER; WATER;

ARTICLE; CONCENTRATION (PARAMETERS); DRUG FORMULATION; DRUG PELLET; PARTICLE SIZE; PELLET EXTRUSION; POROSITY; PRIORITY JOURNAL; SPHERONIZATION; WATER FLOW;

ALGORITHMS; BARIUM SULFATE; CELLULOSE; CONTRAST MEDIA; DRUG COMPOUNDING; EXCIPIENTS; MEMBRANES, ARTIFICIAL; PARTICLE SIZE; POROSITY; POWDERS; PRESSURE; SODIUM DODECYL SULFATE; SOLUBILITY; SURFACE TENSION; SURFACE-ACTIVE AGENTS;

EID: 0037093696     PISSN: 03785173     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0378-5173(02)00064-9     Document Type: Article

References (6)

1. A comparison between the extrusion forces and sphere quality of a gravity feed extruder and a ram extruder
2. Movement of liquids through powder beds
3. The influence of moisture content on the spheronization of extrudate processed by a ram extruder
4. The characterization of wet powder masses suitable for extrusion/spheronization
5. A shape factor to characterize the quality of spheroids