Factors influencing the physical characteristics of pellets obtained by extrusion-spheronization

International Journal of Pharmaceutics

Volumn 232, Issue 1-2, 2002, Pages 91-106

  Sousa, J J ^a   Sousa, A ^a   Podczeck, F ^b   Newton, J M ^b  

^a UNIVERSITY OF COIMBRA   (Portugal)

^b UNIVERSITY OF LONDON   (United Kingdom)

Author keywords

Extrusion force; Extrusion spheronization; Formulation variables (type and level of drugs and fillers); Pellet properties (density, porosity, mechanical strength, size and shape); Statistical analysis

Indexed keywords

BARIUM SULFATE; CALCIUM PHOSPHATE; EPHEDRINE; FILLER; GLUCOSE; IBUPROFEN; LACTOSE; MANNITOL; MICROCRYSTALLINE CELLULOSE; PARACETAMOL; PROPRANOLOL; SALICYLATE SODIUM;

ARTICLE; CANONICAL ANALYSIS; DENSITY; DRUG FORMULATION; DRUG SCREENING; DRUG SOLUBILITY; MOISTURE; PARTICLE SIZE; PELLET EXTRUSION; POROSITY; PRIORITY JOURNAL; REGRESSION ANALYSIS; SPHERONIZATION;

ANALYSIS OF VARIANCE; CHEMISTRY, PHARMACEUTICAL; CHEMISTRY, PHYSICAL; PHARMACEUTICAL PREPARATIONS; SOLUBILITY;

EID: 0037203664     PISSN: 03785173     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0378-5173(01)00908-5     Document Type: Article

References (23)

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3. Influence of extrusion-spheronization processing on the physical properties of d-indobufen pellets containing pH adjusters
4. Modified release beads coated with cellulose derivatives by pan technique
5. Comparative gastrointestinal transit of pellet systems of varying density
6. The effect of lactose particle size on the extrusion properties of microcrystalline cellulose-lactose mixtures
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8. The influence of water content and drug solubility on the formulation of pellets by extrusion and spheronization
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10. The influence of process variables on the preparation and properties of spherical granules by the process of extrusion/spheronization
11. Optimising the manufacturing process for controlled release pellets
12. Effect of amount of added water during extrusion-spheronization process on pharmaceutical properties of granules
13. A shape factor to characterize the quality of spheroids
14. The application of canonical analysis to the evaluation of the influence of changes in the components of standard direct compression tablet formulations
15. Evaluation of a standardised procedure to assess the shape of pellets using image analysis
16. Factors affecting the release of Propranolol hydrochloride from beads coated with aqueous polymeric dispersions
17. The influence of the type and quantity of model drug on the extrusion/spheronization of mixtures with micocrystalline cellulose 1 extrusion parameters
18. Preparation of indobufen pellets by using centrifugal rotary fluidized bed equipment without starting seeds
19. Enhancement of in vitro drug release by using polyethyleneglycol 400 and PEG-40 hydrogenated castor oil in pellets made by extrusion/spheronization
20. Effect of processing variables on particles obtained by extrusion-spheronization processing