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Volumn 14, Issue 6, 2004, Pages 1399-1402

Inhibition of ICAM-1/LFA-1-mediated heterotypic T-cell adhesion to epithelial cells: Design of ICAM-1 cyclic peptides

Author keywords

[No Author keywords available]

Indexed keywords

CYCLOPEPTIDE; INTERCELLULAR ADHESION MOLECULE 1; LYMPHOCYTE FUNCTION ASSOCIATED ANTIGEN 1; PEPTIDE DERIVATIVE;

EID: 1542375100     PISSN: 0960894X     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bmcl.2003.09.100     Document Type: Article
Times cited : (20)

References (21)
  • 19
    • 1542293254 scopus 로고    scopus 로고
    • note
    • 2+-dependent binding studies suggest that the binding region of cIBR peptide is at the metal ion-dependent adhesion site (MIDAS) of the I-domain. The dimensions of the grid were 50.0×50.0×50.0 Å with grid points separated by 0.5 Å. All dihedral angles that can be rotated in the peptide side chains were assigned with the auxiliary program AutoTors and were allowed to rotate freely. A total of 128 runs were performed for each peptide and each simulation run lasted 110 cycles with a starting temperature of 616 K in the first cycle and a temperature reduction factor of 0.95 per cycle. The lowest energy structures produced by AutoDock runs were taken as the possible binding models.


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.