Augmentation of NK cell-mediated cytotoxicity to tumor cells by inhibitory NK cell receptor blockers

International Immunology

Volumn 16, Issue 3, 2004, Pages 385-393

  Tajima, Kyoko ^a   Matsumoto, Naoki ^a   Ohmori, Kazuji ^a   Wada, Haruka ^a   Ito, Masayuki ^a   Suzuki, Kazuhiro ^b   Yamamoto, Kazuo ^a  

^a UNIVERSITY OF TOKYO   (Japan)

^b NATIONAL INSTITUTE OF HEALTH SCIENCES   (Japan)

Author keywords

Ly49; MHC class 1; Mouse; Peptide; Phage display library

Indexed keywords

HEPTAPEPTIDE; LIGAND; MAJOR HISTOCOMPATIBILITY ANTIGEN CLASS 1; PEPTIDE; PEPTIDE LIBRARY; RECOMBINANT RECEPTOR;

ANIMAL CELL; ANTIGEN EXPRESSION; ARTICLE; BACTERIOPHAGE; CELL KILLING; CONTROLLED STUDY; DOWN REGULATION; ESCHERICHIA COLI; GENE EXPRESSION REGULATION; MAMMAL CELL; MOUSE; NATURAL KILLER CELL; NATURAL KILLER CELL MEDIATED CYTOTOXICITY; NONHUMAN; PHAGE DISPLAY; PRIORITY JOURNAL; RECEPTOR BINDING; RECEPTOR BLOCKING; TUMOR CELL;

ANIMALS; ANTIGENS, LY; BACTERIOPHAGES; CELL LINE; CYTOTOXICITY, IMMUNOLOGIC; H-2 ANTIGENS; KILLER CELLS, NATURAL; LECTINS, C-TYPE; MICE; MICE, INBRED BALB C; NEOPLASMS; PEPTIDE LIBRARY; PEPTIDES; RECEPTORS, IMMUNOLOGIC;

EID: 1542359562     PISSN: 09538178     EISSN: None     Source Type: Journal    
DOI: 10.1093/intimm/dxh021     Document Type: Article

References (44)

1. Trinchieri, G. 1989. Biology of natural killer cells. Adv. Immunol. 47:187.
2. Karre, K. 2002. NK cells, MHC class I molecules and the missing self. Scand. J. Immunol. 55:221.
3. + IL-2-activated natural killer cells. Nature 358:66.
4. Moretta, A., Vitale, M., Bottino, C., Orengo, A. M., Morelli, L., Augugliaro, R., Barbaresi, M., Ciccone, E. and Moretta, L. 1993. P58 molecules as putative receptors for major histocompatibility complex (MHC) class I molecules in human natural killer (NK) cells. Anti-p58 antibodies reconstitute lysis of MHC class I-protected cells in NK clones displaying different specificities. J. Exp. Med. 178:597.
5. Colonna, M. and Samaridis, J. 1995. Cloning of immunoglobulin-superfamily members associated with HLA-C and HLA-B recognition by human natural killer cells. Science 268:405.
6. Wagtmann, N., Biassoni, R., Cantoni, C., Verdiani, S., Malnati, M. S., Vitale, M., Bottino, C., Moretta, L., Moretta, A. and Long, E. O. 1995. Molecular clones of the p58 NK cell receptor reveal immunoglobulin- related molecules with diversity in both the extra- and intracellular domains. Immunity 2:439.
7. D'Andrea, A., Chang, C., Franz-Bacon, K., McClanahan, T., Phillips, J. H. and Lanier, L. L. 1995. Molecular cloning of NKB1. A natural killer cell receptor for HLA-B allotypes. J. Immunol. 155:2306.
8. Lanier, L. L. 1998. NK cell receptors. Annu. Rev. Immunol. 16:359.
9. Andre, P., Biassoni, R., Colonna, M., Cosman, D., Lanier, L. L., Long, E. O., Lopez-Botet, M., Moretta, A., Moretta, L., Parham, P., Trowsdale, J., Vivier, E., Wagtmann, N. and Wilson, M. J. 2001. New nomenclature for MHC receptors. Nat. Immunol. 2:661.
10. Chan, P. Y. and Takei, F. 1989. Molecular cloning and characterization of a novel murine T cell surface antigen, YE1/48. J. Immunol. 142:1727.
11. Yokoyama, W. M., Jacobs, L. B., Kanagawa, O., Shevach, E. M. and Cohen, D. I. 1989. A murine T lymphocyte antigen belongs to a supergene family of Type II integral membrane proteins. J. Immunol. 143:1379.
12. Vance, R. E., Tanamachi, D. M., Hanke, T. and Raulet, D. H. 1997. Cloning of a mouse homolog of CD94 extends the family of C-type lectins on murine natural killer cells. Eur. J. Immunol. 27:3236.
13. Ho, E. L., Heusel, J. W., Brown, M. G., Matsumoto, K., Scalzo, A. A. and Yokoyama, W. M. 1998. Murine Nkg2d and Cd94 are clustered within the natural killer complex and are expressed independently in natural killer cells. Proc. Natl Acad. Sci. USA 95:6320.
14. Lazetic, S., Chang, C., Houchins, J. P., Lanier, L. L. and Phillips, J. H. 1996. Human natural killer cell receptors involved in MHC class I recognition are disulfide-linked heterodimers of CD94 and NKG2 subunits. J. Immunol. 157:4741.
15. Wong, S., Freeman, J. D., Kelleher, C., Mager, D. and Takei, F. 1991. Ly-49 multigene family. New members of a superfamily of Type II membrane proteins with lectin-like domains. J. Immunol. 147:1417.
16. Smith, H. R., Karlhofer, F. M. and Yokoyama, W. M. 1994. Ly-49 multigene family expressed by IL-2-activated NK cells. J. Immunol. 153:1068.
17. Brown, M. G., Fulmek, S., Matsumoto, K., Cho, R., Lyons, P. A., Levy, E. R., Scalzo, A. A. and Yokoyama, W. M. 1997. A 2-Mb YAC contig and physical map of the natural killer gene complex on mouse chromosome 6. Genomics 42:16.
18. Takei, F., Brennan, J. and Mager, D. L. 1997. The Ly-49 family: genes, proteins and recognition of class I MHC. Immunol. Rev. 155:67.
19. Tormo, J., Natarajan, K., Margulies, D. H. and Mariuzza, R. A. 1999. Crystal structure of a lectin-like natural killer cell receptor bound to its MHC class I ligand. Nature 402:623.
20. Matsumoto, N., Mitsuki, M., Tajima, K., Yokoyama, W. M. and Yamamoto, K. 2001. The functional binding site for the C-type lectin-like natural killer cell receptor Ly49A spans three domains of its major histocompatibility complex class I ligand. J. Exp. Med. 193:147.
21. d inside and outside of the peptide binding groove. J. Immunol. 166:4422.
22. Matsumoto, N., Ribaudo, R. K., Abastado, J. P., Margulies, D. H. and Yokoyama, W. M. 1998. The lectin-like NK cell receptor Ly-49A recognizes a carbohydrate- independent epitope on its MHC class I ligand. Immunity 8:245.
23. Matsumoto, N., Tajima, K., Mitsuki, M. and Yamamoto, K. 2001. H-2 allele specificity of the NK cell C-type lectin-like MHC class I receptor Ly49A visualized by soluble Ly49A tetramer. Int. Immunol. 13:615.
24. Nagasawa, R., Gross, J., Kanagawa, O., Townsend, K., Lanier, L. L., Chiller, J. and Allison, J. P. 1987. Identification of a novel T cell surface disulfide-bonded dimer distinct from the α/β antigen receptor. J. Immunol. 138:815.
25. Mason, L. H., Yagita, H. and Ortaldo, J. R. 1994. LGL-1: a potential triggering molecule on murine NK cells. J. Leukoc. Biol. 55:362.
26. Ozato, K., Mayer, N. M. and Sachs, D. H. 1982. Monoclonal antibodies to mouse major histocompatibility complex antigens. Transplantation 34:113.
27. Lampson, L. A. and Levy, R. 1980. Two populations of la-like molecules on a human B cell line. J. Immunol. 125:293.
28. Mason, L. H., Ortaldo, J. R., Young, H. A., Kumar, V., Bennett, M. and Anderson, S. K. 1995. Cloning and functional characteristics of murine large granular lymphocyte-1: a member of the Ly-49 gene family (Ly-49G2). J. Exp. Med. 182:293.
29. d on protection against NK cells expressing the inhibitory receptor Ly49G2. Eur. J. Immunol. 28:4198.
30. Chambers, C. A., Kuhns, M. S., Egen, J. G. and Allison, J. P. 2001. CTLA-4-mediated inhibition in regulation of T cell responses: mechanisms and manipulation in tumor immunotherapy. Annu. Rev. Immunol. 19:565.
31. Koh, C. Y., Blazar, B. R., George, T., Welniak, L. A., Capitini, C. M., Raziuddin, A., Murphy, W. J. and Bennett, M. 2001. Augmentation of antitumor effects by NK cell inhibitory receptor blockade in vitro and in vivo. Blood 97:3132.
32. Bauer, S., Groh, V., Wu, J., Steinle, A., Phillips, J. H., Lanier, L. L. and Spies, T. 1999. Activation of NK cells and T cells by NKG2D, a receptor for stress-inducible MICA. Science 285:727.
33. Diefenbach, A., Jamieson, A. M., Liu, S. D., Shastri, N. and Raulet, D. H. 2000. Ligands for the murine NKG2D receptor: expression by tumor cells and activation of NK cells and macrophages. Nat. Immunol. 1:119.
34. Cerwenka, A., Bakker, A. B., McClanahan, T., Wagner, J., Wu, J., Phillips, J. H. and Lanier, L. L. 2000. Retinoic acid early inducible genes define a ligand family for the activating NKG2D receptor in mice. Immunity 12:721.
35. Ikeda, H., Lethe, B., Lehmann, F., van Baren, N., Baurain, J. F., de Smet, C., Chambost, H., Vitale, M., Moretta, A., Boon, T. and Coulie, P. G. 1997. Characterization of an antigen that is recognized on a melanoma showing partial HLA loss by CTL expressing an NK inhibitory receptor. Immunity 6:199.
36. Bakker, A. B., Phillips, J. H., Figdor, C. G. and Lanier, L. L. 1998. Killer cell inhibitory receptors for MHC class I molecules regulate lysis of melanoma cells mediated by NK cells, gamma delta T cells, and antigen-specific CTL. J. Immunol. 160:5239.
37. Le Drean, E., Vely, F., Olcese, L., Cambiaggi, A., Guia, S., Krystal, G., Gervois, N., Moretta, A., Jotereau, F. and Vivier, E. 1998. Inhibition of antigen-induced T cell response and antibody-induced NK cell cytotoxicity by NKG2A: association of NKG2A with SHP-1 and SHP-2 protein-tyrosine phosphatases. Eur. J Immunol. 28:264.
38. Noppen, C., Schaefer, C., Zajac, P., Schutz, A., Kocher, T., Kloth, J., Heberer, M., Colonna, M., De Libero, G. and Spagnoli, G. C. 1998. C-type lectin-like receptors in peptide-specific HLA class I-restricted cytotoxic T lymphocytes: differential expression and modulation of effector functions in clones sharing identical TCR structure and epitope specificity. Eur. J. Immunol. 28:1134.
39. Speiser, D. E., Pittet, M. J., Valmori, D., Dunbar, R., Rimoldi, D., Lienard, D., MacDonald, H. R., Cerottini, J. C., Cerundolo, V. and Romero, P. 1999. In vivo expression of natural killer cell inhibitory receptors by human melanoma-specific cytolytic T lymphocytes. J. Exp. Med. 190:775.
40. Speiser, D. E., Valmori, D., Rimoldi, D., Pittet, M. J., Lienard, D., Cerundolo, V., MacDonald, H. R., Cerottini, J. C. and Romero, P. 1999. CD28-negative cytolytic effector T cells frequently express NK receptors and are present at variable proportions in circulating lymphocytes from healthy donors and melanoma patients. Eur. J. Immunol. 29:1990.
41. + T cells specific for melanocyte differentiation antigens expresses killer inhibitory receptors (KIR) in healthy donors: evidence for a role of KIR in the control of peripheral tolerance. Eur. J. Immunol. 30:1665.
42. Maeda, M., Lohwasser, S., Yamamura, T. and Takei, F. 2001. Regulation of NKT cells by Ly49: analysis of primary NKT cells and generation of NKT cell line. J. Immunol. 167:4180.
43. + T cell responses. Nat. Immunol. 3:189.
44. De Maria, A., Ferraris, A., Guastella, M., Pilia, S., Cantoni, C., Polero, L., Mingari, M. C., Bassetti, D., Fauci, A. S. and Moretta, L. 1997. Expression of HLA class I-specific inhibitory natural killer cell receptors in HIV-specific cytolytic T lymphocytes: impairment of specific cytolytic functions. Proc. Natl. Acad. Sci. USA 94:10285.