Supraspinal and spinal cord opioid receptors are responsible for antinociception following intrathecal morphine injections

European Journal of Anaesthesiology

Volumn 21, Issue 3, 2004, Pages 179-185

  Goodchild, Colin S ^a   Nadeson, R ^a   Cohen, E ^a  

^a MONASH UNIVERSITY   (Australia)

Author keywords

Analgesics, opioid; Central nervous system, spinal cord; Injections, spinal; Pain, measurement; Receptors, neurotransmitter

Indexed keywords

BETA FUNALTREXAMINE; DELTA OPIATE RECEPTOR; HALOTHANE; KAPPA OPIATE RECEPTOR; LIDOCAINE; MORPHINE; MU OPIATE RECEPTOR; NALOXONE; NALTRINDOLE; NORBINALTORPHIMINE; OPIATE ANTAGONIST; OPIATE RECEPTOR;

ANALGESIA; ANIMAL EXPERIMENT; ANIMAL MODEL; ANTINOCICEPTION; ARTICLE; CENTRAL NERVOUS SYSTEM; CONTROLLED STUDY; DOSE RESPONSE; DRUG ANTAGONISM; DRUG RECEPTOR BINDING; ELECTRIC SHOCK; MALE; NAUSEA; NONHUMAN; PAIN THRESHOLD; RAT; RESPIRATION DEPRESSION; SPINAL CORD; STATISTICAL ANALYSIS; TAIL FLICK TEST;

ANALGESICS, OPIOID; ANIMALS; DOSE-RESPONSE RELATIONSHIP, DRUG; INJECTIONS, SPINAL; MALE; MODELS, ANIMAL; MORPHINE; NALOXONE; NALTREXONE; NARCOTIC ANTAGONISTS; NOCICEPTORS; PAIN; PAIN THRESHOLD; RANDOM ALLOCATION; RATS; RATS, WISTAR; REACTION TIME; RECEPTORS, OPIOID; SPINAL CORD; TAIL;

EID: 1542348548     PISSN: 02650215     EISSN: None     Source Type: Journal    
DOI: 10.1017/S0265021504003035     Document Type: Article

References (43)

1. Yaksh TL, Rudy TA. Analgesia mediated by a direct spinal action of narcotics. Science 1976; 192: 1357-1358.
2. Wang JK, Nauss LA, Thomas JE. Pain relief by intrathecally applied morphine in man. Anesthesiology 1979; 50: 149-151.
3. Cousins MJ, Mather LE. Intrathecal and epidural administration of opioids. Anesthesiology 1984; 61: 276-310.
4. Andersen G, Rasmussen H, Rosenstock C, et al. Postoperative pain control by epidural analgesia after transabdominal surgery - efficacy and problems encountered in daily routine. Acta Anaesthesiol Scand 2000; 44: 296-301.
5. Angst MS, Ramaswamy B, Riley ET, Stanski DR. Lumbar epidural morphine in humans and supraspinal analgesia to experimental heat pain. Anesthesiology 2000; 92: 312-324.
6. Bernards CM. Rostral spread of epidural morphine - the expected and the unexpected. Anesthesiology 2000; 92: 299-301.
7. Chaney MA. Side effects of intrathecal and epidural opioids. Can J Anesth 1995; 42: 891-903.
8. Kingery WS. A critical review of controlled clinical trials for peripheral neuropathic pain and complex regional pain syndromes. Pain 1997; 73: 123-139.
9. Rawal N, Allvin R, Neumark J, et al. Epidural and intrathecal opioids for postoperative pain management in Europe - a 17-nation questionnaire study of selected hospitals. Acta Anaesthesiol Scand 1996; 40: 1119-1126.
10. Buerkle H, Yaksh TL. Comparison of the spinal actions of the μ-opioid remifentanil with alfentanil and morphine in the rat. Anesthesiology 1996; 84: 94-102.
11. Borgbjerg FM, Frigast C, Madsen JB, Mikkelsen LF. The effect of intrathecal opioid-receptor agonists on visceral noxious stimulation in rabbits. Gastroenterol 1996; 110: 139-146.
12. Guirimand F, Strimbu-Gozariu M, Willer JC, Le Bars D. Effects of mu, delta and kappa opioid antagonists on the depression of a C-fiber reflex by intrathecal morphine and DAGO in the rat. J Pharmacol Exp Ther 1994; 3: 1007-1020.
13. Hammond DL, Wang HL, Nakashima N, Basbaum AI. Differential effects of intrathecally administered delta and mu opioid receptor agonists on formalin-evoked nociception and on the expression of Fos-like immunoreactivity in the spinal cord of the rat. J Pharmacol Exp Ther 1998; 284: 378-387.
14. Hara K, Saito Y, Kirihara Y, Yamada Y, Sakura S, Kosaka Y. The interaction of antinociceptive effects of morphine and GABA receptor agonists within the rat spinal cord. Anesth Analg 1999; 89: 422-427.
15. Yaksh TL, Rudy TA. Chronic catheterization of the spinal subarachnoid space. Phys Behav 1976; 17: 1031-1036.
16. Irwin S, Houde RW, Bennett DR, Hendershot LC, Seevers MH. The effects of morphine, methadone and meperidine on some reflex responses of spinal animals to nociceptive stimulation. J Pharmacol Exp Ther 1950; 101: 132-143.
17. Heinricher MM, Drasner K. Lumbar intrathecal morphine alters activity of putative nociceptive modulatory neurons in rostral ventromedial medulla. Brain Res 1991; 549: 338-341.
18. Glynn CJ, Mather LE, Cousins MJ, Wilson PR, Graham JR. Spinal narcotics and respiratory depression. Lancet 1979; 2: 356-357.
19. Liolios A, Anderson FH. Selective spinal analgesia. Lancet 1979; 2: 357.
20. Reiz S, Westberg M. Side-effects of epidural morphine. Lancet 1980; 2: 203-204.
21. Baraka A, Noueihid R, Hajj S. Intrathecal injection of morphine for obstetric analgesia. Anesthesiology 1981; 54: 136-140.
22. Gustafsson LL, Schildt B, Jacobsen K. Adverse effects of extradural and intrathecal opiates; report of a nationwide survey in Sweden. Br J Anaesth 1998; 81: 86-93.
23. Yaksh TL. Spinal opiate analgesia; characteristics and principles of action. Pain 1981; 11: 293-346.
24. Goodchild CS, Guo Z, Freeman J, Gent JP. 5-HT spinal antinociception involves mu opioid receptors; cross tolerance and antagonist studies. Br J Anaesth 1997; 78: 563-569.
25. Zimmerman M. Ethical guidelines for investigation of experimental pain on conscious animals. Pain 1983; 16: 109-110.
26. Edwards M, Serrao JM, Gent JP, Goodchild CS. On the mechanism by which midazolam causes spinally mediated analgesia. Anesthesiology 1990; 73: 273-277.
27. A receptors and spinally-mediated antinociception in rats. J Pharmacol Exp Ther 1996; 278: 620-626.
28. Serrao JM, Stubbs SC, Goodchild CS, Gent JP. Intrathecal midazolam and fentanyl in the rat; evidence for different spinal antinociceptive effects. Anesthesiology 1989; 70: 780-786 (erratum Anesthesiology 1989; 71: 482).
29. Serrao JM, Stubbs SC, Goodchild CS, Gent JP. Intrathecal midazolam and fentanyl in the rat; evidence for different spinal antinociceptive effects. Anesthesiology 1989; 70: 780-786 (erratum Anesthesiology 1989; 71: 482).
30. Boulter N, Serrao JM, Gent JP, Goodchild CS. Spinally mediated antinociception following intrathecal chlordiazepoxide - further evidence for a benzodiazepine spinal analgesic effect. Eur J Anaesthesiol 1991; 8: 407-411.
31. Goodchild CS, Guo Z, Musgreave A, Gent JP. Antinociception by intrathecal midazolam involves endogenous neurotransmitters acting at spinal cord delta opioid receptors. Br J Anaesth 1996; 77: 758-763.
32. Goodchild CS, Sanghera S, Serrao JM, Gent JP. Analgesia mediated by spinal κ-opioid receptors. Eur J Anaesthesiol 1991; 8: 227-231.
33. Yaksh TL, Rudy TA. Studies on the direct spinal action of narcotics in the production of analgesia in the rat. J Pharmacol Exp Ther 1977; 202: 411-428.
34. Carroll MN, Lim RKS. Observations on the neuropharmacology of morphine and morphine-like analgesia. Arch Int Pharmacodyn Ther 1960; 125: 383.
35. Yaksh TL, Henry JL. Antinociceptive effects of intrathecally administered human b-endorphin in the rat and cat. Can J Physiol Pharmacol 1978; 56: 754-759.
36. Yu W, Hao JX, Xu XJ, Hökfelt T, Elde R, Wiesenfeld-Hallin Z. Spinal cord ischemia reduces μ-opioid receptors in rats; correlation with morphine insensitivity. Neuroreport 1999; 10: 87-91.
37. Zhang X, Bao L, Shi TJ, Ju G, Elde R, Hokfelt T. Down-regulation of μ-opioid receptors in rat and monkey dorsal root ganglion neurons and spinal cord after peripheral axotomy. Neuroscience 1987; 82: 223-240.
38. Loh HH, Liu HC, Cavalli A, Yang W, Chen YF, Wei LN. Mu opioid receptor knockout in mice; effects on ligand-induced analgesia and morphine lethality. Brain Res Mol Brain Res 1998; 54: 321-326.
39. Matthes HW, Maldonado R, Simonin F, et al. Loss of morphine-induced analgesia, reward effect and withdrawal symptoms in mice lacking the mu-opioid-receptor gene. Nature 1996; 383: 819-823.
40. Narita M, Mizoguchi H, Sora I, Uhl GR, Tseng LF. Absence of G-protein activation by mu-opioid receptor agonists in the spinal cord of mu-opioid receptor knockout mice. Br J Pharmacol 1999; 126: 451-456.
41. Pasternak GW. Incomplete cross tolerance and multiple mu opioid peptide receptors. Trends Pharmacol Sci 2001; 22: 67-70.
42. Schuller AG, King MA, Zhang J, et al. Retention of heroin and morphine-6 beta-glucuronide analgesia in a new line of mice lacking exon 1 of MOR-1. Nat Neurosci 1999; 2: 151-156.
43. Sora I, Takahashi N, Funada M, et al. Opiate receptor knockout mice define mu receptor roles in endogenous nociceptive responses and morphine-induced analgesia. Proc Natl Acad Sci USA 1997; 94: 1544-1549.