Antinociception by intrathecal midazolam involves endogenous neurotransmitters acting at spinal cord delta opioid receptors

British Journal of Anaesthesia

Volumn 77, Issue 6, 1996, Pages 758-763

  Goodchild, C S ^a,b   Guo, Z ^a   Musgreave, A ^a   Gent, J P ^a  

^a UNIVERSITY OF LEEDS   (United Kingdom)

^b MONASH MEDICAL CENTRE   (Australia)

Author keywords

Analgesic techniques, regional, intrathecal; Analgesics opioid; Hypnotics benzodiazepines, midazolam; Pain, experimental; Rat; Receptors, opioid

Indexed keywords

3,4 DICHLORO N METHYL N [2 (1 PYRROLIDINYL)CYCLOHEXYL]BENZENEACETAMIDE METHANESULFONATE; BENZODIAZEPINE DERIVATIVE; DELTA OPIATE RECEPTOR; DELTA OPIATE RECEPTOR ANTAGONIST; FENTANYL; KAPPA OPIATE RECEPTOR ANTAGONIST; LEUCINE ENKEPHALIN[2 DEXTRO SERINE 6 THREONINE]; MIDAZOLAM; NALTRINDOLE; NEUROTRANSMITTER; NORBINALTORPHIMINE; OPIATE; OPIATE ANTAGONIST;

ANIMAL EXPERIMENT; ANTINOCICEPTION; ARTICLE; AVOIDANCE BEHAVIOR; COMPARATIVE STUDY; CONTROLLED STUDY; ELECTRIC CURRENT; INTRATHECAL DRUG ADMINISTRATION; NONHUMAN; PRIORITY JOURNAL; RAT; SPINAL CORD;

EID: 0030454013     PISSN: 00070912     EISSN: None     Source Type: Journal    
DOI: 10.1093/bja/77.6.758     Document Type: Article

References (19)

1. Cripps TP, Goodchild CS. Intrathecal midazolam and the stress response to upper abdominal surgery: adrenocortical, glycemic, and analgesic effects. Clinical Journal of Pain 1988; 4: 125-128.
2. Goodchild CS, Noble J. The effects of intrathecal midazolam on sympathetic nervous system reflexes in man - a pilot study. British Journal of Clinical Pharmacology 1987; 23: 273-285.
3. Goodchild CS, Serrao JM. Intrathecal midazolam in the rat: evidence for spinally-mediated analgesia. British Journal of Anaesthesia 1987; 59: 1563-1570.
4. Yanez A, Sabbe MB, Stevens CW, Yaksh TL. Interaction of midazolam and morphine in the spinal cord of the rat. Neuropharmacology 1990; 29: 359-364.
5. Boulter N, Serrao JM, Gent JP, Goodchild CS. Spinally mediated antinociception following intrathecal chlordiazepoxide - further evidence for a benzodiazepine spinal analgesic effect. European Journal of Anaesthesiology 1991; 8: 407-411.
6. Edwards M, Serrao JM, Gent JP, Goodchild CS. On the mechanism by which midazolam causes spinally mediated analgesia. Anesthesiology 1990; 73: 273-277.
7. A antagonists SR95531 and bicuculline on spinal antinociception induced by midazolam, 5-HT, muscimol and GABA in rats. Canadian Journal of Physiology and Pharmacology 1994; 72: 345.
8. Serrao JM, Goodchild CS, Gent JP. Reversal by naloxone of spinal antinociceptive effects of fentanyl, ketocyclazocine, and midazolam. European Journal of Anaesthesiology 1991; 8: 401-406.
9. B receptor antagonist CI-988. British Journal of Pharmacology 1992; 105: 8-10.
10. Serrao JM, Stubbs SC, Goodchild CS, Gent JP. Intrathecal midazolam and fentanyl in the rat: evidence for different spinal antinociceptive effects. (Published erratum appears in Anesthesiology 1989; 71: 482.) Anesthesiology 1989; 70: 780-786.
11. Arunlakshana O, Schild HO. Some quantitative uses of drug antagonists. British Journal of Pharmacology 1959; 14: 48-58.
12. Guo Z, Gent JP, Goodchild CS. Two GABA mechanisms for spinally-mediated antinociception: evidence from antagonism of 5-hydroxytryptamine (5HT) by bicuculline. British Journal of Anaesthesia 1990; 64: 589P-590P.
13. Mackay D. Receptor classification using antagonists. Trends in Pharmacological Sciences 1991; 12: 181.
14. Mackay D. A new method for estimating dissociation constants of competitive and non-competitive antagonists with no prior knowledge of agonist concentrations. British Journal of Pharmacology 1994; 111: 219-226.
15. Yaksh TL. Spinal opiates: a review of their effect on spinal function with emphasis on pain processing. Acta Anaesthesiologica Scandinavica Supplement 1987; 85: 25-37.
16. Goodchild CS, Sanghera S, Serrao JM, Gent JP. Analgesia mediated by spinal κ-opioid receptors. European Journal of Anaesthesiology 1991; 8: 227-231.
17. Serrao JM. Evaluation of drugs to be used for spinal analgesia. PhD thesis. Leeds: University of Leeds, 1992.
18. Guo Z. The mechanisms of the antinociceptive effects of intrathecally administered 5- hydroxytryptamine and xylazine in the spinal cord. PhD thesis. Leeds: University of Leeds, 1991.
19. Niv D, Davidovich S, Geller E, Urca G. Analgesic and hyperalgesic effects of midazolam: dependence on route of administration. Anesthesia and Analgesia 1988; 67: 1169-1173.