Alpha-1 adrenoceptors: Evaluation of receptor subtype-binding kinetics in intact arterial tissues and comparison with membrane binding

British Journal of Pharmacology

Volumn 141, Issue 3, 2004, Pages 468-476

  Tanaka, Takashi ^a   Zhang, Li ^a   Suzuki, Fumiko ^a   Muramatsu, Ikunobu ^a  

^a UNIVERSITY OF FUKUI   (Japan)

Author keywords

3H prazosin; Intact tissue segment binding; Membrane binding; Radioligand binding experiment; Rat tail artery(RTA) and thoracic aorta(RAO)

Indexed keywords

2 [[2 (2,6 DIMETHOXYPHENOXY)ETHYL]AMINOMETHYL] 1,4 BENZODIOXAN; 8 [2 [4 (2 METHOXYPHENYL) 1 PIPERAZINYL]ETHYL] 8 AZASPIRO[4.5]DECANE 7,9 DIONE; ALPHA 1 ADRENERGIC RECEPTOR; PRAZOSIN; RECEPTOR SUBTYPE; SILODOSIN; TRITIUM;

ANALYTIC METHOD; ANIMAL TISSUE; ARTICLE; BINDING COMPETITION; BINDING KINETICS; CELL MEMBRANE; CONCENTRATION RESPONSE; CONTROLLED STUDY; INTERMETHOD COMPARISON; LIGAND BINDING; MALE; MEMBRANE BINDING; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; RAT; RECEPTOR AFFINITY; RECEPTOR DENSITY; TAIL ARTERY; THORACIC AORTA;

ANIMALS; AORTA, THORACIC; ARTERIES; CELL MEMBRANE; DOSE-RESPONSE RELATIONSHIP, DRUG; KINETICS; MALE; MICROSOMES; PRAZOSIN; PROTEIN BINDING; PROTEIN SUBUNITS; RATS; RATS, WISTAR; RECEPTORS, ADRENERGIC, ALPHA-1;

EID: 1542329722     PISSN: 00071188     EISSN: None     Source Type: Journal    
DOI: 10.1038/sj.bjp.0705627     Document Type: Article

References (47)

1. BRADFORD, M.M. (1976). A rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principle of protein-dye binding. Anal. Biochem., 72, 248-254.
2. BUCKNER, S.A., OHEIM, K.W., MORSE, P.A., KNEPPER, S.M. & HANCOCK, A.A. (1996). Alpha 1-adrenoceptor-induced contractility in rat aorta is mediated by the alpha ID subtype. Eur. J. Pharmacol., 297, 241-248.
3. BURT, R.P., CHAPPLE, C.R. & MARSHALL, I. (1995). Evidence for a functional alpha 1A-(alpha 1C-) adrenoceptor mediating contraction of the rat epididymal vas deferens and an alpha 1B-adrenoceptor mediating contraction of the rat spleen. Br. J. Pharmacol., 115, 467-475.
4. BYLUND, D.B. & YAMAMURA, H.I. (1990). Methods for receptor binding. In: Method in Neurotransmitter Receptor Analysis, ed. Yamamura, H.I., Enna, S.J. & Kuhar, L.C., pp. 1-35. New York: Raven.
5. BYLUND, D.B. & TOEWS, M.L. (1993). Radioligand binding methods: practical guide and tips. Am. J. Physiol., 265, L421-L429.
6. A-adrenoceptors. Biochem. J., 343, 231-239.
7. COLUCCI, W.S., GIMBRONE JR, M.A. & ALEXANDER, R.W. (1981). Regulation of the postsynaptic alpha-adrenergic receptor in rat mesenteric artery. Effects of chemical sympathectomy and epinephrine treatment. Circ. Res., 48, 104-111.
8. DALY, C.J., DEIGHAN, C., MCGEE, A., MENNIE, D., ALIZ, MCBRIDE, M. & MCGRATH, J.C. (2002). A knockout approach indicates a minor vasoconstrictor role for vascular alB-adrenoceptors in mouse. Physiol. Genomics, 9, 85-92.
9. FABER, J.E., YANG, N. & XIN, X.H. (2001). Expression of α-adrenoceptor subtypes by smooth muscle cell and adventitial fibroblast in rat aorta and in cell culture. J. Pharmacol. Exp. Ther., 298, 441-452.
10. 3H]spiroperidol. Brain Res., 136, 578-584.
11. 1- Adrenoceptor subclassification in vascular smooth muscle. Trends Pharmacol. Sci., 7, 347-349.
12. GISBERT, R., MADERERO, Y., SABINO, V., NOGUERA, M.A., IVORRA, M.D. & D'OCON, P. (2003). Functional characterization of alpha(1)-adrenoceptor subtypes in vascular tissues using different experimental approaches: a comparative study. Br. J. Pharmacol., 138, 359-368.
13. GOETS, A.S., KING, H.K., WARD, S.D., TRUE, T.A., RIMELE, T.J. & SAUSSY JR, D.L. (1995). BMY 7378 is a selective antagonist of the D subtype of alpha 1-adrenoceptors. Eur. J. Pharmacol., 272, R5-R6.
14. GRAHAM, R.M., PEREZ, D.M., HWA, J. & PIASCIK, M.T. (1996). Alpha 1-adrenergic receptor subtypes. Molecular structure, function and signaling. Circ. Res., 78, 737-749.
15. HANCOCK, A.A. (1995). Alpha1 adrenoceptor subtypes: a synopsis of their pharmacology and molecular biology. Drug Dev. Res., 39, 54-107.
16. HIEBLE, J.P., BYLUND, D.B., CLARKE, D.E., EIKENBURG, D.C., LANGER, S.Z., LEFKOWITZ, R.J., MINNEMAN, K.P. & RUFFOLO JR, R.R. (1995). International Union of Pharmacology. X. Recommendation for nomenclature of alpha 1-adrenoceptors: consensus update. Pharmacol. Rev., 47, 267-270.
17. 1-adrenoceptor subtypes in the rat prostate. Eur. J. Pharmacol., 366, 119-126.
18. HIRAIZUMI, Y., TANAKA, T., YAMAMOTO, H., SUZUKI, F. & MURAMATSU, I. (2003). Pharmacological identification of alpha-1L adrenoceptor in rabbit ear artery. The Fourth International Symposium on Receptor Mechanisum, Signal Transduction and Drug Effects, P-26 (abstract).
19. KWAN, C.Y., LEE, R.M.K.W. & DANIEL, E.E. (1981). Isolation of plasma membranes from rat mesenteric veins: a comparison of their physical and biochemical properties with arterial membranes. Blood Vessels, 18, 171-186.
20. LACHNIT, W.G., TRAN, A.M., CLARKE, D.E. & FORD, A.P.D.W. (1997). Pharmacological characterization of an alpha 1A-adrenoceptor mediating contractile responses to noradrenaline in isolated caudal artery of rat. Br. J. Pharmacol., 120, 819-826.
21. LEONARDI, A., HIEBLE, J.P., GUARNERI, L., NASELSKY, D.P., POGGESI, E., SIRONI, G., SULPIZIO, A.C. & TESTA, R. (1997). Pharmacological characterization of the uroselective alpha-1 antagonist Rec 15/2739 (SB 216469): role of the alpha-1L adrenoceptor in tissue selectivity, Part I. J. Pharmacol. Exp. Ther., 281, 1272-1283.
22. LOMASNEY, J.W., COTECCHIA, S., LEFKOWITS, R.J. & CARON, M.G. (1991). Molecular biology of alpha-adrenergic receptors: implication for receptor classification and for structure-function relationships. Biochim. Biophys. Acta, 1095, 127-139.
23. 1radrenoceptor ligand binding sites. J. Pharmacol. Exp. Ther., 294, 434-443.
24. MCGRATH, J.C., MACKENZIE, J.F. & DALY, C.J. (1999). Pharmacological implications of cellular localization of alpha1-adrenoceptors in native smooth muscle cells. J. Auton. Pharmacol., 19, 303-310.
25. 1radrenoceptor subtypes. Naunyn-Schmiedeberg's Arch. Pharmacol., 352, 1-10.
26. MICHELOTTI, G.A., PRICE, D.T. & SCHWINN, D.A. (2000). Aladrenergic receptor regulation: basic science and clinical implication. Pharmacol. Therap., 88, 281-309.
27. MOREL, N. & GODFRAIND, T. (1989). Pharmacological properties of voltage-dependent calcium channels in functional microvessels isolated from rat brain. Naunyn-Schmiedeberg's Arch. Pharmacol., 340, 442-451.
28. MURAMATSU, I., MURATA, S., ISAKA, M., PIAO, H.L., ZHU, J., SUZUKI, F., MIYAMOTO, S., OSHITA, M., WATANABE, Y. & TANIGUCHI, T. (1998). Alpha1-adrenoceptor subtypes and two receptor systems in vascular tissues. Life Sci., 62, 1461-1465.
29. MURAMATSU, I., OHMURA, T., HASHIMOTO, S. & OSHITA, M. (1995). Functional subclassification of vascular alpha1 adrenoceptors. Pharmacol. Commun., 6, 23-28.
30. MURAMATSU, I., OHMURA, T., KIGOSHI, S., HASHIMOTO, S. & OSHITA, M. (1990). Pharmacological subclassification of α1-adrenoceptors in vascular smooth muscle. Br. J. Pharmacol., 99, 197-201.
31. MURAMATSU, I., TAKITA, M., SUZUKI, F., MIYAMOTO, S., SAKAMOTO, S. & OHMURA, T. (1996). Subtype selectivity of a new α1-adrenoceptor antagonist, JTH-601: comparison with prazosin. Eur. J. Pharmacol., 300, 155-157.
32. MURATA, S., TANIGUCHI, T. & MURAMATSU, I. (1999). Pharmacological analysis of the novel, selective alpha1-adrenoceptor antagonist, KMD-3213, and its suitability as a tritiated radioligand. Br. J. Pharmacol., 127, 19-26.
33. 1-adrenoceptors in the rabbit iris: pharmacological characterization and expression of mRNA. Br. J. Pharmacol., 127, 1367-1374.
34. 1-adrenoceptor subtypes in rabbit thoracic aorta. Br. J. Pharmacol., 108, 1071-1076.
35. PATON, W.D.M. & RANG, H.P. (1964). The uptake of atropine and related drugs by intestinal smooth muscle of the guinea-pig in relation to acetylcholine receptors. Proc. Roy. Soc. B, 163, 1-44.
36. PIASCIK, M.T., SMITH, M.S., SOLTIS, E.E. & PEREZ, D.M. (1994). Identification of the mRNA for novel alpha 1D-adrenoceptor and two other alpha 1-adrenoceptors in vascular smooth muscle. Mol. Pharmacol., 46, 30-40.
37. PIASCIK, M.T. & PEREZ, D.M. (2001). Alpha1-adrenegic receptors: new insights and directions. J. Pharmacol. Exp. Ther., 298, 403-410.
38. SAUSSY JR, D.L., GOETZ, A.S., QUEEN, K.L., KING, H.K., LUTZ, M.W. & RIMELE, T.J. (1996). Structure activity relationships of a series of buspirone analogs at alpha-1 adrenoceptors: further evidence that rat aorta alpha-1 adrenoceptors are of the alpha-1D-subtype. J. Pharmacol. Exp. Ther., 278, 136-144.
39. SAYET, I., NEUILLY, G., RAKOTOARISOA, L., MIRONNEAU, C. & MIRONNEAU, J. (1993). Relaton between alpha 1-adrenoceptor subtypes and noradrenaline-induced contraction in rat potal vein smooth muscle. Br. J. Pharmacol., 110, 207-212.
40. SCATCHARD, G. (1949). The attractions of proteins for small molecules and ions. Ann. N.Y. Acad. Sci., 51, 660-672.
41. STASSEN, F.R.M., MASS, R.G.H.T., SCHIFFERS, P.M.H., JANSSEN, G.M.J. & DEMEY, J.G.R. (1998). A positive and reversible relationship between adrenergic nerves and alpha-1A adrenoceptors in rat arteries. J. Pharmacol. Exp. Ther., 284, 399-405.
42. STASSEN, F.R.M., WILLEMSEN, M.J.J.M.F., JANSSEN, G.M.J. & DEMEY, J.G.R. (1997). Adrenoceptor subtypes in rat aorta and mesenteric small arteries are preserved during left ventricular dysfunction post-myocardial infraction. Cardiovasc. Res., 33, 706-713.
43. TESTA, R., GUARNERI, L., ANGELICO, P., POGGESI, E., TADDEI, C., SIRONI, G., COLOMBO, D., SULPIZIO, A.C., NASELSKY, D.P., HIEBLE, J.P. & LEONARDI, A. (1997). Pharmacological characterization of the uroselective alpha-1 antagonist Rec 15/2739 (SB 216469): role of the alpha-1L adrenoceptor in tissue selectivity, Part II. J. Pharmacol. Exp.Ther., 281, 1284-1293.
44. WEILAND, G.A. & MOLINOFF, P.B. (1981). Quantitative analysis of drug-receptor interactions: I. Determination of kinetic and equilibrium properties. Life Sci., 29, 313-330.
45. YAMAGISHI, R., AKIYAMA, K., NAKAMURA, S., HORA, M., MASUDA, N., MATSUZAWA, A., MURATA, S., UJIIE, A., KURASHIMA, Y., IIZUKA, K. & KITAZAWA, M. (1996). Effect of KMD-3213, an alpha 1a-adrenoceptor-selective antagonist, on the contractions of rabbit prostate and rabbit and rat aorta. Eur. J. Pharmacol., 315, 73-97.
46. YAMAMURA, H.I., ENNA, S.J. & KUHAR, M.J. (Editors) (1985). Neurotransmitter Receptor Binding, 2nd edn. New York: Raven Press.
47. YANG, M., VERFURTH, F., BUSCHER, R. & MICHEL, M.C. (1997). Is alpha1D-sdrenoceptor protein detectable in rat tissues? Naunyn-Schmiedeberg's Arch. Pharmacol., 335, 438-446.