Swelling properties and mechanical characterization of a semi- interpenetrating chitosan/polyethylene oxide network: Comparison with a chitosan reference gel

S.T.P. Pharma Sciences

Volumn 9, Issue 4, 1999, Pages 359-364

  Khalid, M N ^a   Ho, L ^a   Agnely, F ^a   Grossiord, J L ^a   Couarraze, G ^a  

^a UNIV PARIS SUD   (France)

Author keywords

Chitosan; Crosslinking; Polyethylene oxide; Rheology; Semi interpenatrating network; Swelling

Indexed keywords

CHITOSAN; CROSS LINKING REAGENT; GLYOXAL; MACROGOL;

ARTICLE; BIODEGRADATION; DATA ANALYSIS; DEACETYLATION; DRUG RELEASE; DRUG TARGETING; INFRARED RADIATION; MOLECULAR WEIGHT; PH; REFERENCE VALUE; SHEAR RATE; VISCOMETRY;

EID: 0032885393     PISSN: 11571489     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (15)

1. RICCARDO A. and MUZZARELLI A. - Chitine. - Pergamon Press, Oxford, 1977, Chapter 2.
2. DENUZIERE A. - Etude physicochimique des interactions chitosane-glycosaminoglycannes (chondroitine sulfate et acide hyaluronique). Applications biologiques. - PhD Thesis, Université de Paris-XI, Châtenay-Malabry, 1996.
3. CHANDY T. and SHARMA C.P. - Biodegradable chitosan matrix for the controlled release of steroids. - Biomat. Art. Cells Immob. Biotech., 19 (4), 745-760, 1991.
4. CHANDY T. and SHARMA C.P. - Chitosan matrix for oral sustained delivery of ampicillin. - Biomaterials, 14 (12), 939-944, 1993.
5. AMIJI M.M. and PATEL V.R. - Chitosan/polyethylene oxide hydrogels for pH-sensitive oral drug delivery. - Proc. Int. Symp. Contr. Rel. Bioact. Mater., 22, 330-331, 1995.
6. PATEL V.R. and AMIJI M.M. - pH-sensitive swelling and drug-release properties of chitosan/polyethylene oxide semiinterpenetrating polymer network. - In : Hydrogels and Biodegradable Polymers for Application, R. Ottenbrite, S.J. Huang and K. Park Eds., ACS Symposium Series, 627, American Chemical Society, Washington, 1996, pp. 209-220.
7. BEENA M.S., CHANDY T. and SHARMA C.P. - Heparin immobilized chitosan/polyethylene glycol interpenetrating network: antithrombogenicity. - Art. Cells Blood Subs, Immob. Biotech., 23 (2), 175-192, 1995.
8. PATEL V.R. and AMIJI M.M. - Preparation and characterization of freeze-dried chitosan/polyethylene oxide hydrogels for site-specific antibiotic delivery in the stomach. - Pharm. Res., 13 (4), 588-593, 1996.
9. MIYA M., IWAMOTO R., YOSHIKAWA S. and MIMA S. - IR spectroscopic determination of CONH content in highly deacetylated chitosan. - Int. J. Biol. Macromol., 2, 323-324, 1980.
10. ROBERTS G.A. F. and DOMSZY J.G. - Determination of the viscometric constants for chitosan. - Int. J. Biol. Macromol., 4, 374-377, 1982.
11. WATERS N.E. - The indentation of thin rubber sheets by spherical indentors. - Br. J. Appl. Phys., 16 , 557-563, 1965.
12. YAO K., PENG T., GOOSEN M.F.A., MIN J.M. and HE Y.Y. -pH-sensitivity of hydrogels based on complex forming chitosan: polyether interpenetrating polymer network. - J. Appl. Polym. Sci., 48, 343-354, 1993.
13. PENG T., YAO K., YUAN C. and GOOSEN M.F.A. - Structural changes of pH-sensitive chitosan/polyether hydrogels in different pH solution. -J. Polym. Sci. A : Polymer Chemistry, 32, 591-596, 1994.
14. YAO K., PENG T., FENG H.B. and HE Y.Y. - Swelling kinetics and release characteristics of crosslinked chitosan: polyether network (semi-interpenetrating network) hydrogels - J. Polym. Sci A : Polymer Chemistry, 32, 1213-1223, 1994.
15. YAO K., PENG T., XU M.X, YUAN C., GOOSEN M.F.A., ZHANG Q.Q. and REN L. - pH-dependent hydrolysis and drug release of chitosan/polyether interpenetrating polymer network hydrogel. - Polymer International, 34, 213-219, 1994.