Characterization and partial purification of the rat and human enzyme systems active in the reduction of N-hydroxymelagatran and benzamidoxime

Drug Metabolism and Disposition

Volumn 33, Issue 4, 2005, Pages 570-578

  Andersson, Susanne ^a   Hofmann, Yvonne ^a   Nordling, Åsa ^a   Li, Xue Qing ^b   Nivelius, Sabina ^a   Andersson, Tommy B ^b   Ingelman Sundberg, Magnus ^a   Johansson, Inger ^a  

^a KAROLINSKA INSTITUTE   (Sweden)

^b ASTRAZENECA R AND D   (Sweden)

Author keywords

[No Author keywords available]

Indexed keywords

AMIDINE; AMINE; BENZAMIDOXIME; CYANIDE; CYTOCHROME P450 INHIBITOR; DEFEROXAMINE; HYDROXYLAMINE; HYDROXYMERCURIBENZOIC ACID; LIVER ENZYME; MACROGOL; METHOXYAMINE; N HYDROXYMELAGATRAN; POTASSIUM CYANIDE; PRODRUG; REDUCED NICOTINAMIDE ADENINE DINUCLEOTIDE; UNCLASSIFIED DRUG;

ADIPOSE TISSUE; ANIMAL CELL; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; ELECTRON TRANSPORT; ENZYME ACTIVITY; ENZYME ANALYSIS; ENZYME DENATURATION; ENZYME LOCALIZATION; ENZYME PURIFICATION; ENZYME SUBSTRATE; HUMAN; HUMAN CELL; HUMAN TISSUE; HYDROXYLATION; KIDNEY; LIVER; LIVER MICROSOME; LIVER MITOCHONDRION; NONHUMAN; PRIORITY JOURNAL; RAT; REDUCTION; SEX DIFFERENCE; SOLUBILIZATION;

ADIPOSE TISSUE; AMIDINES; ANIMALS; AZETIDINES; BENZAMIDINES; CHEMICAL FRACTIONATION; CHROMATOGRAPHY, AGAROSE; CYTOCHROME P-450 ENZYME SYSTEM; FEMALE; HUMANS; KIDNEY; MALE; MICROSOMES, LIVER; MITOCHONDRIA, LIVER; ORGAN SPECIFICITY; OXIDATION-REDUCTION; OXIDOREDUCTASES; RATS; SEX FACTORS; SPECIES SPECIFICITY; SUBSTRATE SPECIFICITY;

EID: 15344340048     PISSN: 00909556     EISSN: None     Source Type: Journal    
DOI: 10.1124/dmd.104.002972     Document Type: Article

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