The response to cyclophosphamide in steroid-sensitive nephrotic syndrome is influenced by polymorphic expression of glutathion-S-transferases-M1 and -P1

Pediatric Nephrology

Volumn 20, Issue 4, 2005, Pages 478-481

  Vester, Udo ^a   Kranz, Birgitta ^a   Zimmermann, Stephanie ^b   Büscher, Rainer ^a   Hoyer, Peter F ^a  

^a UNIVERSITY OF DUISBURG ESSEN   (Germany)

^b HANNOVER MEDICAL SCHOOL   (Germany)

Author keywords

Children; Cyclophosphamide; Glutathion S transferase; Nephrotic syndrome; Polymorphism; Sustained remission

Indexed keywords

CYCLOPHOSPHAMIDE; GLUTATHIONE TRANSFERASE; GLUTATHIONE TRANSFERASE M1; GLUTATHIONE TRANSFERASE P1; STEROID; UNCLASSIFIED DRUG;

ARTICLE; CHILD; CLINICAL ARTICLE; CONTROLLED STUDY; DRUG DOSE REGIMEN; DRUG EFFICACY; DRUG RESPONSE; DRUG SENSITIVITY; FEMALE; GENE EXPRESSION; GENETIC POLYMORPHISM; GENOTYPE; HETEROZYGOSITY; HOMOZYGOSITY; HUMAN; MALE; NEPHROTIC SYNDROME; POLYMERASE CHAIN REACTION; PRIORITY JOURNAL; RELAPSE; REMISSION; TREATMENT OUTCOME; WILD TYPE;

ADOLESCENT; ADULT; CHILD; CHILD, PRESCHOOL; CYCLOPHOSPHAMIDE; FEMALE; GLUTATHIONE S-TRANSFERASE PI; GLUTATHIONE TRANSFERASE; HUMANS; IMMUNOSUPPRESSIVE AGENTS; ISOENZYMES; MALE; NEPHROTIC SYNDROME; POLYMORPHISM, GENETIC; REMISSION INDUCTION; STEROIDS;

EID: 15344338782     PISSN: 0931041X     EISSN: None     Source Type: Journal    
DOI: 10.1007/s00467-004-1759-7     Document Type: Article

References (24)

1. Brodehl J (1996) Management of nephrotic syndrome in children. Clin Immunother 5 175-192
2. Latta K, von Schnakenburg C, Ehrich JHH (2001) A meta-analysis of cytotoxic treatment in frequently relapsing nephrotic syndrome in children. Pediatr Nephrol 16:271-282
3. Vester U, Kranz B, Zimmermann S, Hoyer PF (2003) Cyclophosphamide in steroid-sensitive nephrotic syndrome: Outcome and outlook. Pediatr Nephrol 18:661-664
4. Konrad M, Mytilineos J, Ruder H, Opelz G, Schärer K (1997) HLA-DR 7 predicts the response to alkylating agents in steroid-sensitive nephrotic syndrome. Pediatr Nephrol 11:16-19
5. Arbeitsgemeinschaft für Pädiatrische Nephrologie (1982) Effect of cytotoxic drugs in frequent relapsing nephrotic syndrome with and without steroid dependency. N Engl J Med 306:451-454
6. Busse D, Busch FW, Bohnenstengel F, Eichelbaum M, Fischer P, Opalinska J, Schumacher K, Schweizer E, Kroemer HK (1997) Dose escalation of cyclophosphamide in patients with breast cancer: Consequences for pharmacokinetics and metabolism. J Clin Oncol 15:1885-1896
7. Seidegard J, Vorachek WR, Pero RW, Pearson WR (1988) Hereditary differences in the expression of the human glutathione transferase active on trans-stilbene oxide are due to a gene deletion. Proc Natl Acad Sci USA 85:7293-7297
8. Pemble S, Schroeder KR, Spencer SR, Meyer DJ, Hallier E, Bolt HM, Ketterer B, Taylor JB (1994) Human glutathione S-transferase theta (GSTT1): CDNA cloning and the characterization of a genetic polymorphism. Biochem J 300:271-276
9. Zimniak P, Nanduri B, Pikula S, Bandorowicz-Pikula J, Singhal SS, Srivastava SK, Awasthi S, Awasthi YC (1994) Naturally occurring human glutathione S-transferase GSTP1-1 isoforms with isoleucine and valine in position 104 differ in enzymic properties. Eur J Biochem 224:893-899
10. Marshall SE, Bordea C, Haldar NA, Mullighan CG, Wojnarowska F, Morris PJ, Welsh KI (2000) Glutathione S-transferase polymorphisms and skin cancer after renal transplantation. Kidney Int 58:2186-2193
11. Deakin M, Elder J, Hendrickse C, Peckham D, Baldwin D, Pantin C, Wild N, Leopard P, Bell DA, Jones P, Duncan H, Brannigan K, Alldersea J, Fryer AA, Strange RC (1996) Glutathione S-transferase GSTT1 genotypes and susceptibility to cancer: Studies of interactions with GSTM1 in lung, oral, gastric and colorectal cancers. Carcinogenesis 17:881-884
12. Chen H, Sandler DP, Taylor JA, Shore DL, Liu E, Bloomfield CD, Bell DA (1996) Increased risk for myelodysplastic syndromes in individuals with glutathione transferase theta 1 (GSTT1) gene defect. Lancet 347:295-297
13. Harries LW, Stubbins MJ, Forman D, Howard GC, Wolf CR (1997) Identification of genetic polymorphisms at the glutathione S-transferase Pi locus and association with susceptibility to bladder, testicular and prostate cancer. Carcinogenesis 18:641-644
14. Kelsey KT, Hankinson SE, Colditz GA, Springer K, Garcia-Closas M, Spiegelman D, Manson JE, Garland M, Stampfer MJ, Willett WC, Speizer FE, Hunter DJ (1997) Glutathione S-transferase class mu deletion polymorphism and breast cancer: Results from prevalent versus incident cases. Cancer Epidemiol Biomarkers Prev 6:511-515
15. Ambrosone CB, Sweeney C, Coles BF, Thompson PA, McClure GY, Korourian S, Fares MY, Stone A, Kadlubar FF, Hutchins LF (2001) Polymorphisms in glutathione S-transferases (GSTM1 and GSTT1) and survival after treatment for breast cancer. Cancer Res 61:7130-7135
16. Howells RE, redman CW, Dhar KK, Sarhanis P, Musgrove C, Jones PW, Alldersea J, Fryer AA, Hoban PR, Strange RC (1998) Association of glutathione S-transferases GSTM1 and GSTT1 null genotypes with clinical outcome in epithelial ovarian cancer. Clin Cancer Res 4:2439-2445
17. Anderer G, Schrappe M, Brechlin M, Lauten M, Muti P, Welte K, Stanulla M (2000) Polymorphisms within glutathione S-transferase genes and initial response to glucocorticoids in childhood acute lymphoblastic leukaemia. Pharmacogenetics 10:715-726
18. Arbeitsgemeinschaft für Pädiatrische Nephrologie (1979) Alternate-day versus intermittent prednisone in frequently relapsing nephrotic syndrome. Lancet 1:401-403
19. Stanulla M, Schrappe M, Müller Brechlin A, Zimermann M, Welte K (2000) Polymorphisms within glutathione S-transferase genes (GSTM1, GSTT1, GSTP1) and risk of relapse in childhood B-cell precurser acute lymphoblastic leukemia: A case-control study. Blood 95:1222-1228
20. Watson MA, Stewart RK, Smith GB, Massey TE, Bell DA (1998) Human glutathione S-transferase P1 polymorphisms: Relationship to lung tissue enzyme activity and population frequency distribution. Carcinogenesis 19:275-280
21. Heagerty A, Smith A, English J, Lear J, Perkins W, Bowers B, Jones P, Gilford J, Alldersea J, Fryer A, Strange RC (1996) Susceptibility to multiple cutaneous basal cell carcinomas: Significant interactions between glutathione S-transferase GSTM1 genotypes, skin type and male gender. Br J Cancer 73:44-48
22. Tew KD (1994) Glutathione-associated enzymes in anticancer drug resistance. Cancer Res 54:4313-4320
23. Yuan ZM, Smith PB, Brundrett RB, Colvin M, Fenselau C (1991). Glutathione conjugation with phosphoramide mustard and cyclophosphamide. A mechanistic study using tandem mass spectrometry. Drug Metab Dispos 19(3): 625-629
24. Campbell JA, Corrigal AV, Guy A, Kirsch RE (1991). Immunohistologic localization of alpha, mu, and pi class glutathione S-transferases in human tissues. Cancer 67:1608-1613