HLA-DR7 predicts the response to alkylating agents in steroid-sensitive nephrotic syndrome

Pediatric Nephrology

Volumn 11, Issue 1, 1997, Pages 16-19

  Konrad, Martin ^a   Mytilineos, Joannis ^a   Ruder, Hans ^a   Opelz, Gerhard ^a   Schärer, Karl ^a,b  

^a UNIVERSITY OF HEIDELBERG   (Germany)

^b UNIVERSITY HOSPITAL HEIDELBERG   (Germany)

Author keywords

Chlorambucil; Cyclophosphamide; HLA antigens; Steroid sensitive nephrotic syndrome

Indexed keywords

ALKYLATING AGENT; CHLORAMBUCIL; CYCLOPHOSPHAMIDE; HLA DR7 ANTIGEN; PREDNISONE; STEROID;

ADOLESCENT; ARTICLE; CHILD; DNA DETERMINATION; FEMALE; HLA TYPING; HUMAN; KIDNEY BIOPSY; MAJOR CLINICAL STUDY; MALE; NEPHROTIC SYNDROME; PREDICTION; PRIORITY JOURNAL; RELAPSE; REMISSION; SEROLOGY;

ADOLESCENT; AGE OF ONSET; ALKYLATING AGENTS; ANTI-INFLAMMATORY AGENTS; CHILD; CHILD, PRESCHOOL; CHLORAMBUCIL; CYCLOPHOSPHAMIDE; DNA; FEMALE; HLA-DR7 ANTIGEN; HUMANS; INFANT; MALE; NEPHROTIC SYNDROME; POLYMORPHISM, RESTRICTION FRAGMENT LENGTH; PREDNISONE; RETROSPECTIVE STUDIES; STEROIDS;

EID: 0031015455     PISSN: 0931041X     EISSN: None     Source Type: Journal    
DOI: 10.1007/s004670050224     Document Type: Article

References (22)

1. International Study of Kidney Disease in Children (1978) Nephrotic syndrome in children. Prediction of histopathology from clinical and laboratory characteristics at time of diagnosis. Kidney Int 13:159 - 165
2. Kim MS, Grupe WE (1992) The management of primary glomerular disease: alternatives to steroid therapy. In: Edelmann CM (ed) Pediatric kidney disease. Little Brown, Boston, pp 1355 - 1380
3. Barratt TM, Clark AGB (1994) Minimal change nephrotic syndrome and focal segmental glomerulosclerosis. In: Holliday MA, Barratt TM, Avner ED (eds) Pediatric nephrology. Williams and Wilkins. Baltimore, pp 767 - 787
4. Trompeter RS, Barratt TM, Kay R, Turner MW, Soothill JF (1980) HLA, atopy, and cyclophosphamide in steroid-responsive childhood nephrotic syndrome. Kidney Int 17:113 - 117
5. Alfiler CA, Roy LP, Doran T, Sheldon TA, Bashir H (1980) HLA-DRw7 and steroid-responsive nephrotic syndrome in childhood. Clin Nephrol 14:71 - 74
6. De Mouzon-Cambon A, Bouissou F, Dutau G, Barthe P, Parra MT, Sevin A, Ohayon E (1981) HLA-DR7 in children with idiopathic nephrotic syndrome. Correlation with atopy. Tissue Antigens 17:518 - 524
7. Lagueruela CC, Buettner TL, Cole BR, Kissane JM, Robson AM (1990) HLA extended haplotypes in steroid-sensitive nephrotic syndrome of childhood. Kidney Int 38:145 - 150
8. Ruder H, Schärer K, Opelz G, Lenhard V, Waldherr R, Müller-Wiefel DE, Wingen AM, Dippell J (1990) HLA phenotypes and idiopathic nephrotic syndrome in children. Pediatr Nephrol 4:478-481
9. Konrad M, Mytilineos J, Bouissou F, Scherer S, Gulli MP, Meissner I, Cambon-Thomsen A, Opelz G, Schärer K (1994) HLA class II associations with idiopathic nephrotic syndrome in children. Tissue Antigens 43:275 - 280
10. International Study of Kidney Disease in Children (1974) Prospective, controlled trial of cyclophosphamide therapy in children with the nephrotic syndrome. Lancet II:423 - 427
11. Arbeitsgemeinschaft für Pädiatrische Nephrologie (1979) Alternate day vs intermittent prednisone in frequently relapsing nephrotic syndrome. Lancet I:401 - 404
12. Arbeitsgemeinschaft für Pädiatrische Nephrologie (1982) Effect of cytotoxic drugs in frequently relapsing nephrotic syndrome with or without steroid dependence. N Engl J Med 306:451 - 454
13. Arbeitsgemeinschaft für Pädiatrische Nephrologie (1987) Cyclophosphamide treatment of steroid dependent nephrotic syndrome: comparison of eight week with 12 week course. Arch Dis Child 62:1102 - 1106
14. Terasaki PI (1980) Histocompatibility testing 1980. UCLA Tissue Typing Laboratory, Los Angeles
15. Bidwell J (1988) Manual of techniques for DNA-RFLP analysis and genotyping of HLA-DR and -DQ antigens Immunology today 9:18-23
16. Mytilineos J, Scherer S, Opelz G (1990) Comparison of RFLP-DR beta and serological HLA-DR typing in 1500 individuals. Transplantation 50:870 - 873
17. Matthews DE, Farewell V (1985) Using and understanding medical statistics. Karger, Basel, pp 67 - 87
18. Bouissou F, Meissner I, Konrad M, Sommer E, Mytilineos J, Ohayon E, Sierp G, Barthe P, Opelz G, Schärer K, Cambon-Thomsen A (1995) Clinical implications from studies of HLA antigens in idiopathic nephrotic syndrome in children. Clin Nephrol 44:279 - 283
19. Garin EH, Pryor ND, Fennell RS, Richard GA (1978) Pattern of response to prednisone in idiopathic minimal lesion nephrotic syndrome as a criterion in selecting patients for cyclophosphamide therapy J Pediatr 92:304 - 308
20. Shohet I, Meyerovitch J, Aladjem M, Boichis H (1988) Cyclophosphamide in treatment of minimal change nephrotic syndrome. Eur J Pediatr 147:239 - 241
21. Zaki M, Daoud AS, Al Saleh QA, Al Najedr AK, White AG (1994) HLA antigens in Arab children with steroid-responsive nephrotic sydrome. Pediatr Nephrol 8:74 - 75
22. Clark AGB, Vaughan RW, Stephens HAF, Chantier C, Williams DG, Welsh KI (1990) Genes encoding the beta-chains of HLA-DR7 and HLA-DQw2 define major susceptibility determinants for idiopathic nephrotic syndrome. Clin Sci 78:391 - 397