Association of glutathione S-transferase GSTM1 and GSTT1 null genotypes with clinical outcome in epithelial ovarian cancer

Clinical Cancer Research

Volumn 4, Issue 10, 1998, Pages 2439-2445

  Howells, Robert E J ^a   Redman, Charles W E ^a   Dhar, Kalyan K ^a   Sarhanis, Panos ^a   Musgrove, Carolyn ^a   Jones, Peter W ^b   Alldersea, Julie ^b   Fryer, Anthony A ^b   Hoban, Paul R ^b   Strange, Richard C ^b  

^a UNIVERSITY HOSPITAL OF NORTH STAFFORDSHIRE   (United Kingdom)

^b KEELE UNIVERSITY   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

ANTINEOPLASTIC AGENT; CYCLOPHOSPHAMIDE; DOXORUBICIN; GLUTATHIONE TRANSFERASE; PLATINUM;

ADOLESCENT; ADULT; AGED; ARTICLE; CANCER CHEMOTHERAPY; CANCER SURGERY; CANCER SURVIVAL; CONTROLLED STUDY; DRUG RESPONSE; FEMALE; GENOTYPE; HUMAN; MAJOR CLINICAL STUDY; OVARY CANCER; POSTOPERATIVE CARE; PRIORITY JOURNAL; TREATMENT OUTCOME;

ADOLESCENT; ADULT; AGED; AGED, 80 AND OVER; FEMALE; GENOTYPE; GLUTATHIONE TRANSFERASE; HUMANS; MIDDLE AGED; MULTIVARIATE ANALYSIS; NEOPLASMS, GLANDULAR AND EPITHELIAL; OVARIAN NEOPLASMS;

EID: 0031784414     PISSN: 10780432     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (36)

1. Chang, J., Bridgewater, J., Gore, M., Fisher, C., Schofield, J., A'Hern, R., Ponder, B., Jacobs, I., McKeage, M., Kelland, L., and Harap, K. Non-surgical aspects of ovarian cancer. Lancet, 343: 335-341, 1994.
2. Office of Population Censuses and Surveys. Cancer Statistics Registrations. Series mB1 No. 22, London: HMSO Books, 1994.
3. Ozols, R., and Young, R. Chemotherapy of ovarian cancer. Semin. Oncol., 11: 251-263, 1994.
4. Goodwill, A. K., Testa, J. R., and Hamilton, T. C. The biology of ovarian cancer development. Cancer (Phila.), 71: 530-536, 1993.
5. Fathalla, M. F. Incessant ovulation: a factor in ovarian neoplasia. Lancet, ii: 163, 1971.
6. Schildkraut, J. M. Bastos, E., and Berchuck, A. Relationship between lifetime ovulatory cycles and overexpression of mutant p53 in epithelial ovarian cancer. J. Natl. Cancer Inst. (Bethesda), 89: 932-938, 1997.
7. Berek, J. S., Martinez-Maza, O., Hamilton, T., Trope, C., Kaern, J., Baak, J., and Rustin, G. J. S. Molecular and biological factors in the pathogenesis of ovarian cancer. Ann. Oncol., 4: 3-16, 1993.
8. Hayes, J. D., and Strange, R. C. Potential contribution of the glutathione S-transferase supergene family to resistance to oxidative stress. Free Radical Res. Commun., 22: 193-207, 1995.
9. Strange, R. C., and Fryer, A. A. The glutathione S-transferases: influence of polymorphism on susceptibility to cancer. In: P. Boffetta, N. Caporaso, J. Cuzick, M. Lang, and P. Vineis (eds.), Metabolic Polymorphisms and Cancer. Lyon, France: IARC Scientific Publications, in press, 1998.
10. Tew, K. D. Glutathione-associated enzymes in anticancer drug resistance. Cancer Res., 54: 4313-4320, 1994.
11. Singhal, S. S., Zimniak, P., Awasthi, S., Piper, J. T., He, N., Teng. J. I., petersen, D. R., and Awasthi, Y. C. Several closely related glutathione S-transferase isoenzymes catalysing conjugation of 4-hydroxynonenal are differentially expressed in human tissues. Arch. Biochem. Biophys., 311: 242-250, 1994.
12. Baez, S., Segura-Aguilar, J., Widersten, M., Johansson, A-S., and Mannervik, B. Glutathione transferases catalyse the detoxification of oxidised metabolites (o-quinones) of catecholamines and may serve as an antioxidant system preventing degenerative cellular processes. Biochem. J., 324: 25-28, 1997.
13. Wiencke, J. K., Kelsey, K. T., Lamela, R. A., and Toscano, W. A., Jr. Human glutathione S-transferase deficiency as a marker of susceptibility to epoxide-induced cytogenetic damage. Cancer Res., 50: 1585-1590, 1990.
14. Schroeder, K. R., Wibel, F. A., Reich, S., Dannappel, D., Bolt, H. M., and Hallier, E. Glutathione S-transferase (GST) θ polymorphism influences background SCE rate. Arch. Toxicol., 69: 505-507, 1995.
15. Lear, J. T., Heagerty, A. H. M., Smith, A., Bowers, B., Payne, C. R., Smith, C. A. D., Jones, P. W., Gilford, J., Yengi, L., Alldersea, J., Fryer, A. A., and Strange, R. C. Multiple cutaneous basal cell carcinomas: glutathione S-transferase (GSTM1, GSTT1) and cytochrome P450 (CYP2D6, CYP1A1) polymorphisms influence tumor numbers and accrual. Carcinogenesis (Lond.), 17: 1891-1896, 1996.
16. Sarhanis, P., Redman, C., Perrett, C., Brannigan, K., Clayton, R. N., Hand, P., Musgrove, C., Suarez, V., Jones, P., Fryer, A. A., Farrell, W. E., and Strange, R. C. Epithelial ovarian cancer: influence of polymorphism at the glutathione S-transferase GSTM1 and GSTT1 loci. Br. J. Cancer. 74:1-5, 1996.
17. O'Reilly, M. A., Staversky, R. J., Stripp, B. R., and Finkelstein, J. N. Exposure to hyperoxia induces p53 expression in mouse lung epithelium. Am. J. Respir. Cell Mol. Med., 18: 43-50, 1998.
18. Teneriello, M. G., Ebina, M., Linnoila, R. I. Henry, M., Nash, J. D., Park, R. C., and Birrer, M. J. p53 and Ki-ras gene mutations in epithelial ovarian cancers. Cancer Res., 53: 3101-3108, 1993.
19. Herod, J. J. O., Eliopoulos, A. G., Warwick, J., Niedobitek, G., Young, L. S., and Kerr, D. J. The prognostic significance of bcl-2 and p53 expression in ovarian carcinoma. Cancer Res., 56: 2178-2184, 1996.
20. Niwa, K., Itoh, M., Murase, T., Morishita, S., Itoh, N., Mori, H., and Tamaya, T. Alteration of p53 gene in ovarian carcinoma: clinicopathological correlation and pathological significance. Br. J. Cancer, 70: 1191-1197, 1994.
21. Hayes, J. D., and Pultbrd, D. J. The glutathione 5-transferase supergene family: regulation of GST and the contribution of the isoenzymes to cancer chemoprotection and drug resistance. Crit. Rev. Biochem. Mol. Biol., 30: 445-600, 1995.
22. Buttitta, F., Marchetti, A., Gadducci, A., Pellegrini, S., Morganti, M., Camicelli, V., Cosio, S., Gagetti, O., Genazzini, A. R., and Bevilacqua, G. p53 alterations are predictive of chemoresistance and aggressiveness in ovarian carcinomas: a molecular and immunohistochemical study. Br. J. Cancer. 75: 230-235, 1997.
23. Elexpuru-Camiruaga, J., Buxton, N., Kandula, V., Dias, V. S., Campbell, D., McIntosh, J., Broome, J., Jones, P., Inskip, A., Alldersea, J., Fryer, A. A., and Strange, R. C. Susceptibility to astrocytoma and meningioma. Influence of allelism at glutathione S-transferase GSTT1 and GSTM1 and cytochrome P450 CYP2D6 loci. Cancer Res., 55: 4237-4239, 1995.
24. Rosenburger, W. F. Dealing with multiplicities in pharmacoepidemiologic studies. Pharmacoepidem. Drug Safety. 5: 95-100, 1996.
25. Warwick, J., Kehoe, S., Earl, H., Luesley, D., Redman, C., and Chan, K. K. Long term follow up of patients with advanced ovarian cancer treated in randomised clinical trials. Br. J. Cancer, 72: 1513-1517, 1995.
26. Cervantes, A. Prognostic factors in advanced ovarian cancer. Int. J. Gynecol. Cancer, 7: 4-8, 1997.
27. Sykes, P. H., Quinn, M. A., and Rome, R. M. Ovarian tumors of low malignant potential: a retrospective study of 234 patients. Int. J. Gynecol Cancer, 7: 218-226, 1997.
28. Bjrge, T., Engeland, A., Hansen, S., and Trope, C. G. Trends in the incidence of ovarian cancer and borderline tumors in Norway, 1954-1993. Int. J. Cancer. 71: 780-786, 1997.
29. Schisselbauer, J. C., Hogan, W. M., Buetow, K. H., and Tew, K. D. Heterogeneity of glutathione S-transferase enzyme and gene expression in ovarian carcinoma. Pharmacogenetics. 2: 63-72, 1992.
30. Wrigley, E. C., McGown, A. T., Buckley, H., Hall, A., and Crowther, D. Glutathione S-transferase activity and isoenzyme levels measured by two methods in ovarian cancer, and their value as markers of disease outcome. Br. J. Cancer, 73: 763-769, 1996.
31. Webb, G., Vaska, V., Coggan, M., and Board, P. Chromosomal localization of the gene for the human 9 class glutathione transferase (GSTT1). Genomics, 33: 121-123, 1996.
32. Hamada, S., Kamada, M., Furumoto, H., Hirao, T., and Aono, T. Expression of glutathione S-transferase-π in human ovarian cancer as an indicator of resistance to chemotherapy. Gynaecol. Oncol., 52: 313-319, 1994.
33. Hamilton, T. C., Yao, K-S., Beesley, J. S., Johnson, S. W., Godwin, A. K., O'Dwyer, P. J., and Ozols, R. F. The relationship and regulation of glutathione in cancer cells resistant to chemotherapy. In: N. P. E. Vermeulen, G. J. Mulder, H. Nieuwenhuyse, W. H. M. Peters, and P. J. Van Bladeren (eds.). Glutathione S-Transferases: Structure, Function and Clinical Implications, pp. 173-185. London: Taylor and Francis. 1996.
34. Hamaguchi, K., Godwin, A., Yakushiji, M., O'Dwyer, P., Ozols, R., and Hamilton, T. Cross-resistance to diverse drugs is associated with primary cis-platin resistance in ovarian cancer cell lines. Cancer Res., 53: 5225-5232, 1993.
35. Ishikawa, T., and Ali-Osman, F. Glutathione-associated cis-diamminedichloroplatinum(II) metabolism, and ATP-dependent efflux from leukemia cells. J. Biol. Chem., 268: 20116-20125, 1993.
36. Layton, M. A., Jones, P. W., Alldersea, J., Strange, R. C., Fryer, A. A., Dawes, P. T., and Mattey, D. L. The therapeutic response to D-penicillamine in rheumatoid arthritis: influence of glutathione S-transferase polymorphisms. Br. J. Rheumatol., in press, 1998.