Synthesis of 2-semicarbazonomethyl-4,5-methylenedioxyphenylacetic acids as anticonvulsant agents

Farmaco

Volumn 60, Issue 3, 2005, Pages 231-235

  Micale, Nicola ^a   Zappalà, Maria ^a   Zuccalà, Giuseppe ^a   Menniti, Frank S ^b   Ferreri, Guido ^c   De Sarro, Giovambattista ^c   Grasso, Silvana ^d  

^a UNIVERSITY OF MESSINA   (Italy)

^b PFIZER GLOBAL RESEARCH AND DEVELOPMENT   (United States)

^c UNIVERSITY MAGNA GRAECIA OF CATANZARO   (Italy)

^d NONE

Author keywords

4,5 Methylenedioxyphenylacetic acids; AMPA antagonists; Anticonvulsant activity

Indexed keywords

1 (4 AMINOPHENYL) 3,4 DIHYDRO 4 METHYL 3 METHYLCARBAMOYL 7,8 METHYLENEDIOXY 5H 2,3 BENZODIAZEPINE; 1 (4 AMINOPHENYL) 3,5 DIHYDRO 3 N METHYLCARBAMOYL 7,8 METHYLENEDIOXY 4H 2,3 BENZODIAZEPIN 4 ONE; 1 (4 AMINOPHENYL) 4 METHYL 7,8 METHYLENEDIOXY 5H 2,3 BENZODIAZEPINE; 1,3 BENZODIOXOLE DERIVATIVE; 2 [(4 AMINOPHENYL)(4 METHYLSEMICARBAZONO)METHYL] 4,5 METHYLENEDIOXYPHENYLACETIC ACID; 2 [(4 AMINOPHENYL)(4 METHYLTHIOSEMICARBAZONO)METHYL] 4,5 METHYLENEDIOXYPHENYLACETIC ACID; 2 [(4 BROMOPHENYL)(4 METHYLSEMICARBAZONO)METHYL] 4,5 METHYLENEDIOXYPHENYLACETIC ACID; 2 [(4 BROMOPHENYL)(4 METHYLTHIOSEMICARBAZONO)METHYL] 4,5 METHYLENEDIOXYPHENYLACETIC ACID; 2 [(4 CHLOROPHENYL)(4 METHYLSEMICARBAZONO)METHYL] 4,5 METHYLENEDIOXYPHENYLACETIC ACID; 2 [(4 CHLOROPHENYL)(4 METHYLTHIOSEMICARBAZONO)METHYL] 4,5 METHYLENEDIOXYPHENYLACETIC ACID; 2 [(4 FLUOROPHENYL)(4 METHYLSEMICARBAZONO)METHYL] 4,5 METHYLENEDIOXYPHENYLACETIC ACID; 2 [(4 FLUOROPHENYL)(4 METHYLTHIOSEMICARBAZONO)METHYL] 4,5 METHYLENEDIOXYPHENYLACETIC ACID; AMPA RECEPTOR ANTAGONIST; ANTICONVULSIVE AGENT; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; AUDIOGENIC SEIZURE; AUDITORY STIMULATION; COMPARATIVE STUDY; CONTROLLED STUDY; DOSE RESPONSE; DRUG EFFECT; DRUG EFFICACY; DRUG POTENCY; DRUG SCREENING; DRUG SYNTHESIS; MALE; MOUSE; NONHUMAN; PHARMACOLOGICAL BLOCKING; RECEPTOR BLOCKING;

EID: 15244357857     PISSN: 0014827X     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.farmac.2004.11.012     Document Type: Article

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