Synthesis and biological evaluation of 3,4-diphenyl-1,2,5-oxadiazole-2- oxides and 3,4-diphenyl-1,2,5-oxadiazoles as potential hybrid COX-2 inhibitor/nitric oxide donor agents

Bioorganic and Medicinal Chemistry

Volumn 13, Issue 8, 2005, Pages 2749-2757

  Velázquez, Carlos ^a   Rao, P N Praveen ^a   McDonald, Robert ^a   Knaus, Edward E ^a  

^a UNIVERSITY OF ALBERTA   (Canada)

Author keywords

3,4 Diphenyl 1,2,5 oxadiazole 2 oxides; 3,4 Diphenyl 1,2,5 oxadiazoles; COX 2 inhibitors; Methanesulfonyl; Nitric oxide donors; Sulfonamide; Sulfonyl azide

Indexed keywords

1 [4 (METHYLSULFONYL)PHENYL] 2 PHENYLETHYLENE; 3 [4 (AMINOSULFONYL)PHENYL] 4 PHENYL 1,2,5 OXADIAZOLE; 3 [4 (AMINOSULFONYL)PHENYL] 4 PHENYL 1,2,5 OXADIAZOLE 2 OXIDE; 3 [4 (AZIDOSULFONYL)PHENYL] 4 PHENYL 1,2,5 OXADIAZOLE; 3 [4 (AZIDOSULFONYL)PHENYL] 4 PHENYL 1,2,5 OXADIAZOLE 2 OXIDE; 3 [4 (METHYLSULFONYL)PHENYL] 4 PHENYL 1,2,5 OXADIAZOLE; 3 [4 (METHYLSULFONYL)PHENYL] 4 PHENYL 1,2,5 OXADIAZOLE 2 OXIDE; 3,4 DIPHENYL 1,2,5 OXADIAZOLE; 3,4 DIPHENYL 1,2,5 OXADIAZOLE 2 OXIDE; 4 [4 (AMINOSULFONYL)PHENYL] 3 PHENYL 1,2,5 OXADIAZOLE 2 OXIDE; 4 [4 (AZIDOSULFONYL)PHENYL] 3 PHENYL 1,2,5 OXADIAZOLE 2 OXIDE; 4 [4 (METHYLSULFONYL)PHENYL] 3 PHENYL 1,2,5 OXADIAZOLE 2 OXIDE; ACETIC ACID; AMMONIUM HYDROXIDE; BUFFER; CELECOXIB; CYCLOOXYGENASE 1; CYCLOOXYGENASE 2; CYCLOOXYGENASE 2 INHIBITOR; CYSTEINE; ETHYLENE DERIVATIVE; FURAZAN DERIVATIVE; HYDROXIDE; NITRIC OXIDE; NITRIC OXIDE DONOR; PHOSPHATE; ROFECOXIB; SODIUM AZIDE; SODIUM NITRITE; THIOL; UNCLASSIFIED DRUG;

AQUEOUS SOLUTION; ARTICLE; CARDIOVASCULAR EFFECT; CHEMICAL REACTION; CHLORINATION; DRUG INHIBITION; DRUG POTENCY; DRUG SCREENING; DRUG SELECTIVITY; DRUG SYNTHESIS; ENZYME INHIBITION; IC 50; INCUBATION TIME; ISOMER; MOLECULAR MODEL; PH; SEPARATION TECHNIQUE; STRUCTURE ACTIVITY RELATION; SUBSTITUTION REACTION; SULFONATION; ULCEROGENESIS;

EID: 15244340003     PISSN: 09680896     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bmc.2005.02.034     Document Type: Article

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