Reappraisal of the historical selective pressures for the CCR5-Δ32 mutation

Journal of Medical Genetics

Volumn 42, Issue 3, 2005, Pages 205-208

  Duncan, S R ^b   Scott, S ^a   Duncan, C J ^a  

^a UNIVERSITY OF LIVERPOOL   (United Kingdom)

^b UNIVERSITY OF OXFORD   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

CD4 ANTIGEN; CHEMOKINE RECEPTOR CCR5;

ALLELE; GENE FREQUENCY; GENETIC SELECTION; HAPLOTYPE; HEMORRHAGIC FEVER; HISTORY; HUMAN; HUMAN IMMUNODEFICIENCY VIRUS; HUMAN IMMUNODEFICIENCY VIRUS INFECTION; HYPOTHESIS; MATHEMATICAL MODEL; MORTALITY; MUTATION; PLAGUE; POPULATION GENETICS; PRIORITY JOURNAL; REVIEW; SMALLPOX; SURVIVAL; VACCINATION; YERSINIA PESTIS;

DISEASE OUTBREAKS; HEMORRHAGIC FEVERS, VIRAL; HISTORY, 15TH CENTURY; HISTORY, 16TH CENTURY; HISTORY, 17TH CENTURY; HISTORY, MEDIEVAL; HIV INFECTIONS; IMMUNITY, NATURAL; MODELS, GENETIC; PLAGUE; RECEPTORS, CCR5; SELECTION (GENETICS); SEQUENCE DELETION;

HUMAN IMMUNODEFICIENCY VIRUS; VARIOLA VIRUS; YERSINIA PESTIS;

EID: 15044342950     PISSN: 00222593     EISSN: None     Source Type: Journal    
DOI: 10.1136/jmg.2004.025346     Document Type: Review

References (30)

1. Alkhatib G, Combadiere C, Broder CC, Feng Y, Kennedy PE, Murphy PM, Berger EA. CCCKR5: a RANTES, MIP-1α, MIP-1β receptor as a fusion cofactor for macrophage-trophic HIV-1. Science 1996;272:1955-8.
2. Choe H, Farzan M, Sun Y, Sullivan N, Rollins B, Ponath PD, Wu L, Mackay CR, LaRosa G, Newman W, Gerard N, Gerard C, Sodroski J. The β-chemokine receptors CCR3 and CCR5 facilitate infection by primary HIV-1 isolates. Cell 1996;85:1135-48.
3. Deng H, Liu R, Ellmeier W, Choe S, Unutmaz D, Burkhart M, Di Marzio P, Marmon S, Sutton RE, Hill CM, Davis CB, Peiper SC, Schall TJ, Littman DR, Landau NR. Identification of a major co-receptor for primary isolates of HIV-1. Nature 1996;381:661-6.
4. Doranz BJ, Rucker J, Yi Y, Smyth RJ, Samson M, Peiper S, Parmentier M, Collman RG, Doms RW. A dual-tropic primary HIV-1 isolate that uses fusion and the β-chemokine receptor CKR-5, CKR-3 and CKR-2b as fusion cofactors. Cell 1996;85:1149-58.
5. Dean M, Carrington M, Winkler C, Huttley GA, Smith MW, Allikmets R, Goedert JJ, Buchbinder SP, Vittinghoff E, Gomperts E, Donfield S, Vlahov D, Kaslow R, Saah A, Rinaldo C, Detels R, Hemophilia Growth and Development Study, Multicenter AIDS Cohort Study, Multicenter Hemophilia Cohort Study, San Francisco City Cohort, ALIVE Study and O'Brien SJ. Genetic restriction of HIV-1 and progression to AIDS by a deletion allele of the CKR5 structural gene. Science 1996;273:1856-62.
6. Huang Y, Paxton WA, Wolinsky SM, Neumann AU, Zhang L, He T, Kang S, Ceradini D, Jin Z, Yazdanbakhsh K, Kunstman K, Erickson D, Dragon E, Landau NR, Phair J, Ho DD, Koup RA. The role of a mutant CCR5 allele in HIV-1 transmission and disease progression. Nat Med 1996;2:1240-3.
7. Michael NL, Chang G, Louie LG, Mascola JR, Dondero D, Birx DL, Sheppard HW. The role of viral phenotype and CCR-5 gene defects in HIV-1 transmission and disease progression. Nat Med 1997;3:338-40.
8. Samson M, Libert F, Doranz BJ, Rucker J, Liesnard C, Farber C-M, Saragosti S, Lapoumeroulie C, Cognaux J, Forceille C, Muyldermans G, Verhofstede C, Burtonboy G, Georges M, Imai T, Rana S, Yi Y, Smyth RJ, Collman RG, Doms RW, Vassart G, Parmentier M. Resistance to HIV-1 infection in Caucasian individuals bearing mutant alleles of the CCR-5 chemokine receptor gene. Nature 1996;382:722-5.
9. Marmor M, Sheppard HW, Donnell D, Bozeman S, Celum C, Buchbinder S, Koblin B, Seage GR. Homozygous and heterozygous CCR5-Δ32 genotypes are associated with resistance to HIV infection. JAIDS 2001;27:472-81.
10. Stephens JC, Reich DE, Goldstein DB, Shin HD, Smith MW, Carrington M, Winkler C, Huttley GA, Allikmets R, Schriml L, Gerrard B, Malasky M, Ramos MD, Morlot S, Tzetis M, Oddoux C, De Giovine FS, Nasioulas G, Chandler D, Aseev M, Hanson M, Kalaydjieva L, Glavac D, Gasparini P, Kanavakis E, Claustres M, Kambouris M, Ostrer H, Duff G, Baranov V, Sibul H, Mepspalu A, Goldman D, Martin N, Duffy D, Schmidtke J, Estivill X, O'Brien SJ, Dean M. Dating the origin of the CCR5-Δ32 AIDS-resistance allele by the coalescence of haplotypes. Am J Hum Genet 1998;62:1507-15.
11. Libert F, Cochaux P, Beckman G, Samson M, Aksenova M, Cao A, Czeizel A, Claustres M, de la Rua C, Ferrari M, Ferrec C, Glover G, Grinde B, Guran S, Kucinskas V, Lavinha J, Mercier B, Ogur G, Peltonen L, Rosatelli C, Schwartz M, Spitsyn V, Timar L, Beckman L, Parmentier M, Vassart G. The Δccr5 mutation conferring protection against HIV-1 in Caucasian populations has a single and recent origin in Northeastern Europe. Hum Mol Genet 1998;7:399-406.
12. Galvani AP, Slatkin M. Evaluating plague and smallpox as historical selective pressures for the CCR5-Δ32 HIV-resistance allele. Proc Natl Acad Sci USA 2003;100:183-8.
13. Mecsas J, Franklin G, Kuziel WA, Brubaker RR, Falkow S, Mosier DE. CCR5 mutation and plague protection. Nature 2004;427:606.
14. Razzell P. The conquest of smallpox: the impact of inoculation on smallpox mortality in eighteenth-century Britain. Chichester: Calibon, 1977.
15. Creighton C. History of epidemics in Britain. Cambridge: Cambridge University Press, 1894.
16. Scott S, Duncan CJ. Human demography and disease. Cambridge: Cambridge University Press, 1998.
17. Scott S, Duncan CJ. Biology of plagues. Cambridge: Cambridge University Press, 2001.
18. Duncan CJ, Scott S. What caused the Black Death? Postgrad Med J (in press).
19. Livi-Bacci M. A concise history of world population. Cambridge: Cambridge University Press, Cambridge, 1997.
20. Biraben JN. Les hommes et la peste en France et dans les pays Européens et Méditerranéens. Tome I. La peste dans l'histoire. Paris: Mouton and Co and École des Hautes Études en Sciences Sociales, 1975.
21. Duncan SR, Scott S, Duncan CJ. Time series analysis of oscillations in a model population: the effects of plague, pestilence and famine. J Theoret Biol 1992;158:293-311.
22. Coale AJ, Demeny P. Regional model life tables and stable populations. New York, Academic Press, 1983.
23. Scott S, Duncan CJ. Return of the Black Death. Chichester: John Wiley, 2004.
24. Panagiotakopulu EJ. Pharaonic Egypt and the origins of plague. J Biogeog 2004;31:269-75.
25. Coleman M, Scurlock J. Viral haemorrhagic fevers in ancient Mesopotamia. Trop Med Int Health 1997;2:603-6.
26. Dols MW. The Black Death in the Middle East. Princeton: Princeton University Press, 1977.
27. Lalani AS, Masters J, Zeng W, Barrett J, Pannu R, Everett H, Arendt CW, McFadden G. Use of chemokine receptors by poxviruses. Science 1999;286:1968-71.
28. Smith JR. The speckled monster. Hunstanton: Witley Press, 1987.
29. Christensen P. Copenhagen 1711: Danish authorities facing the plague. In: Sheard S, Power H, eds. Body and city. Histories of urban public health. Aldershot: Ashgate Publishing, 2000.
30. Christensen P. "In these perilous times": plague and plague policies in early modern Denmark. Med Hist 2003;47:413-50.