메뉴 건너뛰기




Volumn 33, Issue 5, 2005, Pages 1699-1709

Formation of linear inverted repeat amplicons following targeting of an essential gene in Leishmania

Author keywords

[No Author keywords available]

Indexed keywords

BETA GLUCOSYLHYDROXYMETHYLURACIL; BINDING PROTEIN; MUTANT PROTEIN; PLASMID DNA; PROTEIN JBP1; PROTOZOAL PROTEIN; UNCLASSIFIED DRUG; URACIL DERIVATIVE; CINNAMIC ACID DERIVATIVE; DNA BINDING PROTEIN; DRUG DERIVATIVE; HYGROMYCIN; HYGROMYCIN B; J SPECIFIC DNA BINDING PROTEIN, PROTOZOA; J-SPECIFIC DNA-BINDING PROTEIN, PROTOZOA; PROTOZOAL DNA;

EID: 15044340917     PISSN: 03051048     EISSN: 13624962     Source Type: Journal    
DOI: 10.1093/nar/gki304     Document Type: Article
Times cited : (45)

References (49)
  • 1
    • 0027410144 scopus 로고
    • Plasticity in chromosome number and testing of essential genes in Leishmania by targeting
    • Cruz,A.K., Titus,R. and Beverley,S.M. (1993) Plasticity in chromosome number and testing of essential genes in [i#Leishmania#1i] by targeting. [i#Proc. Natl Acad. Sci. USA#1i], [b#90#1b], 1599-1603.
    • (1993) Proc. Natl. Acad. Sci. USA , vol.90 , pp. 1599-1603
    • Cruz, A.K.1    Titus, R.2    Beverley, S.M.3
  • 2
    • 0029830610 scopus 로고    scopus 로고
    • Gene disruptions indicate an essential function for the LmmCRK1 cdc2-related kinase of Leishmania mexicana
    • Mottram,J.C., McCready,B.P., Brown,K.G. and Grant,K.M. (1996) Gene disruptions indicate an essential function for the LmmCRK1 cdc2-related kinase of [i#Leishmania mexicana. Mol. Microbiol.#1i], [b#22#1b], 573-583.
    • (1996) Mol. Microbiol. , vol.22 , pp. 573-583
    • Mottram, J.C.1    McCready, B.P.2    Brown, K.G.3    Grant, K.M.4
  • 3
    • 0030926411 scopus 로고    scopus 로고
    • Disruption of the trypanothione reductase gene of Leishmania decreases its ability to survive oxidative stress in macrophages
    • Dumas,C., Ouellette,M., Tovar,J., Cunningham,M.L., Fairlamb,A.H., Tamar,S., Olivier,M. and Papadopoulou,B. (1997) Disruption of the trypanothione reductase gene of [i#Leishmania#1i] decreases its ability to survive oxidative stress in macrophages. [i#EMBO J.#1i], [b#16#1b], 2590-2598.
    • (1997) EMBO J. , vol.16 , pp. 2590-2598
    • Dumas, C.1    Ouellette, M.2    Tovar, J.3    Cunningham, M.L.4    Fairlamb, A.H.5    Tamar, S.6    Olivier, M.7    Papadopoulou, B.8
  • 4
    • 0021210054 scopus 로고
    • Unstable DNA amplifications in methotrexate-resistant Leishmania consist of extrachromosomal circles which relocalize during stabilization
    • Beverley,S.M., Coderre,J.A., Santi,D.V. and Schimke,R.T. (1984) Unstable DNA amplifications in methotrexate-resistant [i#Leishmania#1i] consist of extrachromosomal circles which relocalize during stabilization. [i#Cell#1i] [b#38#1b], 431-439.
    • (1984) Cell , vol.38 , pp. 431-439
    • Beverley, S.M.1    Coderre, J.A.2    Santi, D.V.3    Schimke, R.T.4
  • 5
    • 0023692421 scopus 로고
    • The H circles of Leishmania tarentolae are a unique amplifiable system of oligomerc DNAs associated with drug resistance
    • White,T.C., Fase-Fowler,F., van Luenen,H., Calafat,J. and Borst,P. (1988) The H circles of [i#Leishmania tarentolae#1i] are a unique amplifiable system of oligomerc DNAs associated with drug resistance. [i#J. Biol. Chem.#1i], [b#263#1b], 16977-16983.
    • (1988) J. Biol. Chem. , vol.263 , pp. 16977-16983
    • White, T.C.1    Fase-Fowler, F.2    van Luenen, H.3    Calafat, J.4    Borst, P.5
  • 6
    • 0026779424 scopus 로고
    • A novel antifolate resistance gene on the amplified H circle of Leishmania
    • Papadopoulou,B., Roy,G. and Ouellette,M. (1992) A novel antifolate resistance gene on the amplified H circle of [i#Leishmania. EMBO J.#1i], [b#11#1b], 3601-3608.
    • (1992) EMBO J. , vol.11 , pp. 3601-3608
    • Papadopoulou, B.1    Roy, G.2    Ouellette, M.3
  • 7
    • 2642678469 scopus 로고    scopus 로고
    • Linear amplicons as precursors of amplified circles in methotrexate-resistant Leishmania tarentolae
    • Grondin,K., Kundig,C., Roy,G. and Ouellette,M. (1998) Linear amplicons as precursors of amplified circles in methotrexate-resistant [i#Leishmania tarentolae. Nucleic Acids Res.#1i], [b#26#1b], 3372-3378.
    • (1998) Nucleic Acids Res. , vol.26 , pp. 3372-3378
    • Grondin, K.1    Kundig, C.2    Roy, G.3    Ouellette, M.4
  • 8
    • 0024562098 scopus 로고
    • DNA amplification in arsenite-resistant Leishmania
    • Detke,S., Katakura,K. and Chang,K.P. (1989) DNA amplification in arsenite-resistant [i#Leishmania. Exp. Cell. Res.#1i], [b#180#1b], 161-170.
    • (1989) Exp. Cell. Res. , vol.180 , pp. 161-170
    • Detke, S.1    Katakura, K.2    Chang, K.P.3
  • 9
    • 0026022969 scopus 로고
    • Direct and inverted DNA repeats associated with P-glycoprotein gene amplification in drug resistant Leishmania
    • Ouellette,M., Hettema,E., Wust,D., Fase-Fowler,F. and Borst,P. (1991) Direct and inverted DNA repeats associated with P-glycoprotein gene amplification in drug resistant [i#Leishmania. EMBO J.#1i], [b#10#1b], 1009-1016.
    • (1991) EMBO J. , vol.10 , pp. 1009-1016
    • Ouellette, M.1    Hettema, E.2    Wust, D.3    Fase-Fowler, F.4    Borst, P.5
  • 10
    • 0027157185 scopus 로고
    • Homologous recombination between direct repeat sequences yields P-glycoprotein containing amplicons in arsenite resistant Leishmania
    • Grondin,K., Papadopoulou,B. and Ouellette,M. (1993) Homologous recombination between direct repeat sequences yields P-glycoprotein containing amplicons in arsenite resistant [i#Leishmania. Nucleic Acids Res.#1i], [b#21#1b], 1895-1901.
    • (1993) Nucleic Acids Res. , vol.21 , pp. 1895-1901
    • Grondin, K.1    Papadopoulou, B.2    Ouellette, M.3
  • 11
    • 0030924243 scopus 로고    scopus 로고
    • Co-amplification of the gamma-glutamylcysteine synthetase gene gsh1 and of the ABC transporter gene pgpA in arsenite-resistant Leishmania tarentolae
    • Grondin,K., Haimeur,A., Mukhopadhyay,R., Rosen,B.P. and Ouellette,M. (1997) Co-amplification of the gamma-glutamylcysteine synthetase gene [i#gsh#1i]1 and of the ABC transporter gene [i#pgpA#1i] in arsenite-resistant [i#Leishmania tarentolae. EMBO J.#1i], [b#16#1b], 3057-3065.
    • (1997) EMBO J. , vol.16 , pp. 3057-3065
    • Grondin, K.1    Haimeur, A.2    Mukhopadhyay, R.3    Rosen, B.P.4    Ouellette, M.5
  • 12
    • 0025968501 scopus 로고
    • Amplification and molecular cloning of the IMP dehydrogenase gene of Leishmania donovani
    • Wilson,K., Collart,F.R., Huberman,E., Stringer,J.R. and Ullman,B. (1991) Amplification and molecular cloning of the IMP dehydrogenase gene of [i#Leishmania donovani. J. Biol. Chem.#1i], [b#266#1b], 1665-1671.
    • (1991) J. Biol. Chem. , vol.266 , pp. 1665-1671
    • Wilson, K.1    Collart, F.R.2    Huberman, E.3    Stringer, J.R.4    Ullman, B.5
  • 13
    • 0023864576 scopus 로고
    • DNA amplification in tunicamycin-resistant Leishmania mexicana. Multicopies of a single 63-kilobase supercoiled molecule and their expression
    • Detke,S., Chaudhuri,G., Kink,J.A. and Chang,K.P. (1988) DNA amplification in tunicamycin-resistant [i#Leishmania mexicana#1i]. Multicopies of a single 63-kilobase supercoiled molecule and their expression. [i#J. Biol. Chem.#1i], [b#263#1b], 3418-3424.
    • (1988) J. Biol. Chem. , vol.263 , pp. 3418-3424
    • Detke, S.1    Chaudhuri, G.2    Kink, J.A.3    Chang, K.P.4
  • 14
    • 0026720137 scopus 로고
    • Multidrug resistance in Leishmania donovani is conferred by amplification of a gene homologous to the mammalian mdr1 gene
    • Henderson,D.M., Sifri,C.D., Rodgers,M., Wirth,D.F., Hendrickson,N. and Ullman,B. (1992) Multidrug resistance in [i#Leishmania donovani#1i] is conferred by amplification of a gene homologous to the mammalian [i#mdr#1i] gene. [i#Mol. Cell. Biol.#1i], [b#12#1b], 2855-2865.
    • (1992) Mol. Cell. Biol. , vol.12 , pp. 2855-2865
    • Henderson, D.M.1    Sifri, C.D.2    Rodgers, M.3    Wirth, D.F.4    Hendrickson, N.5    Ullman, B.6
  • 15
    • 0025347967 scopus 로고
    • Recurrent de novo appearance of small linear DNAs in Leishmania major and relationship to extra-chromosomal DNAs in other species
    • Beverley,S.M. and Coburn,C.M. (1990) Recurrent de novo appearance of small linear DNAs in [i#Leishmania major#1i] and relationship to extra-chromosomal DNAs in other species. [i#Mol. Biochem. Parasitol.#1i], [b#42#1b], 133-141.
    • (1990) Mol. Biochem. Parasitol. , vol.42 , pp. 133-141
    • Beverley, S.M.1    Coburn, C.M.2
  • 16
    • 0026072572 scopus 로고
    • Gene amplification in Leishmania
    • Beverley,S.M. (1991) Gene amplification in [i#Leishmania. Annu. Rev. Microbiol.#1i], [b#45#1b], 417-444.
    • (1991) Annu. Rev. Microbiol. , vol.45 , pp. 417-444
    • Beverley, S.M.1
  • 17
    • 0027296408 scopus 로고
    • Frequent amplification of a short chain dehydrogenase gene as part of circular and linear amplicons in methotrexate resistant Leishmania
    • Papadopoulou,B., Roy,G. and Ouellette,M. (1993) Frequent amplification of a short chain dehydrogenase gene as part of circular and linear amplicons in methotrexate resistant [i#Leishmania. Nucleic Acids Res.#1i] [b#21#1b], 4305-4312.
    • (1993) Nucleic Acids Res. , vol.21 , pp. 4305-4312
    • Papadopoulou, B.1    Roy, G.2    Ouellette, M.3
  • 20
    • 0032478197 scopus 로고    scopus 로고
    • Beta-D-glucosyl-hydroxymethyluracil is a conserved DNA modification in kinetoplastid protozoans and is abundant in their telomeres
    • van Leeuwen,F., Taylor,M., Mondragon,A., Moreau,H., Gibson,W., Kieft,R. and Borst,P. (1998) Beta-D-glucosyl-hydroxymethyluracil is a conserved DNA modification in kinetoplastid protozoans and is abundant in their telomeres. [i#Proc. Natl Acad. Sci. USA#1i], [b#95#1b], 2366-2371.
    • (1998) Proc. Natl. Acad. Sci. USA , vol.95 , pp. 2366-2371
    • van Leeuwen, F.1    Taylor, M.2    Mondragon, A.3    Moreau, H.4    Gibson, W.5    Kieft, R.6    Borst, P.7
  • 21
    • 0034663668 scopus 로고    scopus 로고
    • Base J originally found in kinetoplastida is also a minor constituent of nuclear DNA of Euglena gracilis
    • Dooijes,D., Chaves,I., Kieft,R., Dirks-Mulder,A., Martin,W. and Borst,P. (2000) Base J originally found in kinetoplastida is also a minor constituent of nuclear DNA of [i#Euglena gracilis. Nucleic Acids Res.#1i] [b#28#1b], 3017-3021.
    • (2000) Nucleic Acids Res. , vol.28 , pp. 3017-3021
    • Dooijes, D.1    Chaves, I.2    Kieft, R.3    Dirks-Mulder, A.4    Martin, W.5    Borst, P.6
  • 22
    • 0033839259 scopus 로고    scopus 로고
    • Tandemly repeated DNA is a target for the partial replacement of thymidine by β-D-glucosyl-hydroxymethyluracil in Trypanosoma brucei
    • van Leeuwen,F., Kieft,R., Cross,M. and Borst,P. (2000) Tandemly repeated DNA is a target for the partial replacement of thymidine by β-D-glucosyl-hydroxymethyluracil in [i#Trypanosoma brucei. Mol. Biochem. Parasitol.#1i], [b#109#1b], 133-145.
    • (2000) Mol. Biochem. Parasitol. , vol.109 , pp. 133-145
    • van Leeuwen, F.1    Kieft, R.2    Cross, M.3    Borst, P.4
  • 24
    • 0037059809 scopus 로고    scopus 로고
    • Recognition of base J in duplex DNA by J-binding protein
    • Sabatini,R., Meeuwenoord,N., van Boom,J.H. and Borst,P. (2002) Recognition of base J in duplex DNA by J-binding protein. [i#J. Biol. Chem.#1i], [b#277#1b], 958-966.
    • (2002) J. Biol. Chem. , vol.277 , pp. 958-966
    • Sabatini, R.1    Meeuwenoord, N.2    van Boom, J.H.3    Borst, P.4
  • 25
    • 0037008765 scopus 로고    scopus 로고
    • Site-specific interactions of JBP with base and sugar moieties in duplex J-DNA. Evidence for both major and minor groove contacts
    • Sabatini,R., Meeuwenoord,N., van Boom,J.H. and Borst,P. (2002) Site-specific interactions of JBP with base and sugar moieties in duplex J-DNA. Evidence for both major and minor groove contacts. [i#J. Biol. Chem.#1i], [b#277#1b], 28150-28156.
    • (2002) J. Biol. Chem. , vol.277 , pp. 28150-28156
    • Sabatini, R.1    Meeuwenoord, N.2    van Boom, J.H.3    Borst, P.4
  • 26
    • 0036035410 scopus 로고    scopus 로고
    • J-binding protein increases the level and retention of the unusual base J in trypanosome DNA
    • Cross,M., Kieft,R., Dirks-Mulder,A., Chaves,I. and Borst,P. (2002) J-binding protein increases the level and retention of the unusual base J in trypanosome DNA. [i#Mol. Microbiol.#1i], [b#46#1b], 37-47.
    • (2002) Mol. Microbiol. , vol.46 , pp. 37-47
    • Cross, M.1    Kieft, R.2    Dirks-Mulder, A.3    Chaves, I.4    Borst, P.5
  • 27
    • 0018601361 scopus 로고
    • Cultivation and in vitro cloning of procyclic culture forms of Trypanosoma brucei in a semi-defined medium
    • Brun,R. and Schonenberger,M. (1979) Cultivation and [i#in vitro#1i] cloning of procyclic culture forms of [i#Trypanosoma brucei#1i] in a semi-defined medium. [i#Acta Trop.#1i], [b#36#1b], 289-292.
    • (1979) Acta Trop. , vol.36 , pp. 289-292
    • Brun, R.1    Schonenberger, M.2
  • 28
    • 0034982341 scopus 로고    scopus 로고
    • Telomere shortening and cell cycle arrest in Trypanosoma brucei expressing human telomeric repeat factor TRF1
    • Munoz-Jordan,J.L. and Cross,G.A. (2001) Telomere shortening and cell cycle arrest in [i#Trypanosoma brucei#1i] expressing human telomeric repeat factor TRF1. [i#Mol. Biochem. Parasitol.#1i], [b#114#1b], 169-181.
    • (2001) Mol. Biochem. Parasitol. , vol.114 , pp. 169-181
    • Munoz-Jordan, J.L.1    Cross, G.A.2
  • 29
    • 7644219918 scopus 로고    scopus 로고
    • The heat shock protein HSP70 and heat shock cognate protein HSC70 contribute to antimony tolerance in the protozoan parasite Leishmania
    • Brochu,C., Haimeur,A. and Ouellette,M. (2004) The heat shock protein HSP70 and heat shock cognate protein HSC70 contribute to antimony tolerance in the protozoan parasite [i#Leishmania. Cell. Stress. Chap.#1i] [b#9#1b], 294-303.
    • (2004) Cell. Stress. Chap. , vol.9 , pp. 294-303
    • Brochu, C.1    Haimeur, A.2    Ouellette, M.3
  • 30
    • 0028070305 scopus 로고
    • Autonomous replication of bacterial DNA plasmid oligomers in Leishmania
    • Papadopoulou,B., Roy,G. and Ouellette,M. (1994) Autonomous replication of bacterial DNA plasmid oligomers in [i#Leishmania. Mol. Biochem. Parasitol.#1i], [b#65#1b], 39-49.
    • (1994) Mol. Biochem. Parasitol. , vol.65 , pp. 39-49
    • Papadopoulou, B.1    Roy, G.2    Ouellette, M.3
  • 32
    • 0021215533 scopus 로고
    • Antigenic variation in Trypanosoma brucei analyzed by electrophoretic separation of chromosome-sized DNA molecules
    • van der Ploeg,L.H., Schwartz,D.C., Cantor,C.R. and Borst,P. (1984) Antigenic variation in [i#Trypanosoma brucei#1i] analyzed by electrophoretic separation of chromosome-sized DNA molecules. [i#Cell#1i] [b#37#1b], 77-84.
    • (1984) Cell , vol.37 , pp. 77-84
    • van der Ploeg, L.H.1    Schwartz, D.C.2    Cantor, C.R.3    Borst, P.4
  • 34
    • 0024577110 scopus 로고
    • Analysis of amplified DNAs from drug-resistant Leishmania by orthogonal-field-alternation gel electrophoresis. The effect of size and topology on mobility
    • Hightower,R.C., Bliska,J.B., Cozzarelli,N.R. and Santi,D.V. (1989) Analysis of amplified DNAs from drug-resistant [i#Leishmania#1i] by orthogonal-field-alternation gel electrophoresis. The effect of size and topology on mobility. [i#J. Biol. Chem.#1i], [b#264#1b], 2979-2984.
    • (1989) J. Biol. Chem. , vol.264 , pp. 2979-2984
    • Hightower, R.C.1    Bliska, J.B.2    Cozzarelli, N.R.3    Santi, D.V.4
  • 35
    • 0020583113 scopus 로고
    • Growth of chromosome ends in multiplying trypanosomes
    • Bernards,A., Michels,P.A., Lincke,C.R. and Borst,P. (1983) Growth of chromosome ends in multiplying trypanosomes. [i#Nature#1i], [b#303#1b], 592-597.
    • (1983) Nature , vol.303 , pp. 592-597
    • Bernards, A.1    Michels, P.A.2    Lincke, C.R.3    Borst, P.4
  • 36
    • 0033869416 scopus 로고    scopus 로고
    • The size difference between Leishmania major Friedlin chromosome one homologues is localized to sub-telomeric repeats at one chromosomal end
    • Sunkin,S., Kiser,P., Myler,P. and Stuart,K. (2000) The size difference between [i#Leishmania major#1i] Friedlin chromosome one homologues is localized to sub-telomeric repeats at one chromosomal end. [i#Mol. Biochem. Parasitol.#1i], [b#109#1b], 1-15.
    • (2000) Mol. Biochem. Parasitol. , vol.109 , pp. 1-15
    • Sunkin, S.1    Kiser, P.2    Myler, P.3    Stuart, K.4
  • 37
    • 0029975465 scopus 로고    scopus 로고
    • Formation of extrachromosomal circular amplicons with director inverted duplications in drug-resistant Leishmania tarentolae
    • Grondin,K., Roy,G. and Ouellette,M. (1996) Formation of extrachromosomal circular amplicons with director inverted duplications in drug-resistant [i#Leishmania tarentolae. Mol. Cell. Biol.#1i], [b#16#1b], 3587-3595.
    • (1996) Mol. Cell. Biol. , vol.16 , pp. 3587-3595
    • Grondin, K.1    Roy, G.2    Ouellette, M.3
  • 38
    • 0026567727 scopus 로고
    • Recurrent polymorphisms in small chromosomes of Leishmania tarentolae after nutrient stress or subcloning
    • Rovai,L., Tripp,C., Stuart,K. and Simpson,L. (1992) Recurrent polymorphisms in small chromosomes of [i#Leishmania tarentolae#1i] after nutrient stress or subcloning. [i#Mol. Biochem. Parasitol.#1i], [b#50#1b], 115-125.
    • (1992) Mol. Biochem. Parasitol. , vol.50 , pp. 115-125
    • Rovai, L.1    Tripp, C.2    Stuart, K.3    Simpson, L.4
  • 39
    • 0035419404 scopus 로고    scopus 로고
    • Effect of large targeted deletions on the mitotic stability of an extra chromosome mediating drug resistance in Leishmania
    • Dubessay,P., Ravel,C., Bastien,P., Lignon,M.F., Ullman,B., Pages,M. and Blaineau,C. (2001) Effect of large targeted deletions on the mitotic stability of an extra chromosome mediating drug resistance in [i#Leishmania. Nucleic Acids Res.#1i], [b#29#1b], 3231-3240.
    • (2001) Nucleic Acids Res. , vol.29 , pp. 3231-3240
    • Dubessay, P.1    Ravel, C.2    Bastien, P.3    Lignon, M.F.4    Ullman, B.5    Pages, M.6    Blaineau, C.7
  • 40
    • 0028007069 scopus 로고
    • Inverted repeat structure and homologous sequences in the LD1 amplicons of Leishmania spp
    • Navarro,M., Liu,J., Muthui,D., Ortiz,G., Segovia,M. and Hamers,R. (1994) Inverted repeat structure and homologous sequences in the LD1 amplicons of [i#Leishmania#1i] spp. [i#Mol. Biochem. Parasitol.#1i], [b#68#1b], 69-80.
    • (1994) Mol. Biochem. Parasitol. , vol.68 , pp. 69-80
    • Navarro, M.1    Liu, J.2    Muthui, D.3    Ortiz, G.4    Segovia, M.5    Hamers, R.6
  • 41
    • 0030602260 scopus 로고    scopus 로고
    • Characterisation of the novel junctions of two minichromosomes of Leishmania major
    • Ortiz,G. and Segovia,M. (1996) Characterisation of the novel junctions of two minichromosomes of [i#Leishmania major. Mol. Biochem. Parasitol.#1i] [b#82#1b], 137-144.
    • (1996) Mol. Biochem. Parasitol. , vol.82 , pp. 137-144
    • Ortiz, G.1    Segovia, M.2
  • 42
    • 0027056924 scopus 로고
    • Creation of null/+ mutants of the α-tubulin gene in Leishmania enriettii by gene cluster deletion
    • Curotto de Lafaille,M.A. and Wirth,D.F. (1992) Creation of null/+ mutants of the α-tubulin gene in [i#Leishmania enriettii#1i] by gene cluster deletion. [i#J. Biol. Chem.#1i], [b#267#1b], 23839-23846.
    • (1992) J. Biol. Chem. , vol.267 , pp. 23839-23846
    • Curotto de Lafaille, M.A.1    Wirth, D.F.2
  • 44
    • 0023047198 scopus 로고
    • DNA amplification-deletion in a spontaneous mutation of the hamster aprt locus: Structure and sequence of the novel joint
    • Nalbantoglu,J. and Meuth,M. (1986) DNA amplification-deletion in a spontaneous mutation of the hamster [i#aprt#1i] locus: Structure and sequence of the novel joint. [i#Nucleic Acids Res.#1i], [b#14#1b], 8361-8371.
    • (1986) Nucleic Acids Res. , vol.14 , pp. 8361-8371
    • Nalbantoglu, J.1    Meuth, M.2
  • 45
    • 0023959559 scopus 로고
    • The multicopy appearance of a large inverted duplication and the sequence at the inversion joint suggest a new model for gene amplification
    • Hyrien,O., Debatisse,M., Buttin,G. and de Saint Vincent,B.R. (1988) The multicopy appearance of a large inverted duplication and the sequence at the inversion joint suggest a new model for gene amplification. [i#EMBO J.#1i], [b#7#1b], 407-417.
    • (1988) EMBO J. , vol.7 , pp. 407-417
    • Hyrien, O.1    Debatisse, M.2    Buttin, G.3    de Saint Vincent, B.R.4
  • 46
    • 0024411328 scopus 로고
    • Recent progress in understanding mechanisms of mammalian DNA amplification
    • Stark,G.R., Debatisse,M., Giulotto,E. and Wahl,G.M. (1989) Recent progress in understanding mechanisms of mammalian DNA amplification. [i#Cell#1i], [b#57#1b], 901-908.
    • (1989) Cell , vol.57 , pp. 901-908
    • Stark, G.R.1    Debatisse, M.2    Giulotto, E.3    Wahl, G.M.4
  • 47
    • 0024457825 scopus 로고
    • Time of replication of ARS elements along yeast chromosome III
    • Reynolds,A.E., McCarroll,R.M., Newlon,C.S. and Fangman,W.L. (1989) Time of replication of ARS elements along yeast chromosome III. [i#Mol. Cell. Biol.#1i], [b#9#1b], 4488-4494.
    • (1989) Mol. Cell. Biol. , vol.9 , pp. 4488-4494
    • Reynolds, A.E.1    McCarroll, R.M.2    Newlon, C.S.3    Fangman, W.L.4
  • 48
    • 0028065674 scopus 로고
    • Adaptive evolution of highly mutable loci in pathogenic bacteria
    • Moxon,E.R., Rainey,P.B., Nowak,M.A. and Lenski,R.E. (1994) Adaptive evolution of highly mutable loci in pathogenic bacteria. [i#Curr. Biol.#1i] [b#4#1b], 24-33.
    • (1994) Curr. Biol. , vol.4 , pp. 24-33
    • Moxon, E.R.1    Rainey, P.B.2    Nowak, M.A.3    Lenski, R.E.4
  • 49
    • 0025060904 scopus 로고
    • Stable expression of the bacterial neor gene in Leishmania enriettii
    • Laban,A., Tobin,J.F., Curotto de Lafaille,M.A. and Wirth,D.F. (1990) Stable expression of the bacterial [i#neor#1i] gene in [i#Leishmania enriettii. Nature#1i], [b#343#1b], 572-574.
    • (1990) Nature , vol.343 , pp. 572-574
    • Laban, A.1    Tobin, J.F.2    Curotto de Lafaille, M.A.3    Wirth, D.F.4


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.