Mechanisms of action of peptide inhibitors of mammalian ribonucleotide reductase targeting quaternary structure

Biopolymers - Peptide Science Section

Volumn 80, Issue 1, 2005, Pages 9-17

  Gao, Ying ^a,b   Kashlan, Ossama B ^a,c   Kaur, Jaskiran ^a   Tan, Chiheng ^a,d   Cooperman, Barry S ^a  

^a UNIVERSITY OF PENNSYLVANIA   (United States)

^b Enzon Pharmaceuticals   (United States)

^c UNIVERSITY OF PITTSBURGH SCHOOL OF MEDICINE   (United States)

^d NOVARTIS INSTITUTES FOR BIOMEDICAL RESEARCH   (United States)

Author keywords

Chemotherapeutic target; Mechanisms of action; Peptide inhibitors; Quaternary structure; Ribonucleotide reductase

Indexed keywords

BIOPOLYMERS; CHEMOTHERAPY; DERIVATIVES; ENZYMES; MONOMERS; TUMORS;

PEPTIDE INHIBITORS; PREFERENTIAL BINDING; RIBONUCLEOTIDE REDUCTASE (MRR);

POLYPEPTIDES;

9 FLUORENYLMETHYL CHLOROFORMATE; RIBONUCLEOTIDE REDUCTASE; SYNTHETIC PEPTIDE; TETRAPEPTIDE;

ARTICLE; BINDING AFFINITY; CATALYSIS; DIMERIZATION; DNA DAMAGE; DRUG TARGETING; ENZYME ACTIVITY; ENZYME INHIBITION; ENZYME SUBUNIT; EQUILIBRIUM CONSTANT; LIGHT SCATTERING; PEPTIDE SYNTHESIS;

ANIMALS; DIMERIZATION; ENZYME INHIBITORS; KINETICS; MAMMALS; MODELS, THEORETICAL; NUCLEIC ACID CONFORMATION; OLIGOPEPTIDES; PEPTIDES; RIBONUCLEOTIDE REDUCTASES; SCATTERING, RADIATION;

MAMMALIA;

EID: 14944350032     PISSN: 00063525     EISSN: None     Source Type: Journal    
DOI: 10.1002/bip.20184     Document Type: Article

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