The structure of Apo R268A human aldose reductase: Hinges and latches that control the kinetic mechanism

Biochimica et Biophysica Acta - Proteins and Proteomics

Volumn 1748, Issue 2, 2005, Pages 201-212

  Bohren, Kurt M ^a   Brownlee, June M ^b   Milne, Amy C ^c   Gabbay, Kenneth H ^a   Harrison, David H T ^b  

^a BAYLOR COLLEGE OF MEDICINE   (United States)

^b ROSALIND FRANKLIN UNIVERSITY OF MEDICINE AND SCIENCE   (United States)

^c BRANDEIS UNIVERSITY   (United States)

Author keywords

Aldose reductase; Apo structure; Enzyme kinetics; Loop movement; X ray structure

Indexed keywords

ALANINE; ALDEHYDE REDUCTASE; AMINO ACID; APOENZYME; ARGININE; HOLOENZYME; NUCLEOTIDE;

AMINO ACID SUBSTITUTION; ARTICLE; CRYSTAL STRUCTURE; CRYSTALLIZATION; ENZYME ASSAY; ENZYME KINETICS; ENZYME MECHANISM; ENZYME STRUCTURE; ENZYME SUBSTRATE; HIGH TEMPERATURE; HYDROGEN BOND; PRIORITY JOURNAL; WILD TYPE;

EID: 14844358218     PISSN: 15709639     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bbapap.2005.01.006     Document Type: Article

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