The temporal and spatial subnuclear organization of skeletal gene regulatory machinery: Integrating multiple levels of transcriptional control

Calcified Tissue International

Volumn 72, Issue 6, 2003, Pages 631-637

  Lian, J B ^a   Stein, G S ^a  

^a UNIVERSITY OF MASSACHUSETTS MEDICAL SCHOOL   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

OSTEOCALCIN; TRANSCRIPTION FACTOR; TRANSCRIPTION FACTOR RUNX2; UNCLASSIFIED DRUG;

BONE CELL; BONE DEVELOPMENT; CELL COMPARTMENTALIZATION; CELL DIFFERENTIATION; CELL GROWTH; CELL NUCLEUS MATRIX; GENE EXPRESSION; GENE EXPRESSION REGULATION; GENETIC TRANSCRIPTION; OSSIFICATION; OSTEOBLAST; PHENOTYPE; PRIORITY JOURNAL; PROMOTER REGION; REVIEW; SOMATIC CELL GENETICS;

ANIMALS; BONE DEVELOPMENT; CELL NUCLEUS; GENE EXPRESSION REGULATION; HUMANS; OSTEOBLASTS; TIME FACTORS; TRANSCRIPTION, GENETIC;

EID: 0042767732     PISSN: 0171967X     EISSN: None     Source Type: Journal    
DOI: 10.1007/s00223-002-1058-x     Document Type: Review

References (64)

1. Aubin JE, Liu F (1996) The osteoblast lineage. In: Bilezikian JP, Raisz LG, Rodan GA (eds) Principles of bone biology. Academic Press, San Diego, pp 51-68
2. Candeliere GA, Liu F, Aubin JE (2001) Individual osteoblasts in the developing calvaria express different gene repertoires. Bone 28:351-361
3. Lian JB, Stein GS (2001) Osteoblast biology. In: Marcus D, Feldman D, Kelsey J (eds) Osteoporosis. Academic Press, San Diego, pp 21-71
4. Whitmarsh AJ, Davis RJ (1999) Signal transduction by MAP kinases: regulation by phosphorylation-dependent switches. Sci STKE 1999: PE1
5. Xiao G, Gopalkrishnan RV, Jiang D, Reith E, Benson R, Franceschi R (2002) Bone morphogenetic proteins, extracellular matrix, and mitogen-activated protein kinase signaling pathways are required for osteoblast-specific gene expression and differentiation in MC3T3-E1 cells. J Bone Miner Res 17:101-110
6. Berezney R, Mortillaro M, Ma H, Meng C, Samarabandu X, Wei X, Somanathan S, Liou WS, Pan SJ, Cheng PC (1996) Connecting nuclear architecture and genomic function. J Cell Biochem 62:223-226
7. Stein GS, Lian JB, Montecino M, van Wijnen AJ, Stein A, Javed A, Zaidi K (2002) Involvement of nuclear architecture in regulating gene expression in bone cells. In: Bilezikian JP, Raisz LG, Rodan GA (eds) Principles of bone biology. Academic Press, San Diego, pp 169-188
8. Wei X, Samarabandu J, Devdhar RS, Siegel AJ, Acharya R, Berezney R (1998) Segregation of transcription and replication sites into higher order domains. Science 281:1502-1505
9. Lian JB, Stein GS, Stein JL, van Wijnen AJ (1998) Osteocalcin gene promoter: unlocking the secrets for regulation of osteoblast growth and differentiation. J Cell Biochem (suppl) 30-31:62-72
10. Stein GS, van Wijnen AJ, Stein JL, Lian JB, Montecino J-Y, Choi J-Y, Zaidi K, Javed A (2000) Intranuclear trafficking of transcription factors: implications for biological control. J Cell Sci 113:2527-2533
11. Westendorf JJ, Hiebert SW (1999) Mammalian runt-domain proteins and their roles in hematopoiesis, osteogenesis, and leukemia. J Cell Biochem (suppl 32-33):51-58
12. Zaidi SK, Sullivan AJ, van Wijnen AJ, Stein JL, Stein GS, Lian JB (2002) Integration of Runx and Smad regulatory signals at transcriptionally active subnuclear sites. Proc Natl Acad Sci USA in press
13. Zeng C, McNeil S, Pockwinse S, Nickerson JA, Shopland JB, Lawrence JB, Penman S, Hiebert SW, Lian JB, van Wijnen GS, Stein JL, Stein GS (1998) Intranuclear targeting of AML/CBFa regulatory factors to nuclear matrix-associated transcriptional domains. Proc Natl Acad Sci USA 95:1585-1589
14. Zeng C, van Wijnen AJ, Stein JL, Meyers S, Sun W, Shopland L, Lawrence JB, Penman S, Lian JB, Stein GS, Hiebert SW (1997) Identification of a nuclear matrix targeting signal in the leukemia and bone-related AML/CBFa transcription factors. Proc Natl Acad Sci USA 94:6746-6751
15. Zhang YW, Yasui N, Ito K, Huang G, Fujii M, Hanai J, Nogami H, Ochi T, Miyazono K, Ito Y (2000) A RUNX2/PEBP2aA/CBFA1 mutation displaying impaired transactivation and Smad interaction in cleidocranial dysplasia. Proc Natl Acad Sci USA 97:10549-10554
16. McNeil S, Zeng C, Harrington KS, Hiebert S, Lian JB, Stein JL, van Wijnen AJ, Stein GS (1999) The t(8;21) chromosomal translocation in acute myelogenous leukemia modifies intranuclear targeting of the AML1/CBFalpha2 transcription factor. Proc Natl Acad Sci USA 96:14882-14887
17. Meyers S, Hiebert SW (2000) Alterations in subnuclear trafficking of nuclear regulatory factors in acute leukemia. J Cell Biochem 35:93-98
18. Lamond AI, Earnshaw WC (1998) Structure and function in the nucleus. Science 280:547-553
19. Dworetzky SI, Wright KL, Fey EG, Penman S, Lian JB, Stein JL, Stein GS (1992) Sequence-specific DNA-binding proteins are components of a nuclear matrix-attachment site. Proc Natl Acad Sci USA 89:4178-4182
20. Guo B, Odgren PR, van Wijnen AJ, Last TJ, Nickerson J, Penman S, Lian JB, Stein JL, Stein GS (1995) The nuclear matrix protein NMP-1 is the transcription factor YY1. Proc Natl Acad Sci USA 92:10526-10530
21. Mancini MA, Shan B, Nickerson JA, Penman S, Lee W-H (1994) The retinoblastoma gene product is a cell cycle-dependent, nuclear matrix-associated protein. Proc Natl Acad Sci USA 91:418-422
22. Stenoien DL, Patel K, Mancini MG, Dutertre M, Smith BW, O'Malley BW, Mancini MA (2001) FRAP reveals that mobility of oestrogen receptor-a is ligand- and proteasome-dependent. Nat Cell Biol 3:15-23
23. van Wijnen AJ, Bidwell JP, Fey EG, Penman S, Lian JB, Stein JL, Stein GS (1993) Nuclear matrix association of multiple sequence-specific DNA binding activities related to SP-1, ATF, CCAAT, C/EBP, OCT-1, and AP-1. Biochemistry 32:8397-8402
24. Alvarez M, Long H, Onyia J, Hock J, Xu W, Bidwell J (1997) Rat osteoblast and osteosarcoma nuclear matrix proteins bind with sequence specificity to the rat type I collagen promoter. Endocrinology 138:482-489
25. Bidwell JP, van Wijnen AJ, Fey EG, Dworetzky S, Penman S, Stein JL, Lian JB, Stein GS (1993) Osteocalcin gene promoter-binding factors are tissue-specific nuclear matrix components. Proc Natl Acad Sci USA 90:3162-3166
26. Choi J-Y, Pratap J, Javed A, Zaidi SK, Xing L, Balint E, Dalamangas S, Boyce B, van Wijnen AJ, Lian JB, Stein SN, Jones SN, Stein GS (2001) Subnuclear targeting of Runx/Cbfa/AML factors is essential for tissue-specific differentiation during embryonic development. Proc Natl Acad Sci USA 98:8650-8655
27. Merriman HL, van Wijnen AJ, Hiebert S, Bidwell JP, Fey J, Lian J, Stein J, Stein GS (1995) The tissue-specific nuclear matrix protein, NMP-2, is a member of the AML/CBF/PEBP2/runt domain transcription factor family: interactions with the osteocalcin gene promoter. Biochemistry 34:13125-13132
28. Nardozza TA, Quigley MM, Getzenberg RH (1996) Association of transcription factors with the nuclear matrix. J Cell Biochem 61:467-477
29. Spelsberg TC, Lauber AH, Sandhu NP, Subramaniam M (1996) A nuclear matrix acceptor site for the progesterone receptor in the avian c-myc gene promoter. Recent Prog Horm Res 51:63-96
30. Zaidi SK, Javed A, Choi J-Y, van Wijnen AJ, Stein JL, Lian JB, Stein GS (2001) A specific targeting signal directs Runx2/Cbfa1 to subnuclear domains and contributes to transactivation of the osteocalcin gene. J Cell Sci 114:3102
31. Tang L, Guo B, Javed A, Choi J-Y, Hiebert S, Lian JB, van Wijnen AJ, Stein JL, Stein GS, Zhou GW (1999) Crystal structure of the nuclear matrix targeting signal of the transcription factor AML-1/PEBP2aB/CBFa2. J Biol Chem 274:33580-33586
32. Davie JR (1997) Nuclear matrix, dynamic histone acetylation and transcriptionally active chromatin. Mol Biol Rep 24:197-207
33. Jackson DA (1997) Chromatin domains and nuclear compartments: establishing sites of gene expression in eukaryotic nuclei. Mol Biol Rep 24:209-220
34. Narlikar GJ, Fan HY, Kingston RE (2002) Cooperation between complexes that regulate chromatin structure and transcription. Cell 108:475-487
35. Gutierrez J, Sierra J, Medina R, Puchi M, Imschenetzky S, Hiebert S, van Wijnen A, Lian JB, Stein G, Stein J, Montecino M (2000) Interaction of CBFa/AML/PEBP2a transcription factors with nucleosomal sequences requires flexibility in the translational positioning of the histone octamer and exposure of the Cbfa site. Biochemistry 39:13565-13574
36. Montecino M, Frenkel B, van Wijnen AJ, Lian JB, Stein JL, Stein JL (1999) Chromatin hyperacetylation abrogates vitamin D-mediated transcriptional upregulation of the tissue-specific osteocalcin gene in vivo. Biochemistry 38:1338-1345
37. Montecino M, Lian J, Stein G, Stein J (1996) Changes in chromatin structure support constitutive and developmentally regulated transcription of the bone-specific osteocalcin gene in osteoblastic cells. Biochemistry 35:5093-5102
38. Paredes R, Gutierrez J, Gutierrez S, Allison L, Puchi M, Imschenetzky M, van Wijnen A, Lian J, Stein G, Stein J, Montecino M (2002) Interaction of the 1alpha,25-dihydroxyvitamin D3 receptor at the distal promoter region of the bone-specific osteocalcin gene requires nucleosomal remodelling. Biochem J 363:667-676
39. Blanco JCG, Wang I-M, Tsai SY, Tsai M-J, O'Malley PW, Jurutka PW, Haussler MR, Ozato K (1995) Transcription factor TFI 1 B and the vitamin D receptor cooperatively activate ligand-dependent transcription. Proc Natl Acad Sci USA 92:1535-1539
40. Shen J, Montecino MA, Lian JB, Stein GS, van Wijnen JL, Stein JL (2002) Histone acetylation in vivo at the osteocalcin locus is functionally linked to vitamin D-dependent, bone tissue-specific transcription. J Biol Chem 277:20284-20292
41. Javed A, Gutierrez S, Montecino M, van Wijnen AJ, Stein GS, Stein GS, Lian JB (1999) Multiple Cbfa/AML sites in the rat osteocalcin promoter are required for basal and vitamin D-responsive transcription and contribute to chromatin organization. Mol Cell Biol 19:7491-7500
42. Pelletier N, Champagne N, Stifani S, Yang XJ (2002) MOZ and MORF histone acetyltransferases interact with the Runt-domain transcription factor Runx2. Oncogene 21:2729-2740
43. Javed A, Guo B, Hiebert S, Choi J-Y, Green J, Zhao S-C, Osborne MA, Stifani S, Stein JL, Lian JB, van Wijnen AJ, Stein GS (2000) Groucho/TLE/R-Esp proteins associate with the nuclear matrix and repress RUNX (CBFa/AML/PEBP2a-dependent activation of tissue-specific gene transcription. J Cell Sci 113:2221-2231
44. Javed A, Barnes GL, Jassanya BO, Stein JL, Gerstenfeld JB, Lian JB, Stein GS (2001) runt homology domain transcription factors (Runx, Cbfa, and AML) mediate repression of the bone sialoprotein promoter: evidence for promoter context-dependent activity of Cbfa proteins. Mol Cell Biol 21:2891-2905
45. Levanon D, Goldstein RE, Bernstein Y, Tang H, Goldenberg D, Stifani S, Paroush Z, Groner Y (1998) Transcriptional repression by AML1 and LEF-1 is mediated by the TLE/Groucho corepressors. Proc Natl Acad Sci USA 95:11590-11595
46. Ogawa E, Inuzuka M, Maruyama M, Satake M, Naito-Fujimoto M, Ito Y, Shigesada K (1993) Molecular cloning and characterization of PEBP2b, the heterodimeric partner of a novel Drosophila runt-related DNA binding protein PEBP2a. Virology 194:314-331
47. Mao S, Frank RC, Zhang J, Miyazaki Y, Nimer SD (1999) Functional and physical interactions between AML1 proteins and an ETS protein, MEF: implications for the pathogenesis of t(8;21)-positive leukemias. Mol Cell Biol 19:3635-3644
48. Xie XQ, Pardali E, Holm M, Sideras P, Grundstrom T (1999) AML and Ets proteins regulate the I alphal germline promoter. Eur J Immunol 29:488-498
49. D'Alonzo RC, Selvamurugan N, Karsenty G, Partridge NC (2002) Physical interaction of the activator protein-1 factors c-Fos and c-Jun with Cbfa1 for collagenase-3 promoter activation. J Biol Chem 277:816-822
50. Hess J, Porte D, Munz C, Angel P (2001) AP-1 and Cbfa/Runt physically interact and regulate PTH-dependent MMP13 expression in osteoblasts through a new OSE2/AP-1 composite element. J Biol Chem 276:20029-20038
51. Hinds PW, Weinberg RA (1994) Tumor suppressor genes. Curr Opin Genet Dev 4:135-141
52. Gutierrez S, Javed A, Tennant D, van Rees M, Montecino GS, Stein GS, Stein JL, Lian JB (2002) CCAAT/enhancer-binding proteins (C/EBP) b and d activate osteocalcin gene transcription and synergize with Runx2 at the C/EBP element to regulate bone-specific expression. J Biol Chem 277:1316-1323
53. Zhang DE, Hetherington CJ, Meyers S, Rhoades KL, Larson CJ, Chen HM, Hiebert SW, Tenen DG (1996) CCAAT enhancer-binding protein (C/EBP) and AML1 (CBFa2) synergistically activate the macrophage colony-stimulating factor receptor promoter. Mol Cell Biol 16:1231-1240
54. Okuda T, van Deursen J, Hiebert SW, Grosveld G, Downing JR (1996) AML1, the target of multiple chromosomal translocations in human leukemia, is essential for normal fetal liver hematopoiesis. Cell 84:321-330
55. Wang Q, Stacy T, Binder M, Marin-Padilla M, Sharpe NA, Speck NA (1996) Disruption of the Cbfa2 gene causes necrosis and hemorrhaging in the central nervous system and blocks definitive hematopoiesis. Proc Natl Acad Sci USA 93:3444-3449
56. Komori T, Yagi H, Nomura S, Yamaguchi A, Sasaki K, Deguchi K, Shimizu Y, Bronson RT, Gao Y-H, Inada M, Sato M, Okamoto R, Kitamura Y, Yoshiki S, Kishimoto T (1997) Targeted disruption of Cbfa1 results in a complete lack of bone formation owing to maturational arrest of osteoblasts. Cell 89:755-764
57. Otto F, Thornell AP, Crompton T, Denzel A, Gilmour IR, Rosewell IR, Stamp GWH, Beddington RSP, Mundlos S, Olsen BR, Selby PB, Owen MJ (1997) Cbfa1, a candidate gene for cleidocranial dysplasia syndrome, is essential for osteoblast differentiation and bone development. Cell 89:765-771
58. Li QL, Ito K, Sakakura C, Fukamachi H, Inoue K, Chi KY, Lee KY, Nomura S, Lee CW, Han SB, Kim HM, Kim WJ, Yamamoto H, Yamashita N, Yano T, Ikeda T, Itohara S, Inazawa J, Abe T, Hagiwara A, Yamagishi H, Ooe A, Kaneda A, Sugimura T, Ushijima T, Bae SC, Ito Y (2002) Causal relationship between the loss of RUNX3 expression and gastric cancer. Cell 109:113-124
59. Levanon D, Brenner O, Negreanu V, Bettoun D, Woolf E, Eilam R, Lotem J, Gat U, Otto F, Speck N, Groner Y (2001) Spatial and temporal expression pattern of Runx3 (Am12) and Runx1 (Am11) indicates non-redundant functions during mouse embryogenesis. Mech Dev 109:413-417
60. Stricker S, Fundele R, Vortkamp A, Mundlos S (2002) Role of runx genes in chondrocyte differentiation. Dev Biol 245:95-108
61. Drissi H, Luc Q, Shakoori R, Chuva de Sousa Lopes S, Choi J-Y, Terry A, Hu M, Jones S, Neil JC, Lian JB, Stein JB, van Wijnen AJ, Stein GS Transcriptional autoregulation of the bone-related CBFA1/RUNX2 gene. J Cell Physiol 184:341-350
62. Hiebert SW, Lutterbach B, Amann J (2001) Role of corepressors in transcriptional repression mediated by the t(8; 21), t(16;21), t(12;21), and inv(16) fusion proteins. Curr Opin Hematol 8:197-200
63. Perry C, Eldor A, Soreq H (2002) Runx1/AML1 in leukemia: disrupted association with diverse protein partners. Leuk Res 26:221-228
64. Stein GS, Montecino M, van Wijnen AJ, Stein JL, Lian JB (2000) Nuclear structure - gene expression interrelationships: implications for aberrant gene expression in cancer. Cancer Res 60:2067-2076