Are current theories of panic falsifiable?

Psychological Bulletin

Volumn 131, Issue 2, 2005, Pages 171-192

  Roth, Walton T ^a,b   Wilhelm, Frank H ^a,b   Pettit, Dean ^a,b  

^a VA PALO ALTO HEALTH CARE SYSTEM   (United States)

^b STANFORD UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

Cognition; Falsifiability; Neuroanatomy; Panic; Respiration; Review; Theory

Indexed keywords

COGNITION; HUMAN; HYPERVENTILATION; PANIC; PSYCHOLOGICAL THEORY; REVIEW;

COGNITION; HUMANS; HYPERVENTILATION; PANIC DISORDER; PSYCHOLOGICAL THEORY;

EID: 14844318093     PISSN: 00332909     EISSN: None     Source Type: Journal    
DOI: 10.1037/0033-2909.131.2.171     Document Type: Review

References (119)

1. Abelson, J., & Nesse, R. (1994). Pentagastrin infusions in patients with panic disorder: I. Symptoms and cardiovascular responses. Biological Psychiatry, 36, 465-466.
2. Abelson, J. L., Nesse, R. M., Weg, J. G., & Curtis, G. C. (1996). Respiratory psychophysiology and anxiety: Cognitive intervention in the doxapram model of panic. Psychosomatic Medicine, 58, 302-313.
3. Alpers, G. W., Wilhelm, F. H., & Roth, W. T. (2001). Does one circle fit all? Evidence for the vicious circle model for panic attacks. Manuscript in preparation.
4. American Psychiatric Association. (1994). Diagnostic and statistical manual of mental disorders (4th ed.). Washington, DC: Author.
5. Aronson, T. A., Whitaker-Azmitia, P., & Caraseti, I. (1989). Differential reactivity to lactate infusions: The relative role of biological, psychological, and conditioning variables. Biological Psychiatry, 25(4), 469-481.
6. Ballenger, J. C., Burrows, G. D., DuPont, R. L., Lesser, I. M., Noyes, R. J., Pecknold, J. C., et al. (1988). Alprazolam in panic disorder and agoraphobia: Results from a multicenter trial: I. Efficacy in short-term treatment. Archives of General Psychiatry, 45, 413-422.
7. Bandettini, P., & Ungerleider, L. (2001). From neuron to BOLD: New connections. Nature Neuroscience, 4, 864-866.
8. Barlow, D. H. (1988). Anxiety and its disorders: The nature and treatment of anxiety and panic. New York: Guilford Press.
9. Barlow, D. H. (1997). Cognitive-behavioral therapy for panic disorder: Current status. Journal of Clinical Psychiatry, 58(Suppl. 2), 32-37.
10. Barlow, D. H. (2002). Anxiety and its disorders: The nature and treatment of anxiety and panic (2nd ed.). New York: Guilford Press.
11. Barlow, D., & Craske, M. (2000). Mastery of your anxiety and panic (3rd ed.). Boulder, CO: Graywind.
12. Baum, M. (1986). An animal model for situational panic attacks. Behaviour Research and Therapy, 24, 509-512.
13. Bouton, M. E., Mineka, S., & Barlow, D. H. (2001). A modern learning theory perspective on the etiology of panic disorder. Psychological Review, 108, 4-32.
14. Brewin, C. (2001). A cognitive neuroscience account of posttraumatic stress disorder and its treatment. Behaviour Research and Therapy, 39, 373-393.
15. Brown, T. A., Chorpita, B. F., & Barlow, D. H. (1998). Structural relationships among dimensions of the DSM-IV anxiety and mood disorders and dimensions of negative affect, positive affect, and autonomic arousal. Journal of Abnormal Psychology, 107, 179-192.
16. Cacioppo, J. T., Tassinary, L. G., & Berntson, G. G. (2000). Psychophysiological science: Handbook of psychophysiology (2nd ed., pp. 3-23). Cambridge, England: Cambridge University press.
17. Clark, D. M. (1986). A cognitive approach to panic. Behaviour Research and Therapy, 24, 461-470.
18. Clark, D. M. (1996). Panic disorder: From theory to therapy. In P. M. Salkovskis (Ed.), Frontiers of cognitive therapy (pp. 318-344). New York: Guilford Press.
19. Clark, D. M., & Ehlers, A. (1993). An overview of the cognitive theory and treatment of panic disorder. Applied and Preventative Psychology, 2, 131-139.
20. Clark, D. M., & Hemsley, D. R. (1982). The effects of hyperventilation: Individual variability and its relation to personality. Journal of Behavior Therapy and Experimental Psychiatry, 13, 41-47.
21. Clark, D. M., Salkovskis, P. M., & Chalkley, A. J. (1985). Respiratory control as a treatment for panic attacks. Journal of Behavior Therapy and Experimental Psychiatry, 16, 23-30.
22. Clark, D. M., Salkovskis, P. M., Hackmann, A., Middleton, H., Anastasiades, P., & Gelder, M. (1994). A comparison of cognitive therapy, applied relaxation and imipramine in the treatment of panic disorder. British Journal of Psychiatry, 164, 759-769.
23. Clark, D. M., Salkovskis, P. M., Öst, L.-G., Breitholtz, E., Koehler, K. A., Westling, B. E., et al. (1997). Misinterpretation of body sensations in panic disorder. Journal of Consulting and Clinical Psychology, 65, 203-213.
24. Cox, B. J., Borger, S. C., & Enns, M. W. (1999). Anxiety sensitivity and emotional disorders: Psychometric studies and their theoretical implications. In S. Taylor (Ed.), Anxiety sensitivity: Theory, research, and treatment of the fear of anxiety (pp. 115-148). Mahwah, NJ: Erlbaum.
25. Craske, M. G., & Freed, S. (1995). Expectations about arousal and nocturnal panic. Journal of Abnormal Psychology, 104, 567-575.
26. Craske, M. G., Lang, A. J., Rowe, M., DeCola, J. P., Simmons, J., Mann, C., et al. (2002). Presleep attributions about arousal during sleep: Nocturnal panic. Journal of Abnormal Psychology, 111, 53-62.
27. Dempsey, J. A., & Pack, A. I. (1995). Regulation of breathing. New York: Marcel Dekker.
28. Ehlers, A., & Breuer, P. (1996). How good are patients with panic disorder at perceiving their heartbeats? Biological Psychology, 42, 165-182.
29. Ehlers, A., & Clark, D. (2000). A cognitive model of posttraumatic stress disorder. Behaviour Research and Therapy, 38, 319-345.
30. Ehlers, A., Margraf, J., Roth, W. T., Taylor, C. B., & Birbaumer, N. (1988). Anxiety induced by false heart rate feedback in patients with panic disorder. Behaviour Research and Therapy, 26, 1-11.
31. Elliott, M. W., Adams, L., Cockcroft, A., MacRae, K. D., Murphy, K., & Guz, A. (1991). The language of breathlessness: Use of verbal descriptors by patients with cardiopulmonary disease. American Review of Respiratory Disease, 144, 826-832.
32. Fowles, D. C. (1980). The three arousal model: Implications of Gray's two-factor learning theory for heart rate, electrodermal activity, and psychopathy. Psychophysiology, 17, 87-104.
33. Garfield, E. (1992). A citationist perspective of psychology: I. Most cited papers, 1986-1990. American Psychological Society Observer, 5(6), 8-9.
34. Garssen, B., Buikhuisen, M., & van Dyck, R. (1996). Hyperventilation and panic attacks. American Journal of Psychiatry, 153, 513-518.
35. Goetz, R., Klein, D., & German, J. (1996). Symptoms essential to the experience of sodium lactate-induced panic. Neuropsychopharmacology, 14, 355-366.
36. Goldstein, A., & Chambless, D. (1978). A reanalysis of agoraphobia. Behavior Therapy, 9, 47-59.
37. Goodwin, R. D., & Eaton, W. W. (2003). Asthma and the risk of panic attacks among adults in the community. Psychological Medicine, 33, 879-885.
38. Gorman, J., Battista, D., Goetz, R., Dillon, D., Liebowitz, M., Fyer, A., et al. (1989). A comparison of sodium bicarbonate and sodium lacatate infusion in the induction of panic attacks. Archives of General Psychiatry, 46, 145-150.
39. Gorman, J. M., Fyer, M. R., Goetz, R., Askanazi, J., Liebowitz, M. R., & Fyer, A. J. (1988). Ventilatory physiology of patients with panic disorder. Archives of General Psychiatry, 45, 31-39.
40. Gorman, J. M., Kent, J. M., Sullivan, G. M., & Coplan, J. D. (2000). Neuroanatomical hypothesis of panic disorder, revised. American Journal of Psychiatry, 157, 493-505.
41. Gorman, J. M., Liebowitz, M. R., Fyer, A. J., & Stein, J. (1989). A neuroanatomical hypothesis for panic disorder. American Journal of Psychiatry, 146, 148-151.
42. Hardonk, H. J., & Beumer, H. M. (1979). Hyperventilation syndrome. In P. J. Vinken & G. W. Bruyn (Eds.), Handbook of clinical neurology (Vol. 38, pp. 309-360). Amsterdam: North-Holland.
43. Harris, L. M., Robinson, J., & Menzies, R. G. (1999). Evidence for fear of restriction and fear of suffocation as components of claustrophobia. Behaviour Research and Therapy, 37, 155-159.
44. Hibbert, G., & Pilsbury, D. (1989). Hyperventilation - Is it a cause of panic attacks? British Journal of Psychiatry, 155, 805-809.
45. Hofmann, S. G. (2003). The cognitive model of panic revisited. In M. A. Reinecke & D. A. Clark (Eds.), Cognitive therapy across the lifespan (pp. 117-137). Cambridge, England: Cambridge University Press.
46. Hornsveld, H. K., Garssen, B., Fiedeldij Dop, M. J. C., van Spiegel, P., & de Haes, J. C. J. M. (1996, July 20). Double-blind placebo-controlled study of the hyperventilation provocation test and the validity of the hyperventilation syndrome. Lancet, 348, 152-158.
47. Jacobs, W. J., & Nadel, L. (1998). Neurobiology of reconstructed memory. Psychology of Public Policy and Law, 4, 1110-1134.
48. Jacobs, W. J., & Nadel, L. (1999). The first panic attack: A neurobiological theory. Canadian Journal of Experimental Psychology, 53, 92-107.
49. Joiner, T. E., Jr., Steer, R. A., Beck, A. T., Schmidt, N. B., Rudd, M. D., & Catanzaro, S. J. (1999). Physiological hyperarousal: Construct validity of a central aspect of the tripartite model of depression and anxiety. Journal of Abnormal Psychology, 108, 290-298.
50. Kenardy, J., Fried, L., Kraemer, H. C., & Taylor, C. B. (1992). Psychological precursors of panic attacks. British Journal of Psychiatry, 160, 668-673.
51. Kenardy, J., & Taylor, C. B. (1999). Expected versus unexpected panic attacks: A naturalistic prospective study. Journal of Anxiety Disorders, 13, 435-445.
52. Klein, D. F. (1980). Anxiety reconceptualized. Comprehensive Psychiatry, 21, 411-427.
53. Klein, D. F. (1993). False suffocation alarms, spontaneous panics, and related conditions. An integrative hypothesis. Archives of General Psychiatry, 50, 306-317.
54. Klein, D. F. (1994). Testing the suffocation false alarm theory of panic disorder. Anxiety, 1, 1-7.
55. Klein, D. F., & Klein, H. M. (1989). The definition and psychopharmacology of spontaneous panic and phobia. In P. Tyrer (Ed.), Psychopharmacology of anxiety (pp. 135-162). New York: Oxford University Press.
56. Kraemer, H. (2001). How do risk factors work together? Mediators, moderators, and independent, overlapping, and proxy risk factors. American Journal of Psychiatry, 158, 848-856.
57. Kuhn, T. S. (1977). Objectivity, value judgment, and theory choice. In T. S. Kuhn (Ed.), The essential tension: Selected studies in scientific tradition and change (pp. 320-339). Chicago: University of Chicago Press.
58. Lang, P. (1988). What are the data of emotion? In V. Hamilton, G. H. Bower, & N. Frijda (Eds.), Cognitive perspectives on emotion and motivation (pp. 173-191). Boston: Martinus Nijhoff.
59. Ley, R. (1985a). Agoraphobia, the panic attack, and the hyperventilation syndrome. Behaviour Research and Therapy, 23, 79-81.
60. Ley, R. (1985b). Blood, breath, and fears: A hyperventilation theory of panic attacks and agoraphobia. Clinical Psychology Review, 5, 271-285.
61. Ley, R. (1987). Panic disorder: A hyperventilation interpretation. In L. Michaelson & M. Ascher (Eds.), Cognitive-behavioral assessment and treatment of anxiety disorders (pp. 191-212). New York: Guilford Press.
62. Ley, R. (1989). Dyspneic-fear and catastrophic cognitions in hyperventilatory panic attacks. Behaviour Research and Therapy, 27, 549-554.
63. Ley, R. (1992a). A hyperventilation interpretation of the termination of panic attacks: A reply to van den Hout, de Jong, Zandbergen and Merckelbach. Behaviour Research and Therapy, 30, 191-192.
64. Ley, R. (1992b). The many faces of Pan: Psychological and physiological differences among three types of panic attacks. Behaviour Research and Therapy, 30, 347-357.
65. Mackie, J. L. (1965). Causes and conditions. American Philosophical Quarterly, 2, 245-264.
66. Maddock, R. J., & Carter, C. S. (1991). Hyperventilation-induced panic attacks in panic disorder with agoraphobia. Biological Psychiatry, 29, 843-854.
67. Margraf, J., Ehlers, A., Herber, B., Meisner, K., & Wrobel, F. (1991). Hyperventilation, Angstanfälle und soziale Ängste [Hyperventilation, anxiety attacks, and social anxieties]. Verhaltenstherapie, 1, 34-46.
68. Margraf, J., Ehlers, A., & Roth, W. T. (1986). Biological models of panic disorder and agoraphobia: A review. Behaviour Research and Therapy, 24, 553-567.
69. Margraf, J., Taylor, C. B., Ehlers, A., Roth, W. T., & Agras, W. S. (1987). Panic attacks in the natural environment. Journal of Nervous and Mental Disease, 175, 558-565.
70. Martinez, J., Papp, L., Coplan, J., Anderson, D., Mueller, C., Klein, D., & Gorman, J. (1996). Ambulatory monitoring of respiration in anxiety. Anxiety, 2, 296-302.
71. McNally, R. J. (1994). Panic disorder: A critical analysis. New York: Guilford Press.
72. McNally, R. J. (1999). Theoretical approaches to the fear of anxiety. In S. Taylor (Ed.), Anxiety sensitivity: Theory, research, and treatment of the fear of anxiety (pp. 3-16). Mahwah, NJ: Erlbaum.
73. McNally, R. J. (2001). On the scientific status of cognitive appraisal models of anxiety disorder. Behaviour Research and Therapy, 39, 513-521.
74. McNally, R. J., Hornig, C. D., & Donnell, C. D. (1995). Clinical vs. nonclinical panic: A test of the suffocation false alarm theory. Behaviour Research and Therapy, 33, 127-131.
75. Meuret, A. E., Wilhelm, F. H., Ritz, T., & Roth, W. T. (2003). Breathing training for treating panic disorder. Useful intervention or impediment? Behavior Modification, 27, 731-754.
76. Meuret, A. E., Wilhelm, F. H., & Roth, W. T. (2004). Effects of capnometry-assisted breathing therapy on symptoms and respiration in panic disorder. Manuscript submitted for publication.
77. Milic-Emili, J., Whitelaw, W. A., & Grassino, A. E. (1981). Measurement and testing of respiratory drive. In T. F. Hornbein (Ed.), Regulation of breathing: II (pp. 675-743). New York: Marcel Dekker.
78. Miller, J., Fletcher, K., & Kabat-Zinn, J. (1995). Three-year follow-up and clinical implications of a mindfulness meditation-based stress reduction intervention in the treatment of anxiety disorders. General Hospital Psychiatry, 17, 192-200.
79. Munjack, D., Crocker, B., Cabe, D., Brown, R., Usigli, R., Zulueta, A., et al. (1989). Alprazolam, propranolol, and placebo in the treatment of panic disorder and agoraphobia with panic attacks. Journal of Clinical Psychopharmacology, 9, 22-27.
80. Nutt, D. J., Glue, P., Lawson, C., & Wilson, S. (1990). Flumazenil provocation of panic attacks: Evidence for altered benzodiazepine receptor sensitivity in panic disorder. Archives of General Psychiatry, 47, 917-925.
81. Otto, M., & Reilly-Harrington, N. (1999). Theoretical approaches to the fear of anxiety. In S. Taylor (Ed.), Anxiety sensitivity: Theory, research, and treatment of the fear of anxiety (pp. 3-16). Mahwah, NJ: Erlbaum.
82. Papp, L. A., Martinez, J. M., Klein, D. F., Coplan, J. D., Norman, R. G., Cole, R., et al. (1997). Respiratory psychophysiology of panic disorder: Three respiratory challenges in 98 subjects. American Journal of Psychiatry, 154, 1557-1565.
83. Popper, K. R. (1959). The logic of scientific discovery. New York City: Basic Books.
84. Poulton, R., & Menzies, R. G. (2002). Non-associative fear acquisition: A review of the evidence from retrospective and longitudinal research. Behaviour Research and Therapy, 40, 127-149.
85. Putnam, H. (1974). The "corroboration" of theories. In P. A. Schilpp (Ed.), The philosophy of Karl Popper (Vol. 14, pp. 221-240). LaSalle, IL: Open Court.
86. Quine, W. V. (1951). Two dogmas of empiricism. Philosophical Review, 60, 20-43.
87. Rachman, S., Lopatka, C., & Levitt, K. (1988). Experimental analyses of panic: II. Panic patients. Behaviour Research and Therapy, 26, 33-40.
88. Razran, G. (1961). The observable unconscious and the inferable conscious in current Soviet psychophysiology: Interoceptive condition, semantic conditioning, and the orienting reflex. Psychological Review, 68, 81-150.
89. Ross, T. (1937). The common neuroses: Their treatment by psychotherapy. An introduction to psychological treatment for students and practitioners (2nd ed.). Baltimore: Wood.
90. Roth, H. L., & Heilman, K. M. (2000). Aphasia: A historical perspective. In S. E. Nadeau, L. J. Gonzalez-Rothi, & B. A. Crosson (Eds.), Aphasia and language: Theory to practice (pp. 3-28). New York: Guilford Press.
91. Roth, W. T., Breivik, G., Jorgensen, P. E., & Hofmann, S. (1996). Activation in novice and expert parachutists while jumping. Psychophysiology, 33, 63-72.
92. Roth, W. T., Wilhelm, F. H., & Trabert, W. (1998). Voluntary breath holding in panic and generalized anxiety disorders. Psychosomatic Medicine, 60, 671-679.
93. Roth, W. T., & Yalom, I. D. (Eds.). (1997). Treating anxiety disorders. San Francisco: Jossey-Bass.
94. 2. British Journal of Psychiatry, 148, 526-532.
95. Schmidt, N. B. (1999). Prospective evaluations of anxiety sensitivity. In S. Taylor (Ed.), Anxiety sensitivity: Theory, research, and treatment of the fear of anxiety (pp. 217-235). Mahwah, NJ: Erlbaum.
96. 2 challenge in patients with panic disorder. Journal of Abnormal Psychology, 106, 630-638.
97. Schmidt, N. B., Woolaway-Bickel, K., Trakowski, J., Santiago, H., Storey, J., Koselka, M., & Cook, J. (2000). Dismantling cognitive-behavioral treatment for panic disorder: Questioning the utility of breathing retraining. Journal of Consulting and Clinical Psychology, 68, 417-424.
98. Simon, P. M., Schwartzstein, R. M., Weiss, J. W., Fencl, V., Teghtsoonian, M., & Weinberger, S. E. (1990). Distinguishable types of dyspnea in patients with shortness of breath. American Review of Respiratory Disease, 142, 1009-1014.
99. Sinha, S. S., Coplan, J. D., Pine, D. S., Martinez, J. A., Klein, D. F., & Gorman, J. M. (1999). Panic induced by carbon dioxide inhalation and lack of hypothalamic-pituitary-adrenal axis activation. Psychiatry Research, 86, 93-98.
100. Sinha, S., Papp, L. A., & Gorman, J. M. (2000). How study of respiratory physiology aided our understanding of abnormal brain function in panic disorder. Journal of Affective Disorders, 61, 191-200.
101. Sloan, R., Shapiro, P., Bagiella, E., Gorman, J., & Bigger, J. J. (1995). Temporal stability of heart period variability during a resting baseline and in response to psychological challenge. Psychophysiology, 32, 191-196.
102. Smoller, J., & Tsuang, M. (1998). Panic and phobic anxiety: Defining phenotypes for genetic studies. American Journal of Psychiatry, 155, 1152-1162.
103. Stein, M. B., Millar, T. W., Larsen, D. K., & Kryger, M. H. (1995). Irregular breathing patterns during sleep in patients with panic disorder. American Journal of Psychiatry, 152, 1168-1173.
104. Stein, M. B., & Rapee, R. M. (1999). Biological aspects of anxiety sensitivity: Is it all in the head? In S. Taylor (Ed.), Anxiety sensitivity: Theory, research, and treatment of the fear of anxiety (pp. 199-215). Mahwah, NJ: Erlbaum.
105. Ströhle, A., Kellner, M., Holsboer, F., & Wiedemann, K. (1999). Behavioral, neuroendocrine, and cardiovascular response to flumazenil: No evidence for an altered benzodiazepine receptor sensitivity in panic disorder. Biological Psychiatry, 45, 321-326.
106. Szasz, T. S. (1961). The myth of mental illness. New York: Dell.
107. Taylor, S. (Ed.). (1999). Anxiety sensitivity: Theory, research, and treatment of the fear of anxiety. Mahwah, NJ: Erlbaum.
108. Taylor, S., & Rachman, S. (1994). Klein's suffocation theory of panic [letter; comment]. Archives of General Psychiatry, 51, 505-506.
109. Uhde, T. W. (2000). Anxiety disorders. In T. R. W. D. M. Kryger (Ed.), Principles and practice of sleep medicine (3rd ed., pp. 1123-1139). Philadelphia: W. B. Saunders.
110. Vaitl, D. (1996). Interoception. Biological Psychology, 42, 1-27.
111. van Zijderveld, G., Veltman, D., van Dyck, R., & van Doornen, L. (1999). Epinephrine-induced panic attacks and hyperventilation. Journal of Psychiatry Research, 33, 73-78.
112. 2, respiratory pattern variability, and transfer function RSA. In J. Fahrenberg (Ed.), Progress in ambulatory assessment (pp. 313-343). Göttingen, Germany: Hogrefe & Huber.
113. Wilhelm, F. H., Gerlach, A. L., & Roth, W. T. (2001). Slow recovery from voluntary hyperventilation in panic disorder. Psychosomatic Medicine, 63, 638-649.
114. Wilhelm, F. H., & Margraf, J. (1997). A cognitive-behavioral treatment package for panic disorder with agoraphobia. In W. T. Roth (Ed.), Treating anxiety (pp. 205-244). San Francisco: Jossey-Bass.
115. Wilhelm, F. H., & Roth, W. T. (2001). The somatic symptom paradox in DSM-IV anxiety disorders: Suggestions for a clinical focus in psychophysiology. Biological Psychology, 57, 1-3.
116. Wilhelm, F. H., Trabert, W., & Roth, W. T. (2001 a). Characteristics of sighing in panic disorder. Biological Psychiatry, 49, 606-614.
117. Wilhelm, F. H., Trabert, W., & Roth, W. T. (2001 b). Physiological instability in panic disorder and generalized anxiety disorder. Biological Psychiatry, 49, 596-605.
118. Wolpe, J., & Rowan, V. C. (1988). Panic disorder: A product of classical conditioning. Behaviour Research and Therapy, 26, 441-450.
119. Zucker, D., Taylor, D. B., Brouillard, M., Ehlers, A., Margraf, J., Telch, M., et al. (1989). Cognitive aspects of panic attacks: Content, course, and relationship to laboratory Stressors. British Journal of Psychiatry, 155, 86-91.