Synthesis and evaluation of new ω-borono-α-amino acids as rat liver arginase inhibitors

Bioorganic and Medicinal Chemistry

Volumn 13, Issue 7, 2005, Pages 2373-2379

  Busnel, Olivier ^a   Carreaux, François ^a   Carboni, Bertrand ^a   Pethe, Stephanie ^b   Goff, Sandrine Vadon Le ^b   Mansuy, Daniel ^b   Boucher, Jean Luc ^b  

^a Campus de Beaulieu   (France)

^b UNIVERSITÉ PARIS DESCARTES   (France)

Author keywords

Boronic acids; Inhibitors; Rat liver arginase; Amino acids

Indexed keywords

2 AMINO 6 BORONOHEXANOIC ACID; 3 DIHYDROXYBORYL DEXTRO PHENYLALANINE; ALKYL GROUP; ALPHA AMINO ACID; AMINO ACID DERIVATIVE; ARGINASE; ARGINASE INHIBITOR; BORONIC ACID DERIVATIVE; ENZYME INHIBITOR; HYDROXIDE; METHYL 2 AMINO 3 [3 (5,5 DIMETHYL 1,3,2 DIOXABORAN 2 YL)PHENYL]PROPIONIC ACID; METHYL 2 [BENZYLOXYCARBONYLAMINO] 3 [3 (5,5 DIMETHYL 1,3,2 DIOXABORAN 2 YL)PHENYL]ACRYLIC ACID; METHYL GROUP; N [(TERT BUTYLOXY)CARBONYL)] S [(4,4,5,5 TETRAMETHYL 1,3,2 DIOXABOROLAN 2 YL)METHYL]HOMOCYSTEINE METHYL ESTER; N [(TERT BUTYLOXY)CARBONYL] S [(4,4,5,5 TETRAMETHYL 1,3,2 DIOXABOROLAN 2 YL)METHYL]CYSTEINE METHYL ESTER; N [(TERT BUTYLOXY)CARBONYL]CYSTINE METHYL ESTER; N [(TERT BUTYLOXY)CARBONYL]HOMOCYSTEINE METHYL ESTER; N,N' BIS[(TERT BUTYLOXY)CARBONYL]CYSTINE DIMETHYL ESTER; N,N' BIS[(TERT BUTYLOXY)CARBONYL]HOMOCYSTINE DIMETHYL ESTER; PHENYL GROUP; S (2 BORONOETHYL)CYSTEINE; S [(DIHYDROXYBORYL)METHYL]CYSTEINE; S [(DIHYDROXYBORYL)METHYL]HOMOCYSTEINE; S [2 DIHYDROXYBORYL)ETHYL] DEXTRO HOMOCYSTEINE; S [2 DIHYDROXYBORYL)ETHYL] DEXTRO PENICILLAMINE; S [2 METHYL 2 (DIHYDROXYBORYL)ETHYL]CYSTEINE; SULFUR; UNCLASSIFIED DRUG;

ADDITION REACTION; ALPHA CHAIN; AMINO ACID SUBSTITUTION; ANIMAL TISSUE; ARTICLE; BINDING AFFINITY; CONFORMATIONAL TRANSITION; CONTROLLED STUDY; DRUG SCREENING; DRUG SYNTHESIS; ENZYME ACTIVE SITE; ENZYME INHIBITION; ENZYME PURIFICATION; LIVER; MALE; MOLECULAR INTERACTION; NONHUMAN; PROTEIN FUNCTION; RAT; RING OPENING; STRUCTURE ANALYSIS; SUBSTITUTION REACTION;

EID: 14844309598     PISSN: 09680896     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bmc.2005.01.053     Document Type: Article

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