Maturation of cellular Fe-S proteins: An essential function of mitochondria

Trends in Biochemical Sciences

Volumn 25, Issue 8, 2000, Pages 352-356

  Lill, Roland ^a   Kispal, Gyula ^b  

^a PHILIPPS UNIVERSITY MARBURG   (Germany)

^b UNIVERSITY OF PÉCS   (Hungary)

Author keywords

[No Author keywords available]

Indexed keywords

ABC TRANSPORTER; CELL PROTEIN; IRON SULFUR PROTEIN;

ARTICLE; BIOSYNTHESIS; CATALYSIS; ELECTRON TRANSPORT; EUKARYOTE; GENE CONTROL; GENE EXPRESSION; MATURATION; MITOCHONDRION; PRIORITY JOURNAL;

EID: 0034255836     PISSN: 09680004     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0968-0004(00)01589-9     Document Type: Note

References (48)

1. Lill R.et al. The essential role of mitochondria in the biogenesis of cellular iron-sulfur proteins. Biol. Chem. 380:1999;1157-1166.
2. Craig E.A.et al. Mitochondrial iron metabolism in the yeast Saccharomyces cerevisiae. Biol. Chem. 380:1999;1167-1173.
3. Zheng L.et al. Assembly of iron-sulfur clusters. Identification of an iscSUA-hscBA-fdx gene cluster from Azotobacter vinelandii. J. Biol. Chem. 273:1998;13264-13272.
4. Dean D.R.et al. Nitrogenase metalloclusters: structures, organization and synthesis. J. Bacteriol. 175:1993;6737-6744.
5. Peters J.W.et al. Nitrogenase structure and function: a biochemical-genetic perspective. Annu. Rev. Microbiol. 49:1995;335-366.
6. Zheng L.et al. Cysteine desulfurase activity indicates a role for NifS in metallocluster biosynthesis. Proc. Natl. Acad. Sci. U. S. A. 90:1993;2754-2758.
7. Yuvaniyama P.et al. NifS-directed assembly of a transient [2Fe-2S] cluster within the NifU protein. Proc. Natl. Acad. Sci. U. S. A. 97:2000;599-604.
8. Hentze M.W., Kuhn L.C. Molecular control of vertebrate iron metabolism: mRNA-based regulatory circuits operated by iron, nitric oxide and oxidative stress. Proc. Natl. Acad. Sci. U. S. A. 93:1996;8175-8182.
9. Rouault T.A., Klausner R.D. Iron-sulfur clusters as biosensors of oxidants and iron. Trends Biochem. Sci. 21:1996;174-177.
10. Strain J.et al. Suppressors of superoxide dismutase (SOD1) deficiency in Saccharomyces cerevisiae. Identification of proteins predicted to mediate iron-sulfur cluster assembly. J. Biol. Chem. 273:1998;31138-31144.
11. Kispal G.et al. The mitochondrial proteins Atm1p and Nfs1p are required for biogenesis of cytosolic Fe/S proteins. EMBO J. 18:1999;3981-3989.
12. Zheng L.et al. Mechanism for the desulfurization of L-cysteine catalysed by the nifS gene product. Biochemistry. 33:1994;4714-4720.
13. Kaiser J.T.et al. Crystal structure of a NifS-like protein from Thermotoga maritima: implications for iron-sulfur cluster assembly. J. Mol. Biol. 297:1994;451-464.
14. Fujii T.et al. Structure of a NifS homologue: X-ray structure analysis of CsdB, an Escherichia coli counterpart of mammalian selenocysteine lyase. Biochemistry. 39:2000;1263-1273.
15. Schilke B.et al. Evidence for a conserved system for iron metabolism in the mitochondria of Saccharomyces cerevisiae. Proc. Natl. Acad. Sci. U. S. A. 96:1999;10206-10211.
16. Garland S.A.et al. Saccharomyces cerevisiae ISU1 and ISU2: members of a well-conserved gene family for iron-sulfur cluster assembly. J. Mol. Biol. 294:1999;897-907.
17. Fu W.et al. nifU gene product from Azotobacter vinelandii is a homodimer that contains two identical [2Fe-2S] clusters. Biochemistry. 33:1994;13455-13463.
18. Agar J.N.et al. Modular organization and identification of a mononuclear iron-binding site within the NifU protein. J. Biol. Inorg. Chem. 5:2000;167-177.
19. Barros M.H., Nobrega F.G. YAH1 of Saccharomyces cerevisiae: a new essential gene that codes for a protein homologous to human adrenodoxin. Gene. 233:1999;197-203.
20. Lange H.et al. A mitochondrial ferredoxin is essential for biogenesis of intra- and extra-mitochondrial Fe/S proteins. Proc. Natl. Acad. Sci. U. S. A. 97:2000;1050-1055.
21. Takahashi Y., Nakamura M. Functional assignment of the ORF2-iscS-iscU-iscA-hscB-hscA-fdx-ORF3 gene cluster involved in the assembly of Fe-S clusters in Escherichia coli. J. Biochem. 126:1999;917-926.
22. Lambeth J.D.et al. Steroidogenic electron transport in adrenal cortex mitochondria. Mol. Cell. Biochem. 45:1985;13-31.
23. Lacour T.et al. Characterization of recombinant adrenodoxin reductase homologue (Arh1p) from yeast. Implication in in vitro cytochrome p45011beta monooxygenase system. J. Biol. Chem. 273:1998;23984-23992.
24. Manzella L.et al. ARH1 of Saccharomyces cerevisiae: a new essential gene that codes for a protein homologous to the human adrenodoxin reductase. Yeast. 14:1998;839-846.
25. Kaut A.et al. Isa1p is a component of the mitochondrial machinery for maturation of cellular iron-sulfur proteins and requires conserved cysteine residues for function. J. Biol. Chem. 275:2000;15955-15961.
26. Jensen L.T., Culotta V.C. Role of Saccharomyces cerevisiae ISA1 and ISA2 in iron homeostasis. Mol. Cell. Biol. 20:2000;3918-3927.
27. Pelzer W.et al. Mitochondrial Isa2p plays a crucial role in the maturation of cellular iron-sulfur proteins. FEBS Lett. 476:2000;134-139.
28. Schilke B.et al. The cold sensitivity of a mutant of Saccharomyces cerevisiae lacking a mitochondrial heat shock protein 70 is suppressed by loss of mitochondrial DNA. J. Cell Biol. 134:1996;603-613.
29. Leighton J., Schatz G. An ABC transporter in the mitochondrial inner membrane is required for normal growth of yeast. EMBO J. 14:1995;188-195.
30. Kispal G.et al. The ABC transporter Atm1p is required for mitochondrial iron homeostasis. FEBS Lett. 418:1997;346-350.
31. Land T., Rouault T.A. Targeting of a human iron-sulfur cluster assembly enzyme, NifS, to different subcellular compartments is regulated through alternative AUG utilization. Mol. Cell. 2:1998;807-815.
32. Nakai Y.et al. cDNA cloning and characterization of mouse NifS-like protein, m-Nfs1: mitochondrial localization of eukaryotic NifS-like proteins. FEBS Lett. 433:1998;143-148.
33. Li J.et al. Yeast mitochondrial protein Nfs1p coordinately regulates iron-sulfur cluster proteins, cellular iron uptake and iron distribution. J. Biol. Chem. 274:1999;33025-33034.
34. Knight S.A.et al. Mt-Hsp70 homolog, Ssc2p, required for maturation of yeast frataxin and mitochondrial iron homeostasis. J. Biol. Chem. 273:1998;18389-18393.
35. Babcock M.et al. Regulation of mitochondrial iron accumulation by Yfh1p, a putative homolog of frataxin. Science. 276:1997;1709-1712.
36. Foury F., Cazzalini O. Deletion of the yeast homologue of the human gene associated with Friedreich's ataxia elicits iron accumulation in mitochondria. FEBS Lett. 411:1997;373-377.
37. Campuzano V.et al. Friedreich's ataxia: autosomal recessive disease caused by an intronic GAA triplet repeat expansion. Science. 271:1996;1423-1427.
38. Rötig A.et al. Aconitase and mitochondrial iron-sulphur protein deficiency in Friedreich ataxia. Nat. Genet. 17:1997;215-217.
39. Foury F. Low iron concentration and aconitase deficiency in a yeast frataxin homologue deficient strain. FEBS Lett. 456:1999;281-284.
40. Csere P.et al. Identification of a human mitochondrial ABC transporter, the functional orthologue of yeast Atm1p. FEBS Lett. 441:1998;266-270.
41. Allikmets R.et al. Mutation of a putative mitochondrial iron transporter gene (ABC7) in X-linked sideroblastic anemia and ataxia (XLSA/A). Hum. Mol. Genet. 8:1999;743-749.
42. Bekri, S. et al. The human ABC7 transporter: gene structure and mutation causing X-linked sideroblastic anemia with ataxia (XLSA/A) with disruption of cytosolic iron-sulfur protein maturation. Blood (in press).
43. Merchant S., Dreyfuss B.W. Post-translational assembly of photosynthetic metalloproteins. Annu. Rev. Plant Physiol. Plant Mol. Biol. 49:1998;25-51.
44. Jaschkowitz K., Seidler A. Role of a NifS-like protein from the cyanobacterium Synechocystis PCC 6803 in the maturation of FeS proteins. Biochemistry. 39:2000;3416-3423.
45. Leibrecht I., Kessler D. A novel L-cysteine/cystine C-S-lyase directing [2Fe-2S] cluster formation of Synechocystis ferredoxin. J. Biol. Chem. 272:1997;10442-10447.
46. Lang T., Kessler D. Evidence for cysteine persulfide as reaction product of L-cyst(e)ine C-S-lyase (C-DES) from Synechocystis. Analyses using cystine analogues and recombinant C-DES. J. Biol. Chem. 274:1999;189-195.
47. Clausen T.et al. Crystal structure of the cystine C-S lyase from Synechocystis: stabilization of cysteine persulfide for FeS cluster assembly. Proc. Natl. Acad. Sci. U. S. A. 97:2000;3856-3861.
48. Andersson S.G.et al. The genome sequence of Rickettsia prowazekii and the origin of mitochondria. Nature. 396:1998;133-140.