Enhanced resistance to Cryptococcus neoformans infection induced by chloroquine in a murine model of meningoencephalitis

Antimicrobial Agents and Chemotherapy

Volumn 41, Issue 4, 1997, Pages 802-807

  Mazzolla, Rosanna ^a   Barluzzi, Roberta ^a   Brozzetti, Annalisa ^a   Boelaert, Johan R ^b   Luna, Tamara ^a   Saleppico, Silvia ^a   Bistoni, Francesco ^a   Blasi, Elisabetta ^a,c  

^a UNIVERSITY OF PERUGIA   (Italy)

^b General Hospital St Jan   (Belgium)

^c UNIVERSITY OF MODENA AND REGGIO EMILIA   (Italy)

Author keywords

[No Author keywords available]

Indexed keywords

CHLOROQUINE;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANTIFUNGAL ACTIVITY; ARTICLE; ASTROCYTE; CELL PH; CRYPTOCOCCUS NEOFORMANS; DRUG EFFECT; ENZYME ACTIVITY; FEMALE; FUNGAL MENINGITIS; HOST RESISTANCE; IMMUNOSTIMULATION; INFECTION RESISTANCE; INTRACEREBRAL DRUG ADMINISTRATION; MICROGLIA; MOUSE; NONHUMAN; OPSONIZATION; PRIORITY JOURNAL; PROTEIN DEGRADATION;

EID: 0030939636     PISSN: 00664804     EISSN: None     Source Type: Journal    
DOI: 10.1128/aac.41.4.802     Document Type: Article

References (45)

1. Blasi, E., R. Barluzzi, V. Bocchini, R. Mazzolla, and F. Bistoni. 1990. Immortalization of murine microglial cells by a v-raf/v-myc carrying retrovirus. J. Neuroimmunol. 27:229-237.
2. Blasi, E., R. Barluzzi, R. Mazzolla, and F. Bistoni. 1993. Differential host susceptibility to intracerebral infections with Candida albicans and Cryptococcus neoformans. Infect. Immun. 61:3476-3481.
3. Blasi, E., R. Barluzzi, R. Mazzolla, P. Mosci, and F. Bistoni. 1992. Experimental model of intracerebral infection with Cryptococcus neoformans. Roles of phagocytes and opsonization. Infect. Immun. 60:3682-3688.
4. Blasi, E., R. Barluzzi, R. Mazzolla, L. Pitzurra, M. Puliti, S. Saleppico, and F. Bistoni. 1995. Biomolecular events involved in anticryptococcal resistance in the brain. Infect. Immun. 63:1218-1222.
5. Blasi, E., R. Barluzzi, R. Mazzolla, B. Tancini, S. Saleppico, M. Puliti, L. Pitzurra, and K. Bistoni. 1995. Role of nitric oxide and melanogenesis in the accomplishment of anticryptococcal activity by the BV-2 microglial cell-line. J. Neuroimmunol. 58:111-116.
6. Blasi, E., A. Bartoli, R. Barluzzi, R. Mazzolla, and F. Bistoni. 1994. Pattern of cytokine gone expression in brains of mice protected by picolinic acid against lethal intracerebral infection with Candida albicans. J. Neuroimmunol. 52:205-213.
7. Blasi, E., R. Mazzolla, R. Barluzzi, P. Mosci, A. Bartoli, and F. Bistoni. 1991. Intracerebral transfer of an in vitro established microglial cell line: local induction of a protective state against lethal challenge with Candida albicans. J. Neuroimmunol. 32:249-257.
8. Blast, E., R. Mazzolla, R. Barluzzi, P. Mosci, and F. Bistoni. 1994. Anticryptococcal resistance in the mouse brain: beneficial effects of local administration of heat-inactivated yeast cells. Infect. Immun. 62:3189-3196.
9. Blasi, E., R. Mazzolla, L. Pitzurra, R. Barluzzi, and F. Bistoni. 1993. Protective effect of picolinic acid on mice intracerebrally infected with lethal doses of Candida albicans. Antimicrob. Agents Chemother. 37:2422-2426.
10. Blasi, E., M. Puliti, L. Pitzurra, R. Barluzzi, R. Mazzolla, C. Adami, G. W. Cox, and F. Bistoni. 1994. Comparative studies on functional and secretory properties of macrophages cell lines derived from different anatomical sites. FEMS Immunol. Med. Microbiol. 9:207-216.
11. Buchmüller-Rouiller, Y., S. B. Corradin, J. Smith, and J. Navël. 1994. Effect of increasing intravesicular pH on nitrite production and leishmanicidal activity of activated macrophages. Biochem. J. 301:243-247.
12. Byrd, T. F., and M. A. Horwitz. 1991. Chloroquine inhibits the intracellular multiplication of Legionella pneumophila by limiting the availability of iron. J. Clin. Invest. 88:351-357.
13. Chao, C. C., S. Hu, G. Gekker, W. J. Novick, Jr., J. S. Remington, and P. K. Peterson. 1993. Effects of cytokines on multiplication of Toxoplasma gondii in microglial cells. J. Immunol. 150:3404-3410.
14. Chao, C. C., S. Hu, T. W. Molitor, E. G. Shaskan, and P. K. Peterson. 1992 Activated microglia mediate neuronal cell injury via a nitric oxide mechanism. J. Immunol. 149:2736-2741.
15. Chomczynski, P., and N. Sacchi. 1987. Single-step method of RNA isolation by acid guanidium thiocyanate-phenol-chloroform extraction. Anal. Biochem. 162:156-159.
16. Chuck, S. L., and M. A. Sande. 1989. Infection with Cryptococcus neoformans in the acquired immunodeficiency syndrome. N. Engl. J. Med. 321:794-799.
17. Connolly, K. M., V. J. Stecher, E. Danis, D. J. Pruden, and T. La Brie. 1988. Alteration of interleukin-1 activity and the acute phase response in adjuvant arthritic rats treated with disease modifying anti-rheumatic drugs. Agents Actions 25:94-105.
18. 3. Antimicrob. Agents Chemother. 34:2217-2222.
19. Ertel, W., M. H. Morrison, A. Ayala, and I. H. Chaudry. 1991. Chloroquine attenuates haemorrhagic shock-induced suppression of Kupffer cell antigen presentation and major histocompatibility complex class II expression though blockade of tumor necrosis factor and prostaglandin release. Blood 78:1781-1788.
20. Fabry, Z., C. S. Raine, and M. N. Hart. 1994. Nervous tissue as an immune compartment: the dialect of the immune response in the CNS Immunol. Today 15:218-224.
21. Fierz, W., B. Endler, K. Reske, H. Wekerle, and A. Fontana. 1985. Astrocytes as antigen-presenting cells. Induction of Ia antigen on astrocytes by T cells via immune Interferon and its effect on antigen presentation. J. Immunol. 134:3785-3790.
22. Fontana, A., K. Frei, S. Bodmer, and E. Hofer. 1987 Immune-mediated encephalitis: on the role of antigen-presenting cells in brain tissue. Immun. Rev. 100:185-201.
23. Frei, K., U. V. Malpiero, T. P. Leist, R. M. Zinkernagel, M. E. Schwab, and A. Fontana. 1989. On the cellular source and function of interleukin 6 produced in the central nervous system in viral diseases. Eur. J. Immunol. 19:689-694.
24. Frei, K., C. Siepl, P. Groscurth, S. Bodmer, C. Schwerdel, and A. Fontana. 1987. Antigen presentation and tumor cytoloxicity by interferon-gamma-treated microglial cells. Eur. J. Immunol. 17:1271-1278.
25. 3H-chloroquine by drug-sensitive acid-resistant strain of the human malaria parasite Plasmodium falciparum. Biochem. Pharmacol. 35:3805-3812.
26. Giulian, D. 1987. Ameboid microglia as effectors of inflammation in the central nervous system. J. Neurosci. Res. 18:155-171.
27. Giulian, D., J. Baker, L. N. Shih, and L. B. Lachman. 1986. Interleukin-1 of the central nervous system is produced by ameboid microglia. J. Exp. Med. 164:594-604.
28. Hidore, M. R., N. Nabavi, F. Sonleitner, and J. W. Murphy. 1991. Murine natural killer cells are fungicidal to Cryptococcus neoformans. Infect. Immun. 59:1747-1754.
29. + T-cell-dependent acquired state of immunity that protects the brain against Cryptococcus neoformans. Infect. Immun. 59:1747-1754.
30. Jensen, P. E. 1988. Protein synthesis in antigen processing. J. Immunol. 141:2545-2550.
31. Krogstad, D. J., and P. H. Schlesinger. 1987. Acid-vesicle function, intracellular pathogens and the action of chloroquine against Plasmodium fatcipanum. N. Engl. J. Med. 317:542-549.
32. Lee, S. C., D. W. Dickson, C. F. Brosnan, and A. Casadevall. 1994. Human astrocytes inhibit Cryptococcus neoformans growth by a nitric oxide-mediated mechanism. J. Exp. Med. 180:365-369.
33. Lieberman, A. P., P. M. Pitha, H. S. Shin, and M. L. Shin. 1989. Production of tumor necrosis factor and other cytokines by astrocytes stimulated with lipopolysaccharide or a neurotropic virus. Proc. Natl. Acad. Sci. USA 86: 6348-6356.
34. Miller, M. F., and T. G. Mitchell. 1991. Killing of Cryptococcus neoformans strains by human neutrophils and monocytes. Infect. Immun. 59:24-28.
35. + (L3T4) lymphocytes in vivo impairs murine host defense to Cryptococcus neoformans. J. Immunol. 144:1472-1477.
36. Murphy, J. W. 1988. Influence of cryptococcal antigens on cell-mediated immunity. Rev. Infect. Dis. 10:5432-5435.
37. Newman, S. L., L. Gooteel, G. Brunner, and G. S. Deepe, Jr. 1994. Chloroquine induces human macrophage killing of Histoplasma capsulatum by limiting the availability of intracellular iron and is therapeutic in a murine model of histoplasmosis. J. Clin. Invest. 93:1422-1429.
38. Pietroski, N. A., D. Pharm, and J. J. Stern. 1990. Cryptococcal meningitis and other fungal infections of the central nervous system. Curr. Opin. Infect. Dis. 3:608-613.
39. Poole, B., and S. Ohkuma. 1981. Effect of weak bases on the intralysosomal pH in mouse peritoneal macrophages. J. Cell Biol. 90:665-669.
40. Seglen, P. O. 1983. Inhibitors of lysosomal function. Methods Enzymol. 96:737-747.
41. Sperber, K., T. H. Kalb, V. J. Stecher, R. Banerjee, and L. Mayer. 1993. Inhibition of human immunodeficiency virus type 1 replication by hydroxychloroquine in T cells and monocytes. AIDS Res. Hum. Retroviruses 9:91-98.
42. Titus, E. O. 1989. Recent developments in the understanding of the pharmacokinetics and mechanism of action of chloroquine. Ther. Drug Monit. 11:369-379.
43. Watabe, K., D. Osborne, and K. Su. 1989. Phagocytic activity of human adult astrocytes and oligodendrocytes in culture. J. Neuropathol. Exp. Neurol. 48:499-506.
44. Wernsdorfer, W. H., and D. Payne. 1991. The dynamics of drug resistance in Plasmodium falciparum. Pharmacol. Ther. 50:95-121.
45. Zielasek, J. M., M. Tausch, K. V. Toyka, and H. P. Hartung. 1992. Production of nitrite by neonatal rat microglial cells/brain macrophages. Cell. Immunol. 141:111-120.