Chloroquine and the fungal phagosome

Current Opinion in Microbiology

Volumn 3, Issue 4, 2000, Pages 349-353

  Weber, Stephen M ^a   Levitz, Stuart M ^a   Harrison, Thomas S ^b  

^a BOSTON UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b ST GEORGE'S UNIVERSITY OF LONDON   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

ANTIMALARIAL AGENT; CHLOROQUINE; IRON;

ANIMAL MODEL; ANTIFUNGAL ACTIVITY; CRYPTOCOCCUS NEOFORMANS; DRUG EFFECT; DRUG MECHANISM; HISTOPLASMA CAPSULATUM; INFLAMMATION; MONONUCLEAR PHAGOCYTE; MYCOSIS; NONHUMAN; PHAGOSOME; REVIEW;

EID: 0033903288     PISSN: 13695274     EISSN: None     Source Type: Journal    
DOI: 10.1016/S1369-5274(00)00102-8     Document Type: Review

References (31)

1. 4-Aminoquinolines - Past, present, and future: A chemical perspective
2. Chloroquine inhibits the intracellular multiplication of Legionella pneumophila by limiting the availability of iron. A potential new mechanism for the therapeutic effect of chloroquine against intracellular pathogens
3. Growth of Francisella tularensis LVS in macrophages: The acidic intracellular compartment provides essential iron required for growth
4. Chloroquine induces human macrophage killing of Histoplasma capsulatum by limiting the availability of intracellular iron and is therapeutic in a murine model of histoplasmosis
5. Histoplasma capsulatum modulates the acidification of phagolysosomes
6. Regulation of the macrophage vacuolar ATPase and phagosome-lysosome fusion by Histoplasma capsulatum
7. Cloning and sequence analysis of an H(+)-ATPase-encoding gene from the human dimorphic pathogen Histoplasma capsulatum
8. Inhibition of growth of Histoplasma capsulatum yeast cells in human macrophages by the iron chelator VUF 8514 and comparison of VUF 8514 with deferoxamine
9. Iron limitation and the gamma interferon-mediated antihistoplasma state of murine macrophages
10. Inhibition of intracellular growth of Histoplasma capsulatum yeast cells by cytokine-activated human monocytes and macrophages
11. Chloroquine induces human mononuclear phagocytes to inhibit and kill Cryptococcus neoformans by a mechanism independent of iron deprivation
12. Enhanced resistance to Cryptococcus neoformans infection induced by chloroquine in a murine model of meningoencephalitis
13. Cryptococcus neoformans resides in an acidic phagolysosome of human macrophages
14. Conditional lethality of the diprotic weak bases chloroquine and quinacrine against Cryptococcus neoformans
15. Susceptibility of melanized and nonmelanized Cryptococcus neoformans to the melanin-binding compounds trifluoperazine and chloroquine
16. Acidification of the lysosome-like vacuole and the vacuolar H+-ATPase are deficient in two yeast mutants that fail to sort vacuolar proteins
17. Disruption of genes encoding subunits of yeast vacuolar H(+)-ATPase causes conditional lethality
18. Calcineurin is required for virulence of Cryptococcus neoformans
19. Sensitivity of yeast glycolytic enzymes to chloroquine
20. Uptake of chloroquine and hydroxychloroquine by human blood leucocytes in vitro: Relation to cellular concentrations during antirheumatic therapy
21. Animal toxicity and pharmacokinetics of hydroxychloroquine sulfate
22. Chloroquine inhibits macrophage tumour necrosis factor-alpha mRNA transcription
23. Inhibition of human immunodeficiency virus type 1 replication by hydroxychloroquine in T cells and monocytes
24. Hydroxychloroquine treatment of patients with human immunodeficiency virus type 1
25. The preferential inhibition of Bacillus subtilis spore outgrowth by chloroquine
26. The effect of pH on the inhibitory activity of chloroquine against Escherichia coli
27. Effect of quinacrine, chloroquine and primaquine on the multiplication of Mycobacterium leprae in mice
28. Inhibition of tubercle bacilli in cultured human macrophages by chloroquine used alone and in combination with streptomycin, isoniazid, pyrazinamide, and two metabolites of vitamin D3
29. Inhibition of the Salmonella typhi oral vaccine strain, Ty21a, by mefloquine and chloroquine
30. Antimicrobial activities of mefloquine and a series of related compounds
31. Chloroquine interferes with lipopolysaccharide-induced TNFα gene expression by a non-lysosomotrophic mechanism