Protective of the isoflavonoid equol against hairless mouse skin carcinogenesis induced by UV radiation alone or with a chemical cocarcinogen

Photochemistry and Photobiology

Volumn 81, Issue 1, 2005, Pages 32-37

  Widyarini, Sitarina ^a   Husband, Alan J ^a   Reeve, Vivienne E ^a  

^a UNIVERSITY OF SYDNEY   (Australia)

Author keywords

[No Author keywords available]

Indexed keywords

BIOLOGICAL MARKER; COCARCINOGEN; DIMETHYLBENZ[A]ANTHRACENE; EQUOL; GENISTEIN; ISOFLAVONOID; ORNITHINE DECARBOXYLASE; CARCINOGEN; FLAVONOID;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ANTINEOPLASTIC ACTIVITY; ANTIOXIDANT ACTIVITY; CANCER INHIBITION; CONFERENCE PAPER; CONTROLLED STUDY; ESTROGEN ACTIVITY; FEMALE; MOUSE; NONHUMAN; NUDE MOUSE; SKIN CARCINOGENESIS; SOYBEAN; SQUAMOUS CELL CARCINOMA; TUMOR GROWTH; TUMOR PROMOTION; ULTRAVIOLET RADIATION; ANIMAL; ARTICLE; CHEMICALLY INDUCED DISORDER; CLASSIFICATION; COCARCINOGENESIS; ENZYMOLOGY; HAIRLESS MOUSE; METABOLISM; RADIATION INJURY; SKIN; SKIN TUMOR;

GLYCINE MAX; MUS MUSCULUS;

ANIMALS; CARCINOGENS; COCARCINOGENESIS; FEMALE; FLAVONOIDS; MICE; MICE, INBRED HRS; NEOPLASMS, RADIATION-INDUCED; ORNITHINE DECARBOXYLASE; SKIN; SKIN NEOPLASMS;

EID: 14744269668     PISSN: 00318655     EISSN: None     Source Type: Journal    
DOI: 10.1562/2004-06-02-RA-183.1     Document Type: Conference Paper

References (29)

1. Aldercreutz, H. (1995) Phytoestrogens: epidemiology and possible role in cancer protection. Environ. Health Perspect. 103 (Suppl. 7), 103-112.
2. Akiyama, T., J. Ishida, S. Nakagawa, H. Ogawara, S. Watanabe, N. Itoh, M. Shibuya and Y. Fukami (1987) Genistein, a specific inhibitor of tyrosine-specific protein kinases. J. Biol. Chem. 262, 5592-5595.
3. Tham, D. M., C. D. Gardner and W. L. Haskell (1998) Potential health benefits of dietary phytoestrogens: a review of the clinical, epidemiological, and mechanistic evidence. J. Clin. Endocrinol. Metab. 83, 2223-2235.
4. Cay, Q. Y. and H. C. Wei (1996) Effect of dietary genistein on antioxidant enzyme activities in Sencar mice. Nutr. Cancer 25, 1-7.
5. Widyarini, S., N. Spinks, A. J. Husband, and V. E. Reeve (2001) Isoflavonoid compounds from red clover (Trifolium pratense) protect from inflammation and immune suppression induced by UV radiation. Photochem. Photobiol. 74, 465-470.
6. Kripke, M. L. (1994) Ultraviolet radiation and immunology: something new under the sun-presidential address. Cancer Res. 54, 6102-6105.
7. Yuspa, S. H. and A. A. Dlugosz (1991) Cutaneous carcinogenesis: natural and experimental. In Physiology, Biochemistry, and Molecular Biology of the Skin (Edited by L. A. Goldsmith), pp. 1365-1389. Oxford University Press, New York.
8. Epstein, J. H. (1989) Photocarcinogenesis, skin cancer, and aging. In Aging and the Skin (Edited by A. K. Balin and A. M. Kligman), pp. 307-325. Raven Press, New York.
9. Dipple, A. (1988) Formation, metabolism, and mechanism of action of polycyclic aromatic hydrocarbons. Cancer Res. 48 (Suppl.), 24225-24253.
10. Stenback, F. (1975) Studies on the modifying effect of UV radiation on chemical skin carcinogenesis. J. Investig. Dermatol. 64, 235-257.
11. Reeve, V. E., M. Bosnic and C. Boehm-Wilcox (1990) Effect of ultraviolet (UV) radiation and UVB-absorbing sunscreen ingredients on 7,12-dimethylbenz(a) anthracene-initiated skin tumorigenesis in hairless mice. Photodermatol. Photoimmunol. Photomed. 7, 222-221.
12. Gensler, H. L. (1988) Enhancement of chemical carcinogenesis in mice by systemic effects of ultraviolet irradiation. Cancer Res. 48, 620-623.
13. Gensler, H. L. (1989) Prevention of chemically induced two-stage skin carcinogenesis in mice by systemic effects of ultraviolet irradiation. Carcinogenesis 9, 767-769.
14. Das, M., D. R. Bickers, R. M. Santella and H. Mukhtar (1985) Altered patterns of cutaneous xenobiotic metabolism in UVB-induced squamous cell carcinoma in Skh-1 mice. J. Investig. Dermatol. 84, 532-536.
15. Verma, A. K., C. L. Ashendel and R. K. Boutwell (1980) Inhibition by prostaglandin synthesis inhibitors of the induction of epidermal ornithine decarboxylase activity, the accumulation of prostaglandins, and tumor promotion caused by 12-O-tetradecanoyl-phorbol-13 acetate. Cancer Res. 40, 308-316.
16. Miller, C. C., P. Hale and A. P. Pentland (1994) Ultraviolet B injury increases prostaglandin synthesis through a tyrosine kinase-dependent pathway. Am. Soc. Biochem. Mol. Biol. 269, 3529-3553.
17. Majumdar, A. P. N. (1990) Role of tyrosine kinases in gastrin induction of ornithine decarboxylase in colonic mucosa. Am. J. Physiol. 259, G626-G630.
18. Canfield, P. J., G. E. Greenoak, E. N. Macasaet, V. E. Reeve and C. H. Gallagher (1988) The characterization of squamous cell carcinoma induced by ultraviolet irradiation in hairless mice. Pathology 20, 109-117.
19. Gallagher, C. H., P. J. Canfield, G. E. Greenoak and V. E. Reeve (1984) Characterization and histogenesis of tumours in hairless mouse produced by low-dosage incremental ultraviolet radiation. J. Investig. Dermatol. 83, 169-174.
20. O'Brien, T. G. (1976) The induction of ornithine decarboxylase as an early possible obligatory event in mouse skin carcinogenesis. Cancer Res. 36, 2644-2653.
21. 14C)-ornithine. Polyamine protocols. Methods Mol. Biol. 2, 41-44.
22. Lowry, O. H., N. J. Rosenbrough, A. L. Fair and R. J. Randall (1951). Protein measurement with the folin phenol reagent. J. Biol. Chem. 193, 265-275.
23. Chae, Y. H., C. B. Marcus, D. K. Ho, J. M. Cassady and W. M. Baird (1991) Effects of synthetic and naturally occurring flavonoids on benzo(a)pyrene metabolism by hepatic microsomes prepared from rat treated with cytochrome P-450. Cancer Lett. 60, 15-24.
24. Tyrrell, R. M. (1996) Oxidant, antioxidant status and photocarcinogenesis: the role of gene activation. Photochem. Photobiol. 63, 381-382.
25. Wei, H., Q. Cai and R. O. Rahn (1996) Inhibition of UV light-and Fenton reaction-induced oxidative DNA damage by the soybean isoflavone genistein. Carcinogenesis 17, 73-77.
26. Tseng, C. P. and A. K. Verma (1996) Inhibition of 12-O- tetradecanoylphorbol-13-acetate-induced ornithine decarboxylase activity by genistein, a tyrosine kinase inhibitor. Mol. Pharmacol. 50, 249-257.
27. Wei, H., R. Bowen, X. Zhang and M. Lebwohl (1998) Isoflavone genistein inhibits the initiation and promotion of two-stage skin carcinogenesis in mice. Carcinogenesis 19, 1509-1514.
28. Birt, D. F., D. Mitchell, B. Gold, P. Pour and H. C. Pinch (1997) Inhibition of ultraviolet light induced skin carcinogenesis in SKH-1 mice by apigenin, a plant flavonoid. Anticancer Res. 17, 85-91.
29. Cai, Q. and H. Wei (1996) Effect of dietary genistein on antioxidant enzyme activities in SENCAR mice. Nutr. Cancer 25, 1-7.