Anal fissure: The changing management of a surgical condition

Langenbeck's Archives of Surgery

Volumn 390, Issue 1, 2005, Pages 1-7

  Acheson, A G ^a,b   Scholefield, J H ^a  

^a QUEEN S MEDICAL CENTRE   (United Kingdom)

^b NONE   (United Kingdom)

Author keywords

Botulinum toxin; Chronic anal fissure; Diltiazem; Glyceryl trinitrate; Nifedipine; Sphincterotomy

Indexed keywords

ARGININE; BETHANECHOL; BOTULINUM TOXIN; CALCIUM CHANNEL BLOCKING AGENT; CARBACHOL; DILTIAZEM; GLYCERYL TRINITRATE; INDORAMIN; NIFEDIPINE; NITRATE; SALBUTAMOL;

ANUS FISSURE; ANUS SPHINCTER; BLOOD FLOW; CLINICAL TRIAL; DEFECATION; DIET; DISEASE CLASSIFICATION; DISEASE SEVERITY; DRUG EFFECT; DRUG EFFICACY; DRUG MECHANISM; DRUG SCREENING; DRUG USE; FECES INCONTINENCE; FOLLOW UP; HEADACHE; HEALING; HUMAN; INJECTION; MORBIDITY; MUSCLE RELAXATION; PAIN; POSTOPERATIVE COMPLICATION; PRIORITY JOURNAL; RECURRENCE RISK; RECURRENT DISEASE; REVIEW; SEX DIFFERENCE; SIDE EFFECT; SMOOTH MUSCLE; SPHINCTEROTOMY; SURGICAL PATIENT; SURGICAL TECHNIQUE; SYMPTOM; TREATMENT OUTCOME;

ALGORITHMS; ANAL CANAL; BOTULINUM TOXINS; CALCIUM CHANNEL BLOCKERS; FISSURE IN ANO; HUMANS; NITROGLYCERIN; PRESSURE;

EID: 14644425436     PISSN: 14352443     EISSN: None     Source Type: Journal    
DOI: 10.1007/s00423-003-0430-2     Document Type: Review

References (70)

1. Goligher J (1984) Surgery of the anus, rectum and colon. Bialliere Tindall, London
2. Lock MR, Thomson JP (1977) Fissure-in-ano: the initial management and prognosis. Br J Surg 64:355-358
3. McDonald P, Driscoll AM, Nicholls RJ (1983) The anal dilator in the conservative management of acute anal fissures. Br J Surg 70:25-26
4. Gibbons CP, Read NW (1986) Anal hypertonia in fissures: cause or effect? Br J Surg 73:443-445
5. Hancock BD (1977) The internal sphincter and anal fissure. Br J Surg 64:92-95
6. Nothmann BJ, Schuster MM (1974) Internal anal sphincter derangement with anal fissures. Gastroenterology 67:216-220
7. Klosterhalfen B, Vogel P, Rixen H, Mittermayer C (1989) Topography of the inferior rectal artery: a possible cause of chronic, primary anal fissure. Dis Colon Rectum 32:43-52
8. Lund JN, Binch C, McGrath J, Sparrow RA, Scholefield JH (1999) Topographical distribution of blood supply to the anal canal. Br J Surg 86:496-498
9. Schouten WR, Briel JW, Auwerda JJ (1994) Relationship between anal pressure and anodermal blood flow. The vascular pathogenesis of anal fissures. Dis Colon Rectum 37:664-669
10. Jensen SL (1988) Diet and other risk factors for fissure-in-ano. Prospective case control study. Dis Colon Rectum 31:770-773
11. Khubchandani IT, Reed JF (1989) Sequelae of internal sphincterotomy for chronic fissure in ano. Br J Surg 76:431-434
12. Pernikoff BJ, Eisenstat TE, Rubin RJ, Oliver GC, Salvati EP (1994) Reappraisal of partial lateral internal sphincterotomy. Dis Colon Rectum 37:1291-1295
13. Jost WH (1997) One hundred cases of anal fissure treated with botulin toxin: early and long-term results. Dis Colon Rectum 40:1029-1232
14. Jonas M, Neal KR, Abercrombie JF, Scholefield JH (2001) A randomized trial of oral vs. topical diltiazem for chronic anal fissures. Dis Colon Rectum 44:1074-1078
15. Lund JN, Scholefield JH (1997) A randomised, prospective, double-blind, placebo-controlled trial of glyceryl trinitrate ointment in treatment of anal fissure. Lancet 349:11-14
16. Jonas M, Lobo DN, Gudgeon AM (1999) Lateral internal sphincterotomy is not redundant in the era of glyceryl trinitrate therapy for chronic anal fissure. J R Soc Med 92:186-188
17. Loder PB, Kamm MA, Nicholls RJ, Phillips RK (1994) 'Reversible chemical sphincterotomy' by local application of glyceryl trinitrate. Br J Surg 81:1386-1389
18. Gorfine SR (1995) Topical nitroglycerin therapy for anal fissures and ulcers. N Engl J Med 333:1156-1157
19. Lund JN, Armitage NC, Scholefield JH (1996) Use of glyceryl trinitrate ointment in the treatment of anal fissure. Br J Surg 83:776-7777
20. Schouten WR, Briel JW, Auwerda JJ, Boerma MO, Graatsma BH, Wilms EB (1995) Intra-anal application of isosorbide dinitrate in chronic anal fissure. Ned Tijdschr Geneeskd 139:1447-1449
21. Schouten WR, Briel JW, Boerma MO, Auwerda JJ, Wilms EB, Graatsma BH (1996) Pathophysiological aspects and clinical outcome of intra-anal application of isosorbide dinitrate in patients with chronic anal fissure. Gut 39:465-469
22. Bacher H, Mischinger HJ, Werkgartner G, Cerwenka H, El-Shabrawi A, Pfeifer J, et al. (1997) Local nitroglycerin for treatment of anal fissures: an alternative to lateral sphincterotomy? Dis Colon Rectum 40:840-845
23. Carapeti EA, Kamm MA, McDonald PJ, Chadwick SJ, Melville D, Phillips RK (1999) Randomised controlled trial shows that glyceryl trinitrate heals anal fissures, higher doses are not more effective, and there is a high recurrence rate. Gut 44:727-730
24. Chaudhuri S, Pal AK, Acharya A, Dey A, Chowdhury A, Santra A, et al. (2001) Treatment of chronic anal fissure with topical glyceryl trinitrate: a double-blind, placebo-controlled trial. Indian J Gastroenterol 20:101-102
25. Oettle GJ (1997) Glyceryl trinitrate vs. sphincterotomy for treatment of chronic fissure-in-ano: a randomized, controlled trial. Dis Colon Rectum 40:1318-1320
26. Altomare DF, Rinaldi M, Milito G, Arcana F, Spinelli F, Nardelli N, et al. (2000) Glyceryl trinitrate for chronic anal fissure - healing or headache? Results of a multicenter, randomized, placebo-controlled, double-blind trial. Dis Colon Rectum 43:174-179; discussion 179-181
27. Beck D, Rafferty J, Yee L, Binderow S, Group FS (2000) GTN paste as a treatment for anal fissure. Dis Colon Rectum 43:A35
28. Hasegawa H, Radley S, Morton DG, Dorricott NJ, Campbell DJ, Keighley MR (2000) Audit of topical glyceryl trinitrate for treatment of fissure-in-ano. Ann R Coll Surg Engl 82:27-30
29. Hyman NH, Cataldo PA (1999) Nitroglycerin ointment for anal fissures: effective treatment or just a headache? Dis Colon Rectum 42:383-385
30. Watson SJ, Kamm MA, Nicholls RJ, Phillips RK (1996) Topical glyceryl trinitrate in the treatment of chronic anal fissure. Br J Surg 83:771-775
31. Libertiny G, Farouk R (1999) How long is topical 0.2% GTN effective for? (abstract). Colorectal Dis 1 [Suppl 1]:54
32. Lund JN, Parsons SL, Scholefield JH (1996) Spasm of the internal anal sphincter in anal fissure - cause or effect? (abstract). Gastroenterology 110:A711
33. Lund JN, Scholefield JH (1998) Follow-up of patients with chronic anal fissure treated with topical glyceryl trinitrate. Lancet 352:1681
34. Griffin N, Zimmerman DD, Briel JW, Gruss HJ, Jonas M, Acheson AG, et al. (2002) Topical L-arginine gel lowers resting anal pressure: possible treatment for anal fissure. Dis Colon Rectum 45:1332-1336
35. Hechtman HB, Barlow C (1996) Moderation of anal sphincter tone with nitric oxide agonists and antagonists. Arch Surg 131:775-784
36. Jankovic J, Brin MF (1991) Therapeutic uses of botulinum toxin. N Engl J Med 324:1186-1194
37. Munchau A, Bhatia KP (2000) Uses of botulinum toxin injection in medicine today. BMJ 320:161-165
38. Jost WH, Schimrigk K (1993) Use of botulinum toxin in anal fissure. Dis Colon Rectum 36:974
39. Jost WH, Schimrigk K (1995) Botulinum toxin in therapy of anal fissure. Lancet 345:188-189
40. Brisinda G, Maria G, Bentivoglio AR, Cassetta E, Gui D, Albanese A (1999) A comparison of injections of botulinum toxin and topical nitroglycerin ointment for the treatment of chronic anal fissure. N Engl J Med 341:65-69
41. Gui D, Cassetta E, Anastasio G, Bentivoglio AR, Maria G, Albanese A (1994) Botulinum toxin for chronic anal fissure. Lancet 344:1127-1128
42. Maria G, Brisinda G, Bentivoglio AR, Cassetta E, Gui D, Albanese A (1998) Botulinum toxin injections in the internal anal sphincter for the treatment of chronic anal fissure: long-term results after two different dosage regimens. Ann Surg 228:664-669
43. Maria G, Cassetta E, Gui D, Brisinda G, Bentivoglio AR, Albanese A (1998) A comparison of botulinum toxin and saline for the treatment of chronic anal fissure. N Engl J Med 338:217-220
44. Maria G, Brisinda G, Bentivoglio AR, Cassetta E, Gui D, Albanese A (2000) Influence of botulinum toxin site of injections on healing rate in patients with chronic anal fissure. Am J Surg 179:46-50
45. Mason PF, Watkins MJ, Hall HS, Hall AW (1996) The management of chronic fissure in-ano with botulinum toxin. J R Coll Surg Edinb 41:235-238
46. Burleigh DE, D'Mello A, Parks AG (1979) Responses of isolated human internal anal sphincter to drugs and electrical field stimulation. Gastroenterology 77:484-490
47. Carapeti EA, Kamm MA, Evans BK, Phillips RK (1999) Topical diltiazem and bethanechol decrease anal sphincter pressure without side effects. Gut 45:719-722
48. Jones OM, Brading AF, Mortensen NJ (2002) The mechanism of action of botulinum toxin on the internal anal sphincter. Colorectal Dis 4 [Suppl 1]:71
49. Lysy J, Israelit-Yatzkan Y, Sestiery-Ittah M, Weksler-Zangen S, Keret D, Goldin E (2001) Topical nitrates potentiate the effect of botulinum toxin in the treatment of patients with refractory anal fissure. Gut 48:221-224
50. Lindsey I, Jones OM, George BD, Cunningham C, Mortensen NJM (2001) Botulinum toxin therapy for chronic anal fissure: second-line therapy after failed GTN. Colorectal Dis 3 [Suppl 1):74
51. Jost WH, Schanne S, Mlitz H, Schimrigk K (1995) Perianal thrombosis following injection therapy into the external anal sphincter using botulin toxin. Dis Colon Rectum 38:781
52. Espi A, Melo F, Minguez M (1998) Therapeutic use of botulinum toxin in anal fissures. Int J Colorectal Dis 12:163
53. Minguez M, Melo F, Espi A, Garcia-Granero E, Mora F, Lledo S, et al. (1999) Therapeutic effects of different doses of botulinum toxin in chronic anal fissure. Dis Colon Rectum 42:1016-1021
54. Fernandez Lopez F, Conde Freire R, Rios Rios A, Garcia Iglesias J, Cainzos Fernandez M, Potel Lesquereux J (1999) Botulinum toxin for the treatment of anal fissure. Dig Surg 16:515-518
55. Jost WH, Schimrigk K (1994) Therapy of anal fissure using botulin toxin. Dis Colon Rectum 37:1340
56. Jost WH, Schrank B (1999) Repeat botulin toxin injections in anal fissure: in patients with relapse and after insufficient effect of first treatment. Dig Dis Sci 44:1588-1589
57. Tack J, Janssens J, Vantrappen G (1991) Non-surgical treatment of achalasia. Hepatogastroenterology 38:493-497
58. Chrysos E, Xynos E, Tzovaras G, Zoras OJ, Tsiaoussis J, Vassilakis SJ (1996) Effect of nifedipine on rectoanal motility. Dis Colon Rectum 39:212-216
59. Cook TA, Humphreys MM, McC Mortensen NJ (1999) Oral nifedipine reduces resting anal pressure and heals chronic anal fissure. Br J Surg 86:1269-1273
60. Antropoli C, Perrotti P, Rubino M, Martino A, De Stefano G, Migliore G, et al. (1999) Nifedipine for local use in conservative treatment of anal fissures: preliminary results of a multicenter study. Dis Colon Rectum 42:1011-1015
61. Ezri T, Susmallian S (2003) Topical nifedipine vs. topical glyceryl trinitrate for treatment of chronic anal fissure. Dis Colon Rectum 46:805-808
62. Carapeti EA, Kamm MA, Phillips RK (2000) Topical diltiazem and bethanechol decrease anal sphincter pressure and heal anal fissures without side effects. Dis Colon Rectum 43:1359-1362
63. Knight JS, Birks M, Farouk R (2001) Topical diltiazem ointment in the treatment of chronic anal fissure. Br J Surg 88:553-556
64. Jonas M, Speake W, Scholefield JH (2002) Diltiazem heals glyceryl trinitrate-resistant chronic anal fissures: a prospective study. Dis Colon Rectum 45:1091-1095
65. Jonas M, Scholefield JH, Wilson VG (2001) GTN and diltiazem have an additive effect on isolated sheep internal anal sphincter. Br J Surg 88 [Suppl 1]:71
66. O'Kelly TJ, Brading A, Mortensen NJ (1993) In vitro response of the human anal canal longitudinal muscle layer to cholinergic and adrenergic stimulation: evidence of sphincter specialization. Br J Surg 80:1337-1341
67. Parks AG, Fishlock DJ, Cameron JD, May H (1969) Preliminary investigation of the pharmacology of the human internal anal sphincter. Gut 10:674-677
68. Pitt J, Craggs MM, Henry MM, Boulos PB (2000) Alpha-1 adrenoceptor blockade: potential new treatment for anal fissures. Dis Colon Rectum 43:800-803
69. Pitt J, Dawson PM, Hallan RI, Boulos PB (2001) A double blind randomised placebo-controlled trial of oral indoramin to treat chronic anal fissure. Colorectal Dis 3:165-168
70. Pitt J, Ojo-aromokudu O, Craggs MD, Boulos PB (1999) The role of alpha and beta adrenoreceptors in chronic fissure-in-ano (abstract). Colorectal Dis 1 [Suppl 1]:55