Local nitroglycerin for treatment of anal fissures: An alternative to lateral sphincterotomy?

Diseases of the Colon and Rectum

Volumn 40, Issue 7, 1997, Pages 840-845

  Bacher, Heinz ^a,b   Mischinger, Hans Jörg ^a   Werkgartner, Georg ^a   Cerwenka, Herwig ^a   El Shabrawi, Azab ^a   Pfeifer, Johann ^a   Schweiger, Wolfgang ^a  

^a UNIVERSITY OF GRAZ   (Austria)

^b NONE   (Austria)

Author keywords

Anal fissure; Clinical and manometric results; Topical glyceryl trinitrate

Indexed keywords

GLYCERYL TRINITRATE; LIDOCAINE;

ACUTE DISEASE; ADULT; ANORECTAL PRESSURE; ANUS FISSURE; ANUS SPHINCTER; ARTICLE; CHRONIC DISEASE; CLINICAL ARTICLE; CLINICAL TRIAL; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; FEMALE; HEADACHE; HUMAN; MALE; RANDOMIZED CONTROLLED TRIAL; SPHINCTEROTOMY; TOPICAL DRUG ADMINISTRATION;

ACUTE DISEASE; ADMINISTRATION, RECTAL; ADMINISTRATION, TOPICAL; ADULT; ANAL CANAL; ANESTHETICS, LOCAL; CHRONIC DISEASE; FEMALE; FISSURE IN ANO; FOLLOW-UP STUDIES; GELS; HEADACHE; HUMANS; LIDOCAINE; MALE; MANOMETRY; MIDDLE AGED; MUSCLE CONTRACTION; MUSCLE RELAXATION; NEUROTRANSMITTER AGENTS; NITRIC OXIDE; NITROGLYCERIN; PRESSURE; PROSPECTIVE STUDIES; VASODILATOR AGENTS; WOUND HEALING;

EID: 0030849015     PISSN: 00123706     EISSN: None     Source Type: Journal    
DOI: 10.1007/BF02055444     Document Type: Article

References (30)

1. Fung HL, Chung SJ, Bauer JA, Chong S, Kowaluk EA. Biochemical mechanism of organic nitrate action. Am J Cardiol 1992;70:4B-10B.
2. Lynn RB, Sankey SL, Chakder S, Rattan S. Colocalization of NADPH-diaphorase staining and VIP immunoreactivity in neurons in opossum internal anal sphincter. Dig Dis Sci 1995;40:781-91.
3. Chakder S, Rattan S. Distribution of VIP binding sites in opossum internal anal sphincter circular smooth muscle. J Pharmacol Exp Ther 1995;272:385-91.
4. Chakder S, Rattan S. Release of nitric oxide by activation of nonadrenergic noncholinergic neurons of internal anal sphincter. Am J Physiol 1993;264:G7-12.
5. Rattan S, Sarkar A, Chakder S. Nitric oxide pathway in rectoanal inhibitory reflex of opossum internal anal sphincter. Gastroenterology 1992;103:43-50.
6. Rattan S, Chakder S. Role of nitric oxide as a mediator of internal sphincter relaxation. Am J Physiol 1992;262: G107-12.
7. Savonitto S, Motolese M, Agabiti Rosei E. Antianginal effect of transdermal nitroglycerin and oral nitrates given for 24 hours a day in 2,456 patients with stable angina pectoris. Int J Clin Pharmacol Ther 1995;33: 194-203.
8. Borges FD. A new approach to the pharmacologic treatment of impotence. Int J Impot Res 1994;6:137-43.
9. Franks AG Jr. Topical glyceryl trinitrate as adjunctive treatment in Raynaud's disease. Lancet 1982;1:76-7.
10. Manahan AP, Burkman KA, Malesker MA, Benecke GW. Clinical ohsrevation on the use of topical nitroglycerin in the management of severe shoulder hand syndrome. Nebr Med J 1993;78:87-9.
11. Mahajan RP, Ramachandran R, Saxena N. Topical nitroglycerin prevents the pressor response to tracheal intubation and sternotomy in patients undergoing coronary artery bypass graft surgery. Anaesthesia 1993;48: 297-300.
12. Romanelli M, Katz MH, Alvarez AF, Eaglstein WH, Falanga V. The effect of topical nitroglycerin on transcutaneous oxygen. Br J Dermatol 1991;124:354-7.
13. Zekert O. Austria Codex. Wien: Österreichische Apotheker Verlagsgesellschaft m.b. H., 1993.
14. Bogaert MG. Clinical pharmacokinetics of glyceryl trinitrate following the use of systemic and topical preparations. Clin Pharmacokinet 1987;12:1-11.
15. Guillemot F, Leroi H, Lone YC, Rousseau CG, Lamblin MD, Cortot A. Action of in situ nitroglycerin on upper anal canal pressure of patients with terminal constipation: a pilot study. Dis Colon Rectum 1993;36:372-6.
16. Loder P, Kamm M, Nicholls R, Phillips R. Reversible chemical sphincterotomy by local application of glyceryl trinitrate. Br J Surg 1994;81:1386-9.
17. Schouten WR, Briel JW, Auwerda JJ. Relationship between anal pressure and anodermal blood flow: the vascular pathogenesis of anal fissures. Dis Colon Rectum 1994;37:664-9.
18. Goligher J. Surgery of the anus, rectum and colon. London: Bailliere Tindall, 1984:170-91.
19. Nicholls J. Fissure in ano and anorectal sepsis. Verh Dtsch Ges Inn Med 1988;94:225-229.
20. Crapp AR, Alexander-Williams J. Fissure in ano and anal stenosis. Part I. Conservative management. Clin Gastroenterol 1975;4:619-28.
21. Pocock ST. Clinical trials. New York: John Wiley and Sons, 1983:73-6.
22. Stebbing JF, Brading AF, Mortensen NJ. Nitrergic innervation and relaxant response of rectal circular smooth muscle. Dis Colon Rectum 1996;39:294-9.
23. Gorfine SR. Treatment of benign anal disease with topical nitroglycerin. Dis Colon Rectum 1995;38:453-7.
24. Gibbons CP, Read NW. Anal hypertonia in fissures: cause or effect? Br J Surg 1986;73:443-5.
25. Lin JK. Anal manometric studies in hemorrhoids and anal fissures. Dis Colon Rectum 1989;32:839-42.
26. Farouk R, Duthie GS, MacGregor AB, Bartolo DC. Sustained internal sphincter hypertonia in patients with chronic anal fissure. Dis Colon Rectum 1994;37:424-9.
27. McNamara MJ, Percy JP, Fielding IR. A manometric study of anal fissure treated by subcutaneous lateral internal sphincterotomy. Ann Surg 1990;211:235-8.
28. Shub HA, Salvati EP, Rubin RJ. Conservative treatment of anal fissure: an unselected, retrospective and continuous study. Dis Colon Rectum 1978;21:582-3.
29. Gough MJ, Lewis A. The conservative treatment of fissure in ano. Br J Surg 1983;70:175-6.
30. McDonald P, Driscoll AM, Nicholls PJ. The anal dilator in the conservative management of acute anal fissures. Br J Surg 1983;70:25-6.