Oral nifedipine reduces resting anal pressure and heals chronic anal fissure

British Journal of Surgery

Volumn 86, Issue 10, 1999, Pages 1269-1273

  Cook, T A ^a   Smilgin Humphreys, M M ^a   McC Mortensen, N J ^a  

^a JOHN RADCLIFFE HOSPITAL   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

CALCIUM CHANNEL BLOCKING AGENT; NIFEDIPINE;

ADULT; ANORECTAL PRESSURE; ANUS FISSURE; ARTICLE; CLINICAL ARTICLE; CLINICAL TRIAL; FEMALE; FLUSHING; HEADACHE; HEALING; HUMAN; HUMAN EXPERIMENT; INCONTINENCE; MALE; NORMAL HUMAN; ORAL DRUG ADMINISTRATION; ORTHOSTATIC HYPOTENSION; PRIORITY JOURNAL; TOPICAL DRUG ADMINISTRATION;

ADMINISTRATION, ORAL; ADULT; CALCIUM CHANNEL BLOCKERS; CHRONIC DISEASE; FEMALE; FISSURE IN ANO; HUMANS; MALE; MIDDLE AGED; NIFEDIPINE; PAIN; PRESSURE; TIME FACTORS; WOUND HEALING;

EID: 0032821329     PISSN: 00071323     EISSN: None     Source Type: Journal    
DOI: 10.1046/j.1365-2168.1999.01292.x     Document Type: Article

References (17)

1. Khubchandani IT, Reed JF. Sequelae of internal sphincterotomy for chronic fissure in ano. Br J Surg 1989; 76: 431-4.
2. Lund JN, Scholefield JH. A prospective, randomised, double blind, placebo-controlled trial of glyceryl trinitrate in anal fissure. Lancet 1997; 349: 11-14.
3. Watson SJ, Kamm MA, Nicholls RJ, Phillips RK. Topical glyceryl trinitrate in the treatment of chronic anal fissure. Br J Surg 1996; 83: 771-5.
4. Hyman NH, Cataldo PA. Nitroglycerin ointment for anal fissures: effective treatment or just a headache? Dis Colon Rectum 1999; 42: 383-5.
5. Traube M, Dubovik S, Lange RC, McCallum RW. The role of nifedipine therapy in achalasia: results of a randomized, double-blind, placebo-controlled study. Am J Gastroenterol 1989; 84: 1259-62.
6. Coccia G, Bortolotti M, Michetti P, Dodero M. Prospective clinical and manometric study comparing pneumatic dilatation and sublingual nifedipine in the treatment of oesophageal achalasia. Gut 1991; 32: 604-6.
7. Cook TA, Brading AF, Mortensen NJM. Differences in contractile properties of anorectal smooth muscle and the effect of calcium channel blockade. Br J Surg 1999; 86: 70-5.
8. Elliott RA, Norman RI, Parker SG, Whitaker RP, Castleden CM. Effect of treatment with calcium antagonists in vitro and in vivo on the contractile response of isolated rat and human detrusor muscle. Clin Sci 1996; 91: 467-74.
9. Palmer RM, Ferrige AG, Moncada S. Nitric oxide release accounts for the biological activity of endothelium-derived relaxing factor. Nature 1987; 327: 524-6.
10. O'Kelly TJ, Brading AF, Mortensen NJ. Nitric oxide mediates cholinergic relaxation of human internal anal sphincter muscle in vitro. Gut 1992; 33: A48 (Abstract).
11. Pitt J, Henry MM, Craggs MD, Boulos PB. A potential new medical therapy for chronic anal fissure. Int J Colorectal Dis 1997; 12: 169 (Abstract).
12. Jonard P, Essamri B. Diltiazem and internal anal sphincter. Lancet 1987; i: 754 (Letter).
13. Carapeti EA, Kamm MA, Evans BK, Phillips RK. Diltiazem lowers resting anal sphincter pressure; a potential low side-effect alternative to glyceryl trinitrate (GTN) for fissures. Gut 1998; 42: A97 (Abstract).
14. Chrysos E, Xynos E, Tzovaras G, Zoras OJ, Tsiaoussis J, Vassilakis SJ. Effect of nifedipine on rectoanal motility. Dis Colon Rectum 1996; 39: 212-16.
15. Celik AF, Katsinelos P, Read NW, Khan MI, Donnelly TC. Hereditary proctalgia fugax and constipation: report of a second family. Gut 1995; 36: 581-4.
16. Maria G, Cassetta E, Gui D, Brisinda G, Bentivoglio AR, Albanese A. A comparison of botulinum toxin and saline for the treatment of chronic anal fissure. N Engl J Med 1998; 338:217-20.
17. Jost WH, Schanne S, Mlitz H, Schimrift K. Perianal thrombosis following injection therapy into the external anal sphincter using botulin toxin. Dis Colon Rectum 1995; 38: 781 (Letter).