Altered dose-to-effect of propofol due to pharmacokinetics in rats with experimental diabetes mellitus

Journal of Pharmacy and Pharmacology

Volumn 57, Issue 3, 2005, Pages 317-325

  Leal, N ^a,b   Calvo, R ^a   Agrad, F Z ^a   Lukas, J C ^a,c   De La Fuente, L ^d   Suarez, E ^a  

^a UNIVERSITY OF THE BASQUE COUNTRY UPV EHU   (Spain)

^b Dynakin Ltd   (Spain)

^c UNIVERSITY OF ATHENS   (Greece)

^d Edificio BEAZ   (Spain)

Author keywords

[No Author keywords available]

Indexed keywords

ALBUMIN; CHOLESTEROL; GLUCOSE; PROPOFOL; STREPTOZOCIN; TRIACYLGLYCEROL;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CHOLESTEROL BLOOD LEVEL; CONTROLLED STUDY; DIABETES MELLITUS; DOSE RESPONSE; DOSE TIME EFFECT RELATION; DRUG CLEARANCE; DRUG INFUSION; DRUG TISSUE LEVEL; GLUCOSE BLOOD LEVEL; HYPNOSIS; IN VITRO STUDY; MALE; NONHUMAN; PHARMACODYNAMICS; PROTEIN BINDING; RAT; RIGHTING REFLEX; STEADY STATE; TRIACYLGLYCEROL BLOOD LEVEL; ULTRAFILTRATION; VALIDATION PROCESS;

ANESTHETICS, INTRAVENOUS; ANIMALS; BLOOD GLUCOSE; BLOOD PROTEINS; BRAIN; CHOLESTEROL; CHROMATOGRAPHY, HIGH PRESSURE LIQUID; DIABETES MELLITUS, EXPERIMENTAL; DOSE-RESPONSE RELATIONSHIP, DRUG; MALE; PROPOFOL; PROTEIN BINDING; RATS; RATS, SPRAGUE-DAWLEY; SERUM ALBUMIN; TISSUE DISTRIBUTION; TRIGLYCERIDES;

EID: 14644388083     PISSN: 00223573     EISSN: None     Source Type: Journal    
DOI: 10.1211/0022357055498     Document Type: Article

References (43)

1. Adachi, Y. U., Watanabe, K., Higuchi, H., Satoh, T. (2001) The determinants of propofol induction of anesthesia dose. Anesth. Analg. 92: 656-661
2. Altmayer, P., Büch, U., Büch, H. P. (1995) Propofol binding to human blood proteins. Drug Res. 45: 1053-1055
3. Chan, K., So, A. P. (1990) The measurement of propofol in human blood samples by liquid chromatography. Methods Find. Exp. Pharmacol. 12: 135-139
4. Chassard, D., Berrada, K., Bryssine, B., Guiraud, M., Bouletreau, P. (1996) Influence of body compartments on propofol induction dose in female patients. Acta Anaesthesiol. Scand. 90: 889-891
5. Cockshott, I. D., Douglas, E. F., Plummer, G. F., Simons, P. J. (1992) The pharmacokinetics of propofol in laboratory animals. Xenobiotiba 22: 369-375
6. Courteix, C., Bourget, P., Caussade, F., Bardin, M., Coudore, F., Fialip, J., Eschalier, A. (1998) Is the reduced efficacy of morphine in diabetic rats caused by alteration of opiate receptors or of morphine pharmacokinetics? J. Pharmacol. Exp. Ther. 285: 63-70
7. Danhof, J. M., Hisaake, M., Levy, G. (1985) Kinetics of drug action in disease states. Effect of experimental diabetes on phenobarbital concentration in rats at onset of loss of righting reflex. J. Pharmacol. Exp. Ther. 232: 435-438
8. Danhof, M., Levy, G. (1998) Kinetics of drug action in disease states. I. Effect of infusion rate on phenobarbital concentrations in serum, brain and cerebrospinal fluid of normal rats at onset of loss of righting reflex. J. Pharmacol. Exp. Ther. 229: 44-50
9. de la Fuente, L., Lukas, J. C., Jaureguizar, N., Vazquez, J., Calvo, R., Suarez, E. (2002) Prediction of unbound propofol concentrations in a diabetic population. Ther. Drug Monit. 24: 689-695
10. De Paepe, P., Belpaire, F. M., Rosseel, M. T., Hoey, G. V., Boon, P. A., Buylaert, M. D. (2000) Influence of hypovolemia on the pharmacokinetics and the electroencephalographic effect of propofol in the rat. Anesthesiology 93: 1482-1490
11. De Paepe, P., Belpaire, F. M., Hoey, G. V., Boon, P. A., Buylaert, M. D. (2001) The influence of endotoxemia on the pharmacokinetics and the electroencephalographic effect of propofol in the rat. J. Pharm. Sci. 92: 104-114
12. Dutta, S., Matsumoto, Y., Gothgen, N. U., Ebling, W. F. (1997) Concentration-EEG relationship of propofol in rats. J. Pharm. Sci. 85: 37-43
13. Dutta, S., Matsumoto, Y., Muramatsu, A., Matsumoto, M., Fukuoka, M., Ebling, W. F. (1998) Steady-state propofol brain: plasma and brain: blood partition coefficients and the effect-site equilibration paradox. Br. J. Anesth. 81: 422-424
14. Emami, J., Pasutto, F. M., Jamali, F. (1998) Effect of experimental diabetes mellitus and arthritis on the pharmacokinetics of hydroxychloroquine enantiomers in rats. Pharm. Res. 15: 897-903
15. Gilbert, R., Cooper, M., Krum, H. (1998) Drug administration in patients with diabetes mellitus. Drug Safety 18: 441-445
16. Gustafsson, L. L., Ebling, W. F., Osaki, E., Stanki, D. R. (1996) Quantitation of depth of thiopental anesthesia in the rat. Anesthesiology 84: 415-427
17. Gwilt, P. R., Nahhas, R. R., Tracewell, W. G. (1991) The effects of diabetes mellitus on pharmacokinetics and pharmacodynamics in humans. Clin. Pharmacokinet. 20: 477-490
18. Izumi, T., Hosiyama, K., Enomoto, S., Sasahara, K., Sugiyama, Y. (1997) Pharmacokinetics of troglitazone, an antidiabetic agent: prediction of in vivo stereoselective sulfation and glucuronidation from in vitro data. J. Pharmacol. Exp. Ther. 280: 1392-1400
19. Kataria, B. K., Ved, S. A., Nicodemus, H. F., Hoy, G. R., Lea, D., Dubois, M.Y., Mandema, J. W., Shafer, S. L. (1994) The pharmacokinetics of propofol in children using three different data analysis approaches. Anesthesiology 80: 104-122
20. Kazama, T., Ikeda, K., Morita, K., Kikura, M., Doi, M., Ikeda, T., Kurita, T., Nakajima, Y. (1999) Comparison of the effect-site (ke0)s of propofol for blood pressure and EEG bispectral index in elderly and younger patients. Anesthesiology 90: 1517-1527
21. Knibbe, C. A., Zuiderveld, K. P., De Jongh, J., Kurks, P. F., Aarts, L. P., Danhof, M. (2002) Population pharmacokinetic modeling of propofol for long-term sedation in critically ill patients: a comparison between propofol 6% and 1%. Clin. Pharmacol. Ther. 72: 670-684
22. Leslie, K., Crankshaw, D. P. (1991) Lean tissue mass is a useful predictor of induction dose requirements for propofol. Anaesth. Intensive Care 19: 57-60
23. Michel, A., Bonnet, P. A., Fernandez, J. P., Chambon, C., Doucet, D. (1992) Pharmacokinetic study of gadolinium-DOTA in control and streptozotocin diabetic rats. J. Pharm. Pharmacol. 44: 902-906
24. Ohsawa, M., Kamei, J. (1997) Pretreatment with the protein kinase C activator phorbol 12,13-dibutyrate attenuates the ethanol-induced loss of the righting reflex in mice: modification by diabetes. Brain Res. 764: 244-248
25. Preston, R. A., Epstein, M. (1999) Effects of diabetes on cardiovascular drug metabolism. Diabetes Care 22: 982-987
26. Ramanathan, M., Jaiswal, A. K., Bhattacharya, S. K. (1998) Differential effects of diazepam on anxiety in streptozotocin induced diabetic and non-diabetic rats. Psychopharmacology 135:361-367
27. rd edn, Williams & Wilkins, Media PA, pp 137-155
28. Ruiz-Cabelló, F., Erill, S. (1984) Abnormal serum protein binding of acidic drugs in diabetes mellitus. Clin. Pharmacol. Ther. 36: 691-695
29. Schnider, T., Minto, C. H., Gambus, P., Andersen, C., Goodale, D., Shafer, S., Youns, E. (1998) The influence of method of administration and covariates on the pharmacokinetics of propofol on adult volunteers. Anesthesiology 88: 1170-1182
30. Schnider, T. W., Minto, C. F., Shafer, S. L., Gambus, P. L., Andresen, C., Goodale, D. B., Youngs, E. J. (1999) The influence of age on propofol pharmacodynamics. Anesthesiology 90: 1502-1516
31. Schuttler, J., Ihmsen, H. (2000) Population pharmacokinetics of propofol. Anesthesiology 92: 727-738
32. Servin, F. S., Bourgeois, B., Gomeni, R., Mentre, F., Farinotti, R., Desmonts, J. M. (2003) Pharmacokinetics of propofol administered by target-controlled infusion to alcoholic patients. Anesthesiology 99: 576-585
33. Short, T. G., Chui, P. T. (1991) Propofol and midazolam act synergistically in combination. Anesth. Analg. 72: 578-583
34. Simon, G. S., Dewey, W. (1981) Narcotics and diabetes. I. Effects of streptozotocin-induced diabetes on the antinociceptive potency of morphine. J. Pharmacol. Exp. Ther. 218: 318-323
35. Simon, G. S., Borzellece, J., Dewey, W. (1981) Narcotics and diabetes. II. Streptozotocin-induced diabetes selectively alters the potency of certain analgesics. Mechanism of diabetes: morphine interaction. J. Pharmacol. Exp. Ther. 218: 324-329
36. Stokes, D. N., Hutton, P. (1991) Rate-dependent induction phenomena with propofol: implications for the relative potency of intravenous anesthetics. Anesth. Analg. 72: 578-583
37. Tanaka, Y., Sawamoto, T., Suzuku, A., Kimura, T. (1993) Pharmacokinetics of zenarestat, an aldose reductase inhibitor, in male and female diabetic rats. Drug Metab. Dispos. 21: 677-681
38. Trancede, G., Rousseau-Migneron, S., Nadeau, A. (1983) Long-term changes in the diabetic state induced by different doses of streptozotocin in rats. Br. J. Exp. Pathol. 64: 117-123
39. Vega, P., Gaule, C., Mancilla, J., del Villar, E. (1993) Comparison of alloxan and streptozotocin induced diabetes in rats: differential effects on microsomal drug metabolism. Gen. Pharmacol. 24: 489-495
40. Vuyk, K. J., Oostwonder, C. J., Vletter, A., Burm, A. G., Bovill, J. G. (2001) Gender differences in the pharmacokinetics of propofol in the elderly patients during and after continuous infusion. Br. J. Anaesth. 86: 183-188
41. Wakeling, H., Zimmermen, J., Howel, S., Glass, P. (1999) Targeting effect compartment or central compartment concentration of propofol. What predicts loss of consciousness? Anesthesiology 90: 92-97
42. Xiaotao, Q., Hall, S. D. (1995) Enantioselective effects of experimental diabetes mellitus on the metabolism of ibuprofen. J. Pharm. Exp. Ther. 274: 1192-1198
43. Zamacona, M. K., Suárez, E., García, E., Aguirre, C., Calvo, R. (1998) The significance of lipoproteins in serum binding variations of propofol. Anesth. Analg. 87: 1147-1151