TUP1 disruption reveals biological differences between MATa and MATα strains of Cryptococcus neoformans

Molecular Microbiology

Volumn 55, Issue 4, 2005, Pages 1222-1232

  Lee, Hyeseung ^a   Chang, Yun C ^a   Kwon Chung, K J ^a  

^a NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ARTICLE; CELL STRUCTURE; CONTROLLED STUDY; CRYPTOCOCCUS NEOFORMANS; FUNGAL STRAIN; FUNGUS GROWTH; GENE DISRUPTION; GENE SEGREGATION; GENETIC TRANSCRIPTION; MATING; MATING TYPE; NONHUMAN; PHENOTYPIC VARIATION; PRIORITY JOURNAL; REPRESSOR GENE; STRAIN DIFFERENCE; SURVIVAL RATE; TEMPERATURE DEPENDENCE; TEMPERATURE SENSITIVITY; TUP1 GENE;

BACTERIAL PROTEINS; CRYPTOCOCCUS NEOFORMANS; GENE EXPRESSION REGULATION, BACTERIAL; GENETIC COMPLEMENTATION TEST; PEPTIDES; REPRESSOR PROTEINS; SEQUENCE DELETION; SPECIES SPECIFICITY; TEMPERATURE;

EID: 14544275475     PISSN: 0950382X     EISSN: None     Source Type: Journal    
DOI: 10.1111/j.1365-2958.2004.04458.x     Document Type: Article

References (49)

1. Alexopoulos, C.J., Mims, C.W., and Blackwell, M. (1996) Introductory Mycology. New York: John Wiley & Sons.
2. Armesilla, A.L., Thurston, C.F., and Yague, E. (1994) CEL1: a novel cellulose binding protein secreted by Agaricus bisporus during growth on crystalline cellulose. FEMS Microbiol Lett 116: 293-299.
3. Bobrowicz, P., Pawlak, R., Correa, A., Bell-Pedersen, D., and Ebbole, D.J. (2002) The Neurospora crassa pheromone precursor genes are regulated by the mating type locus and the circadian clock. Mol Microbiol 45: 795-804.
4. Braun, B.R., and Johnson, A.D. (1997) Control of filament formation in Candida albicans by the transcriptional repressor TUP1. Science 277: 105-109.
5. Braun, B.R., Head, W.S., Wang, M.X., and Johnson, A.D. (2000) Identification and characterization of TUP1-regulated genes in Candida albicans. Genetics 156: 31-44.
6. Byer, B. (1981) Cytology of the yeast life cycle. In Molecular Biology of the Yeast Saccharomyces: Life Cycle and Inheritance. Strathern, N.J. (ed.). Cold Spring Harbor, NY: Cold Spring Harbor Laboratory Press, p. 59.
7. Chang, Y.C., and Kwon-Chung, K.J. (1994) Complementation of a capsule-deficient mutation of Cryptococcus neoformans restores its virulence. Mol Cell Biol 14: 4912-4919.
8. Chang, Y.C., and Kwon-Chung, K.J. (1998) Isolation of the third capsule-associated gene, CAP60, required for virulence in Cryptococcus neoformans. Infect Immun 66: 2230-2236.
9. Chang, Y.C., Wickes, B.L., and Kwon-Chung, K.J. (1995) Further analysis of the CAP59 locus of Cryptococcus neoformans: structure defined by forced expression and description of a new ribosomal protein-encoding gene. Gene 167: 179-183.
10. Chang, Y.C., Penoyer, L.A., and Kwon-Chung, K.J. (1996) The second capsule gene of Cryptococcus neoformans, CAP64, is essential for virulence. Infect Immun 64: 1977-1983.
11. Chang, Y.C., Wickes, B.L., Miller, G.F., Penoyer, L.A., and Kwon-Chung, K.J. (2000) Cryptococcus neoformans STE12alpha regulates virulence but is not essential for mating. J Exp Med 191: 871-882.
12. Chang, Y.C., Miller, G.F., and Kwon-Chung, K.J. (2003) Importance of a developmentally regulated pheromone receptor of Cryptococcus neoformans for virulence. Infect Immun 71: 4953-4960.
13. Davidson, R.C., Moore, T.D., Odom, A.R., and Heitman, J. (2000) Characterization of the MFalpha pheromone of the human fungal pathogen Cryptococcus neoformans. Mol Microbiol 38: 1017-1026.
14. DeRisi, J.L., Iyer, V.R., and Brown, P.O. (1997) Exploring the metabolic and genetic control of gene expression on a genomic scale. Science 278: 680-686.
15. Edman, J.C., and Kwon-Chung, K.J. (1990) Isolation of the URA5 gene from Cryptococcus neoformans var. neoformans and its use as a selective marker for transformation. Mol Cell Biol 10: 4538-4544.
16. Fraser, J.A., and Heitman, J. (2004) Evolution of fungal sex chromosomes. Mol Microbiol 51: 299-306.
17. Fujita, A., Misumi, Y., Ikehara, Y., and Kobayashi, H. (1992) The yeast SFL2 gene may be necessary for mating-type control. Gene 112: 85-90.
18. Hicks, J., Lockington, R.A., Strauss, J., Dieringer, D., Kubicek, C.P., Kelly, J., and Keller, N. (2001) RcoA has pleiotropic effects on Aspergillus nidulans cellular development. Mol Microbiol 39: 1482-1493.
19. Huang, C., Nong, S.H., Mansour, M.K., Specht, C.A., and Levitz, S.M. (2002) Purification and characterization of a second immunoreactive mannoprotein from Cryptococcus neoformans that stimulates T-cell responses. Infect Immun 70: 5485-5493.
20. Hull, C.M., Davidson, R.C., and Heitman, J. (2002) Cell identity and sexual development in Cryptococcus neoformans are controlled by the mating-type-specific homeodomain protein Sxi1alpha. Genes Dev 16: 3046-3060.
21. Johnson, A.D., and Herskowitz, I. (1985) A repressor (MATalpha2 product) and its operator control expression of a set of cell type specific genes in yeast. Cell 42: 237-247.
22. Karos, M., Chang, Y.C., McClelland, C.M., Clarke, D.L., Fu, J., Wickes, B.L., and Kwon-Chung, K.J. (2000) Mapping of the Cryptococcus neoformans MATalpha locus: presence of mating type-specific mitogen-activated protein kinase cascade homologs. J Bacteriol 182: 6222-6227.
23. Keleher, C.A., Redd, M.J., Schultz, J., Carlson, M., and Johnson, A.D. (1992) Ssn6-Tup1 is a general repressor of transcription in yeast. Cell 68: 709-719.
24. Kwon-Chung, K.J. (1976) Morphogenesis of Filobasidiella neoformans, the sexual state of Cryptococcus neoformans. Mycologia 68: 942-946.
25. Kwon-Chung, K.J. (1980) Nuclear genotypes of spore chains in Filobasidiella neoformans (Cryptococcus neoformans) Mycologia 72: 418-422.
26. Kwon-Chung, K.J., and Bennett, J.E. (1978) Distribution of alpha and alpha mating types of Cryptococcus neoformans among natural and clinical isolates. Am J Epidemiol 108: 337-340.
27. Kwon-Chung, K.J., and Bennett, J.E. (1992) Medical Mycology. Philadelphia, PA: Lea & Febiger.
28. Kwon-Chung, K.J., and Hill, W.B. (1981) Sexuality and pathogenicity of Filobasidiellla neoformans (Cryptococcus neoformans). In Sexuality and Pathogenicity of Fungi. Vanbreuseghem, R., and DeVroey, C. (eds). New York: Masson, pp. 243-250.
29. Kwon-Chung, K.J., Bennett, J.E., and Rhodes, J.C. (1982) Taxonomic studies on Filobasidiella species and their anamorphs. Antonie Van Leeuwenhoek 48: 25-38.
30. Kwon-Chung, K.J., Edman, J.C., and Wickes, B.L. (1992) Genetic association of mating types and virulence in Cryptococcus neoformans. Infect Immun 60: 602-605.
31. Lemontt, J.F., Fugit, D.R., and Mackay, V.L. (1980) Pleiotrophic mutations at the TUP1 locus that affect the expression of mating-type dependent functions in Saccharomyces cerevisiae. Genetics 94: 899-920.
32. Lengeler, K.B., Fox, D.S., Fraser, J.A., Allen, A., Forrester, K., Dietrich, F.S., and Heitman, J. (2002) Mating-type locus of Cryptococcus neoformans: a step in the evolution of sex chromosomes. Eukaryot Cell 1: 704-718.
33. Lipke, P.N., and Hull-Pillsbury, C. (1984) Flocculation of Saccharomyces cerevisiae tup1 mutants. J Bacteriol 159: 797-799.
34. McClelland, C.M., Fu, J., Woodlee, G.L., Seymour, T.S., and Wickes, B.L. (2002) Isolation and characterization of the Cryptococcus neoformans MATa pheromone gene. Genetics 160: 935-947.
35. McClelland, C.M., Chang, Y.C., Varma, A., and Kwon-Chung, K.J. (2004) Uniqueness of the mating system in Cryptococcus neoformans. Trends Microbiol 12: 208-212.
36. Manney, T.R., Jackson, P., and Meade, J. (1983) Two temperature-sensitive mutants of Saccharomyces cerevisiae with altered expression of mating-type functions. J Cell Biol 96: 1592-1600.
37. Moore, T.D., and Edman, J.C. (1993) The alpha-mating type locus of Cryptococcus neoformans contains a peptide pheromone gene. Mol Cell Biol 13: 1962-1970.
38. Mukai, Y., Matsuo, E., Roth, S.Y., and Harashima, S. (1999) Conservation of histone binding and transcriptional repressor functions in a Schizosaccharomyces pombe Tup1p homolog. Mol Cell Biol 19: 8461-8468.
39. Murad, A.M., d'Enfert, C., Gaillardin, C., Tournu, H., Tekaia, F., Talibi, D., et al. (2001) Transcript profiling in Candida albicans reveals new cellular functions for the transcriptional repressors CaTup1, CaMig1 and CaNrg1. Mol Microbiol 42: 981-993.
40. Sakai, Y., Murdanoto, A.P., Konishi, T., Iwamatsu, A., and Kato, N. (1997) Regulation of the formate dehydrogenase gene, FDH1, in the methylotrophic yeast Candida boidinii and growth characteristics of an FDH1-disrupted strain on methanol, methylamine, and choline. J Bacteriol 179: 4480-4485.
41. Shen, W.C., Davidson, R.C., Cox, G.M., and Heitman, J. (2002) Pheromones stimulate mating and differentiation via paracrine and autocrine signaling in Cryptococcus neoformans. Eukaryot Cell 1: 366-377.
42. Todd, R.B., Greenhalgh, J.R., Hynes, M.J., and Andrianopoulos, A. (2003) TupA, the Penicillium marneffei Tup1p homologue, represses both yeast and spore development. Mol Microbiol 48: 85-94.
43. Toffaletti, D.L., Rude, T.H., Johnston, S.A., Durack, D.T., and Perfect, J.R. (1993) Gene transfer in Cryptococcus neoformans by use of biolistic delivery of DNA. J Bacteriol 175: 1405-1411.
44. Verna, J., and Ballester, R. (1999) A novel role for the mating type (MAT) locus in the maintenance of cell wall integrity in Saccharomyces cerevisiae. Mol Gen Genet 261: 681-689.
45. Wang, P., Perfect, J.R., and Heitman, J. (2000) The G-protein beta subunit GPB1 is required for mating and haploid fruiting in Cryptococcus neoformans. Mol Cell Biol 20: 352-362.
46. Wickes, B.L., Mayorga, M.E., Edman, U., and Edman, J.C. (1996) Dimorphism and haploid fruiting in Cryptococcus neoformans: association with the alpha-mating type. Proc Natl Acad Sci USA 93: 7327-7331.
47. Williams, F.E., and Trumbly, R.J. (1990) Characterization of TUP1, a mediator of glucose repression in Saccharomyces cerevisiae. Mol Cell Biol 10: 6500-6511.
48. Xu, J., Ali, R.Y., Gregory, D.A., Amick, D., Lambert, S.E., Yoell, H.J., et al. (2000) Uniparental mitochondrial transmission in sexual crosses in Cryptococcus neoformans. Curr Microbiol 40: 269-273.
49. Yamashiro, C.T., Ebbole, D.J., Lee, B.D., Brown, R.E., Bourland, C., Madi, L., and Yanofsky, C. (1996) Characterization of rco-1 of Neurospora crassa, a pleiotropic gene affecting growth and development that encodes a homolog of Tup1 of Saccharomyces cerevisiae. Mol Cell Biol 16: 6218-6228.