On the structural basis of peptide-bond formation and antibiotic resistance from atomic structures of the large ribosomal subunit

FEBS Letters

Volumn 579, Issue 4 SPEC. ISS., 2005, Pages 955-958

  Steitz, Thomas A ^a,b  

^a YALE UNIVERSITY   (United States)

^b HOWARD HUGHES MEDICAL INSTITUTE   (United States)

Author keywords

Antibiotics; Peptidyl transferase mechanism; Ribosome structure; Ribozyme; RNA structure

Indexed keywords

ANTIBIOTIC AGENT; NUCLEOTIDE; PEPTIDE; PEPTIDYLTRANSFERASE; RIBOSOME PROTEIN; RIBOZYME; TRANSFER RNA; ANTIINFECTIVE AGENT; RNA 23S;

ANTIBIOTIC RESISTANCE; ANTIMICROBIAL ACTIVITY; ATOM; COMPLEX FORMATION; CONFERENCE PAPER; DRUG DESIGN; ENZYME INHIBITION; ENZYME MECHANISM; HALOARCULA MARISMORTUI; PEPTIDE SYNTHESIS; PRIORITY JOURNAL; PROTEIN CROSS LINKING; PROTEIN FOLDING; PROTEIN INTERACTION; PROTEIN STRUCTURE; RIBOSOME SUBUNIT; RNA STRUCTURE; STRUCTURE ANALYSIS; CHEMICAL STRUCTURE; CHEMISTRY; CONFORMATION; DRUG EFFECT; METABOLISM; PHYSIOLOGY; PROTEIN SYNTHESIS; REVIEW; RIBOSOME; RNA TRANSLATION;

HALOARCULA MARISMORTUI;

ANTI-BACTERIAL AGENTS; DRUG RESISTANCE, MICROBIAL; HALOARCULA MARISMORTUI; MOLECULAR STRUCTURE; NUCLEIC ACID CONFORMATION; PEPTIDE CHAIN ELONGATION, TRANSLATIONAL; PEPTIDYL TRANSFERASES; PROTEIN BIOSYNTHESIS; RIBOSOMAL PROTEINS; RIBOSOMES; RNA, RIBOSOMAL, 23S; RNA, TRANSFER;

EID: 14544268235     PISSN: 00145793     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.febslet.2004.11.053     Document Type: Conference Paper

References (18)

1. P.B. Moore, and T.A. Steitz Annu. Rev. Biochem. 72 2003 813 850
2. T.A. Steitz, and P.B. Moore RNA, Trends Biochem. Sci. 28 2003 411 418
3. N. Ban, B. Freeborn, P. Nissen, P. Penczek, R.A. Grassuci, R. Sweet, J. Frank, P.B. Moore, and TA. Steitz Cell 92 1998 1105 1115
4. W.M. Clemons Jr., J.L.C. May, B.T. Wimberly, J.P. McCutcheon, M.S. Capel, and V. Ramakrishnan Nature 400 1999 833 847
5. J.H. Cate, M.M. Yusupov, G.Z. Yusupova, T.N. Earnest, and H.F. Noller Science 285 1999 2095 2104
6. D.J. Klein, T.M. Schmeing, P.B. Moore, and T.A. Steitz EMBO J. 20 2001 4214 4221
7. P. Nissen, J.A. Ippolito, N. Ban, P.B. Moore, and T.A. Steitz Proc. Natl. Acad. Sci. USA 98 2001 4899 4903
8. A. Liljas Int. Rev. Cytol. 124 1991 103 136
9. P. Nissen, J. Hansen, N. Ban, P.B. Moore, and T.A. Steitz Science 289 2000 9290 9390
10. E.M. Youngman, J.L. Brunelle, A.B. Kochaniak, and R. Green The active site of the ribosome is composed of two layers of conserved nucleotides with distinct roles in peptide bond formation and peptide release Cell 117 2004 589 599
11. J.L. Hansen, T.M. Schmeing, P.B. Moore, and T.A. Steitz Structural insights into peptide bond formation Proc. Natl. Acad. Sci. USA 99 2002 11670 11675
12. S. Dorner, C. Panuschka, W. Schmid, and A. Barta Nano nucleotide derivatives as ribosomal P-site substrates reveal an important contribution of the 2′-OH of activity Nucleic Acids Res. 31 2003 6536 6542
13. J.S. Weinger, K.M. Parnell, S. Dorner, R. Green, and S.A. Strobel Substrate-assisted catalysis of peptide bond formation by the ribosome Nature Struct. Mol. Biol. 11 2004 1101 1106
14. J.L. Hansen, J.A. Ippolito, N. Ban, P. Nissen, P.B. Moore, and T.A. Steitz The structures of four macrolide antibiotics bound to the large ribosomal subunit Mol. Cell 10 2002 117 128
15. J.L. Hansen, P.B. Moore, and T.A. Stetiz Structures of five antibiotics bound at the peptidyl transferase center of the large ribosomal subunit J. Mol. Biol. 330 2003 1061 1075
16. F. Schleunzen, R. Zarivach, J. Harms, A. Bashan, A. Tocilj, R. Albrecht, A. Yonath, and F. Franceschi Structural basis for interaction of antibiotics with peptidyl transferase centre in eubacteria Nature 413 2001 814 821
17. M. Leeb Nature 431 2004 892 893
18. C. Nathan Nature 431 2004 899 902