Protein kinase C-dependent in vivo phosphorylation of prourokinase leads to the formation of a receptor competitive antagonist

Journal of Biological Chemistry

Volumn 273, Issue 42, 1998, Pages 27734-27740

  Franco, Paola ^a   Massa, Ornella ^a   Garcia Roeha, Mar ^b   Chiaradonna, Ferdinando ^a   Iaccarino, Ciro ^a   Correas, Isabel ^b   Mendez, Enrique ^b   Avila, Jesus ^b   Blasi, Francesco ^c   Stoppeli, M Patrizia ^a,d  

^a INSTITUTE OF GENETICS AND BIOPHYSICS ADRIANO BUZZATI TRAVERSO   (Italy)

^b UNIVERSIDAD AUTÓNOMA DE MADRID   (Spain)

^c UNIVERSITY OF MILAN   (Italy)

^d CNR   (Italy)

Author keywords

[No Author keywords available]

Indexed keywords

CALCIUM ION; GLUTAMINE; PHORBOL 13 ACETATE 12 MYRISTATE; PHOSPHOLIPID; PROTEIN KINASE C; PROUROKINASE; RECEPTOR; SERINE; UROKINASE;

ARTICLE; CELL ADHESION; CELL MOTILITY; CONTROLLED STUDY; ENZYME ACTIVITY; ENZYME LINKED IMMUNOSORBENT ASSAY; ENZYME PHOSPHORYLATION; HUMAN; HUMAN CELL; POLYACRYLAMIDE GEL ELECTROPHORESIS; PRIORITY JOURNAL; RECEPTOR BINDING;

AMINO ACID SEQUENCE; ANIMALS; BRAIN; CELL ADHESION; DOWN-REGULATION; ENZYME PRECURSORS; GENE EXPRESSION REGULATION, ENZYMOLOGIC; HUMANS; ISOENZYMES; MOLECULAR SEQUENCE DATA; OLIGOPEPTIDES; PHOSPHORYLATION; PROTEIN KINASE C; RATS; RECEPTORS, CELL SURFACE; RECOMBINANT PROTEINS; SERINE; SIGNAL TRANSDUCTION; TUMOR CELLS, CULTURED; U937 CELLS; URINARY PLASMINOGEN ACTIVATOR;

EID: 14444287267     PISSN: 00219258     EISSN: None     Source Type: Journal    
DOI: 10.1074/jbc.273.42.27734     Document Type: Article

References (46)

1. Danø, K, Behrendt, N., Brunner, N., Ellis, V., Ploug, M., and Pyke, C (1994) Fibrinolysis 8, 189-203
2. Vassalli, J. D., Baccino, D., and Belin, D (1985) J. Cell Biol. 100, 86-92
3. Stoppelli, M. P., Corti, A., Soffientini, A., Cassani, G., Blasi, F., and Assoian, R. K (1985) Proc. Natl. Acad. Sci. U. S. A. 82, 4939-4943
4. Stoppelli, M. P., Tacchetti, C., Cubellis, M. V., Corti, A., Hearing, V. J., Cassani, G., Appella, E., and Blasi, F (1986) Cell 45, 675-684
5. Mimuro, J., Schleef, R. R., and Loskutoff, D. J (1987) Blood 70, 721-728
6. Blasi, F., Conese, M., Moller, L. B., Pedersen, N., Cavallaro, U., Cubellis, M. V., Soria, M. R., Stoppelli, M. P., Talarico, D., Teesalu, T., and Valcamonica, S (1994) Fibrinolysis 8, 182-188
7. Carriero, M. V., Del Vecchio, S., Franco, P., Potena, M. I., Chiaradonna, F., Botti, G., Stoppelli, M. P., and Salvatore, M (1997) Clin. Cancer Res. 3, 1299-1308
8. Patthy, L (1983) Cell 41, 657-663
9. Nowak, U. K., Li, X., Teuten, A. J., Smith, R. A., and Dobson, C. M (1993) Biochemistry 32, 298-309
10. Andreasen, P. A., Nielsen, L. S., Kristensen, P., Grondahl-Hansen, J., Skriver, L., and Dano, K. (1986), J. Biol. Chem. 261, 7644-7651
11. Ellis, V (1996) J. Biol. Chem. 271, 14779-14784
12. Waltz, D. A., Sailor, L. Z., Chapman, H. A (1993) J. Clin. Invest. 91,1541-1552
13. Resnati, M., Guttinger, M., Valcamonica, S., Sidenius, N., Blasi, F., and Fazioli, F (1996) EMBO J. 15, 1572-1582
14. Verde, P., Boast, S., Franzé, A., Robbiati, F., and Blasi, F (1988) Nucleic Acids Res. 16, 10699-10716
15. Lengyel, E., Wang, H., Stepp, E., Juarez, J., Wang, Y., Doe, W., Pfarr, C. M., and Boyd, D (1996) J. Biol. Chem. 271, 23176-23184
16. Besser, D., Bardelli, A., Didichenko, S., Thelen, M., Comoglio, P. M., Ponzetto, C., and Nagamine, Y (1997) Oncogene 14, 705-711
17. Nishizuka, Y (1992) Science 258, 607-614
18. Dekker, L. V., and Parker, P. J (1994) Trends Biochem. Sci. 19, 73-77
19. Stoppelli, M. P., Verde, P., Grimaldi, G., Locatelli, E., and Blasi, F (1986) J. Cell Biol. 102, 1235-1241
20. Picone, R., Kajtaniak, E., Nielsen, L. S., Beherendt, N., Mastronicola, M. R., Cubellis, M. V., Stoppelli, M. P., Pedersen, S., Dano, K., and Blasi, F (1989) J. Cell Biol. 108, 693-702
21. Ando, Y., and Jensen, P. J (1996) J. Cell. Physiol. 167, 500-511
22. Mastronicola, M. R., Stoppelli, M. P., Migliaccio, A., Auricchio, F., and Blasi, F (1990) FEBS Lett. 266, 109-114
23. Mastronicola, M. R., Franco, P., De Cesare, D., Massa, O., and Stoppelli, M. P (1992) Fibrinolysis 6, 117-120
24. Franco, P., Mastronicola, M. R., De Cesare, D., Nolli, M. L., Wun, T. C., Verde, P., Blasi, F., and Stoppelli. M. P (1992) J. Biol. Chem. 267, 19369-19372
25. Takahashi, K., Kwaan, H. C., Ikeo, K., and Koh, E (1992) Biochem. Biophys. Res. Commun. 182, 1466-1472
26. Takahashi K., Kwaan, H. C., Koh, E., and Tanabe, M (1992) Biochem. Biophys. Res. Commun. 182, 1473-1481
27. Barlati, S., Paracini, F., Bellotti, D., and De Petro, G (1991) FEBS Lett. 281, 137-140
28. Barlati, S., De Petro, G., Bona, C., Paracini, F., and Tonelli M (1995) FEBS Lett. 363, 170-174
29. Franco, P., Iaccarino, C., Chiaradonna, F., Brandazza, A., Iavarone, C., Mastronicola, M. R., Nolli, M. L., and Stoppelli, M. P (1997) J. Cell Biol. 137, 779-791
30. Nolli, M. L., Corti, A., Soffientini, A., and Cassani, G. (1986), Thromb. Haemostasis 56, 214-218
31. Laemmli, U. K. (1970), Nature 227, 680-685
32. Walsh, M. P., Valentine, K. A., Ngai, C. A., Carruthers, C. A., Hollenberg, M. D (1984) Biochem. J. 224, 117-127
33. Kikkawa, U., Kisnimoto, A., and Nishizuka, Y (1989) Annu. Rev. Biochem. 58, 31-44
34. Pearson, R. B., Kemp, B. E. (1991) Methods Enzymol. 200, 62-81
35. Orsini, G., Brandazza, A., Sarmientos, P., Molinari, A. Lansen, J., and Cauet, G. (1991) Eur. J. Biochem. 195, 691-697
36. Gibrat, J. F., Gamier, J., and Robson, B (1987) J. Mol. Biol. 198, 425-443
37. Li, C., Liu, J. N., and Gurewich V (1995) J. Biol. Chem. 270, 30282-30285
38. Jaken, S (1996) Curr. Opin. Cell Biol. 8, 168-173
39. Bastani, B., Yang, L., Baldassare, J. J., Pollo, D. A., and Gardner, J. D (1995) Biochim. Biophys. Acta 1269, 307-315
40. Hogan, M. V., Pawlowska, Z., Yang, H. A., Kornecki, E., and Ehrlich, Y. H (1995) J. Neurochem. 65, 2022-2030
41. Rand, M. D., Kalafatis, M., and Mann, K. J (1994) Blood 83, 2180-2190
42. Gechtman, Z., and Shaltiel, S (1997) Eur. J. Biochem. 243, 493-501
43. Schreuder, H., Tardif, C., Trump-Kallmeyer, S., Soffientini, A., Sarubbi, E., Akeson, A., Bowlin, T., Yanofsly, S., and Barrett, R. W (1997) Nature 386, 194-200
44. Chen, Y., Liu, F., and Massagué, J (1997) EMBO J. 16, 3866-3876
45. Nakao, A., Afrakhte, M., Moren, A., Nakayama, T., Christian, J. L., Heuchel, R., Itoh, S., Kawabata, M., Heldin, N. E., Heldin, C. H., and Ten Dijke, P (1997) Nature 389, 631-635
46. Schweitzer, R., Howes, R., Smith, R., Shilo, B. Z., and Freeman, M (1995) Nature 376, 699-702